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Information on EC 2.5.1.6 - methionine adenosyltransferase
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2.5.1.6 methionine adenosyltransferaseSpecify your search results
Word Map
- 2.5.1.6
- monolayers
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self-assembled
- gold
-
film
- alkanethiols
-
photoelectron
-
infrared
-
fabric
-
electrode
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electrochemical
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tunnel
-
voltammetry
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coverage
-
interfacial
-
ellipsometry
-
impedance
- s-adenosylhomocysteine
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thiolate
-
silicon
-
photoemission
-
electrochemistry
-
well-ordered
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photovoltaic
-
wafer
-
large-area
-
transistor
-
transmethylation
-
semiconductor
-
nanoscopic
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field-effect
-
close-packed
-
stamp
-
photolithography
-
wettabl
-
nanopatterns
-
polycrystalline
-
electroless
-
thin-film
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chemisorption
- drug development
-
lithography
-
microcontact
-
fermi
-
headgroups
-
wettability
- synthesis
- medicine
-
micropatterned
-
microbalance
-
silane
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statin-associated
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transsulfuration
- ferrocene
The enzyme appears in viruses and cellular organisms
Synonyms
sams, mat2a, methionine adenosyltransferase, mat1a, s-adenosylmethionine synthetase, adomet synthetase, sam synthetase, mat ii, matalpha2, s-adenosyl-l-methionine synthetase, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
adenosylmethionine synthetase
-
-
-
-
AdoMet synthease
AdoMet synthetase
AdoMetS
ATP-methionine adenosyltransferase
-
-
-
-
EC 2.4.2.13
-
-
formerly
-
MAT
MAT I
MAT II
MAT III
MAT1A
MAT2
MAT2A
MATalpha1
methionine adenosyltransferase
methionine adenosyltransferase 2A
methionine adenosyltransferase alpha1
methionine S-adenosyltransferase
-
-
-
-
methionine-activating enzyme
-
-
-
-
MetK
Mj-MAT
MJ1208
S-adenosyl-L-methionine synthetase
S-adenosyl-Lmethionine synthetase
S-adenosylmethionine synthase
S-adenosylmethionine synthetase
SAM synthase
SAM synthetase
SAM-s
Sam1
SAM2
SAMS
SAMS1
SSO0199
AdoMet synthetase
-
-
-
-
methionine adenosyltransferase
-
-
-
-
S-adenosyl-L-methionine synthetase
-
-
-
-
S-adenosylmethionine synthase
-
-
-
-
S-adenosylmethionine synthetase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine
mechanism
-
ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine
steady state ordered Bi Ter mechanism with ATP adding before L-methionine and S-adenosylmethionine being the first product released, random release of phosphate and diphosphate
-
ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine
mechanism of inhibiton by product analogues and implications for reaction
ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine
mechanism, key role of K182 in the correct positioning of the substrates, and D135 in stabilizing the sulfonium group formed in the product
ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine
neutral H14 acts as an acid to cleave the C5-O5 bond of ATP, S of methionine makes a nucleophilic attack on the C5 to form the product
ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine
catalysis of a SN2 reaction through hydrogen bonding of the liberated oxygen-5' to the histidine, charge neutralization by the two Mg2+ ions, and stabilization of the product sulfonium cation through a close, non-bonded, contact between the sulfur and the ribose oxygen-4'
ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
adenosyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
ATP:L-methionine S-adenosyltransferase
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CAS REGISTRY NUMBER
COMMENTARY
9012-52-6
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + (2S)-2-amino-4-(but-3-yn-1-ylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(but-3-yn-1-ylselanyl)butanoic acid
ATP + (2S)-2-amino-4-(but-3-yn-1-ylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(but-3-yn-1-ylsulfanyl)butanoic acid
ATP + (2S)-2-amino-4-(butylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(butylselanyl)butanoic acid
ATP + (2S)-2-amino-4-(butylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(butylsulfanyl)butanoic acid
27% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(ethylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(ethylselanyl)butanoic acid
76% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(ethylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(ethylsulfanyl)butanoic acid
84% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(prop-2-en-1-ylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(prop-2-en-1-ylselanyl)butanoic acid
30% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(prop-2-en-1-ylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(prop-2-en-1-ylsulfanyl)butanoic acid
27% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(prop-2-yn-1-ylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(prop-2-yn-1-ylselanyl)butanoic acid
28% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(prop-2-yn-1-ylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(prop-2-yn-1-ylsulfanyl)butanoic acid
36% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(propan-2-ylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(propan-2-ylselanyl)butanoic acid
40% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(propan-2-ylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(propan-2-ylsulfanyl)butanoic acid
53% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(propylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(propylselanyl)butanoic acid
66% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(propylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(propylsulfanyl)butanoic acid
44% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(2-azido ethyl)sulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(2-azido ethyl)sulfanyl]butanoic acid
50% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(2-methyl propyl)sulfanyl] butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(2-methyl propyl)sulfanyl]butanoic acid
57% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(2-methylprop-2-en-1-yl)selanyl]butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-[(2-methylprop-2-en-1-yl)selanyl]butanoic acid
46% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(2-methylprop-2-en-1-yl)sulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(2-methylprop-2-en-1-yl)sulfanyl]butanoic acid
15% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(2E)-but-2-en-1-ylsulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(2E)-but-2-en-1-ylsulfanyl]butanoic acid
27% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(2E)-penta-2,4-dien-1-ylsulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(2E)-penta-2,4-dien-1-ylsulfanyl]butanoic acid
25% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(3-azido propyl)sulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(3-azido propyl)sulfanyl]butanoic acid
60% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(3-methyl butyl)sulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(3-methyl butyl)sulfanyl] butanoic acid
36% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(3-methylbut-2-en-1-yl)selanyl]butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-[(3-methylbut-2-en-1-yl)selanyl]butanoic acid
44% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(3-methylbut-2-en-1-yl)sulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(3-methylbut-2-en-1-yl)sulfanyl]butanoic acid
12% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(cyanomethyl) sulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[(cyanomethyl)sulfanyl]butanoic acid
68% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[(cyanomethyl)selanyl]butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-[(cyanomethyl)selanyl]butanoic acid
12% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[[(2E)-4-aminobut-2-en-1-yl]selanyl]butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-[[(2E)-4-aminobut-2-en-1-yl]selanyl]butanoic acid
38% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[[(2E)-4-azidobut-2-en-1-yl]selanyl]butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-[[(2E)-4-azidobut-2-en-1-yl]selanyl]butanoic acid
24% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-[[(2E)-4-azidobut-2-en-1-yl]sulfanyl]butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-[[(2E)-4-azidobut-2-en-1-yl]sulfanyl]butanoic acid
28% of the turnover rate compared to L-methionine
-
-
?
ATP + (3S)-3-amino-5-(methylthio)pentan-2-ol + H2O
phosphate + diphosphate + ?
-
-
-
?
ATP + D-methionine + H2O
S-adenosyl-D-methionine + phosphate + diphosphate
-
-
-
?
ATP + L-ethionine + H2O
phosphate + diphosphate + S-adenosyl-L-ethionine
-
-
-
?
ATP + L-methionine methyl ester + H2O
S-adenosyl-L-methionine methyl ester + phosphate + diphosphate
-
-
-
?
ATP + L-selenomethionine + H2O
phosphate + diphosphate + Se-adenosyl-L-selenomethionine
as active as L-methionine
-
-
?
CTP + L-methionine + H2O
S-cytosyl-L-methionine + phosphate + diphosphate
-
-
-
?
GTP + L-methionine + H2O
S-guanosyl-L-methionine + phosphate + diphosphate
-
-
-
?
UTP + L-methionine + H2O
S-urasyl-L-methionine + phosphate + diphosphate
-
-
-
?
2'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
2'-deoxy-ATP + L-methionine + H2O
?
-
completely specific for ATP
-
-
?
3'-deoxy-ATP + L-methionine + H2O
?
-
-
-
-
?
3'-deoxy-ATP + L-methionine + H2O
?
-
completely specific for ATP
-
-
?
ATP + (2S)-2-amino-4-(but-3-yn-1-ylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(but-3-yn-1-ylselanyl)butanoic acid
10% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(but-3-yn-1-ylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(but-3-yn-1-ylselanyl)butanoic acid
10% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(but-3-yn-1-ylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(but-3-yn-1-ylsulfanyl)butanoic acid
30% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(but-3-yn-1-ylsulfanyl)butanoic acid + H2O
phosphate + diphosphate + S-adenosyl-(2S)-2-amino-4-(but-3-yn-1-ylsulfanyl)butanoic acid
30% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(butylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(butylselanyl)butanoic acid
70% of the turnover rate compared to L-methionine
-
-
?
ATP + (2S)-2-amino-4-(butylselanyl)butanoic acid + H2O
phosphate + diphosphate + Se-adenosyl-(2S)-2-amino-4-(butylselanyl)butanoic acid
70% of the turnover rate compared to L-methionine
-
-
?
ATP + L-ethionine + H2O
S-adenosyl-L-ethionine + phosphate + diphosphate
-
-
-
?
ATP + L-ethionine + H2O
S-adenosyl-L-ethionine + phosphate + diphosphate
-
-
-
?
ATP + L-ethionine + H2O
S-adenosyl-L-ethionine + phosphate + diphosphate
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
aspartate family biosynthesis pathway and methionine metabolism, regulation, S-adenosyl-L-methionine activates threonine synthase expression and negatively regulates the transcript level of the cystathionine gamma-synthase, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
S-adenosylmethionine synthetase 3 is important for pollen tube growth
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
S-adenosyl-L-methionine is required for betaine synthesis and also for the synthesis of other compounds, especially lignin, transcript levels of the enzyme are co-regulated with those of phosphoethanolamine N-methyltransferase and choline monooxygenase to supply S-adenosyl-L-methionine for betaine synthesis in the leaves, overview, enzyme regulation pattern in plant tissues, overview
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
-
-
-
?
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine