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Synonyms
carboxypeptidase n, kininase i, procpb, anaphylatoxin inactivator, carboxypeptidase n1, bradykininase, cpase n, creatine kinase conversion factor, lysine carboxypeptidase, kininase ia,
more
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acetyl-Phe-Ser-Pro-Phe-Arg + H2O
acetyl-Phe-Ser-Pro-Phe + Arg
-
-
-
-
?
activated complement C3a + H2O
?
-
-
-
-
?
activated complement C5a + H2O
?
-
-
-
-
?
Ala-Ser-His-Leu-Gly-Leu-Ala-Arg + H2O
Ala-Ser-His-Leu-Gly-Leu-Ala + Arg
-
reaction is less efficient than reaction with EC 3.4.17.20
-
?
anaphylatoxin + H2O
?
-
-
-
-
?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + Arg
benzoyl-Ala-Arg + H2O
benzoyl-Ala + Arg
-
-
-
-
?
benzoyl-Ala-Lys + H2O
?
-
-
-
-
?
benzoyl-argininic acid + H2O
?
-
-
-
-
?
benzoyl-Gly-Arg + H2O
benzoyl-Gly + Arg
benzoyl-Gly-argininic acid + H2O
benzoyl-Gly + argininic acid
benzoyl-Gly-Lys + H2O
benzoyl-Gly + Lys
benzyloxycarbonyl-Ala-Arg + H2O
benzyloxycarbonyl-Ala + Arg
-
-
-
-
?
benzyloxycarbonyl-Val-Gly-Lys-Lys + H2O
Lys + benzyloxycarbonyl-Val-Gly-Lys
-
-
-
?
dansyl-Phe-Ala-Arg + H2O
dansyl-Phe-Ala + L-arginine
-
-
-
-
?
fibrinopeptide A + H2O
Arg + ?
-
very low activity
-
?
fibrinopeptide alphaArg96-104 + H2O
?
-
-
-
?
fibrinopeptide B + H2O
Arg + ?
-
-
-
?
fibrinopeptide betaLys125-133 + H2O
?
-
-
-
?
fibrinopeptide gammaLys54-62 + H2O
?
-
-
-
?
fibrinopeptide gammaLys77-85 + H2O
?
-
-
-
?
fibrinopeptide-alpha-Arg96-104 + H2O
?
-
-
-
?
fibrinopeptide-beta-Lys125-133 + H2O
?
-
-
-
?
fibrinopeptide-gamma-Lys54-62 + H2O
?
-
-
-
?
fibrinopeptide-gamma-Lys77-85 + H2O
?
-
-
-
?
furylacryloyl-Ala-Arg + H2O
furylacryloyl-Ala + Arg
-
-
-
-
?
furylacryloyl-Ala-L-Lys + H2O
furylacryloylalanine-Ala + Lys
furylacryloyl-Gly-Arg + H2O
furylacryloyl-Gly + Arg
-
-
-
-
?
furylacryloyl-Gly-Lys + H2O
furylacryloyl-Gly + Lys
-
-
-
-
?
furylacryloyl-L-Ala-L-Lys + H2O
furylacryloyl-L-Ala + Lys
-
-
-
-
?
Gly-His-Lys + H2O
Gly-His + Lys
-
-
-
?
hippuryl-Arg + H2O
hippuric acid + Arg
Hippuryl-L-Arg + H2O
Hippuric acid + L-Arg
Hippuryl-L-argininic acid + H2O
Hippuric acid + argininic acid
-
-
-
-
?
hippuryl-L-His-L-Leu + H2O
hippuryl-L-His + L-Leu
-
-
-
-
?
Hippuryl-L-Lys + H2O
Hippuric acid + L-Lys
hippuryl-L-Lys-L-Leu + H2O
hippuryl-L-Lys + L-Leu
-
-
-
-
?
His-Lys-Asp-Met-Gln-Leu-Gly-Arg + H2O
His-Lys-Asp-Met-Gln-Leu-Gly + Arg
-
i.e. C5a, reaction is less efficient than reaction with EC 3.4.17.20
-
?
His-tagged C3f peptide + H2O
?
-
CPN cleaves the C-terminal Arg of C3f_R1310-R1320 to produce C3f_R1310-L1319
-
-
?
kallikrein + H2O
?
-
plasma or urinary
-
-
?
Leu-Trp-Met-Arg + H2O
Leu-Trp-Met + Arg
-
-
-
?
Phe-Ser-Pro-Phe-Arg + H2O
Phe-Ser-Pro-Phe + Arg
-
-
-
-
?
plasmin + H2O
?
-
-
-
-
?
Pro-Gly-Lys-Ala-Arg + H2O
Pro-Gly-Lys-Ala + Arg
-
-
-
?
Pro-Phe-Gly-Lys + H2O
Pro-Phe-Gly + Lys
-
-
-
?
Pro-Phe-Lys + H2O
Pro-Phe + Lys
-
-
-
-
?
Pro-Phe-Lys-Gly + H2O
Pro-Phe-Lys + Gly
-
-
-
-
?
salmine + H2O
Arg + ?
-
-
-
?
Thr-Pro-Arg-Lys + H2O
Thr-Pro-Arg + Lys
-
-
-
?
thrombin-cleaved osteopontin + H2O
?
-
-
-
-
?
trypsin + H2O
?
-
-
-
-
?
YFPGQFAFSK + H2O
YFPGQFAFS + lysine
bioacivity of 10-mer chemerin peptide, chemerin 149-158, is enhanced by removing the carboxyl-terminal lysine
-
-
?
YFPGQFAFSKALPRS + H2O
?
sequential cleavage of prochemerin peptide, chemerin 149-163, by CPB increases chemotactic activities
-
-
?
additional information
?
-
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + Arg
-
-
-
-
?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + Arg
-
i.e. bradykinin, removal of C-terminal Arg
-
-
?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + Arg
-
-
-
-
?
benzoyl-Gly-Arg + H2O

