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2'-deoxy-ATP + L-methionine + H2O
?
3'-deoxy-ATP + L-methionine + H2O
?
ATP + (2S)-2-amino-4-(but-3-yn-1-ylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(but-3-yn-1-ylselanyl)butanoic acid
ATP + (2S)-2-amino-4-(but-3-yn-1-ylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(but-3-yn-1-ylsulfanyl)butanoic acid
ATP + (2S)-2-amino-4-(butylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(butylselanyl)butanoic acid
ATP + (2S)-2-amino-4-(butylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(butylsulfanyl)butanoic acid
27% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(ethylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(ethylselanyl)butanoic acid
76% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(ethylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(ethylsulfanyl)butanoic acid
84% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(prop-2-en-1-ylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(prop-2-en-1-ylselanyl)butanoic acid
30% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(prop-2-en-1-ylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(prop-2-en-1-ylsulfanyl)butanoic acid
27% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(prop-2-yn-1-ylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(prop-2-yn-1-ylselanyl)butanoic acid
28% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(prop-2-yn-1-ylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(prop-2-yn-1-ylsulfanyl)butanoic acid
36% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(propan-2-ylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(propan-2-ylselanyl)butanoic acid
40% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(propan-2-ylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(propan-2-ylsulfanyl)butanoic acid
53% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(propylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(propylselanyl)butanoic acid
66% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(propylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(propylsulfanyl)butanoic acid
44% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(2-azido ethyl)sulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(2-azido ethyl)sulfanyl]butanoic acid
50% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(2-methyl propyl)sulfanyl] butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(2-methyl propyl)sulfanyl]butanoic acid
57% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(2-methylprop-2-en-1-yl)selanyl]butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-[(2-methylprop-2-en-1-yl)selanyl]butanoic acid
46% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(2-methylprop-2-en-1-yl)sulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(2-methylprop-2-en-1-yl)sulfanyl]butanoic acid
15% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(2E)-but-2-en-1-ylsulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(2E)-but-2-en-1-ylsulfanyl]butanoic acid
27% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(2E)-penta-2,4-dien-1-ylsulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(2E)-penta-2,4-dien-1-ylsulfanyl]butanoic acid
25% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(3-azido propyl)sulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(3-azido propyl)sulfanyl]butanoic acid
60% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(3-methyl butyl)sulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(3-methyl butyl)sulfanyl] butanoic acid
36% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(3-methylbut-2-en-1-yl)selanyl]butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-[(3-methylbut-2-en-1-yl)selanyl]butanoic acid
44% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(3-methylbut-2-en-1-yl)sulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(3-methylbut-2-en-1-yl)sulfanyl]butanoic acid
12% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(cyanomethyl) sulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(cyanomethyl)sulfanyl]butanoic acid
68% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(cyanomethyl)selanyl]butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-[(cyanomethyl)selanyl]butanoic acid
12% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[[(2E)-4-aminobut-2-en-1-yl]selanyl]butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-[[(2E)-4-aminobut-2-en-1-yl]selanyl]butanoic acid
38% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[[(2E)-4-azidobut-2-en-1-yl]selanyl]butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-[[(2E)-4-azidobut-2-en-1-yl]selanyl]butanoic acid
24% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[[(2E)-4-azidobut-2-en-1-yl]sulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[[(2E)-4-azidobut-2-en-1-yl]sulfanyl]butanoic acid
28% of the turnover rate compared to L-methionine
-
-
?
ATP + D,L-methionine-(methyl-D3) + H2O
?
ATP + D-methionine + H2O
S-adenosyl-D-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-ethionine + H2O
phosphate + diphosphate + S-adenosyl-L-ethionine
-
-
-
?
ATP + L-ethionine + H2O
S-adenosyl-L-ethionine + phosphate + diphosphate
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
ATP + L-methionine ethyl ester + H2O
?
ATP + L-methionine methyl ester + H2O
?
ATP + L-methionine methyl ester + H2O
S-adenosyl-L-methionine methyl ester + phosphate + diphosphate
-
-
-
?
ATP + L-selenomethionine + H2O
phosphate + diphosphate + Se-adenosyl-L-selenomethionine
as active as L-methionine
-
-
?
ATP + methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
CTP + L-methionine + H2O
S-cytosyl-L-methionine + phosphate + diphosphate
-
-
-
?
GTP + L-methionine + H2O
S-guanosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ITP + L-methionine + H2O
?
tripolyphosphate + H2O
diphosphate + phosphate
UTP + L-methionine + H2O
S-urasyl-L-methionine + phosphate + diphosphate
-
-
-
?
additional information
?
-
2'-deoxy-ATP + L-methionine + H2O

?
-
-
-
-
?
2'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
2'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
2'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
ir
2'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
2'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
2'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
2'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
2'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
2'-deoxy-ATP + L-methionine + H2O
?
-
completely specific for ATP
-
-
?
2'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
2'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
3'-deoxy-ATP + L-methionine + H2O

?
-
-
-
-
?
3'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
3'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
3'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
ir
3'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
3'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
3'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
3'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
3'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
3'-deoxy-ATP + L-methionine + H2O
?
-
completely specific for ATP
-
-
?
3'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
3'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
ATP + (2S)-2-amino-4-(but-3-yn-1-ylselanyl)butanoic acid + H2O

phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(but-3-yn-1-ylselanyl)butanoic acid
10% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(but-3-yn-1-ylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(but-3-yn-1-ylselanyl)butanoic acid
10% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(but-3-yn-1-ylsulfanyl)butanoic acid + H2O

phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(but-3-yn-1-ylsulfanyl)butanoic acid
30% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(but-3-yn-1-ylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(but-3-yn-1-ylsulfanyl)butanoic acid
30% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(butylselanyl)butanoic acid + H2O

phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(butylselanyl)butanoic acid
70% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(butylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(butylselanyl)butanoic acid
70% of the turnover rate compared to L-methionine
-
-
?
ATP + D,L-methionine-(methyl-D3) + H2O

?
-
-
-
-
?
ATP + D,L-methionine-(methyl-D3) + H2O
?
-
-
-
-
?
ATP + L-ethionine + H2O

