Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Fusobacterium nucleatum cell wall extract | stimulation | Homo sapiens | |
phorbol 12-myristate 13-acetate | stimulation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-butanol | inhibition of enzyme, leading to block of beta-defensin-2 up-regulation by cell wall extract of Fusobacterium nucleatum or phorbol 12-myristate 13-acetate | Homo sapiens | |
ethanol | inhibition of enzyme, leading to block of beta-defensin-2 up-regulation by cell wall extract of Fusobacterium nucleatum or phorbol 12-myristate 13-acetate | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | up-regulation of beta-defensin-2 by cell wall extract of Fusobacterium nucleatum or phorbol 12-myristate 13-acetate is mediated by phospholipase D | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HGEC cell | human gingival epithelial cell. Constitutive expression of PLD1alpha and PLD1beta splice variants and PLD1 protein, whereas PLD2 is expressed at much lower levels than PLD1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | up-regulation of beta-defensin-2 by cell wall extract of Fusobacterium nucleatum or phorbol 12-myristate 13-acetate is mediated by phospholipase D | Homo sapiens | ? | - |
? |