KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.47 | - |
dTDP | pH 7.5, 35°C, isozyme NDPK2 | Trypanosoma cruzi strain CL Brener | |
0.86 | - |
dTDP | pH 7.5, 35°C, isozyme NDPK1 | Trypanosoma cruzi strain CL Brener |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | mainly | Trypanosoma cruzi strain CL Brener | 5829 | - |
mitochondrion | slightly | Trypanosoma cruzi strain CL Brener | 5739 | - |
additional information | subcellular localization analysis, overview | Trypanosoma cruzi strain CL Brener | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Trypanosoma cruzi strain CL Brener |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dTDP | Trypanosoma cruzi strain CL Brener | - |
ADP + dTTP | - |
r | |
additional information | Trypanosoma cruzi strain CL Brener | kinetic parameters and regulation mechanisms of NDPK1 and NDPK2, overview | ? | - |
? | |
NTP + NDP | Trypanosoma cruzi strain CL Brener | - |
NDP + NTP | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi strain CL Brener | Q4E256 | multiple enzyme isoforms | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epimastigote | - |
Trypanosoma cruzi strain CL Brener | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dTDP | - |
Trypanosoma cruzi strain CL Brener | ADP + dTTP | - |
r | |
additional information | kinetic parameters and regulation mechanisms of NDPK1 and NDPK2, overview | Trypanosoma cruzi strain CL Brener | ? | - |
? | |
NTP + NDP | - |
Trypanosoma cruzi strain CL Brener | NDP + NTP | - |
r | |
NTP + NDP | the high-energy phosphate is mainly supplied by ATP, but the enzymes have broad substrate specificity and use the ribose and deoxyribose forms of both, purine and pyrimidine nucleotides, ping-pong mechanism with a phosphoenzyme/phosphohistidine intermediary involved in the transfer reaction, overview | Trypanosoma cruzi strain CL Brener | NDP + NTP | - |
r |
Subunits | Comment | Organism |
---|---|---|
More | NDPK1 is a short enzyme isoform, whereas NDPK2 is a long one containing a DM10 motif | Trypanosoma cruzi strain CL Brener |
Synonyms | Comment | Organism |
---|---|---|
NDPK | - |
Trypanosoma cruzi strain CL Brener |
nucleoside diphosphate kinase | - |
Trypanosoma cruzi strain CL Brener |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
35 | - |
assay at | Trypanosoma cruzi strain CL Brener |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Trypanosoma cruzi strain CL Brener |