S-adenosyl-L-ethionine + phosphate + diphosphate
-
-
-
-
ATP + L-ethionine + H2O
S-adenosyl-L-ethionine + phosphate + diphosphate
-
-
-
?
ATP + L-ethionine + H2O
S-adenosyl-L-ethionine + phosphate + diphosphate
-
-
-
-
ATP + L-methionine + H2O

phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
aspartate family biosynthesis pathway and methionine metabolism, regulation, S-adenosyl-L-methionine activates threonine synthase expression and negatively regulates the transcript level of the cystathionine gamma-synthase, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
S-adenosyl-L-methionine is required for betaine synthesis and also for the synthesis of other compounds, especially lignin, transcript levels of the enzyme are co-regulated with those of phosphoethanolamine N-methyltransferase and choline monooxygenase to supply S-adenosyl-L-methionine for betaine synthesis in the leaves, overview, enzyme regulation pattern in plant tissues, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
biosynthesis of the key compound in the trans-methylation reactions
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
-
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
the S(MK) box, a conserved RNA motif in the 5'-untranslated region of the metK gene, is a SAM-binding RNA responsible for translational regulation of the enzyme, it binds specifically to S-adenosyl-L-methionine in vitro and in vivo causing a structural RNA rearrangement that causes a sequestration of the Shine-Dalgarno sequence, structural mapping and mechanism, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
-
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
-
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
an essential enzyme that catalyzes the formation of the principal methyl donor S-adenosylmethionine, S-adenosyl-L-methionine is also a key metabolite that regulates hepatocyte growth, death and differentiation, molecular mechanism, overview, abnormalities in MAT and decreased S-adenosyl-L-methionine levels occur in humans with alcoholic liver disease, chronic hepatic S-adenosyl-L-methionine deficiency can result in the spontaneous development of steatohepatitis and hepatocellular carcinoma, overview, hepatic S-adenosyl-L-methionine biosynthesis and methionine metabolism, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
rate-limiting enzyme of the S-adenosyl-L-methionine synthesis pathway, cell methionine and S-adenosylmethionine contents increase in response to hyperoxia in SAE and A549 cells, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
Q9U6Q8;
-
-
-
-
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
-
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
a post-translational mechanism is involved in MAT regulation, the enzyme is down-regulated in pathological processes such as liver cirrhosis, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
-
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
biosynthesis of S-adenosyl-L-methionine
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
two-step reaction in which reaction of ATP and methionine initially yields the S-adenosyl-L-methionine and tripolyphosphate. The tripolyphosphate remains enzyme-bound and is cleaved to diphosphate and phosphate before product release
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
biosynthesis of S-adenosyl-L-methionine
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
two-step reaction in which reaction of ATP and methionine initially yields the S-adenosyl-L-methionine and tripolyphosphate. The tripolyphosphate remains enzyme-bound and is cleaved to diphosphate and phosphate before product release
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
regulation of methionine metabolism, S-adenosyl-L-methionine metabolic pathway, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
aspartate family biosynthesis pathway and methionine metabolism,regulation, S-adenosyl-L.methionine activates threonine synthase expression and negatively regulates the transcript level of the cystathionine gamma-synthase, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
the enzyme plays a key role in the biogenesis of S-adenosyl-L-methionine
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
typhus group rickettsiae have the capability of synthesizing as well as transporting SAM
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O

S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
ir
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
methyl donor in transmethylation reactions and as propylamine donor for polyamine biosynthesis
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
mechanism
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
the product S-adenosylmethionine is important as a direct metabolic donor of methyl and alpha-amino-n-butyryl groups
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
two reaction steps: S-adenosylmethionine synthesis and tripolyphosphate hydrolysis. Tripolyphosphate hydrolysis is the rate determining reaction
-
-
-
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
MAT activity controls cellular glutathione levels, polyamine synthesis and folate cycling
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
completely specific for ATP
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
used as aminopropyl group donor in synthesis of polyamines and is also the methyl group donor for most cellular methyltransferase reactions
-
?
ATP + L-methionine ethyl ester + H2O

?
-
excellent substrate
-
-
?
ATP + L-methionine ethyl ester + H2O
?
-
excellent substrate
-
-
?
ATP + L-methionine methyl ester + H2O

?
-
-
-
-
?
ATP + L-methionine methyl ester + H2O
?
-
-
-
-
?
ATP + methionine + H2O

S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ITP + L-methionine + H2O

?
-
-
-
-
?
ITP + L-methionine + H2O
?
-
-
-
-
?
tripolyphosphate + H2O

diphosphate + phosphate
-
-
-
-
tripolyphosphate + H2O
diphosphate + phosphate
-
tripolyphosphatase activity
-
?
tripolyphosphate + H2O
diphosphate + phosphate
-
tripolyphosphatase activity
-
?
tripolyphosphate + H2O
diphosphate + phosphate
-
tripolyphosphatase activity
-
?
tripolyphosphate + H2O
diphosphate + phosphate
Q9U6Q8;
-
-
-
-
tripolyphosphate + H2O
diphosphate + phosphate
-
-
-
-
-
tripolyphosphate + H2O
diphosphate + phosphate
-
tripolyphosphatase activity
-
?
tripolyphosphate + H2O
diphosphate + phosphate
-
tripolyphosphatase activity
-
?
tripolyphosphate + H2O
diphosphate + phosphate
-
two isoenzymes with different behavior on exogenous S-adenosylmethionine addition
-
?
tripolyphosphate + H2O
diphosphate + phosphate
-
tripolyphosphatase activity
-
?
additional information