benzoyl-Gly + Arg
-
-
-
?
benzoyl-Gly-Arg + H2O
benzoyl-Gly + Arg
-
-
-
-
?
benzoyl-Gly-Arg + H2O
benzoyl-Gly + Arg
-
-
-
?
benzoyl-Gly-argininic acid + H2O

benzoyl-Gly + argininic acid
-
-
-
-
?
benzoyl-Gly-argininic acid + H2O
benzoyl-Gly + argininic acid
-
-
-
-
?
benzoyl-Gly-argininic acid + H2O
benzoyl-Gly + argininic acid
-
-
-
?
benzoyl-Gly-Lys + H2O

benzoyl-Gly + Lys
-
-
-
?
benzoyl-Gly-Lys + H2O
benzoyl-Gly + Lys
-
-
-
-
?
benzoyl-Gly-Lys + H2O
benzoyl-Gly + Lys
-
-
-
?
bradykinin + H2O

?
-
-
-
?
bradykinin + H2O
?
-
inactivates bradykinin
-
-
?
bradykinin + H2O
?
-
-
-
-
?
C3a69-77 + H2O

?
-
-
-
?
C3a69-77 + H2O
?
peptide derived from bradykinin
-
-
?
C5a66-74 + H2O

?
-
-
-
?
C5a66-74 + H2O
?
peptide derived from bradykinin
-
-
?
chemerin + H2O

?
-
-
-
?
chemerin + H2O
?
CPB enhances the bioactivity of 10-mer chemerin peptide NH2-YFPGQFAFSK-COOH by removing the carboxyl-terminal lysine
-
-
?
chemerin + H2O
?
CPN enhances the bioactivity of 10-mer chemerin peptide NH2-YFPGQFAFSK-COOH by removing the carboxyl-terminal lysine
-
-
?
furylacryloyl-Ala-L-Lys + H2O

furylacryloylalanine-Ala + Lys
-
-
-
?
furylacryloyl-Ala-L-Lys + H2O
furylacryloylalanine-Ala + Lys
-
-
-
-
?
furylacryloyl-Ala-L-Lys + H2O
furylacryloylalanine-Ala + Lys
-
low reaction rate
-
?
hippuryl-Arg + H2O

hippuric acid + Arg
-
-
-
?
hippuryl-Arg + H2O
hippuric acid + Arg
-
-
-
?
hippuryl-Arg + H2O
hippuric acid + Arg
-
-
-
?
hippuryl-Arg + H2O
hippuric acid + Arg
-
-
?
hippuryl-Arg + H2O
hippuric acid + Arg
-
-
-
?
hippuryl-Arg + H2O
hippuric acid + Arg
-
-
-
?
Hippuryl-L-Arg + H2O

