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Information on EC 3.1.4.17 - 3',5'-cyclic-nucleotide phosphodiesterase
for references in articles please use BRENDA:EC3.1.4.17
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EC Tree 3 Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase
IUBMB Comments
Acts on 3′,5′-cyclic AMP, 3′,5′-cyclic dAMP, 3′,5′-cyclic IMP, 3′,5′-cyclic GMP and 3′,5′-cyclic CMP.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
- 3.1.4.17
- cyclase
- adenylate
- rolipram
- cardiac
- artery
- pka
- guanosine
- agonist
-
camp-dependent
- forskolin
- ibmx
-
contractile
-
adenylyl
- theophylline
- milrinone
- cilostazol
- platelet
- isoproterenol
- prostaglandin
- striatal
-
schizophrenia
- 3-isobutyl-1-methylxanthine
-
vasodilator
- zaprinast
- papaverine
-
inotropic
- dipyridamole
-
spiny
-
camp-mediated
-
beta-adrenergic
-
guanylyl
- sildenafil
- 3',5'-monophosphate
-
prkar1a
-
cardiotonic
- phosphodiesterase-4
- amrinone
- isobutylmethylxanthine
- trifluoperazine
- isoprenaline
-
bronchodilator
- methylxanthines
-
low-km
-
antilipolytic
- ehna
- aminophylline
- roflumilast
- molecular biology
- vardenafil
- medicine
- tadalafil
-
camp-elevating
showSynonyms
pde4d, cyclic nucleotide phosphodiesterase, pde10a, camp phosphodiesterase, pde3a, pde3b, pde2a, camp-pde, phosphodiesterase 3, pde11a, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3',5'-cyclic nucleoside monophosphate phosphodiesterase
-
-
-
-
3',5'-cyclic nucleotide phosphodiesterase
3',5'-cyclonucleotide phosphodiesterase
-
-
-
-
3',5'-nucleotide phosphodiesterase
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-
-
-
3':5'-CNP
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-
-
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3':5'-cyclic nucleotide 5'-nucleotidohydrolase
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-
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61 kDa Cam-PDE
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63 kDa Cam-PDE
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Cam-PDE 1A
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-
-
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Cam-PDE 1B
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-
-
-
Cam-PDE 1C
-
-
-
-
cAMP phosphodiesterase
cAMP-PDE
cg2761
CGB-PDE
-
-
-
-
CGIP1
-
-
-
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CGIPDE1
-
-
-
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cGMP-binding cGMP-specific phosphodiesterase
-
-
-
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CGS-PDE
-
-
-
-
cGSPDE
-
-
-
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CpdA
cyclic 3',5'-mononucleotide phosphodiesterase
-
-
-
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cyclic 3',5'-nucleotide phosphodiesterase
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-
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cyclic 3',5'-phosphodiesterase
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-
-
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cyclic 3',5-nucleotide monophosphate phosphodiesterase
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-
-
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Cyclic GMP stimulated phosphodiesterase
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-
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cyclic nucleotide phosphodiesterase
DPDE1
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-
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DPDE2
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-
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DPDE3
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DPDE4
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dual-specificity PDE
Dunce protein
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-
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GMP-PDE alpha
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GMP-PDE beta
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-
-
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GMP-PDE delta
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-
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GMP-PDE gamma
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-
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HCP1
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-
-
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High-affinity cAMP phosphodiesterase
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-
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Learning/ memory process protein
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-
-
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Low-affinity cAMP phosphodiesterase
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-
-
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MMPDE8
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-
-
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nucleoside 3',5'-cyclic phosphate diesterase
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-
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nucleoside-3',5-monophosphate phosphodiesterase
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p17 protein
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P2A
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PDE
PDE V-B1