?
-
-
protein S-nitrosylation by NO represents a redox-based regulation mechanism playing a pivotal role in plants, MAT catalyzes the synthesis of the ethylene precursor S-adenosylmethionine and NO influences ethylene production in plants, the enzyme probably mediates the cross-talk between ethylene and NO signaling, overview
-
-
-
additional information
?
-
-
genes in the S-box family are regulated by binding of S-adenosylmethionine to the 5' region of the mRNA of the regulated gene, SAM binding promotes a rearrangement of the RNA structure that results in premature termination of transcription in vitro and repression of expression of the downstream coding sequence, the S-box RNA element therefore acts as a SAM-binding riboswitch in vitro
-
-
-
additional information
?
-
-
N-acetyl-L-methionine and N,N-dimethyl-L-methionine are very poor substrates
-
-
-
additional information
?
-
-
ATP can be substituted by 3'-deoxy-ATP,8-bromo-ATP, formycin triphosphate, adenyl-5'yl imidodiphosphate
-
-
-
additional information
?
-
-
ATP can be substituted by 3'-deoxy-ATP,8-bromo-ATP, formycin triphosphate, adenyl-5'yl imidodiphosphate
-
-
-
additional information
?
-
S-adenosylmethionine synthesis and tripolyphosphatase activity messured for six aspartate-mutants
-
-
-
additional information
?
-
transmethylation and transsulfuration pathways, overview
-
-
-
additional information
?
-
-
no activity with methional, methioninol, 3-methylthiopropylamine
-
-
-
additional information
?
-
-
N-acetyl-L-methionine and N,N-dimethyl-L-methionine are very poor substrates
-
-
-
additional information
?
-
-
S-adenosylmethionine synthetase A exhibits tripolyphosphatase activity
-
-
-
additional information
?
-
-
S-adenosylmethionine synthetase B exhibits tripolyphosphatase activity
-
-
-
additional information
?
-
the enzyme has the ability to produce a range of differentially alkylated AdoMet analogs in the presence of non-native methionine analogs and ATP
-
-
-
additional information
?
-
the enzyme has the ability to produce a range of differentially alkylated AdoMet analogs in the presence of non-native methionine analogs and ATP
-
-
-
additional information
?
-
-
ATP can be substituted by 3'-deoxy-ATP,8-bromo-ATP, formycin triphosphate, adenyl-5'yl imidodiphosphate
-
-
-
additional information
?
-
-
methionine can be substituted by selenomethionine, alpha-methyl-DL-methionine
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
additional information
?
-
ATP + L-methionine + H2O

phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
aspartate family biosynthesis pathway and methionine metabolism, regulation, S-adenosyl-L-methionine activates threonine synthase expression and negatively regulates the transcript level of the cystathionine gamma-synthase, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
Q6F3F0, Q6F3F1, Q6F3F3, Q7XZR1
S-adenosyl-L-methionine is required for betaine synthesis and also for the synthesis of other compounds, especially lignin, transcript levels of the enzyme are co-regulated with those of phosphoethanolamine N-methyltransferase and choline monooxygenase to supply S-adenosyl-L-methionine for betaine synthesis in the leaves, overview, enzyme regulation pattern in plant tissues, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
Q9K5E4
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
Q9K5E4
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
Q6J2L0
biosynthesis of the key compound in the trans-methylation reactions
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
the S(MK) box, a conserved RNA motif in the 5'-untranslated region of the metK gene, is a SAM-binding RNA responsible for translational regulation of the enzyme, it binds specifically to S-adenosyl-L-methionine in vitro and in vivo causing a structural RNA rearrangement that causes a sequestration of the Shine-Dalgarno sequence, structural mapping and mechanism, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
Q9NZL9
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
P31153, Q00266
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
an essential enzyme that catalyzes the formation of the principal methyl donor S-adenosylmethionine, S-adenosyl-L-methionine is also a key metabolite that regulates hepatocyte growth, death and differentiation, molecular mechanism, overview, abnormalities in MAT and decreased S-adenosyl-L-methionine levels occur in humans with alcoholic liver disease, chronic hepatic S-adenosyl-L-methionine deficiency can result in the spontaneous development of steatohepatitis and hepatocellular carcinoma, overview, hepatic S-adenosyl-L-methionine biosynthesis and methionine metabolism, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
P31153
rate-limiting enzyme of the S-adenosyl-L-methionine synthesis pathway, cell methionine and S-adenosylmethionine contents increase in response to hyperoxia in SAE and A549 cells, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
a post-translational mechanism is involved in MAT regulation, the enzyme is down-regulated in pathological processes such as liver cirrhosis, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
A4ULF8
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
biosynthesis of S-adenosyl-L-methionine
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
biosynthesis of S-adenosyl-L-methionine
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
regulation of methionine metabolism, S-adenosyl-L-methionine metabolic pathway, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
aspartate family biosynthesis pathway and methionine metabolism,regulation, S-adenosyl-L.methionine activates threonine synthase expression and negatively regulates the transcript level of the cystathionine gamma-synthase, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
Q8TZW1
the enzyme plays a key role in the biogenesis of S-adenosyl-L-methionine
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
typhus group rickettsiae have the capability of synthesizing as well as transporting SAM
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
P43280
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
Q3HW35
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
Q72I53
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
Q72I53
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O

S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
ir
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
methyl donor in transmethylation reactions and as propylamine donor for polyamine biosynthesis
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
the product S-adenosylmethionine is important as a direct metabolic donor of methyl and alpha-amino-n-butyryl groups
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
two reaction steps: S-adenosylmethionine synthesis and tripolyphosphate hydrolysis. Tripolyphosphate hydrolysis is the rate determining reaction
-
-
-
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
MAT activity controls cellular glutathione levels, polyamine synthesis and folate cycling
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
S-adenosyl-L-methionine + phosphate + diphosphate
-
used as aminopropyl group donor in synthesis of polyamines and is also the methyl group donor for most cellular methyltransferase reactions
-
?
additional information

