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Literature summary for 2.7.4.6 extracted from

  • Reigada, C.; Saye, M.; Girolamo, F.D.; Valera-Vera, E.A.; Pereira, C.A.; Miranda, M.R.
    Role of Trypanosoma cruzi nucleoside diphosphate kinase 1 in DNA damage responses (2020), Mem. Inst. Oswaldo Cruz, 115, e200019 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.6

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli or in Saccharomyces cerevisiae Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi Q4E256
-
-
Trypanosoma cruzi CL Brener Q4E256
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epimastigote
-
 Trypanosoma cruzi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme has nuclease activity and DNA-binding properties in vitro Trypanosoma cruzi ?
-
-
additional information the enzyme has nuclease activity and DNA-binding properties in vitro Trypanosoma cruzi CL Brener ?
-
-

Synonyms

Synonyms Comment Organism
nucleoside diphosphate kinase 1
-
 Trypanosoma cruzi
TcNDPK1
-
 Trypanosoma cruzi

General Information

General Information Comment Organism
physiological function parasites overexpressing TcNDPK1 are able to withstand genotoxic stresses caused by hydrogen peroxide, phleomycin and hidroxyurea. They also present less genomic damage and augmented levels of poly(ADP) ribose and poly(ADP)ribose polymerase, an enzyme involved in DNA repair Trypanosoma cruzi