Information on EC 3.1.4.4 - phospholipase D

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY
3.1.4.4
-
RECOMMENDED NAME
GeneOntology No.
phospholipase D
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
transphosphatidylation
-
-
ethanol, aliphatic alcohols with more than 5 carbons e.g. geraniol, aromatic or heterocylic compounds, saccharides, polyalcohols, steroids serve as acceptors; methanol, ethanolamine, glycerol serve as acceptors; simultaneously to hydrolysis
-
PATHWAY
KEGG Link
MetaCyc Link
choline biosynthesis III
-
Ether lipid metabolism
-
Glycerophospholipid metabolism
-
Metabolic pathways
-
phosphatidate metabolism, as a signaling molecule
-
phospholipases
-
SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine phosphatidohydrolase
Also acts on other phosphatidyl esters.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
AtPLDalpha1
-
-
-
-
AtPLDalpha1
Q38882
-
AtPLDalpha2
-
-
-
-
AtPLDbeta1
-
-
-
-
AtPLDbeta2
-
-
-
-
AtPLDdelta
-
-
-
-
AtPLDdelta
Q9C5Y0
-
AtPLDepsilon
-
-
-
-
AtPLDgamma1
-
-
-
-
AtPLDgamma2
-
-
-
-
AtPLDgamma3
-
-
-
-
AtPLDp1
-
-
-
-
AtPLDp2
-
-
-
-
AtPLDzeta
-
-
-
-
Ca2+-dependent phospholipase D
-
-
choline phosphatase
-
-
-
-
D type phospholipase
-
-
dermonecrotic toxin
A4USB4
-
endonuclease Nuc
-
high sequence identity
hPLD1
-
-
-
-
hPLD2
-
-
-
-
lecithinase D
-
-
-
-
LePLDalpha1
-
-
LePLDbeta1
-
-
lipophosphodiesterase II
-
-
-
-
LiRecDT1
P0CE81
-
LiRecDT2
P0CE83
-
LiRecDT3
Q2XQ09
-
mPLD1
-
-
-
-
mPLD2
-
-
-
-
N-acylphosphatidylethanolamine-hydrolyzing phospholipase D
-
-
NAPE-PLD
-
-
phosphatidylcholine choline hydrolase
-
-
Phosphatidylcholine-hydrolyzing phospholipase D1
-
-
-
-
Phosphatidylcholine-hydrolyzing phospholipase D2
-
-
-
-
phosphatidylinositol-4,5-bisphosphate-dependent PLD
-
-
phospholipase D
-
-
phospholipase D
-
-
phospholipase D
-
-
phospholipase D
O82549, P55939
-
phospholipase D
-
-
phospholipase D
O14939, Q13393
-
phospholipase D
Q8VWE9, Q8W1B2
-
phospholipase D
-
-
phospholipase D
P70496, P70498
-
phospholipase D
Q53728
-
phospholipase D
-
-
phospholipase D
B0FZD9
-
phospholipase D
-
-
phospholipase D
-
-
phospholipase D alpha
-
-
phospholipase D alpha
Fragaria x ananassa Duch
-
-
-
phospholipase D delta
Q9C5Y0
-
phospholipase D epsilon
-
-
phospholipase D1
-
-
phospholipase D1
-
-
phospholipase D1
-
-
phospholipase D1
Q8W1B2
-
phospholipase D1
Q5WR67
-
Phospholipase D1 PHOX and PX containing domain
-
-
-
-
phospholipase D1beta
Q13393
-
phospholipase D2
-
-
phospholipase D2
-
-
phospholipase D2
Q8VWE9
-
Phospholipase D2 PHOX and PX containing domain
-
-
-
-
phospholipase D2alpha
O14939, Q13393
-
phospholipase Dalpha
-
-
phospholipase Dalpha
-
-
phospholipase Dalpha
-
-
phospholipase Dalpha1
-
-
phospholipase Dalpha1
Q38882
-
phospholipase Dalpha1
-
-
phospholipase Dalpha3
-
-
phospholipase Dalpha3
Q9C888
-
phospholipase Dbeta
-
-
phospholipase Dzeta2
-
-
PIP2-dependent PLD
-
-
PIP2-independent PLD
D7P5E0
-
PIP2-PLD
-
-
PLD
-
-
-
-
PLD
D2E4A5
-
PLD
D7P5D9, D7P5E0, D7P5E1
-
PLD
B0FZD9
-
PLD
-
-
PLD delta
-
-
-
-
PLD epsilon
-
-
-
-
PLD type 2
-
-
PLD zeta
-
-
-
-
PLD1
-
-
PLD1
-
-
PLD1
Q8W1B2
-
PLD1
P70496
-
PLD103
Streptomyces racemochromogenes 10-3
E0D7I2
-
-
PLD1C
-
-
-
-
PLD2
A2BG86
-
PLD2
-
-
PLD2
Q8VWE9
-
PLD2
P70498
-
PLD2a
-
-
PLD2alpha
-
-
PLDalpha
-
-
-
-
PLDalpha
D2E4A5
-
PLDalpha
D7P5D9
-
PLDalpha
-
-
PLDalpha1
Q38882
-
PLDalpha2
-
-
PLDalpha3
-
-
-
-
PLDalpha3
Q9C888
-
PLDalpha3
D7P5D9
-
PldB
Dictyostelium discoideum AX3
-
-
-
PLDbeta
-
-
-
-
PLDbeta
D7P5E0
-
PLDbeta1
D7P5E0
