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Literature summary for 2.7.4.6 extracted from

  • Valenti, D.; Vacca, R.A.; de Pinto, M.C.; De Gara, L.; Marra, E.; Passarella, S.
    In the early phase of programmed cell death in Tobacco Bright Yellow 2 cells the mitochondrial adenine nucleotide translocator, adenylate kinase and nucleoside diphosphate kinase are impaired in a reactive oxygen species-dependent manner (2007), Biochim. Biophys. Acta, 1767, 66-78.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information heat shock causes a non-competitive inhibition of the enzyme, which is partly prevented by ascorbate, effects of heat shock on mitochondrial metabolism overview Nicotiana tabacum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane NDPK is attached to the outer side of the inner the membrane Nicotiana tabacum 5743
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mitochondrion after 2 h from heat shock, rate of ADT/ATP exchange by adenine nucleotide translocator activity, adenylate kinase activity EC 2.7.4.3 and nucleoside diphosphate kinase are inhibited in a non-competitive-like manner. Externally added ascorbate prevents the inhibition Nicotiana tabacum 5739
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Organism

Organism UniProt Comment Textmining
Nicotiana tabacum
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study on mitochondria during programmed cell death
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Nicotiana tabacum
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cv. Bright Yellow 2
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Purification (Commentary)

Purification (Comment) Organism
native enzyme partially by mitochondrion preparation from protoplasts Nicotiana tabacum

Source Tissue

Source Tissue Comment Organism Textmining
TBY-2 cell
-
Nicotiana tabacum
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TBY-2 cell i.e. Tobacco Bright Yellow 2 cells Nicotiana tabacum
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Tobacco Bright Yellow 2 cell
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Nicotiana tabacum
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + CDP
-
Nicotiana tabacum ADP + CTP
-
r
ATP + TDP
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Nicotiana tabacum ADP + TTP
-
r
ATP + UDP
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Nicotiana tabacum ADP + UTP
-
r

Synonyms

Synonyms Comment Organism
NDPK
-
Nicotiana tabacum
nucleoside diphosphate kinase
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Nicotiana tabacum