Literature summary for 2.7.11.24 extracted from

Qin, W.; Li, S.; Miao, Y.; Shi, Q.; Wang, Y.; Li, J.; Chen, Z.; Wang, J.; Ling, C.
Triptolide induces mitochondrial apoptosis through modulating dual specificity phosphatase 1/mitogen-activated protein kinases cascade in osteosarcoma cells (2018), Neoplasma, 65, 21-33 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
PD98059	ERK inhibitor	Homo sapiens
SB203580	p38 inhibitor	Homo sapiens
SP600125	JNK1/2 inhibitor	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MG-63 cell	-	Homo sapiens	-
osteosarcoma cell	-	Homo sapiens	-
U2-OS cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ERK1/2	-	Homo sapiens
JNK1/2	-	Homo sapiens
MAP kinase	-	Homo sapiens
MAPK	-	Homo sapiens
p38	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	enzyme inhibition can counteract triptolide-induced apoptosis	Homo sapiens
physiological function	the modulation of dual-specificity protein phosphatase1/mitogen-activated protein kinase cascade is associated with the apoptosis of osteosarcoma cells. The dual-specificity protein phosphatase1-dependent activation of the enzyme enhances antitumor effect of triptolide	Homo sapiens

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Release 2023.1 (January 2023)