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Enzyme Nomenclature
Information on EC 2.7.4.6 - nucleoside-diphosphate kinase
for references in articles please use BRENDA:EC2.7.4.6
Word Map on EC 2.7.4.6
- 2.7.4.6
- carcinoma
- triphosphate
- breast
- gdp
- node
- lymph
- adenylate
- metastases
-
squamous
- tumour
-
autophosphorylation
- guanine
- melanoma
- colorectal
-
hexameric
- dictyostelium
-
clinicopathological
-
gamma-phosphate
-
gtp-binding
- discoideum
-
anti-metastatic
- creatine
-
transphosphorylation
- myxococcus
- deoxynucleoside
-
prune
-
phosphoenzyme
-
phosphohistidine
-
metastasis-associated
- xanthus
-
non-metastatic
-
phytochrome
- deoxyribonucleoside
- succinyl-coa
- dntp
-
metastasis-related
-
c-erbb-2
- drug development
- medicine
- mastoparan
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
2.7.4.6
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RECOMMENDED NAME
GeneOntology No.
nucleoside-diphosphate kinase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors
-
-
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
the catalytic mechanism involves a phosphoenzyme intermediate
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
the catalytic mechanism involves a phosphoenzyme intermediate
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
the catalytic mechanism involves a phosphoenzyme intermediate
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
the catalytic mechanism involves a phosphoenzyme intermediate
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
phosphoenzyme intermediate with 2-4 mol phosphate per mol of enzyme
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
phosphoenzyme intermediate with 2-4 mol phosphate per mol of enzyme
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
phosphoenzyme intermediate with 2-4 mol phosphate per mol of enzyme
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
mechanism, role of 3-OH moiety of nucleotide
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
two-step ping-pong mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
isozyme NDPKB shows a ping-pong phospho-transfer mechanism, salt and nucleotide dependent NDPKB assembly is dynamic and requires its catalytic activity
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
ping pong mechanism with formation of an enzyme intermediate phosphorylated at His118
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
ping pong mechanism with formation of an enzyme intermediate phosphorylated at His118
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
the reaction catalyzed by NDK starts with the transfer of a phosphate from ATP to His117. ADP is then released and the acceptor nucleoside diphosphate is bound and phosphorylated. Nucleotide phosphates are coordinated by a network of basic Arg and His residues, and a polar Thr. All NDKs follow a ping-pong enzymatic mechanism involving a phosphorylated histidine residue in the active site
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
two-step ping-pong mechanism
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
ATP:nucleoside-diphosphate phosphotransferase
Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.
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CAS REGISTRY NUMBER
COMMENTARY
9026-51-1
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
cv. Bright Yellow 2; study on mitochondria during programmed cell death
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-
enzyme forms complexes with G protein beta gamma dimers and contributes to G protein activation
-
-
infected by bacteriophage T4, host-coded enzyme from infected Escherichia coli is part of bacteriophage T4 dNTP-synthesizing multi-enzyme complex
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-
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642633, 642634, 642635, 642641, 642656, 642661, 642665, 642669, 642672, 642680, 642682, 661420, 674398, 691523, 705675, 721737, 723631
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-
haloalkaliphilic archaeon, enzyme binds specifically to natronobacterial flagellins
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isozyme NDPK3; recombinant isoform Ndpk3, enzyme additionally has nuclease activity cleaving supercoiled plasmid DNA, tRNAs or the 3UTR of atp9 mRNA
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-
-
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
evolution
enzymes from Halomonas sp strain 593 and Chromohalobacter salexigens strain DSM3043 show very high sequence homology to each other, in both enzymes, residue C139 is conserved
evolution
enzymes from Halomonas sp strain 593 and Chromohalobacter salexigens strain DSM3043 show very high sequence homology to each other, in both enzymes, residue C139 is conserved