?
-
-
protein S-nitrosylation by NO represents a redox-based regulation mechanism playing a pivotal role in plants, MAT catalyzes the synthesis of the ethylene precursor S-adenosylmethionine and NO influences ethylene production in plants, the enzyme probably mediates the cross-talk between ethylene and NO signaling, overview
-
-
-
additional information
?
-
-
genes in the S-box family are regulated by binding of S-adenosylmethionine to the 5' region of the mRNA of the regulated gene, SAM binding promotes a rearrangement of the RNA structure that results in premature termination of transcription in vitro and repression of expression of the downstream coding sequence, the S-box RNA element therefore acts as a SAM-binding riboswitch in vitro
-
-
-
additional information
?
-
P31153
transmethylation and transsulfuration pathways, overview
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2S,4S)-amino-4,5-epoxypentanoic acid
-
1-(3-(2-ethoxyphenyl)ureidoacetyl)-4-(2-methyl-5-nitrophenyl)semicarbazide
-
binding to adenosyl region of the active site
1-(4-chloro-2-nitrophenyl)-3-(4-sulfamoylphenyl)-urea
-
binding to adenosyl region of the active site
1-aminocyclopentanecarboxylic acid
-
-
1-methyluric acid
10 mM, 43.4% inhibition
1-Methylxanthine
10 mM, 35.9% inhibition
2,6-diaminopurine
10 mM, 29.3% inhibition
2,6-dichloropurine
10 mM, 35.5% inhibition
2-amino-6-carboxyethylmercaptopurine
10 mM, 31.9% inhibition
2-amino-6-chloropurine riboside
10 mM, 17.2% inhibition
2-amino-6-chloropurine-9-acetic acid
10 mM, 23.5% inhibition
2-Aminopurine
10 mM, 11.0% inhibition
2-Hydroxypurine
10 mM, 33.8% inhibition
3,7-dimethyluric acid
10 mM, 27.9% inhibition
3-morpholinosydnoniimide
-
loss of liver MAT activity in vivo
5-amino-L-norvaline
10-25% inhibition with 5 mM; 10-25% inhibition with 5 mM; 10-25% inhibition with 5 mM
5-azacytidine
-
0.2 mM leads to significant reduction of AdoMetS protein expression
6-benzyloxypurine
10 mM, 17.7% inhibition
6-bromopurine
10 mM, 31.4% inhibition
6-Chloropurine
10 mM, 31.4% inhibition
6-Chloropurine riboside
10 mM, 17.1% inhibition
6-Cyanopurine
10 mM, 24.2% inhibition
6-dimethylallylaminopurine riboside
10 mM, 41.6% inhibition
6-Dimethylaminopurine
10 mM, 28.0% inhibition
6-Mercaptopurine
10 mM, 40.1% inhibition
6-mercaptopurine riboside
10 mM, 30.0% inhibition
6-propoxypurine
10 mM, 27.9% inhibition
7-hydroxypropyl theophylline
10 mM, 16.1% inhibition
7-Methyluric acid
10 mM, 11.4% inhibition
7-methylxanthine
10 mM, 36.3% inhibition
8-aza-2,6-diaminopurine
10 mM, 40.0% inhibition
8-Azaguanine
; 10 mM, 81.7% inhibition
8-chlorotheophylline
10 mM, 7.0% inhibition
Adenyl-5'-ylimidodiphosphate
-
competitive with ATP
ADP
35-50% inhibition with 5 mM; 35-50% inhibition with 5 mM; 35-50% inhibition with 5 mM
alpha,beta-methylene-adenosine tetraphosphate
-
-
alpha,beta-methylene-ATP
-
-
alpha-methyl-DL-methionine
10 mM, 18.8% inhibition
AMP
-
causes complete inactivation of the enzyme
Azathioprine
; 10 mM, 75.5% inhibition
Ba2+
-
70.70% residual activity at 5 mM
bacterial lipopolysaccharide
-
beta,gamma-methylene-ATP
-
-
Br-
-
93.33% residual activity at 5 mM
carbon tetrachloride
-
depletion of glutathione levels reduces MAT I/III activities in vivo
CH3COO-
-
92.25% residual activity at 5 mM
Cl-
-
85.27% residual activity at 5 mM
Co2+
-
about 45% residual activity at 10 mM
diimidotriphosphate
-
mechanism
DL-2-Amino-trans-4-hexenoic acid
-
-
ethanol
25 mM ethanol substantially decreases the enzymatic activity of MAT II
Ethionine
32-38% inhibition with 5 mM; 32-38% inhibition with 5 mM; 32-38% inhibition with 5 mM
F-
-
88.84% residual activity at 5 mM
Fumarylacetoacetate
-
reduces MAT I/III activity
glycerol
-
inhibits kidney isoenzyme gamma
GSH
-
causes complete inactivation of the enzyme
I-
-
87.91% residual activity at 5 mM
L-2-Amino-4-hexynoic acid
-
-
L-2-Amino-4-methoxy-cis-but-3-enoic acid
L-2-Amino-4-methylthio-cis-but-3-enoic acid
-
-
L-buthionine-(S,R)-sulfoximine
L-ethioninamide
10 mM, 23.9% inhibition
L-methionine methyl ester
10 mM, 17.7% inhibition
L-Methionine sulfone
10 mM, 9.2% inhibition
L-methionine sulfoxide
10 mM, 4.0% inhibition
L-methionine sulfoximine
10 mM, 12.6% inhibition
L-Penicillamine
10 mM, 15.0% inhibition
Li+
-
81.40% residual activity at 5 mM
methanol
2.4% methanol depresses methionine adenosyltransferase specific activity, this effect is not observed with 0.8% methanol
methylthio propionaldehyde
10 mM, 18.4% inhibition
Mg2+
-
inhibitory above 8.5 mM
N-ethylmaleimide
-
time-dependent inactivation of both MAT activities
Ni2+
-
about 1% residual activity at 10 mM
nitrosoglutathione
-
reversibly inhibits the isozyme MAT1 via NO binding to Cys114, no inhibition of isozymes MAT2 and MAT3, molecular mechanism for S-nitrosylation of the enzyme
O-methylguanine
10 mM, 60.3% inhibition
putrescine
15-25% inhibition with 5 mM; 15-25% inhibition with 5 mM; 15-25% inhibition with 5 mM
S-adenosyl-L-ethionine
-
-
S-adenosyl-L-homocysteine
S-adenosyl-L-methionine
-
feedback inhibition of isozyme MAT II
S-carbamylcysteine
-
competitive with methionine
S-nitrosoglutathione monoethyl ester
-
inactivates
S-nitrosylated glutathione
-
rapid and dose-dependent loss of enzymatic activity of MAT I/III
S-Trifluoromethyl-L-homocysteine
-
-
SIN-1
-
rapid and dose-dependent loss of enzymatic activity of MAT I/III
spermidine
15-34% inhibition with 5 mM; 15-34% inhibition with 5 mM; 15-34% inhibition with 5 mM
spermine
30-40% inhibition with 5 mM; 30-40% inhibition with 5 mM; 30-40% inhibition with 5 mM
uric acid
10 mM, 45.6% inhibition
xanthine
10 mM, 35.4% inhibition
ATP