-
PLDbeta1
-
-
PLDdelta
D7P5E1
-
PLDdelta1
-
-
-
-
PLDzeta1
-
-
-
-
PLDzeta2
-
-
-
-
pPLD1
Q8W1B2
-
pPLD2
Q8VWE9
-
rPLD1
-
-
-
-
rPLD2
-
-
-
-
TH-2PLD
Streptomyces septatus TH-2
-
-
-
Meiosis-specific sporulation protein SPO14
-
-
-
-
additional information
-
the enzyme belongs to the PLD superfamily containing two HKD motifs
CAS REGISTRY NUMBER
COMMENTARY
9001-87-0
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
strain ATCC 19606
-
-
Manually annotated by BRENDA team
diverse strains from soil, isolated from 25 soil samples in Setagaya, Tokyo, Japan
-
-
Manually annotated by BRENDA team
; isozymes PLDalpha1, PLDdelta, and PLDepsilon
-
-
Manually annotated by BRENDA team
Columbia ecotype
-
-
Manually annotated by BRENDA team
ecotype Columbia-O
-
-
Manually annotated by BRENDA team
gene pldepsilon
-
-
Manually annotated by BRENDA team
isoform PLDgamma1
SwissProt
Manually annotated by BRENDA team
isoform PLDgamma2
SwissProt
Manually annotated by BRENDA team
isoform PLDzeta2
SwissProt
Manually annotated by BRENDA team
isozyme PLDalpha, mechanically wounded leaves
-
-
Manually annotated by BRENDA team
isozyme PLDalpha1
-
-
Manually annotated by BRENDA team
isozyme PLDalpha3
-
-
Manually annotated by BRENDA team
isozyme PLDbeta
-
-
Manually annotated by BRENDA team
isozyme PLDdelta
SwissProt
Manually annotated by BRENDA team
isozyme PLDzeta1, comparison to other isozymes
SwissProt
Manually annotated by BRENDA team
PLDalpha, PLDbeta
-
-
Manually annotated by BRENDA team
commercial preparation
-
-
Manually annotated by BRENDA team
drought tolerant lines Tifton 8 and A13, moderate line Georgia green and drought sensitive line PI 196754
SwissProt
Manually annotated by BRENDA team
L. cv. Handate
-
-
Manually annotated by BRENDA team
cultivar Bug
-
-
Manually annotated by BRENDA team
isozymes PLD1 and PLD2
-
-
Manually annotated by BRENDA team
phosphatidylinositol bisphosphate independent isoform PLDalpha, phosphatidylinositol 4,5-bisphosphate dependent isoform PLDbeta/gamma, oleate-stimulated PLDdelta
-
-
Manually annotated by BRENDA team
Winter rape
-
-
Manually annotated by BRENDA team
cabbage, best source of enzyme tested
-
-
Manually annotated by BRENDA team
commercial preparation
-
-
Manually annotated by BRENDA team
isoform PLD2
-
-
Manually annotated by BRENDA team
isoform PLDalpha2
SwissProt
Manually annotated by BRENDA team
recombinant
-
-
Manually annotated by BRENDA team
var. capitata
-
-
Manually annotated by BRENDA team
white cabbage, isozyme PLD2alpha
-
-
Manually annotated by BRENDA team
madagascar periwinkles
-
-
Manually annotated by BRENDA team
patients with acute coronary syndromes infected with Chlamydophila pneumoniae
-
-
Manually annotated by BRENDA team
gene pld1
-
-
Manually annotated by BRENDA team
PLD2; isozyme PLD2 encoded by gene pld2
UniProt
Manually annotated by BRENDA team
isozyme PLDA; three isozymes PLDA, PLDB, and PDLC, encoded by genes plda, pldb, and pldc
UniProt
Manually annotated by BRENDA team
isozyme PLDB; three isozymes PLDA, PLDB, and PDLC, encoded by genes plda, pldb, and pldc
UniProt
Manually annotated by BRENDA team
isozyme PLDC; three isozymes PLDA, PLDB, and PDLC, encoded by genes plda, pldb, and pldc
UniProt
Manually annotated by BRENDA team
Dictyostelium discoideum AX3
gene pldB
-
-
Manually annotated by BRENDA team
Fragaria x ananassa Duch
Duch
-
-
Manually annotated by BRENDA team
soybean
-
-
Manually annotated by BRENDA team
gene HaPLDalpha
-
-
Manually annotated by BRENDA team
isoform D2
SwissProt