evolution
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enzymes from Halomonas sp strain 593 and Chromohalobacter salexigens strain DSM3043 show very high sequence homology to each other, in both enzymes, residue C139 is conserved
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evolution
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enzymes from Halomonas sp strain 593 and Chromohalobacter salexigens strain DSM3043 show very high sequence homology to each other, in both enzymes, residue C139 is conserved
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malfunction
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loss of Nm23-H1 in diploid cells leads to cytokinetic furrow regression, followed by cytokinesis failure and generationof tetraploid cells. The loss of Nm23-H1, an event suspected to promote metastasis, additionally functions at an earlier stage of tumor development to drive the acquisition of chromosomal instability
malfunction
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the stable knockout mutant Mtb Ndk-AS displays attenuated intracellular survival along with reduced persistence in the lungs of infected mice. Mutant Mtb Ndk-AS, which lost the capacity to disrupt Rac1-p67phox interaction, induces a strong ROS production. Given the established link between NOX2 activation and apoptosis, the proportion of Annexin V positive cells and levels of intracellular active caspase 3 are significantly higher in cells infected with Mtb Ndk-AS compared to wild-type Mtb. Knockdown of Ndk converts Mtb into a pro-apoptotic mutant strain that has a phenotype of increased susceptibility to intracellular killing and reduced virulence in vivo, phenotype, overview. Disruption of Ndk expression converts Mtb into a mutant strain that induces strong ROS and apoptosis responses. This phenotype is associated with reduced survival of Ndk mutant in vitro and in vivo
metabolism
nucleoside diphosphate kinase and flagellin from Pseudomonas aeruginosa induce interleukin 1 expression via the Akt/NF-kappaB signaling pathways
metabolism
proteomic analysis in wild-type and knockout mutant plants under normal or phenanthrene stress conditions, genes expression analysis, overview
metabolism
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proteomic analysis in wild-type and knockout mutant plants under normal or phenanthrene stress conditions, genes expression analysis, overview
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physiological function
NDPK-D is proposed to couple ATP export through adenine nucleotide translocator to the synthesis of the other nucleoside triphosphates e.g. GTP
physiological function
-
isoform NDPK-D alters membrane organisation in terms of fluidity, hydration and lipid clusterin, mediates contact sites and contributes to the mitochondrial intermembrane space structuring
physiological function
there is a strong interaction between isoform NDPK2 and CAT1 in R3-1 plants, which possibly plays a vital role in the antioxidant defense against reactive oxygen species
physiological function
-
nucleoside diphosphate kinase exhibits GTPase activating protein activity towards Rab5 and Rab7. The enzyme is a putative virulence factor that inhibits phagosome maturation and promotes survival of mycobacteria within the macrophage
physiological function
-
the enzyme inhibits phagocytosis (but not amoeboid motility) and macropinocytosis which contrasts with its positive regulatory role in micropinocytosis. The enzyme has no effect on multicellular development and promotes growth in liquid
physiological function
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nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis
physiological function
key enzyme in maintaining cellular pools of all nucleoside triphosphates
physiological function
the enzyme catalyzes the third phosphorylation of nucleoside diphosphates, leading to nucleoside triphosphates for DNA replication. Enzyme NDK may phosphorylate nucleotide analogues to inhibit the viral infections that attack this organism
physiological function
-
nucleoside diphosphate kinase is involved in the catalysis of the transfer of gamma-phosphate from nucleoside triphosphate to nucleoside diphosphate and thus maintains the nucleotide pool. The dNTPs that are formed are used as precursors for DNA and RNA synthesis. NTPs, specifically GTP, are important for cellular macromolecular synthesis and signalling mechanisms. Ndk plays a pivotal role in crucial events like bacterial growth, signal transduction, and pathogenicity
physiological function