-
-
ATP
-
ATP and methionine act as a switch between two different MAT III isoforms
ATP
-
causes complete inactivation of the enzyme
bacterial lipopolysaccharide

-
decreases MAT activity in vivo
-
bacterial lipopolysaccharide
-
results in the accumulation of nitrites and nitrates in serum and in the inactivation of MAT I/III
-
Ca2+

-
about 5% residual activity at 10 mM
Ca2+
-
86.36% residual activity at 5 mM
CTP

60-70% inhibition with 5 mM; 60-70% inhibition with 5 mM; 60-70% inhibition with 5 mM
CTP
-
; 20 mM, 37% inhibition, S-adenosylmethionine synthetase B; 20 mM, 40% inhibition, S-adenosylmethionine synthetase A
Cu2+

-
complete inhibition at 10 mM
Cu2+
isozyme subunit MATalpha2 is inhibited by 0.25 mM Cu2+ in the presence or absence of dithiothreitol, strong reduction in MAT2B gene expression induced by Cu2+ (60%), copper effects can only be prevented by buthionine sulfoximine, whereas N-acetylcysteine and neocuproine are ineffective
Cu2+
-
25.74% residual activity at 5 mM
cycloleucine

-
competitive
cycloleucine
1-aminocyclopentane-1-carboxylic acid, specific MAT inhibitor
cycloleucine
10 mM, 25.8% inhibition
cycloleucine
-
25 mM, 56% inhibition, S-adenosylmethionine synthetase A; inhibits only at sub saturating concentrations of methionine
Dimethylsulfoxide

-
-
Dimethylsulfoxide
-
weak inhibition of liver isoenzyme
Dimethylsulfoxide
-
slight inhibition of gamma isoenzyme from kidney
diphosphate

-
-
diphosphate
-
inhibition for S-adenosylmethionine and L-methonine
diphosphate
-
individually a weak inhibitor, in combination with phosphate there is a marked synergistic effect
diphosphate
-
inhibits high-MW isoenzyme, no effect on low-MW enzyme
diphosphate
-
; 20 mM, 30% inhibition, S-adenosylmethionine synthetase A; 20 mM, 49% inhibition, S-adenosylmethionine synthetase B
Fe2+

-
about 15% residual activity at 10 mM
Fe2+
-
59.22% residual activity at 5 mM
GTP

not accepted as a substrate but inhibits the reaction in the presence of ATP, 70-80% inhibition with 5 mM; not accepted as a substrate but inhibits the reaction in the presence of ATP, 70-80% inhibition with 5 mM; not accepted as a substrate but inhibits the reaction in the presence of ATP, 70-80% inhibition with 5 mM
GTP
-
competitive with respect to ATP and noncompetitive with L-methionine
GTP
-
; 20 mM, 50% inhibition, S-adenosylmethionine synthetase B; 20 mM, 56% inhibition, S-adenosylmethionine synthetase A
hydrogen peroxide

-
reduces MAT I/III activity
hydrogen peroxide
-
inactives CHO cells-MAT, prevented by desferoxamine. Time- and dose-dependent inactivation of MAT I/III, activity recovered by addition of glutathione
K+

-
-
K+
-
85.27% residual activity at 5 mM
L-2-Amino-4-methoxy-cis-but-3-enoic acid

-
-
L-2-Amino-4-methoxy-cis-but-3-enoic acid
-
-
L-buthionine-(S,R)-sulfoximine

-
inhibits glutathione synthesis and this decreases MAT activity in vivo. Prevented by the administration of glutathione-ethyl ester
L-buthionine-(S,R)-sulfoximine
-
inactivates hepatic MAT, prevented by the administration of glutathione-ethyl ester
L-ethionine

-
1.2 mM leads to significant reduction of AdoMetS protein expression
L-ethionine
-
competitive with respect to methionine for S-adenosylmethionine formation and noncompetitive with respect to ATP
L-ethionine
10 mM, 20.4% inhibition
L-methionine

-
-
L-methionine
-
ATP and methionine act as a switch between two different MAT III isoforms
L-methionine
30% reduction in total activity is detected at 5 mM L-methionine; 30% reduction in total activity is detected at 5 mM L-methionine; 30% reduction in total activity is detected at 5 mM L-methionine
methylthioadenosine

-
lowers expression of MAT2A and MAT2beta
methylthioadenosine
1 mM downregulates MAT2A expression
Mn2+

-
about 80% residual activity at 10 mM
Mn2+
-
73.49% residual activity at 5 mM
Mn2+
-
inhibition in presence of Mg2+
Na+

-
80.16% residual activity at 5 mM
Na+
-
in presence of Mg2+
nitric oxide

-
two MAT III isoforms, one with low tripolyphosphatase activity that is insensitive to NO and another with high tripolyphosphatase activity that is inhibited by NO
nitric oxide
-
inactivates hepatic MAT
p-chloromercuribenzoate

-
-
p-chloromercuribenzoate
-
reduces MAT I/III activity
p-chloromercuribenzoate
-
alpha and beta isoenzymes completely inhibited, gamma isoenzyme slightly inhibited
phosphate

-
-
phosphate
-
competitive toward both ATP and methionine
phosphate
-
individually a weak inhibitor, in combination with diphosphate there is a synergistic inhibitory effect
phosphate
-
; 10 mM, 19% inhibition, S-adenosylmethionine synthetase B; 10 mM, 45% inhibition, S-adenosylmethionine synthetase A
S-adenosyl-L-homocysteine

-
-
S-adenosyl-L-homocysteine
-
not inhibitory
S-adenosyl-L-homocysteine
-
-
S-adenosylmethionine

