Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Collagen | adhesion of myeloid-macrophage cell lines to fibronectin is accompanied by marked stimulation of enzyme activity | Homo sapiens | |
fibronectin | adhesion of primary neutrophils and monocyte-derived macrohages as well as myeloid-macrophage cell lines to fibronectin is accompanied by marked stimulation of enzyme activity | Homo sapiens | |
additional information | adhesion of myeloid-macrophage cell lines to fibronectin is accompanied by marked stimulation of enzyme activity | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | depletion of enzyme by siRNA in macrophages results in significant inhibition of phagocyte adhesion and is accompanied by reductions in total cellular F-actin | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | enzyme exhibits partial co-localization with actin filaments at the adherent interface in proximity to paxilin protein | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | adhesion of primary neutrophils and monocyte-derived macrohages to fibronectin is accompanied by marked stimulation of enzyme activity. Similarly, adhesion of myeloid-macrophage cell lines to fibronectin, collagen, or plastic results in significant activation. Stimulation of enzyme is rapid and persists for at least 90 min | Homo sapiens | - |