Manually annotated by BRENDA team
isoform PL D1
-
-
Manually annotated by BRENDA team
isoform PLD1
SwissProt
Manually annotated by BRENDA team
isoform PLD2
-
-
Manually annotated by BRENDA team
isozyme PLD1
SwissProt
Manually annotated by BRENDA team
isozyme PLD2
-
-
Manually annotated by BRENDA team
isozymes PLD1 and PLD2, and two splice variants of PLD1, PLD1a and PLD1b
-
-
Manually annotated by BRENDA team
isozymes PLD1 and PLD2, PLD2 has three splice variants, PLD2a, 2b, and 2c
SwissProt
Manually annotated by BRENDA team
isozymes PLD1, PLD2
-
-
Manually annotated by BRENDA team
isozymes PLD1b and PLD2a
-
-
Manually annotated by BRENDA team
isozynmes PLD1 and PLD2
-
-
Manually annotated by BRENDA team
N-acylethanolamine-specific phospholipase D, NAPE-PLD
-
-
Manually annotated by BRENDA team
PLD1; isozyme PLD1
SwissProt
Manually annotated by BRENDA team
PLD1; isozymes PLD1beta and PLD2alpha
SwissProt
Manually annotated by BRENDA team
PLD2; isozyme PLD2
SwissProt
Manually annotated by BRENDA team
PLD2; isozyme PLD2alpha
SwissProt
Manually annotated by BRENDA team
recombinant
-
-
Manually annotated by BRENDA team
isozyme PLDalpha, gene PLD
UniProt
Manually annotated by BRENDA team
isoform 6
SwissProt
Manually annotated by BRENDA team
isoform LiRecDT2
SwissProt
Manually annotated by BRENDA team
isoform LiRecDT3
SwissProt
Manually annotated by BRENDA team
isozymes PLD1 and PDL2
-
-
Manually annotated by BRENDA team
isozymes PLD1, PLD2, regulation of enzyme activity
-
-
Manually annotated by BRENDA team
isoform N-acyl phosphatidylethanolamine phospholipase D
-
-
Manually annotated by BRENDA team
isoform PLD1
SwissProt
Manually annotated by BRENDA team
isoform PLD2
SwissProt
Manually annotated by BRENDA team
isozyme PLD2
-
-
Manually annotated by BRENDA team
isozymes PLD1 and PLD2
-
-
Manually annotated by BRENDA team
isozymes PLD1 and PLD2, and two splice variants of PLD1, PLD1a and PLD1b
-
-
Manually annotated by BRENDA team
male BALB/c mice
-
-
Manually annotated by BRENDA team
PLD1 and PLD2
-
-
Manually annotated by BRENDA team
Mycobacterium marinum 1218R
1218R
-
-
Manually annotated by BRENDA team
Mycobacterium smegmatis mc(2)155
mc(2)155
-
-
Manually annotated by BRENDA team
strain H37Rv and strain H37Ra
-
-
Manually annotated by BRENDA team
cv. Samsun and Bright Yellow 2, different isozymes
UniProt
Manually annotated by BRENDA team
cv. Samsun and Bright Yellow 2, isozyme PLDbeta1
UniProt
Manually annotated by BRENDA team
cv. Samsun and Bright Yellow 2, isozyme PLDdelta
UniProt
Manually annotated by BRENDA team
phosphatidylinositol-4,5-bisphosphate-dependent isozyme
-
-
Manually annotated by BRENDA team
tabacco
Uniprot
Manually annotated by BRENDA team
isozymes PLD2 and PLD1
-
-
Manually annotated by BRENDA team
cv. Nipponbare
-
-
Manually annotated by BRENDA team
isoform PLDbeta1; identification of 17 phospholipase D genes including isoform SP-PLD harboring a signal peptide at the N-terminus. Most genes are differentially expressed in different tissues, are induced by hormones or stress conditions
SwissProt
Manually annotated by BRENDA team
rice
-
-
Manually annotated by BRENDA team
subsp. japonica cv. Nipponbare, 17 PLD genes encoding isozymes, e.g. genes OsPLDalpha1, OsPLDalpha5, and OsPLDbeta1
-
-
Manually annotated by BRENDA team
L. Vajovecky
SwissProt
Manually annotated by BRENDA team
not all strains carry the gene pldA
-
-
Manually annotated by BRENDA team
female and male Sprague-Dawley rats, isozyme PLD1
-
-
Manually annotated by BRENDA team
isozyme PLD1
-
-
