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Literature summary for 3.1.3.4 extracted from
- Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase (1997), J. Biol. Chem., 272, 24572-24578.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cloning of two Mg2+-independent isoenzymes, PAP-2a and PAP-2b | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | post-Golgi localization | Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | two Mg2+-independent isoenzymes: phosphatidic acid phosphatase PAP-1a and PAP-2b | Homo sapiens |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32158 | - |
x * 32158, isoenzyme PAP-2a, calculation from nucleotide sequence | Homo sapiens |
| 35119 | - |
x * 35119, isoenzyme PAP-2b, calculation from nucleotide sequence | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | critical roles of the enzyme in cell growth and differentiation | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | the two Mg2+-independent isoenzymes, PAP-2a and PAP-2b are glycoproteins | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| colon | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| leukocyte | peripheral blood | Homo sapiens | - |
| additional information | isoenzyme PAP-2b is almost ubiquitously in all human tissues, isoenzyme PAP-2a is undetectable in thymus, placenta and leukocytes | Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| prostate gland | isoenzyme PAP2a | Homo sapiens | - |
| skeletal muscle | - |
Homo sapiens | - |
| small intestine | - |
Homo sapiens | - |
| spleen | - |
Homo sapiens | - |
| testis | - |
Homo sapiens | - |
| thymus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ceramide-1-phosphate + H2O | isoenzyme PAP-2a and PAP-2b | Homo sapiens | ? | - |
? | |
| lysophosphatidate + H2O | isoenzyme PAP-2a and PAP-2b | Homo sapiens | ? | - |
? | |
| additional information | critical roles of the enzyme in cell growth and differentiation | Homo sapiens | ? | - |
? | |
| phosphatidic acid + H2O | - |
Homo sapiens | 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| sphingosine 1-phosphate + H2O | hydrolysis by isoenzyme PAP-2b, no hydrolysis by isoenzyme PAP-2a | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 32158, isoenzyme PAP-2a, calculation from nucleotide sequence | Homo sapiens |
| ? | x * 35119, isoenzyme PAP-2b, calculation from nucleotide sequence | Homo sapiens |
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