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5'-methyl,5'-deoxymethylthioadenosine + putrescine
?
putrescine + (methyl-14C)-S-adenosylmethioninamine
spermidine + ?
-
-
-
-
?
putrescine + S-5'-deoxyadenosyl-(5')-3-methylthiopropylamine
spermidine + ?
-
-
-
-
?
putrescine + S-adenosylmethioninamine
spermidine + 5'-methylthioadenosine
S-5'-deoxyadenosyl-5'-3-butylthiopropylamine + 1,4-diaminobutane
?
-
-
-
-
?
S-5'-deoxyadenosyl-5'-3-ethylthiopropylamine + 1,4-diaminobutane
?
S-5'-deoxyadenosyl-5'-3-propylthiopropylamine + 1,4-diaminobutane
?
S-adenosyl 3-(methylsulfanyl)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
S-adenosyl 3-(methylthio)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,3-diaminopropane
?
-
weak substrate
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diamino-2-butene
5'-methylthioadenosine + N-3-aminopropyl-1,4-diamino-2-butene
-
-
in a lower yield than with the natural combination
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diamino-2-butene
?
-
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diamino-2-butene
N-3-aminopropyl-1,4-diamino-2-butene + 5'-methylthioadenosine
-
-
forms with a low yield
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
?
-
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,6-diaminohexane
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1-methyl-1,4-butanediamine
?
-
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 2,2-difluoro-1,4-diaminobutane
?
-
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 2-chloro-1,4-diaminobutane
?
-
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 2-hydroxy-1,4 butanediamine
?
-
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 2-methyl-1,4-diaminobutane
?
-
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + spermidine
5'-methylthioadenosine + spermine
S-adenosyl-(5')-3-methylthiopropylamine + 1,4-diaminobutane
?
-
-
-
-
?
S-adenosyl-3-butylthio-1-propylamine + 1,4-diaminobutane
?
-
prostate enzyme
-
-
?
S-adenosyl-3-carboxymethylthio-1-propylamine + 1,4-diaminobutane
?
-
-
-
-
?
S-adenosyl-3-ethylthio-1-propylamine + 1,4-diaminobutane
?
S-adenosyl-3-methylthio-1-propylamine + 1,3-diaminopentane
?
-
poor substrate
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
S-adenosyl-3-propylthio-1-propylamine + 1,4-diaminobutane
?
S-adenosyl-3-thiopropylamine sulfone + 1,4-diaminobutane
?
-
-
-
-
?
S-adenosyl-3-thiopropylamine sulfoxide + 1,4-diaminobutane
?
S-adenosyl-5',1-methyl-3-methylthiopropylamine + 1,4-diaminobutane
?
S-adenosyl-L-ethionine + 1,4-diaminobutane
?
S-adenosyl-L-homocysteine sulfone + 1,4-diaminobutane
?
S-adenosyl-L-methionine + 1,4-diaminobutane
?
S-adenosylmethioninamine + putrescine
5'-methylthioadenosine + spermidine
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
S-adenosylmethioninamine + putrescine
spermidine + 5'-methylthioadenosine
spermidine + S-adenosylmethioninamine
spermine + 5'-methylthioadenosine
in contrast to mammalian spermidine synthases, spermidine can replace to some extent putrescine as the aminopropyl acceptor
-
-
?
additional information
?
-
5'-methyl,5'-deoxymethylthioadenosine + putrescine
?
low activity
-
-
?
5'-methyl,5'-deoxymethylthioadenosine + putrescine
?
low activity
-
-
?
putrescine + S-adenosylmethioninamine
spermidine + 5'-methylthioadenosine
-
-
-
-
?
putrescine + S-adenosylmethioninamine
spermidine + 5'-methylthioadenosine
-
-
-
-
?
putrescine + S-adenosylmethioninamine
spermidine + 5'-methylthioadenosine
-
-
-
ir
putrescine + S-adenosylmethioninamine
spermidine + 5'-methylthioadenosine
-
-
-
?
putrescine + S-adenosylmethioninamine
spermidine + 5'-methylthioadenosine
-
-
-
-
?
putrescine + S-adenosylmethioninamine
spermidine + 5'-methylthioadenosine
-
-
-
?
S-5'-deoxyadenosyl-5'-3-ethylthiopropylamine + 1,4-diaminobutane
?
-
-
-
-
?
S-5'-deoxyadenosyl-5'-3-ethylthiopropylamine + 1,4-diaminobutane
?
-
-
-
-
?
S-5'-deoxyadenosyl-5'-3-propylthiopropylamine + 1,4-diaminobutane
?
-
-
-
-
?
S-5'-deoxyadenosyl-5'-3-propylthiopropylamine + 1,4-diaminobutane
?
-
-
-
-
?
S-adenosyl 3-(methylsulfanyl)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosyl 3-(methylsulfanyl)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosyl 3-(methylsulfanyl)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosyl 3-(methylsulfanyl)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosyl 3-(methylsulfanyl)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
the enzyme is highly specific for putrescine as an amine acceptor. When using cadaverine or 1,6-hexanediamine, a diamine with longer chain length, there is no detectable product formation
-
-
?
S-adenosyl 3-(methylsulfanyl)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosyl 3-(methylsulfanyl)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
the enzyme is highly specific for putrescine as an amine acceptor. When using cadaverine or 1,6-hexanediamine, a diamine with longer chain length, there is no detectable product formation
-
-
?
S-adenosyl 3-(methylsulfanyl)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosyl 3-(methylsulfanyl)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
derivatives of 1,4-diaminobutane are substrates too. Substitution of 1,4-diaminobutane in the immediate vicinity of an amino group produces weak substrates, whereas substituents in the 2-position are tolerated
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
analogues of decarboxylated S-adenosylmethionine act as propylamine donors
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
the reaction is linear from 1 to 10 nmol of spermidine
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
ir
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
+ H+
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
linear at least up to 6 nmol of spermidine formed, linearity not maintained in the absence of DTT
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
the enzyme transfers only the aminopropyl group, not an aminoethyl or aminobutyl groups
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
sulfonium analogs must carry the aminopropyl group to qualify as a substrate
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
analogues of decarboxylated S-adenosylmethionine act as propylamine donors
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
synthetic diamines are substrates too
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
the enzyme transfers only the aminopropyl group, not an aminoethyl or aminobutyl groups
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
sulfonium analogs must carry the aminopropyl group to qualify as a substrate
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
analogues of decarboxylated S-adenosylmethionine act as propylamine donors
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
linear at least up to 6 nmol of spermidine formed, linearity not maintained in the absence of DTT
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,6-diaminohexane
?
-
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,6-diaminohexane
?
-
1% the reaction rate than with 1,4-diaminobutane
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,6-diaminohexane
?
-
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + spermidine
5'-methylthioadenosine + spermine
-
at a reduced rate
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + spermidine
5'-methylthioadenosine + spermine
-
at a reduced rate
the reaction rate is slower than with 1,4-diaminobutane
?
S-adenosyl-(5')-3-methylthio-1-propylamine + spermidine
5'-methylthioadenosine + spermine
-
weak substrate
-
-
?
S-adenosyl-3-ethylthio-1-propylamine + 1,4-diaminobutane
?
-
-
-
-
?
S-adenosyl-3-ethylthio-1-propylamine + 1,4-diaminobutane
?
-
prostate enzyme
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
i.e. S-adenosylmethioninamine or decarboxylated S-adenosylmethionine + putrescine, involved in polyamine biosynthetic pathway
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
2.5.1.16 spermidine synthase
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