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Information on EC 2.7.4.6 - nucleoside-diphosphate kinase
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2.7.4.6 nucleoside-diphosphate kinaseIUBMB Comments
Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.
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Word Map
- 2.7.4.6
- triphosphate
- node
- gdp
- lymph
- adenylate
- metastases
- colorectal
- guanine
-
autophosphorylation
- melanoma
- dictyostelium
- creatine
-
hexameric
- discoideum
-
gamma-phosphate
-
anti-metastatic
-
gtp-binding
- dntp
- deoxyribonucleoside
-
heterotrimeric
-
polymerases
-
transphosphorylation
-
phosphohistidine
-
translesion
- deoxynucleoside
- succinyl-coa
- myxococcus
-
phytochrome
-
prune
-
phosphoenzyme
- mastoparan
-
metastasis-associated
- xanthus
-
c-erbb-2
-
metastasis-related
-
nonmetastatic
- drug development
- medicine
The enzyme appears in viruses and cellular organisms
Synonyms
nm23-h1, nucleoside diphosphate kinase, ndp kinase, nm23-h2, ndpk2, ndpk-b, nucleoside diphosphokinase, ndk-1, nucleoside diphosphate kinase a, ndpk-d, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ASNDK
HsNDK
kinase, nucleoside diphosphate (phosphorylating)
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-
-
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MJ1265
NDK
NDK B
NDKB
NDP kinase
NDPK
NDPK-3
NDPK-C
NDPK-D
NDPK1
NDPK2
NDPK3
NDPKB
NM23
Nm23-H1
nucleoside 5'-diphosphate kinase
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-
-
-
nucleoside diphosphate (UDP) kinase
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-
-
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nucleoside diphosphate kinase
nucleoside diphosphate kinase 1
nucleoside diphosphate kinase 2
nucleoside diphosphate kinase B
nucleoside diphosphate kinase C
nucleoside diphosphate kinase D
nucleoside diphosphate phosphotransferase
nucleoside diphosphokinase
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-
-
-
nucleotide phosphate kinase
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-
-
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TcNDPK1
UDP kinase
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-
-
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uridine diphosphate kinase
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-
-
-
additional information
NDK
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-
-
-
NDK
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
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-
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nucleoside diphosphate kinase
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-
nucleoside diphosphate kinase
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
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-
-
additional information
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the enzyme belongs to the nucleoside diphosphate kinase family
additional information
-
the enzyme belongs to the nucleoside diphosphate kinase gene family
additional information
-
enzyme is able to specifically interact with proteins encoded by the bacteriophage T4
additional information
-
the enzyme belongs to the nucleoside diphosphate kinase family
additional information
the enzyme belongs to the nucleoside diphosphate kinase family
additional information
the enzyme belongs to the nucleoside diphosphate kinase family
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors
-
-
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
the catalytic mechanism involves a phosphoenzyme intermediate
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
the catalytic mechanism involves a phosphoenzyme intermediate
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
the catalytic mechanism involves a phosphoenzyme intermediate
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
the catalytic mechanism involves a phosphoenzyme intermediate
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
phosphoenzyme intermediate with 2-4 mol phosphate per mol of enzyme
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
phosphoenzyme intermediate with 2-4 mol phosphate per mol of enzyme
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
phosphoenzyme intermediate with 2-4 mol phosphate per mol of enzyme
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
mechanism, role of 3’-OH moiety of nucleotide
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
mechanism
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
two-step ping-pong mechanism
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
isozyme NDPKB shows a ping-pong phospho-transfer mechanism, salt and nucleotide dependent NDPKB assembly is dynamic and requires its catalytic activity
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
ping pong mechanism with formation of an enzyme intermediate phosphorylated at His118
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
ping pong mechanism with formation of an enzyme intermediate phosphorylated at His118
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ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
the reaction catalyzed by NDK starts with the transfer of a phosphate from ATP to His117. ADP is then released and the acceptor nucleoside diphosphate is bound and phosphorylated. Nucleotide phosphates are coordinated by a network of basic Arg and His residues, and a polar Thr. All NDKs follow a ping-pong enzymatic mechanism involving a phosphorylated histidine residue in the active site
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
two-step ping-pong mechanism
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
MetaCyc
adenosine deoxyribonucleotides de novo biosynthesis, adenosine deoxyribonucleotides de novo biosynthesis II, CMP phosphorylation, guanosine deoxyribonucleotides de novo biosynthesis I, guanosine deoxyribonucleotides de novo biosynthesis II, guanosine ribonucleotides de novo biosynthesis, ppGpp biosynthesis, purine deoxyribonucleosides salvage, pyrimidine deoxyribonucleotide phosphorylation, pyrimidine deoxyribonucleotides biosynthesis from CTP, pyrimidine deoxyribonucleotides de novo biosynthesis I, pyrimidine deoxyribonucleotides de novo biosynthesis II, pyrimidine deoxyribonucleotides de novo biosynthesis III, pyrimidine deoxyribonucleotides de novo biosynthesis IV, superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli), UTP and CTP de novo biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
ATP:nucleoside-diphosphate phosphotransferase
Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.
