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Literature summary for 3.4.21.122 extracted from

  • Afar, D.E.; Vivanco, I.; Hubert, R.S.; Kuo, J.; Chen, E.; Saffran, D.C.; Raitano, A.B.; Jakobovits, A.
    Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia (2001), Cancer Res., 61, 1686-1692 .
    View publication on PubMed
Search for more literature for 3.4.21.122

Cloned(Commentary)

Cloned (Comment) Organism
expressed in 293T cells by transient transfection Homo sapiens

Protein Variants

Protein Variants Comment Organism
R255Q mutation results in a loss of autoproteolytic cleavage. The mutant enzyme appeared as a single protein species with an apparent molecular weight of 70000, the cleaved 32000 MW protease domain is not detected Homo sapiens
S441A mutation results in a loss of autoproteolytic cleavage. The mutant enzyme appeared as a single protein species with an apparent molecular weight of 70000, the cleaved 32000 MW protease domain is not detected Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information localized to granular structures within the cell Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
 TMPRSS2-encoded serine protease is expressed as a 70000 MW full-length form and a cleaved 32000 MW protease domain Homo sapiens
70000
-
 TMPRSS2-encoded serine protease is expressed as a 70000 MW full-length form and a cleaved 32000 MW protease domain Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15393
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification TMPRSS2-encoded serine protease is expressed as a 70000 MW full-length form and a cleaved 32000 MW protease domain. The proteolytic cleavage is dependent on catalytic activity, suggesting that it occurs as a result of autocleavage. The cleavage site is at Arg255 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
prostate gland highest expression of TMPRSS2 at the apical side of prostate and prostate cancer secretory epithelia and within the lumen of the glands Homo sapiens
-

Synonyms

Synonyms Comment Organism
TMPRSS2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens down-regulated in androgen-independent prostate cancer xenograft tissue derived from a bone metastasis down

General Information

General Information Comment Organism
drug target TMPRSS2 is a secreted protease that is highly expressed in prostate and prostate cancer, making it a potential target for cancer therapy and diagnosis Homo sapiens