Manually annotated by BRENDA team
isozyme PLD2
-
-
Manually annotated by BRENDA team
isozymes PLD1 and PLD2
-
-
Manually annotated by BRENDA team
isozymes PLD1 and PLD2, and two splice variants of PLD1, PLD1a and PLD1b
-
-
Manually annotated by BRENDA team
N-acylethanolamine-specific phospholipase D, NAPE-PLD
-
-
Manually annotated by BRENDA team
Wistar rats
-
-
Manually annotated by BRENDA team
castor bean
-
-
Manually annotated by BRENDA team
strain Madrid Evir, a virulent revertant of the attenuated Madrid E strain, gene pld
-
-
Manually annotated by BRENDA team
ATCC type strain
SwissProt
Manually annotated by BRENDA team
Streptomyces halstedii subsp. scabies K6
-
-
-
Manually annotated by BRENDA team
Streptomyces racemochromogenes 10-3
-
UniProt
Manually annotated by BRENDA team
strain TH-2
-
-
Manually annotated by BRENDA team
strain TH-2, recombinant enzyme
-
-
Manually annotated by BRENDA team
Streptomyces septatus TH-2
-
-
-
Manually annotated by BRENDA team
Streptomyces septatus TH-2
strain TH-2
-
-
Manually annotated by BRENDA team
Streptomyces septatus TH-2
strain TH-2, recombinant enzyme
-
-
Manually annotated by BRENDA team
PMF strain
Uniprot
Manually annotated by BRENDA team
strain CS-57
-
-
Manually annotated by BRENDA team
strain PMF, commercial preparation
-
-
Manually annotated by BRENDA team
YU100, optimal culture conditions
-
-
Manually annotated by BRENDA team
Streptomyces sp. AA586
AA586
-
-
Manually annotated by BRENDA team
Streptomyces sp. CS-57
strain CS-57
-
-
Manually annotated by BRENDA team
Streptomyces spp.
-
-
-
Manually annotated by BRENDA team
elevated activity during early logarithmic growth phase
-
-
Manually annotated by BRENDA team
mung bean
-
-
Manually annotated by BRENDA team
cow pea
Uniprot
Manually annotated by BRENDA team
L. Walp, isozyme PLDalpha, recombinant enzyme
-
-
Manually annotated by BRENDA team
L. Walp, recombinant protein
-
-
Manually annotated by BRENDA team
enzyme expression and activity are increased at beginning of heat acclimation
SwissProt
Manually annotated by BRENDA team
maize
-
-
Manually annotated by BRENDA team
ORGANIC SOLVENT
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
benzene
-
isolation of mutants that maintain their activites after 1 h incubation in benzene
benzene
Streptomyces septatus TH-2
-
isolation of mutants that maintain their activites after 1 h incubation in benzene
-
Ethanol
-
enzyme shows high activity to the non-micelle form of phosphatidylcholine in an aequeous solution containing methanol, ethanol, iso-propanol, or n-propanol
Ethyl acetate
-
isolation of mutants that maintain 85% of activites after 1 h incubation in ethyl acetate
Ethyl acetate
Streptomyces septatus TH-2
-
isolation of mutants that maintain 85% of activites after 1 h incubation in ethyl acetate
-
Glycerol
-
for measurement of transfer reaction, 2 M included in media to suppress hydrolytic reaction
isopropanol
-
enzyme shows high activity to the non-micelle form of phosphatidylcholine in an aequeous solution containing methanol, ethanol, isopropanol, or n-propanol
n-propanol
-
enzyme shows high activity to the non-micelle form of phosphatidylcholine in an aequeous solution containing methanol, ethanol, isopropanol, or n-propanol
Methanol
-
assay in presence of 50% ethanol
additional information
Brassica oleracea, Streptomyces spp.
-
addition of n-hexane/2-octanol to suppress hydrolytic byproduct
additional information
-
correlation of enzyme activity and membrane dynamics by monomolecular film technique