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CAS REGISTRY NUMBER
COMMENTARY
9026-51-1
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2',3'-dehydro-3'-deoxyTDP + ATP
2',3'-dehydro-3'-deoxyTTP + ADP
-
-
-
?
3'-fluoro-2',3'-dideoxyUDP + ATP
3'-fluoro-2',3'-dideoxyUTP + ADP
better than 2’,3’-dideoxyUDP, but much poorer than 2’-deoxyUDP
-
-
?
3'-fluoro-3'-deoxyTDP + ATP
3'-fluoro-3'-deoxyTTP + ADP
-
-
-
?
ATP + XDP
ADP + XTP
-
reaction at 37% the rate of UDP
-
-
?
GTP-bound Ras protein + NDP
GDP-bound Ras protein + NTP
-
in vitro, inactivation of mutant oncogenic Ras proteins
-
-
?
ATP + 8-bromoinosine 5'-diphosphate
ADP + 8-bromoinosine 5'-triphosphate
-
-
-
-
?
ATP + 8-bromoinosine 5'-diphosphate
ADP + 8-bromoinosine 5'-triphosphate
-
-
-
-
?
ATP + ADP
ADP + ATP
-
less effective dinucleotide substrate
-
?
ATP + ADP
ADP + ATP
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reaction at 94% the rate of UDP
-
?
ATP + CDP
ADP + CTP
-
outer mitochondrial membrane-bound NDPK activity is involved in functional coupling to oxidative phosphorylation
-
-
?
ATP + CDP
ADP + CTP
-
reaction at 92% the rate of UDP
-
-
?
ATP + dADP
ADP + dATP
-
reaction at 59% the rate of UDP
-
-
?
ATP + dCDP
ADP + dCTP
-
reaction at 61% the rate of UDP
-
-
?
ATP + dGDP
ADP + dGTP
dGDP is preferred over dTDP as an acceptor
-
-
?
ATP + dGDP
ADP + dGTP
-
less effective dinucleotide substrate
-
?
ATP + dGDP
ADP + dGTP
-
reaction at 55% the rate of UDP
-
?
ATP + dNDP
ADP + dNTP
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
-
-
?
ATP + dNDP
ADP + dNTP
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
-
-
?
ATP + dNDP
ADP + dNTP
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
-
-
?
ATP + dTDP
ADP + dTTP
-
in decreasing order of activity: UDP, dUDP, dCDP, GDP, dGDP, CDP
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-
?
ATP + dTDP
ADP + dTTP
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in decreasing order of activity: dGDP, IDP, UDP, dUDP, CDP, GDP, dCDP
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?
ATP + dTDP
ADP + dTTP
-
highly effective dinucleotide substrate
-
?
ATP + dTDP
ADP + dTTP
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reaction at 27% the rate of UDP
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-
?
ATP + dUDP
?
-
reaction at 39% the rate of UDP
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-
?
ATP + GDP
ADP + GTP
assay by spontaneous release of GDP from G proteins. This GDP serves as a substrate for phosphotransfer by the NDPK, and the formed GTP then binds back to the G protein. NDPK is able to transfer phosphate also onto denatured proteins and thus also on the covalently linked GDP
-
-
r
ATP + GDP
ADP + GTP
-
an essential function of NDP kinase in ROS is phosphorylation of GDP to GTP, which is crucial for providing the functional cycle of transducin independently of its activation
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-
?
ATP + GDP
ADP + GTP
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assay by spontaneous release of GDP from G proteins. This GDP serves as a substrate for phosphotransfer by the NDPK, and the formed GTP then binds back to the G protein. NDPK is able to transfer phosphate also onto denatured proteins and thus also on the covalently linked GDP
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-
r
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
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-
?
