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Literature summary for 2.7.4.6 extracted from

  • Gross, S.; Devraj, K.; Feng, Y.; Macas, J.; Liebner, S.; Wieland, T.
    Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation (2017), J. Cereb. Blood Flow Metab., 37, 2471-2484 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.6

Organism

Organism UniProt Comment Textmining
Mus musculus Q01768
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-

Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Mus musculus
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endothelial cell
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 Mus musculus
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Synonyms

Synonyms Comment Organism
NDPK-B
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 Mus musculus
nucleoside diphosphate kinase B
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 Mus musculus

General Information

General Information Comment Organism
malfunction nucleoside diphosphate kinase B depletion alone impairs caveolae formation, vascular endothelial growth factor (VEGF)-induced phosphorylation of c-Src/Cav-1 but not of ERK1/2/AKT/eNOS. Primary mouse brain endothelial cells from nucleoside diphosphate kinase Bx02-/-x02 mice show no change in caveolae content and transendothelial-electrical resistance upon VEGF stimulation. Nucleoside diphosphate kinase Bx02-/-x02 primary mouse brain endothelial cells display an accumulation of intracellular vesicles and increased caveolin-1 levels. Dextran tracer analysis shows increased vascular permeability in the brain of nucleoside diphosphate kinase Bx02-/-x02 mice compared to wild type Mus musculus
physiological function the enzyme is required for nucleoside triphosphate homeostasis. It is also required for the correct localization of caveolin-1 at the plasma membrane and the formation of caveolae Mus musculus