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Literature summary for 2.7.4.6 extracted from

  • Kandeel, M.; Miyamoto, T.; Kitade, Y.
    Bioinformatics, enzymologic properties, and comprehensive tracking of Plasmodium falciparum nucleoside diphosphate kinase (2009), Biol. Pharm. Bull., 32, 1321-1327.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli JM109 cells Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.42
-
dTDP
-
Plasmodium falciparum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ the presence of Mg2+ enhances enthalpy changes by stabilizing water molecule hydrogen bonding network, resulting in favorable enthalpy changes, the absence of Mg2+ induces a noticeable loss in binding enthalpies and positive favorable entropic changes in GDP binding, indicating a more unstable enzyme-ligand complex formation and lesser complex tightening Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
18000
-
SDS-PAGE Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + NDP Plasmodium falciparum
-
ADP + NTP
-
?
ATP + NDP Plasmodium falciparum FCR-3
-
ADP + NTP
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-
Plasmodium falciparum FCR-3
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Talon metal affinity resin column chromatography and Sephacryl S300 gel filtration Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + dTDP
-
Plasmodium falciparum ADP + dTTP
-
?
ATP + dTDP
-
Plasmodium falciparum FCR-3 ADP + dTTP
-
?
ATP + GDP
-
Plasmodium falciparum ADP + GTP
-
?
ATP + GDP
-
Plasmodium falciparum FCR-3 ADP + GTP
-
?
ATP + NDP
-
Plasmodium falciparum ADP + NTP
-
?
ATP + NDP
-
Plasmodium falciparum FCR-3 ADP + NTP
-
?

Synonyms

Synonyms Comment Organism
NDK
-
Plasmodium falciparum
nucleoside diphosphate kinase
-
Plasmodium falciparum
nucleoside diphosphate phosphotransferase
-
Plasmodium falciparum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25 42
-
Plasmodium falciparum

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50 70 enzyme activity is decreased by 70% at 50°C and completely lost after preincubation at 60°C, irreversible loss of activity is detected after treating the samples at temperatures above 70°C Plasmodium falciparum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.2
-
Plasmodium falciparum

pH Range

pH Minimum pH Maximum Comment Organism
6 9
-
Plasmodium falciparum

pH Stability

pH Stability pH Stability Maximum Comment Organism
7.5 9 the activity markedly drops as pH exceeds 7.8, about 25% relative activity at pH8.0-9.0 Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
ATP
-
Plasmodium falciparum