ATP + NDP
ADP + NTP
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contributes to the maintenance of the cellular pools of all nucleosides triphosphates, enzyme is able to specifically interact with proteins encoded by the bacteriophage T4
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-
?
ATP + NDP
ADP + NTP
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contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
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contributes to the maintenance of the cellular pools of all nucleosides triphosphates, NM23 metastasis suppressor involved in inactivation of oncogenic forms of Ras proteins
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-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleoside triphosphates
-
-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleoside triphosphates, excreted enzyme enters the nucleus of HeLa and COS-1 cells and nicks chromosomal DNA in situ
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
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-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates, extracellular enzyme contributes to ATP-induced cell death of macrophages
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-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates, extracellular enzyme contributes to ATP-induced cell death of macrophages
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-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleoside triphosphates, involved in coleoptile elongation and anaerobic stress response
-
-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleosides triphosphates, broad substrate specificity, in plants involved in different signaling pathways
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + nucleoside diphosphate
ADP + nucleoside triphosphate
-
analysis of ATP binding by the enzyme at different concentrations and pH values, overview
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-
r
ATP + nucleoside diphosphate
ADP + nucleoside triphosphate
this reaction is a reversible phosphate transfer to both ribonucleoside and deoxyribonucleoside diphosphates using NTP as a phosphate donor to provide adequate nucleosides for RNA or DNA synthesis
-
-
r
ATP + TDP
ADP + TTP
the enzyme activity depends largely upon the membrane-bound state
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-
r
ATP + TDP
ADP + TTP
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the enzyme activity depends largely upon the membrane-bound state
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-
r
ATP + UDP
ADP + UTP
NDPK regulates a variety of eukaryotic cellular activities including cell proliferation, development, and differentiation
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-
r
ATP + UDP
ADP + UTP
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reverse reaction at 32% the rate of the reaction ATP plus ADP
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r
ATP + UDP
ADP + UTP
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best dinucleotide substrate
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r
dATP + ADP
dADP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
dATP + ADP
dADP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
dCTP + ADP
dCDP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
dCTP + ADP
dCDP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
dGTP + ADP
dGDP + ATP
the wild-type enzyme is not active when using dGTP as the phosphate donor. The Pyrobaculum aerophilum NDP kinase sequence contains two unique segments not present in other NDP kinases, comprising residues 66–100 and 156–165. Deletion mutants of the NDP kinase lacking either or both of these inserts have an altered substrate specificity, allowing dGTP as the phosphate donor
-
-
?
dGTP + ADP
dGDP + ATP
the wild-type enzyme is not active when using dGTP as the phosphate donor. The Pyrobaculum aerophilum NDP kinase sequence contains two unique segments not present in other NDP kinases, comprising residues 66–100 and 156–165. Deletion mutants of the NDP kinase lacking either or both of these inserts have an altered substrate specificity, allowing dGTP as the phosphate donor
-
-
?
dTTP + ADP
dTDP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
dTTP + ADP
dTDP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
GTP + ADP
GDP + ATP
-
GDP is less effective dinucleotide substrate
-
r
GTP + ADP
GDP + ATP
-
reverse reaction at 62% the rate of UDP
-
r
GTP + GDP
GDP + GTP
-
in decreasing order of activity: UTP, dGTP, dTTP, CTP, dCTP, dUTP
-
?
ITP + ADP
IDP + ATP
-
reverse reaction at 42% the rate of UDP
-
?
