Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O | Homo sapiens | - |
1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene INPP4B | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant enzyme | Homo sapiens | - |
LNCaP cell | - |
Homo sapiens | - |
additional information | INPP4B expression is evaluated by quantitative RT-PCR | Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
VCaP cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O | - |
Homo sapiens | 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate | - |
? | |
additional information | inositol polyphosphate 4-phosphatase type II is a class II phosphatase that preferentially hydrolyzes the 4 position of PI(3,4)P2 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
inositol polyphosphate 4-phosphatase type II | - |
Homo sapiens |
INPP4B | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | optimal induction of INPP4B by an androgen receptor required the expression of the transcriptional coactivator NCoR | up |
General Information | Comment | Organism |
---|---|---|
malfunction | silenced INPP4B expression in malignant proerythroblast is associated with increased activated-Akt levels that can be alleviated by the reexpression of INPP4B. Knockdown of INPP4B in LNCaP cells enhances proliferation | Homo sapiens |
additional information | INPP4B is regulated by androgens at the level of transcription. INPP4B mRNA expression is induced in both LNCaP and VCaP AR-expressing prostate cancer cells. INPP4B and PTEN expression are correlated with the recurrence rate of patients with high and low expression levels of the proliferation marker Ki67 | Homo sapiens |
physiological function | INPP4B regulates proliferation and Akt phosphorylation in prostate cancer cells | Homo sapiens |