Hippuric acid + L-Arg
-
-
-
-
?
Hippuryl-L-Arg + H2O
Hippuric acid + L-Arg
-
-
-
?
Hippuryl-L-Arg + H2O
Hippuric acid + L-Arg
-
-
-
-
?
Hippuryl-L-Arg + H2O
Hippuric acid + L-Arg
-
-
-
-
?
Hippuryl-L-Arg + H2O
Hippuric acid + L-Arg
-
-
-
?
Hippuryl-L-Arg + H2O
Hippuric acid + L-Arg
-
-
-
-
?
Hippuryl-L-Lys + H2O

Hippuric acid + L-Lys
-
-
-
-
?
Hippuryl-L-Lys + H2O
Hippuric acid + L-Lys
-
-
-
?
Hippuryl-L-Lys + H2O
Hippuric acid + L-Lys
-
-
-
-
?
Hippuryl-L-Lys + H2O
Hippuric acid + L-Lys
-
-
-
-
?
Hippuryl-L-Lys + H2O
Hippuric acid + L-Lys
-
-
-
-
?
polylysine + H2O

Lys
-
-
-
-
?
polylysine + H2O
Lys
-
-
-
?
prochemerin + H2O

?
sequential cleavages of either a prochemerin peptide or recombinant full-length prochemerin by plasmin and CPN/CPB substantially increases their chemotactic activities
-
-
?
prochemerin + H2O
?
sequential cleavages of either a prochemerin peptide or recombinant full-length prochemerin by plasmin and CPN/CPB substantially increases their chemotactic activities. Endogenous CPN present in circulating plasma enhances the activity of plasmin-cleaved prochemerin
-
-
?
additional information

?
-
-
the enzyme cleaves C-terminal Lys faster than Arg in most substrates
-
-
?
additional information
?
-
-
the enzyme is involved in regulation of inflammation, overview, the enzyme acts as anaphylatoxin inactivator
-
-
?
additional information
?
-
-
the enzyme is responsible for regulatory C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation
-
-
?
additional information
?
-
-
C-terminal cleavage of stromal cell-derived factor-1alpha reducing the substrate's biological activity, SDF-1alpha
-
-
?
additional information
?
-
-
the enzyme releases C-terminal Arg and Lys from peptide substrates, such as bradykinin, kallidin, or Met-Lys-bradykinin
-
-
?
additional information
?
-
-
CPN is identified as a fibrin clot-bound protein using Western blotting. Using surface plasmon resonance it is shown CPN can bind to fibrinogen as well as to fibrin
-
-
?
additional information
?
-
carboxypeptidase N is not an acute phase protein under inflammatory conditions
-
-
?
additional information
?
-
-
carboxypeptidase N is not an acute phase protein under inflammatory conditions
-
-
?
additional information
?
-
carboxypeptidase N is not an acute phase protein under inflammatory conditions
-
?
additional information
?
-
-
carboxypeptidase N is not an acute phase protein under inflammatory conditions
-
?
additional information
?
-
-
the enzyme is involved in regulation of inflammation, overview, the enzyme acts as anaphylatoxin inactivator
-
-
?
additional information
?
-
-
the enzyme releases C-terminal Arg and Lys from peptide substrates, such as bradykinin, kallidin, or Met-Lys-bradykinin
-
-
?
additional information
?
-
-
activated CPB removes the newly exposed carboxyl terminal lysines in the partially digested fibrin clot
-
-
?
additional information
?
-
-
activated CPB removes the newly exposed carboxyl terminal lysines in the partially digested fibrin clot
-
-
?
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bradykinin + H2O
?
-
inactivates bradykinin
-
-
?
additional information
?
-
additional information