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-
-
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PDE V-C1
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-
-
-
PDE1
PDE10
PDE10A
PDE11
PDE11A
PDE1A
PDE1B
PDE1C
PDE2
PDE21
-
-
-
-
PDE2A
PDE3
PDE32
-
-
-
-
PDE3A
PDE3B
PDE43
-
-
-
-
PDE46
-
-
-
-
PDE9A6
PDE9X-100
PDE9X-120
PDE9X-175
PdeA
PDEase
-
-
-
-
PDEase regA
-
-
-
-
PdeB
phosphodiesterase 1
phosphodiesterase 2
phosphodiesterase type 3A
phosphodiesterase, cyclic 3',5'-nucleotide
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-
-
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TM1595
TM22
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-
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cyclic nucleotide phosphodiesterase
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-
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PDE10A
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hydrolyses both 3',5'-cAMP and 3',5'-cGMP although with different kinetic parameters
PDE10A
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hydrolyses both 3',5'-cAMP and 3',5'-cGMP although with different kinetic parameters
PdeA
-
has 3',5'- and 2',3'-cAMP phosphodiesterase and phosphomonoesterase activities
PdeB
-
has 3',5'- and 2',3'-cAMP phosphodiesterase and phosphomonoesterase activities
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate
-
-
-
-
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate
mechanism
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
3',5'-cyclic-nucleotide 5'-nucleotidohydrolase
Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
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CAS REGISTRY NUMBER
COMMENTARY
9040-59-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2',3'-cAMP + H2O
3'-AMP
-
Substrates: in PdeB the phosphodiesterase activity for 2',3'-cAMP is about 1.7fold higher than that for 3',5'-cAMP
Products: -
Products: -
?
cAMP + H2O
5'-AMP
-
Substrates: degradation of extracellular cAMP by isoforms PDE1, PDE7. Degradation of intracellular cAMP by isoform PDE2
Products: -
Products: -
?
cGMP + H2O
5'-GMP
-
Substrates: degradation of intracellular cGMP by isoform PDE3
Products: -
Products: -
?
UDP-D-glucose + H2O
?
-
Substrates: UDP-D-glucose is hydrolyzed by PdeB, but not by PdeA
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
-
Substrates: -
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
Substrates: -
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
-
Substrates: specific for 3',5'-cGMP and 3',5'-cAMP, PDE1
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
-
Substrates: specific for 3',5'-cGMP and 3',5'-cAMP, PDE11
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
-
Substrates: -
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
-
Substrates: inhibition of cAMP hydrolysis by cGMP is likely to contribute to cGMP-mediated signaling in myocardium
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
-
Substrates: activity with 3',5'-cGMP and 3',5'-cAMP is nearly identical, PDE11
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
-
Substrates: activity with 3',5'-cGMP and 3',5'-cAMP is nearly identical, PDE2
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
-
Substrates: activity with 3',5'-cGMP is higher than with 3',5'-cAMP
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
-
Substrates: maximal velocity for cAMP is 4fold to 10fold higher than for cGMP, PDE11A4
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
-
Substrates: 3',5'-cAMP is predominantly hydrolyzed by PDE3A
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
-
Substrates: 3',5'-cAMP is completely hydrolyzed to adenosine when incubated with PdeA for a prolonged time
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
-
Substrates: -
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
Substrates: the enzyme is preferentially degrading linear dinucleotides, such as 5'-pApA, 5'-pGpG, and 5'-pApG, compared with cyclic dinucleotide substrates
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
Substrates: the enzyme is preferentially degrading linear dinucleotides, such as 5'-pApA, 5'-pGpG, and 5'-pApG, compared with cyclic dinucleotide substrates
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
-
Substrates: -
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
Substrates: -
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
-
Substrates: specific for 3',5'-cGMP and 3',5'-cAMP, PDE1
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
-
Substrates: specific for 3',5'-cGMP and 3',5'-cAMP, PDE11
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
-
Substrates: -
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
-
Substrates: activity with 3',5'-cGMP and 3',5'-cAMP is nearly identical, PDE11
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
-
Substrates: activity with 3',5'-cGMP and 3',5'-cAMP is nearly identical, PDE2
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
-
Substrates: activity with 3',5'-cGMP is higher than with 3',5'-cAMP
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
-
Substrates: maximal velocity for cAMP is 4fold to 10fold higher than for cGMP, PDE11A4
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
-
Substrates: highest affinity for 3',5'-cGMP
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
-
Substrates: highest affinity for 3',5'-cGMP
Products: -
Products: -
?