nucleoside diphosphate kinase is a key enzyme in the control of cellular concentrations of nucleoside triphosphates, and plays important roles in many cellular processes
physiological function
nucleoside diphosphate kinase mediates bacterially induced toxicity against eukaryotic cells. Bacterial Ndk, with the aid of an additional bacterial factor, flagellin, induces expression of the proinflammatory cytokines interleukin-1alpha and -1beta in human host cells A-549. Cytokine induction appears to be dependent on the kinase activity of Ndk and is mediated via the NF-kappaB signaling pathway. Flagellin is required for the induction of the IL-1alpha and IL-1beta genes. Ndk activates the Akt signaling pathway, which acts upstream of NF-kappaB, as well as caspase-1, which is a key component of inflammasome
physiological function
Arabidopsis thaliana nucleoside diphosphate kinase, NDPK-3, is involved in stress signaling in response to polycyclic aromatic hydrocarbon exposure. Isozyme NDPK3 is a positive regulator in the Arabidopsis response to phenanthrene stress
physiological function
role of interaction and nucleoside diphosphate kinase B in regulation of the cystic fibrosis transmembrane conductance regulator function by cAMP-dependent protein kinase A, overview. Nucleoside diphosphate kinase B selectively forms a functional complex with CFTR, the nucleotide binding domain 1 (NBD1, aa 351-727) of CFTR constitutes an NDPK-B interaction site with CFTR, but NDPK-B associates only with cell surface CFTR. A functional interaction between CFTR, AMPKalpha1 and NDPK-A exists which is independent of NDPK-B. NDPK-B is important for the cAMP/PKA regulation of CFTR function
physiological function
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the enzyme is involved in the mechanism of Mycobacterium tuberculosis persistence in the host macrophage and inactivates small GTPases leading to evasion of innate immunity. Nucleoside diphosphate kinase contributes to phagosome maturation arrest via inactivation of Rab5 and Rab7. Ndk also targets and inactivates the small GTPase Rac1, an essential component of the macrophage NADPH oxidase (NOX2) complex. Ndk-dependent inactivation of Rac1 is associated with reduced NOX2-mediated production of reactive oxygen species (ROS) and ROS-dependent apoptosis. Ndk-mediated inhibition of ROS reduces the macrophage killing capability. The organism uses Ndk as GAP activity towards macrophage Rac1
physiological function
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Arabidopsis thaliana nucleoside diphosphate kinase, NDPK-3, is involved in stress signaling in response to polycyclic aromatic hydrocarbon exposure. Isozyme NDPK3 is a positive regulator in the Arabidopsis response to phenanthrene stress
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physiological function
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the enzyme inhibits phagocytosis (but not amoeboid motility) and macropinocytosis which contrasts with its positive regulatory role in micropinocytosis. The enzyme has no effect on multicellular development and promotes growth in liquid
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physiological function
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key enzyme in maintaining cellular pools of all nucleoside triphosphates
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physiological function
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nucleoside diphosphate kinase is a key enzyme in the control of cellular concentrations of nucleoside triphosphates, and plays important roles in many cellular processes
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additional information
LvNDK has a nucleotide-binding site and a catalytic histidine nucleophile His117, which is part of a phosphorelay that transfers a phosphoryl group obtained from ATP to the nucleoside diphosphate, substrate binding structures, overview
additional information
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LvNDK has a nucleotide-binding site and a catalytic histidine nucleophile His117, which is part of a phosphorelay that transfers a phosphoryl group obtained from ATP to the nucleoside diphosphate, substrate binding structures, overview
additional information
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Acinetobacter baumannii NDK structure comparison with the structure of the Myxococcus xanthus enzyme NDK. Acinetobacter baumannii NDK might share a similar catalytic mechanism with Myxococcus xanthus NDK
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2',3'-dehydro-3'-deoxyTDP + ATP
2',3'-dehydro-3'-deoxyTTP + ADP
-
-
-
?
3'-fluoro-2',3'-dideoxyUDP + ATP
3'-fluoro-2',3'-dideoxyUTP + ADP
better than 2,3-dideoxyUDP, but much poorer than 2-deoxyUDP
-
-
?
3'-fluoro-3'-deoxyTDP + ATP
3'-fluoro-3'-deoxyTTP + ADP
-
-
-
?
ATP + XDP
ADP + XTP
-
reaction at 37% the rate of UDP
-
-
?
GTP-bound Ras protein + NDP
GDP-bound Ras protein + NTP
-
in vitro, inactivation of mutant oncogenic Ras proteins
-
-
?
ATP + 8-bromoinosine 5'-diphosphate
ADP + 8-bromoinosine 5'-triphosphate
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-
-
-
?
ATP + 8-bromoinosine 5'-diphosphate
ADP + 8-bromoinosine 5'-triphosphate
-
-
-
-
?
ATP + ADP
ADP + ATP
-
less effective dinucleotide substrate
-
?
ATP + ADP
ADP + ATP
-
reaction at 94% the rate of UDP
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?
ATP + CDP
ADP + CTP
-
outer mitochondrial membrane-bound NDPK activity is involved in functional coupling to oxidative phosphorylation
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-
?
ATP + CDP
ADP + CTP
-
reaction at 92% the rate of UDP
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?
ATP + dADP
ADP + dATP
-
reaction at 59% the rate of UDP
-
-
?
ATP + dCDP
ADP + dCTP
-
reaction at 61% the rate of UDP
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-
?
ATP + dGDP
ADP + dGTP
dGDP is preferred over dTDP as an acceptor
-
-
?
ATP + dGDP
ADP + dGTP
-
less effective dinucleotide substrate
-
?
ATP + dGDP
ADP + dGTP
-
reaction at 55% the rate of UDP
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?
ATP + dNDP
ADP + dNTP
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
-
-
?
ATP + dNDP
ADP + dNTP
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
-
-
?
ATP + dNDP
ADP + dNTP
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
-
-
?
ATP + dTDP
ADP + dTTP
-
in decreasing order of activity: UDP, dUDP, dCDP, GDP, dGDP, CDP
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-
?
ATP + dTDP
ADP + dTTP
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in decreasing order of activity: dGDP, IDP, UDP, dUDP, CDP, GDP, dCDP
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?
ATP + dTDP
ADP + dTTP
-
highly effective dinucleotide substrate
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?
ATP + dTDP
ADP + dTTP
-
reaction at 27% the rate of UDP
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-
?
ATP + dUDP
?
-
reaction at 39% the rate of UDP
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-
?
ATP + GDP
ADP + GTP
assay by spontaneous release of GDP from G proteins. This GDP serves as a substrate for phosphotransfer by the NDPK, and the formed GTP then binds back to the G protein. NDPK is able to transfer phosphate also onto denatured proteins and thus also on the covalently linked GDP
-
-
r
ATP + GDP
ADP + GTP
-
an essential function of NDP kinase in ROS is phosphorylation of GDP to GTP, which is crucial for providing the functional cycle of transducin independently of its activation
-
-
?