-
-
S-adenosylmethionine
-
non competitive with ATP at low methionine concentration
S-adenosylmethionine
-
lowers expression of MAT2A and MAT2beta
S-adenosylmethionine
-
non competitive inhibition
S-adenosylmethionine
-
more than 50% inhibition at 1 mM
S-adenosylmethionine
-
noncompetitive inhibitor with respect to ATP and methionine
S-adenosylmethionine
5 mM downregulates MAT2A expression
S-adenosylmethionine
-
inhibition of rat kidney enzyme and rat liver MAT-II, weak inhibition of rat liver MAT-I
S-adenosylmethionine
-
above 0.3 mM inhibits both high-MW and low-MW isoenzymes
S-adenosylmethionine
-
inhibits the A form but not the B form; non-competitive, S-adenosylmethionine synthetase A; slight inhibition of S-adenosylmethionine synthetase B
S-nitrosoglutathione

-
inhibits S-adenosylmethionine sinthetase activity
S-nitrosoglutathione
-
inactivates MATI/III by 70%
Tetrapolyphosphate

-
-
Tetrapolyphosphate
-
; 10 mM, 40% inhibition, S-adenosylmethionine synthetase B; 10 mM, 50% inhibition, S-adenosylmethionine synthetase A
tripolyphosphate

-
-
tripolyphosphate
strong inhibitor; strong inhibitor; strong inhibitor
tripolyphosphate
-
competitive with ATP
tripolyphosphate
-
competitive with ATP and non competitive with L-methionine
tripolyphosphate
-
competitive with ATP; non competitive with L-methionine
tripolyphosphate
-
activation or inhibition, depending on isoenzyme, S-adenosylmethionine and tripolyphosphate concentration
tripolyphosphate
-
1.0 mM, 57% inhibition, S-adenosylmethionine synthetase A; 1.0 mM, 62% inhibition, S-adenosylmethionine synthetase B
UTP

-
-
Zn2+

-
about 10% residual activity at 10 mM
Zn2+
-
22.17% residual activity at 5 mM
additional information

-
addition of reducing agents has no effect; addition of reducing agents has no effect; addition of reducing agents has no effect
-
additional information
addition of reducing agents has no effect; addition of reducing agents has no effect; addition of reducing agents has no effect
-
additional information
addition of reducing agents has no effect; addition of reducing agents has no effect; addition of reducing agents has no effect
-
additional information
addition of reducing agents has no effect; addition of reducing agents has no effect; addition of reducing agents has no effect
-
additional information
-
overview of the regulatory properties, effect of L-methionine analogues and influence of L-methionine concentration on activating and inhibiting effects, effect of tripolyphosphate and p-hydroxymercuribenzoate
-
additional information
-
reactive oxygen and nitrogen species induce the inactivation of MAT I/III
-
additional information
-
no inhibition with cycloleucine, L-homocysteine, L-norleucine, L-cis-2-amino-4-methoxy-3-butenoic acid, S-adenosylhomocysteine, 5'-methylthioadenosine, sinefungin
-
additional information
not inhibitory: (R)-methioninol, 1,3,7-trimethyluric acid, 6-methylpurine
-
additional information
-
MAT is inactivated after 6 h of incubation in hypoxia (3% O2) in rat hepatocytes, prevented by NG-monomethyl-L-arginine methyl ester. Hepatic MAT s a sensible target for free radicals in vivo
-
additional information
-
no effect on activity at 0.1 mM Ni2+
-
additional information
-
overexpression of yeast AdoMet synthase plus cap guanine-N7 methyltransferase affords greater resistance to sinefungin than either enzyme alone
-
additional information
-
S-adenosyl(5')-3-methylthiopropylamine does not inhibit
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP
-
tripolyphosphatase activity stimulated by preincubation with ATP and methionine
cycloheximide
-
cycloheximide inhibition of protein synthesis increases isozyme MAT2 mRNA level in the logarithmic phase only, an indication that the gene is regulated in promastigotes at the posttranscriptional level by protein factors that targets the transcript for degradation
dithiothreitol
-
required for alpha and beta isoenzymes activity, not required for gamma enzyme
E2F1
-
present continually in the MAT2A promoter during liver regeneration
-
E2F3
-
present continually in the MAT2A promoter during liver regeneration
-
E2F4
-
present continually in the MAT2A promoter during liver regeneration
-
forskolin
-
induction of enzyme in organ cell culture
glycerol
-
activates rat liver isoenzymes alpha and beta
insulin-like growth factor 1
-
isoproterenol
-
induction of enzyme in organ cell culture
L-methionine
17% increase is observed at 60 mM L-methionine; 17% increase of activity is observed at 60 mM L-methionine
methanol
-
53.26% increased yield of S-adenosyl-L-methionine at 1.0% methanol
methionine
-
stimulation of activity demonstrated in vivo. Tripolyphosphatase activity stimulated by preincubation with ATP and methionine
n-heptane
-
53.26% increased yield of S-adenosyl-L-methionine at 1.0% n-heptane
norepinephrine
-
induction of enzyme in organ cell culture
SH-reagents
-
liver enzyme: requirement, tumor enzyme: no requirement
-
sorbitol
-
53.26% increased yield of S-adenosyl-L-methionine at 1.2% sorbitol
Sp1
-
binding of Sp1 to the MAT2A promoter is essential for the transcriptional up-regulation of the gene
-
tripolyphosphates
-
activation or inhibition, depending on isoenzyme, S-adenosylmethionine and tripolyphosphate concentration
Tumor necrosis factor alpha
-
induces expression of variant 1 (but not variant 2) MAT2beta
-
Dimethylsulfoxide

-
activates isoform from kidney and isoform MAT-III from liver
Dimethylsulfoxide
-
activates alpha and beta isoenzymes from liver
Dimethylsulfoxide
-
activates the beta isozyme from liver 13-15fold; weak activation of the alpha isozyme from liver
Epidermal growth factor

-
100 ng/ml upregulates MAT2A (but not MAT2beta) expression
Epidermal growth factor
100 ng/ml upregulates MAT2A (but not MAT2beta) expression
insulin-like growth factor 1

-
100 ng/ml upregulates MAT2A (but not MAT2beta) expression
-
insulin-like growth factor 1
100 ng/ml upregulates MAT2A (but not MAT2beta) expression
-
leptin

-
100 ng/ml upregulates MAT2A (but not MAT2beta) expression
-
leptin
-
induces the expression of MAT2A and MAT2beta
-
leptin
100 ng/ml upregulates MAT2A (but not MAT2beta) expression
-
S-adenosylmethionine

