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Literature summary for 3.1.4.4 extracted from

  • Brandenburg, L.O.; Konrad, M.; Wruck, C.; Koch, T.; Pufe, T.; Lucius, R.
    Involvement of formyl-peptide-receptor-like-1 and phospholipase D in the internalization and signal transduction of amyloid beta 1-42 in glial cells (2008), Neuroscience, 156, 266-276.
    View publication on PubMed
Search for more literature for 3.1.4.4

Activating Compound

Activating Compound Comment Organism Structure
amyloid beta peptide residues 1-42, i.e. Abeta1-42, a formyl-peptid-receptor-like 1 agonist, activates 3-4fold in microglia and astrocytes, respectively, at 0.001 mM. Endocytosis of Abeta1-42 in glial cells is PLD-dependent Rattus norvegicus
formylmethionyl-leucyl-proline i.e. fMLF, activates 4fold in microglia and astrocytes, respectively, at 0.001 mM, the activation is inhibited by WRW4, a formyl-peptid-receptor-like 1 antagonist Rattus norvegicus
additional information no inhibition of PLD by WRW4 Rattus norvegicus
phorbol 12-myristate 13-acetate activates 13fold at 0.001 mM in microglia and astrocytes Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus PLD catalyzes the hydrolysis of phospholipids resulting in the generation of phosphatidic acid and the release of the polar head group. The enzyme also catalyzes a transphosphatidylation reaction, in which the aliphatic chain of the primary alcohol is transferred to the phosphatidyl moiety of the phosphatidic acid product ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 Wistar rats
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte primary Rattus norvegicus
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brain
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 Rattus norvegicus
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glial cell
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 Rattus norvegicus
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microglia
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 Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 quantification of transphosphatidylation activity of PLD in glial cells, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PLD catalyzes the hydrolysis of phospholipids resulting in the generation of phosphatidic acid and the release of the polar head group. The enzyme also catalyzes a transphosphatidylation reaction, in which the aliphatic chain of the primary alcohol is transferred to the phosphatidyl moiety of the phosphatidic acid product Rattus norvegicus ?
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 ?
additional information PLD also performs transphosphatidylation using ethanol as phosphatidyl acceptor Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
PLD
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 Rattus norvegicus

General Information

General Information Comment Organism
physiological function PLD mediates amyloid beta peptides endocytosis into glial cells, and ERK1/2 phosphorylation by a formyl-peptid-receptor-like 1, FPRL1, agonists in glial cells Rattus norvegicus