NDP + NTP
NTP + NDP
-
may be involved in regulation of growth, development and signal-transduction processes
-
-
-
NDP + NTP
NTP + NDP
-
enzyme forms complexes with G protein beta gamma dimers and contributes to G protein activation
-
-
r
NDP + NTP
NTP + NDP
-
overview on roles in metabolic pathways and nucleic acid synthesis
-
-
-
NDP + NTP
NTP + NDP
-
major component of nucleoside triphosphate synthetic pathway
-
-
-
NDP + NTP
NTP + NDP
-
autophosphorylation and phosphorylation of histone H1
-
-
-
NTP + NDP
NDP + NTP
NDPK is a key metabolic enzyme that catalyzes the synthesis of non-adenine nucleoside triphosphate by transferring the terminal phosphate between NDP and NTP
-
-
r
NTP + NDP
NDP + NTP
the high-energy phosphate is mainly supplied by ATP, but the enzymes have broad substrate specificity and use the ribose and deoxyribose forms of both, purine and pyrimidine nucleotides, ping-pong mechanism with a phosphoenzyme/phosphohistidine intermediary involved in the transfer reaction, overview
-
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
no substrates are several nucleoside monophosphates
-
-
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the nature of the nucleoside triphosphate controls the rate of the reaction
-
-
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate 8-aza-UDP, human erythrocytic pI-variant 5.8
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
-
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
in decreasing order of activity: UTP, dTTP, CTP, dATP, ATP, dGTP, GTP
-
-
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
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trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
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r
NTP + nucleoside diphosphate
NDP + NTP
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substrates: 6-aza-UDP, 8-aza-GDP
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r
NTP + nucleoside diphosphate
NDP + NTP
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the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
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r
NTP + nucleoside diphosphate
NDP + NTP
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transfers gamma-phosphate from NTP to any nucleoside diphosphate
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r
NTP + nucleoside diphosphate
NDP + NTP
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dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
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r
NTP + nucleoside diphosphate
NDP + NTP
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many ribo- and deoxyribonucleoside triphosphates act as donors
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r
NTP + nucleoside diphosphate
NDP + NTP
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trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
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r
NTP + nucleoside diphosphate
NDP + NTP
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substrates: 6-aza-UDP, 8-aza-GDP
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r
NTP + nucleoside diphosphate
NDP + NTP
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the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
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r
NTP + nucleoside diphosphate
NDP + NTP
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transfers gamma-phosphate from NTP to any nucleoside diphosphate
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r
NTP + nucleoside diphosphate
NDP + NTP
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dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
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r
NTP + nucleoside diphosphate
NDP + NTP
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many ribo- and deoxyribonucleoside triphosphates act as donors
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?
NTP + nucleoside diphosphate
NDP + NTP
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transfers gamma-phosphate from NTP to any nucleoside diphosphate
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?
UTP + CDP
UDP + CTP
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in decreasing order of activity: dATP, ITP, dTTP, ATP, dGTP, GTP, dCTP, CTP
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UTP + dCDP
UDP + dCTP
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in decreasing order of activity: ITP, dATP, dTTP, dGTP, GTP, ATP, CTP, dCTP
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?
UTP + dTDP
UDP + dTDP
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in decreasing order of activity: ITP, dATP, dTTP, GTP, ATP, dGTP, dUTP, CTP, dCTP
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?
UTP + dTDP
UDP + dTDP
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nucleoside triphosphates in decreasing order of activity: dTTP, CTP, dCTP, dATP, dGTP, GTP
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?
UTP + dTDP
UDP + dTDP
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nucleoside diphosphates in decreasing order of activity: CDP, UDP, GDP, dGDP, dCDP, dADP, ADP
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additional information
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role of enzyme in dUTP detoxification to compensate for the absence of a dUTPase in Mimivirus
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additional information
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preferential affinity for deoxypyrimidine nucleotides
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additional information
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the enzyme catalyzes transfer of the gamma-phosphate from a nucleoside triphosphate (NTP) to a nucleoside diphosphate (NDP)
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additional information
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NDPK is involved in multiple signaling pathways in mammalian systems, including G-protein signaling. Physical interaction between NDPK2 and small G proteins, as well as the heterotrimeric G protein GPA1. NDPK2 can stimulate their GTPase activities, but the dimeric form of NDPK2 is also unable to enhance the GTPase activities of both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
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additional information
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NDPK is involved in multiple signaling pathways in mammalian systems, including G-protein signaling. Physical interaction between NDPK2 and small G proteins, as well as the heterotrimeric G protein GPA1. NDPK2 can stimulate their GTPase activities, but the dimeric form of NDPK2 is also unable to enhance the GTPase activities of both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
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additional information
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NDPK2 is a H2O2 signaling protein that performs autophosphorylation. NDPK2 and H2O2 are involved in salt resistance, overview
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additional information