-
enhances tripolyphosphatase activity
S-adenosylmethionine
-
nonessential activator of tripolyphosphatase activity in the range of 0.005-0.100 mM
S-adenosylmethionine
-
activation of rat liver MAT-III
S-adenosylmethionine
-
below 0.3 mM activates low-MW isoenzyme
S-adenosylmethionine
-
activates the tripolyphosphatase activity of A isoform
additional information

-
lysine enhances methionine content by modulating the expression of S-adenosylmethionine synthase, overview
-
additional information
-
salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview; salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview; salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview; salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview
-
additional information
salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview; salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview; salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview; salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview
-
additional information
salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview; salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview; salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview; salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview
-
additional information
salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview; salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview; salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview; salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview
-
additional information
salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview; salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview; salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview; salt stress induces the enzyme, differential effects on betaine and lignin biosynthesis, overview
-
additional information
cell methionine and S-adenosylmethionine contents increase in response to hyperoxia in SAE and A549 cells, enzyme activity increases by 2fold within 5 days, S-adenosylmethionine content by 5fold, overview
-
additional information
-
methanol induces enzyme expression and S-adenosyl-L-methionine production, while glycerol does not
-
additional information
-
fasting for 10-16 h increases expression and activity of isozymes MAT I and MAT III, effects on methionine/S-adenosyl-L-methionine metabolism, overview
-
additional information
-
no effect with ADP and methionine or S-adenosylmethionine
-
additional information
-
no significant effect in the presence of n-dodecane
-
additional information
-
no requirement for reducing agents
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0056 - 0.74
L-ethionine
0.0023 - 3.3
L-methionine
2.6
L-methionine methyl esther
-
-
0.0013 - 0.026
tripolyphosphate
additional information
additional information
-
0.002
ATP

-
beta form from liver
0.005
ATP
-
alpha form from liver
0.0145
ATP
pH 8.0, 65°C, cosubstrate: L-methionine
0.026
ATP
-
G6 mutant, S-adenosylmethionine synthesis
0.045
ATP
-
RLL and G8 mutants, S-adenosylmethionine synthesis
0.0592
ATP
pH 8.0, 65°C, cosubstrate: L-ethionine
0.065
ATP
-
S-adenosylmethionine synthetase A
0.0686
ATP
pH 8.0, 37°C, cosubstrate: L-methionine
0.069
ATP
-
G7 mutants, S-adenosylmethionine synthesis
0.073
ATP
-
wild-type S-adenosylmethionine synthesis
0.083
ATP
-
wild-type, pH 8.0
0.087
ATP
-
G5 mutant S-adenosylmethionine synthesis
0.0969
ATP
pH 8.0, 37°C, cosubstrate: L-ethionine
0.1
ATP
-
mutant W387F/Y170W, 55°C; mutant W387F/Y226W, 55°C
0.11
ATP
-
mutant W387F, 55°C; mutant W387F/Y371W, 55°C; mutant W387F/Y72W, 55°C
0.13
ATP
-
mutant D107C, pH 8.0; mutant G105C, pH 8.0
0.13
ATP
-
mutant W387F/Y120W, 55°C
0.156
ATP
-
S-adenosylmethionine synthetase B
0.18
ATP
-
mutant G105R1, pH 8.0
0.18
ATP
-
mutant W387F/Y49W, 55°C
0.19
ATP
-
mutant W387F/Y255W, 55°C; wild-type, 55°C
0.2
ATP
-
mutant W387F/Y233W, 55°C; mutant W387F/Y267W, 55°C
0.21
ATP
-
mutant W387F/Y85W, 55°C
0.22
ATP
-
saturated with KCl
0.22
ATP
-
mutant W387F/Y323W, 55°C; mutant W387F/Y344W, 55°C
0.24
ATP
-
mutant W387F/Y273W, 55°C
0.493
ATP
mutant C35S, presence of dithiothreitol
0.53
ATP
wild-type, presence of glutathione
0.588
ATP
wild-type, presence of dithiothreitol
0.631
ATP
-
at pH 8.0 and 35°C
0.778
ATP
mutant C35S, presence of glutathione
0.92
ATP
in 100 mM Tris-Cl pH 8.0, 20 mM MgCl2, at 37°C
1.72
ATP
-
at pH 8.5 and 45°C
2.07
ATP
at pH 8.5 and 35°C
2.54
ATP
mutant C61S, presence of glutathione
2.84
ATP
-
at pH 8.5 and 40°C
3.25
ATP
mutant C61S, presence of dithiothreitol
4.19
ATP
-
at pH 8.0 and 70°C
6.54
ATP
-
at pH 8.0 and 37°C
0.0056
L-ethionine

