EC Number   |
General Information |
Reference |
|---|
    3.1.4.4 | evolution |
the enzyme belongs to the PLD superfamily, PLD superfamily members share a common core structure, and a common catalytic mechanism |
730075 |
| 3.1.4.4 | evolution |
the enzyme belongs to the PLD superfamily, PLD superfamily members share a common core structure, and thereby, a common catalytic mechanism |
-, 730075 |
| 3.1.4.4 | malfunction |
cells lacking PldB preferentially sort to the stalk in chimeric fruiting bodies with wild-type cells |
-, 714690 |
| 3.1.4.4 | malfunction |
disruption of phospholipase D causes a reduction in the organism's ability to thrive in serum, a deficiency in epithelial cell invasion, and diminished pathogenesis in a murine model of pneumonia |
708718 |
| 3.1.4.4 | malfunction |
inhibition of Pld1 function, by siRNA-mediated downregulation or 1-butanol, does not strongly impair the dorsal-ventral guidance of primary/secondary motor axons |
708280 |
| 3.1.4.4 | malfunction |
inhibition of RalA or PKC, activators of PLD, also inhibits endocytosis of EGFR |
707549 |
| 3.1.4.4 | malfunction |
knockdown of OsPLD-1 affects H+-ATPase- and Na+/H+ antiporter-related gene expression and inhibits salt-induced increase of H+-ATPase activity |
715830 |
| 3.1.4.4 | malfunction |
lipase-inactive PLD1 or inhibition of PLD1 by pharmacological inhibitors blocks PKD1 activation under oxidative stress |
709222 |
| 3.1.4.4 | malfunction |
phospholipase D isozymes are overexpressed in various human tumor tissues and involved in tumorigenesis. The increased expression of PLD and its enzymatic activity in the glioma stimulate the secretion and expression of matrix metalloproteinase 2, MMP-2 and induce the invasiveness of glioma cells, mechanism, overview |
708012 |
| 3.1.4.4 | malfunction |
phospholipase D, a phosphatidic acid-synthesizing enzyme, is linked to multiple aspects of normal brain function and to Alzheimer's disease, the most common neurodegenerative disorder, an imbalance in phospholipids is involved in development of Alzheimer's disease, overview |
707572 |