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nucleoside diphosphate kinase is a housekeeping enzyme that maintains the intracellular levels of all (d)NTPs used in biosynthesis except ATP, but it also plays a significant role in signal transduction pathways involved in oxidative stress. The enzyme protects the plants against reactive ocygen species, heat, and salt stress, overview
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additional information
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NDPK2 interacts with plant small G proteins in vitro, both Pra2 and Pra3both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
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additional information
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NDPK2 interacts with plant small G proteins in vitro, both Pra2 and Pra3both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
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additional information
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the enzyme's primary function is to maintain dNTP pools by converting deoxynucleotide diphosphates to triphosphates using ATP as the major phosphate donor
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additional information
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the enzyme's primary function is to maintain dNTP pools by converting deoxynucleotide diphosphates to triphosphates using ATP as the major phosphate donor
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additional information
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strong preference for D-enantiomers of antiviral nucleotide analogs like ddATP, ddCTP, 3'-deoxy-3'-thymidine, 2',3'-didehydro-2',3'-dideoxythymidine
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additional information
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binding affinity of NDPs with the recombinant enzyme measured by isothermal titration calorimetry, indicate that the purines nucleotides show higher binding affinity compared with pyrimidines. The recombinant enzyme rNDPK has a definite nuclease activity in vitro, which cleaves supercoiled plasmid DNA, but has no effect on dsDNA and ssDNA. No or poor activity with CDP and UDP
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additional information
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NDPK catalyzes the transfer of gamma-phosphate from nucleoside triphosphates to nucleoside diphosphates
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additional information
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substrate specificities of wild-type and G114R mutant enzymes, overview
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additional information
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critical role of the two amino acid residues, E134 and E135, at the carboxy-terminal region of NDK in determining the halophilic characteristics of the protein, overview
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additional information
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in the absence of nucleoside diphosphates the enzyme undergoes Mg2+-dependent stoichiometric autophosphorylation using ATP, GTP or gamma-thiotriphosphate as phosphate donor, 2 mol phosphate per mol enzyme
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additional information
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MDA-MB-435S cell-secreted NDPK-B supports tumour formation by modulating ATP levels locally to activate endothelial cell P2Y receptor-mediated angiogenesis, overview
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additional information
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NDPKA is a housekeeping enzyme essential for the synthesis of nonadenine nucleoside and deoxynucleoside 5'-triphosphate
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additional information
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the enzyme catalyzes transfer of the gamma-phosphate from a nucleoside triphosphate, NTP, to a nucleoside diphosphate, NDP
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additional information
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the transfer of high energetic phosphate by NDPK and/or the beta subunit of G proteins can induce G protein activation. Interaction of nucleoside diphosphate kinase B with heterotrimeric G protein betagamma dimers influencing the G protein activation and stability, mechanism, detailed overview
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additional information
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NDPK B acts as histidine kinase in a NDPK B/Gbetagamma complex, NDPK B/Gbetagamma complex formation, structure, and mode of action, overview. Nucleoside diphosphate kinase is a ubiquitous enzyme that catalyses the transfer of the gamma-phosphate from nucleoside 5'-triphosphates to nucleoside 5'-diphosphates by a ping-pong mechanism involving the formation of a high energy phosphate intermediate on His118
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additional information
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NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways
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additional information
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isoform NDPK-D is able to bind in a non-negligible manner to zwitterionic phosphatidylcholine
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additional information
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nucleoside diphosphate kinase B forms a functional complex with cell surface CFTR, binding analysis using peptide NDPK-B 36-54 (V36AMKFLRAS44EEHLKQHYID54), this region of NDPK-B, may constitute a key NDPK-B interaction domain for CFTR, the nucleotide binding domain 1 (NBD1, aa 351-727) of CFTR constitutes an NDPK-B interaction site with CFTR, surface plasmon resonance and NDPK-B and NBD1 protein-protein docking analysis
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additional information
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NdK is a stable enzyme capable of decreasing extracellular ATP levels
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additional information
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both recombinant and native Leishmania NdK utilized ATP to produce expected nucleoside triphosphates in the presence of nucleoside diphosphates in excess
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additional information
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NdK is a stable enzyme capable of decreasing extracellular ATP levels
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additional information
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both recombinant and native Leishmania NdK utilized ATP to produce expected nucleoside triphosphates in the presence of nucleoside diphosphates in excess
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additional information
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in the absence of nucleoside diphosphates the enzyme undergoes Mg2+-dependent stoichiometric autophosphorylation using ATP, GTP or gamma-thiotriphosphate as phosphate donor, 2 mol phosphate per mol enzyme
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additional information
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NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways
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