pH 8.0, 37°C
0.007
L-ethionine
pH 8.0, 65°C
0.0023
L-methionine

pH 8.0, 37°C
0.0028
L-methionine
pH 8.0, 65°C
0.0061
L-methionine
-
pH 7.0, 37°C
0.0075
L-methionine
-
erythrocyte extract, alpha and beta subunit
0.01
L-methionine
-
isoenzyme A; S-adenosylmethionine synthetase A
0.0125
L-methionine
-
erythrocyte extract, alpha subunit
0.015
L-methionine
-
endogenous MAT II
0.016
L-methionine
-
alpha2-transfected MAT II, two kinetic forms
0.017
L-methionine
-
alpha form from liver
0.02
L-methionine
-
isoenzyme B
0.02
L-methionine
-
recombinant MAT II co-expressing alpha2 and beta subunits
0.022 - 0.024
L-methionine
-
ro subunit
0.022
L-methionine
-
crude extract
0.022
L-methionine
one kinetic form of alpha-two subunit in the presence of beta subunit
0.024
L-methionine
-
S-adenosylmethionine synthetase B
0.024
L-methionine
-
wild-type
0.03 - 0.038
L-methionine
-
one kinetic form of alpha subunit in the presence of beta subunit
0.03
L-methionine
-
mutant D249N, pH 8.0
0.031
L-methionine
pH 8.0, 80°C
0.036
L-methionine
-
mutant D166N, pH 8.0
0.038
L-methionine
-
mutant D19N, presence of 0.05 mM S-adenosyl methionine, pH 8.0
0.04
L-methionine
-
wild-type, pH 8.0
0.041
L-methionine
-
MAT-I isoenzyme
0.041
L-methionine
-
mutant K280A, pH 8.0
0.045
L-methionine
-
mutant D121N, presence of 0.05 mM S-adenosyl methionine, pH 8.0
0.05
L-methionine
-
mutant D249N, presence of 0.05 mM S-adenosyl methionine, pH 8.0
0.06
L-methionine
-
uninduced E. coli NM522 strain extract alpha subunit at low L-methionine concentrations
0.06 - 0.1
L-methionine
alpha-two subunit
0.065 - 0.08
L-methionine
-
alpha subunit at low L-methionine concentrations
0.074
L-methionine
-
mutant K280A, presence of 0.05 mM S-adenosyl methionine, pH 8.0
0.075
L-methionine
-
alpha2-transfected MAT II, two kinetic forms
0.076
L-methionine
one kinetic form of alpha-two subunit in the presence of beta subunit
0.08 - 0.09
L-methionine
-
alpha subunit at high L-methionine concentrations. Also one kinetic form of alpha subunit in the presence of beta subunit
0.08
L-methionine
-
induced E. coli NM522 strain extract alpha subunit at low L-methionine concentrations and uninduced E. coli NM522 strain extract alpha subunit at high L-methionine concentrations
0.08
L-methionine
-
S283T mutant
0.088
L-methionine
-
Q113A mutant, S-adenosylmethionine synthesis
0.092
L-methionine
-
wild-type, S-adenosylmethionine synthesis
0.096
L-methionine
-
pH 8.2, 37°C
0.11
L-methionine
-
wild-type, pH 8.0
0.11
L-methionine
pH 8.0, 37°C
0.12
L-methionine
-
pH 8.0, 37°C
0.13
L-methionine
-
mutant W387F/Y323W, 55°C; mutant W387F/Y72W, 55°C
0.137
L-methionine
-
mutant D282N, presence of 0.05 mM S-adenosyl methionine, pH 8.0; mutant H17N, presence of 0.05 mM S-adenosyl methionine, pH 8.0
0.14
L-methionine
-
pH 8.0, 58°C
0.141
L-methionine
-
mutant D282N, pH 8.0
0.147
L-methionine
-
mutant D166N, presence of 0.05 mM S-adenosyl methionine, pH 8.0
0.17
L-methionine
-
mutant K256A, pH 8.0; mutant K256A, presence of 0.05 mM S-adenosyl methionine, pH 8.0
0.176
L-methionine
-
mutant H17A, presence of 0.05 mM S-adenosyl methionine, pH 8.0
0.18
L-methionine
-
mutant D107R1, pH 8.0
0.19
L-methionine
-
mutant D107R1, pH 8.0
0.2
L-methionine
-
induced E. coli NM522 strain extract alpha subunit at high L-methionine concentrations
0.215
L-methionine
-
MAT-III isoenzyme
0.22
L-methionine
-
wild-type
0.23
L-methionine
-
RLL mutant, S-adenosylmethionine synthesis
0.25
L-methionine
-
mutant W387F/Y371W, 55°C
0.26
L-methionine
in 100 mM Tris-Cl pH 8.0, 20 mM MgCl2, at 37°C
0.287
L-methionine
-
wild-type, presence of 0.05 mM S-adenosyl methionine, pH 8.0
0.288
L-methionine
37°C, pH 8.2
0.29
L-methionine
-
mutant D107C, pH 8.0
0.3
L-methionine
-
saturated with KCl
0.3
L-methionine
-
G6 mutant, S-adenosylmethionine synthesis
0.3
L-methionine
-
mutant W387F/Y226W, 55°C; mutant W387F/Y273W, 55°C
0.31
L-methionine
-
mutant W387F, 55°C; wild-type, 55°C
0.31
L-methionine
-
at pH 8.0 and 37°C
0.33
L-methionine
-
mutant W387F/Y344W, 55°C
0.45
L-methionine
-
mutant G105C, pH 8.0
0.45
L-methionine
-
mutant W387F/Y267W, 55°C
0.47
L-methionine
-
mutant W387F/Y233W, 55°C
0.49
L-methionine
-
G7 mutant, S-adenosylmethionine synthesis
0.5
L-methionine
-
mutant W387F/Y255W, 55°C
0.51
L-methionine
at pH 8.5 and 35°C
0.527
L-methionine
-
at pH 8.0 and 35°C
0.54
L-methionine
-
mutant W387F/Y120W, 55°C
0.57
L-methionine
-
mutant W387F/Y85W, 55°C
0.62
L-methionine
-
G8 mutant, S-adenosylmethionine synthesis
0.66
L-methionine
-
mutant W387F/Y49W, 55°C
0.75
L-methionine
-
mutant G105R1, pH 8.0
0.77
L-methionine
-
G5 mutant, S-adenosylmethionine synthesis
0.85
L-methionine
-
at pH 8.5 and 45°C
1
L-methionine
-
mutant W387F/Y170W, 55°C
1.2
L-methionine
-
at pH 8.0 and 70°C
1.47
L-methionine
-
at pH 8.5 and 40°C
0.0083
methionine

-
MAT-II isoenzyme
0.222
methionine
mutant C35S, presence of dithiothreitol
0.246
methionine
wild-type, presence of dithiothreitol
0.449
methionine
mutant C35S, presence of glutathione
0.5
methionine
-
beta form from liver
0.756
methionine
mutant C61S, presence of dithiothreitol
0.794
methionine
mutant C61S, presence of glutathione
1.12
methionine
wild-type, presence of glutathione
0.006
Mg2+

-
alpha form from liver
0.007
Mg2+
-
beta form from liver
0.0013
tripolyphosphate

-
wild type, tripolyphosphatase activity, in the presence of 0.1 mM of S-adenosylmethionine
0.0015
tripolyphosphate
-
G7 mutant, tripolyphosphatase activity, in absence of S-adenosylmethionine
0.0016
tripolyphosphate
-
G8 mutant, tripolyphospha