ATP + GDP
ADP + GTP
-
assay by spontaneous release of GDP from G proteins. This GDP serves as a substrate for phosphotransfer by the NDPK, and the formed GTP then binds back to the G protein. NDPK is able to transfer phosphate also onto denatured proteins and thus also on the covalently linked GDP
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-
r
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates, enzyme is able to specifically interact with proteins encoded by the bacteriophage T4
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-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates, NM23 metastasis suppressor involved in inactivation of oncogenic forms of Ras proteins
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-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleoside triphosphates
-
-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleoside triphosphates, excreted enzyme enters the nucleus of HeLa and COS-1 cells and nicks chromosomal DNA in situ
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-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates, extracellular enzyme contributes to ATP-induced cell death of macrophages
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-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates, extracellular enzyme contributes to ATP-induced cell death of macrophages
-
-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleoside triphosphates, involved in coleoptile elongation and anaerobic stress response
-
-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleosides triphosphates, broad substrate specificity, in plants involved in different signaling pathways
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + nucleoside diphosphate
ADP + nucleoside triphosphate
-
analysis of ATP binding by the enzyme at different concentrations and pH values, overview
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-
r
ATP + nucleoside diphosphate
ADP + nucleoside triphosphate
-
-
-
r
ATP + nucleoside diphosphate
ADP + nucleoside triphosphate
this reaction is a reversible phosphate transfer to both ribonucleoside and deoxyribonucleoside diphosphates using NTP as a phosphate donor to provide adequate nucleosides for RNA or DNA synthesis
-
-
r
ATP + TDP
ADP + TTP
the enzyme activity depends largely upon the membrane-bound state
-
-
r
ATP + TDP
ADP + TTP
-
the enzyme activity depends largely upon the membrane-bound state
-
-
r
ATP + UDP
ADP + UTP
NDPK regulates a variety of eukaryotic cellular activities including cell proliferation, development, and differentiation
-
-
r
ATP + UDP
ADP + UTP
-
reverse reaction at 32% the rate of the reaction ATP plus ADP
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r
ATP + UDP
ADP + UTP
-
best dinucleotide substrate
-
r
dATP + ADP
dADP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
dATP + ADP
dADP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
dCTP + ADP
dCDP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
dCTP + ADP
dCDP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
dGTP + ADP
dGDP + ATP
the wild-type enzyme is not active when using dGTP as the phosphate donor. The Pyrobaculum aerophilum NDP kinase sequence contains two unique segments not present in other NDP kinases, comprising residues 66100 and 156165. Deletion mutants of the NDP kinase lacking either or both of these inserts have an altered substrate specificity, allowing dGTP as the phosphate donor
-
-
?
dGTP + ADP
dGDP + ATP
the wild-type enzyme is not active when using dGTP as the phosphate donor. The Pyrobaculum aerophilum NDP kinase sequence contains two unique segments not present in other NDP kinases, comprising residues 66100 and 156165. Deletion mutants of the NDP kinase lacking either or both of these inserts have an altered substrate specificity, allowing dGTP as the phosphate donor
-
-
?
dTTP + ADP
dTDP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
dTTP + ADP
dTDP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
GTP + ADP
GDP + ATP
-
GDP is less effective dinucleotide substrate
-
r
GTP + ADP
GDP + ATP
-
reverse reaction at 62% the rate of UDP
-
r
GTP + GDP
GDP + GTP
-
in decreasing order of activity: UTP, dGTP, dTTP, CTP, dCTP, dUTP
-
?
ITP + ADP
IDP + ATP
-
reverse reaction at 42% the rate of UDP
-
?
NDP + NTP
NTP + NDP
-
may be involved in regulation of growth, development and signal-transduction processes
-
-
-
NDP + NTP
NTP + NDP
-
enzyme forms complexes with G protein beta gamma dimers and contributes to G protein activation
-
-
r
NDP + NTP
NTP + NDP
-
overview on roles in metabolic pathways and nucleic acid synthesis
-
-
-
NDP + NTP
NTP + NDP
-
major component of nucleoside triphosphate synthetic pathway
-
-
-
NDP + NTP
NTP + NDP
-
autophosphorylation and phosphorylation of histone H1
-
-
-
NTP + NDP
NDP + NTP
NDPK is a key metabolic enzyme that catalyzes the synthesis of non-adenine nucleoside triphosphate by transferring the terminal phosphate between NDP and NTP
-
-
r
NTP + NDP
NDP + NTP
the high-energy phosphate is mainly supplied by ATP, but the enzymes have broad substrate specificity and use the ribose and deoxyribose forms of both, purine and pyrimidine nucleotides, ping-pong mechanism with a phosphoenzyme/phosphohistidine intermediary involved in the transfer reaction, overview
-
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
no substrates are several nucleoside monophosphates
-
-
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the nature of the nucleoside triphosphate controls the rate of the reaction
-
-
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate 8-aza-UDP, human erythrocytic pI-variant 5.8
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r