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Literature summary for 2.7.4.6 extracted from

  • Conery, A.R.; Sever, S.; Harlow, E.
    Nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis (2010), Proc. Natl. Acad. Sci. USA, 107, 15461-15466.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.6

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
foreskin
-
 Homo sapiens
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HBE135-E6E7 cell
-
 Homo sapiens
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HEK-293T cell
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 Homo sapiens
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HeLa cell
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 Homo sapiens
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keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GDP
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 Homo sapiens ADP + GTP
-
 ?

Synonyms

Synonyms Comment Organism
NDK
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 Homo sapiens
Nm23-H1
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 Homo sapiens
nucleoside diphosphate kinase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction loss of Nm23-H1 in diploid cells leads to cytokinetic furrow regression, followed by cytokinesis failure and generationof tetraploid cells. The loss of Nm23-H1, an event suspected to promote metastasis, additionally functions at an earlier stage of tumor development to drive the acquisition of chromosomal instability Homo sapiens
physiological function nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis Homo sapiens