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Literature summary for 2.7.4.6 extracted from

  • Adam, K.; Lesperance, J.; Hunter, T.; Zage, P.
    The potential functional roles of NME1 histidine kinase activity in neuroblastoma pathogenesis (2020), Int. J. Mol. Sci., 21, 3319 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.6

Application

Application Comment Organism
medicine NME1 expression is associated with reduced overall and event-free survival of neuroblastoma patients and with the strongest associations of any of the NME family member genes. NME1 expression is also higher in tumors with MYCN oncogene amplification and in tumors from patients with stage 4 disease. Isoforms NME1/NMe2 and multiple phosphorylated His-containing proteins are found in all tested neuroblastoma cell lines and in xenograft neuroblastoma tumors. NME1 expression is asssociated with neuroblastoma cell migration and differentiation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
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Organism

Organism UniProt Comment Textmining
Homo sapiens P15531 additionally displays histidine kinase activity, EC 2.7.13.3
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation at residue H118 Homo sapiens

Synonyms

Synonyms Comment Organism
NM23
-
 Homo sapiens
NME1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function NME1 depletion impacts migration and differentiation but not proliferation in neuroblastoma cells. Candidate targets of NME1 histidine kinase activity include ENO1, GAPDH, and PKM Homo sapiens