?
-
-
the enzyme is involved in regulation of inflammation, overview, the enzyme acts as anaphylatoxin inactivator
-
-
?
additional information
?
-
-
the enzyme is responsible for regulatory C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation
-
-
?
additional information
?
-
-
CPN is identified as a fibrin clot-bound protein using Western blotting. Using surface plasmon resonance it is shown CPN can bind to fibrinogen as well as to fibrin
-
-
?
additional information
?
-
carboxypeptidase N is not an acute phase protein under inflammatory conditions
-
-
?
additional information
?
-
-
carboxypeptidase N is not an acute phase protein under inflammatory conditions
-
-
?
additional information
?
-
carboxypeptidase N is not an acute phase protein under inflammatory conditions
-
?
additional information
?
-
-
carboxypeptidase N is not an acute phase protein under inflammatory conditions
-
?
additional information
?
-
-
the enzyme is involved in regulation of inflammation, overview, the enzyme acts as anaphylatoxin inactivator
-
-
?
additional information
?
-
-
activated CPB removes the newly exposed carboxyl terminal lysines in the partially digested fibrin clot
-
-
?
additional information
?
-
-
activated CPB removes the newly exposed carboxyl terminal lysines in the partially digested fibrin clot
-
-
?
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2,3-dimercatopropan-1-ol
-
-
2-mercaptomethyl-3-guanidinoethylthiopropanoic acid
-
-
4-aminomethyl-cyclohexane carboxylic acid
-
with benzoyl-Gly-Lys as substrate
5-amino-n-pentanoic acid
-
-
Argininic acid
-
inhibition of peptidase activity and esterase activity; with benzoyl-Gly-Lys, hippuryl-argininic acid or with benzoyl-Gly-Arg as substrate
Benzyloxycarbonyl-Arg
-
with benzoyl-Gly-Arg as substrate
bromoacetyl-D-Arg
-
irreversible
DL-2-mercaptomethyl-3 guanidinoethylthiopropanoic acid
specific inhibitor for CPN but not CPB
DL-mercaptomethyl-3-guanidinoethylthiopropanoic acid
-
Guanidinoethylmercaptosuccinic acid
guanidinopropylsuccinic acid
-
weak
hippuric acid
-
with benzoyl-Gly-Arg as substrate
Hippuryl-L-argininic acid
-
with benzoyl-Gly-Arg as substrate
Nalpha-acetyl-Arg
-
with benzoyl-Gly-Lys or benzoyl-Gly-Arg as substrate
Nalpha-acetyl-Lys
-
with benzoyl-Gly-Lys as substrate
Peptide fragments of bradykinin
-
-
-
potato carboxypeptidase inhibitor
-
-
1,10-phenanthroline

-
-
6-aminohexanoic acid

-
-
6-aminohexanoic acid
-
with benzoyl-Gly-Lys or hippuryl-argininic acid as substrate
Arg

-
-
Arg
-
D-Arg; L-Arg; with benzoyl-Gly-Lys or hippuryl-argininic acid as substrate
benzoyl-L-Arg

-
-
benzoyl-L-Arg
-
with benzoyl-Gly-Arg as substrate
Cd2+

-
-
EDTA

-
-
EF6265

-
i.e. (S)-7-amino-2-[([(R)-2-methyl-1-(3-phenylpropanoylamino)propyl]hydroxyphosphinoyl)methyl]heptanoic acid, IC50: 0.00593 mM
EF6265
-
i.e. (S)-7-amino-2-[([(R)-2-methyl-1-(3-phenylpropanoylamino)propyl]hydroxyphosphinoyl)methyl]heptanoic acid, IC50: 0.0128 mM
Guanidinoethylmercaptosuccinic acid

-
weak
Guanidinoethylmercaptosuccinic acid
-
-
Hg2+

-
-
Lys

-
-
Lys
-
with hippuryl-argininic acid as substrate
additional information

-
no inhibition by CKPAKNARC, i.e. CPI-2KR
-
additional information
-
the enzyme expression level is unaffected by lipopolysaccharides
-
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Adenocarcinoma
Kininase I, kininase II and aminopeptidase levels in patients with gastrointestinal tumors.
Alzheimer Disease
[Activity of peptidyl-dipeptidase A and carboxypeptidase N in the serum of patients with Alzheimer disease]
Anaphylaxis
Aggregate anaphylaxis and carboxypeptidase N.
Anaphylaxis
Plasma protease inhibitor and anaphylatoxin inactivator levels in chronic urticaria/angioedema and in patients experiencing anaphylactoid reactions to radiographic contrast media.
Angina, Unstable
Conversion of MM creatine kinase isoforms in human plasma by carboxypeptidase N.
Angioedema
Examination of baseline levels of carboxypeptidase N and complement components as potential predictors of angioedema associated with the use of an angiotensin-converting enzyme inhibitor.
Angioedema
Familial carboxypeptidase N deficiency.
Angioedema
The role of complement in urticaria and angioedema.
Arthritis
Carboxypeptidase N (kininase I) activity in blood and synovial fluid from patients with arthritis.
Arthritis, Gouty
Tissue factor pathway inhibitor and thrombin-activatable carboxypeptidase B for prediction of early atherosclerosis in gouty arthritis.
Arthritis, Psoriatic
Carboxypeptidase N (kininase I) activity in blood and synovial fluid from patients with arthritis.
Arthritis, Rheumatoid
Carboxypeptidase N (kininase I) activity in blood and synovial fluid from patients with arthritis.
Arthritis, Rheumatoid
Thrombin-activatable carboxype