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Literature summary for 3.1.4.4 extracted from

  • Liu, Y.; Fanburg, B.L.
    Phospholipase D signaling in serotonin-induced mitogenesis of pulmonary artery smooth muscle cells (2008), Am. J. Physiol. Lung Cell Mol. Physiol., 295, L471-L478.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.4

Activating Compound

Activating Compound Comment Organism Structure
serotonin i.e. 5-hydroxytryptamine, 5-HT, activates PLD via the 5-HT 2A receptor, leading to the generation of phosphatidic acid that promotes smooth muscle cell proliferation through activations of mammalian target of rapamycin, mTOR, S6K1 and MAPK but not the Rho or PI3-kinase/Akt signaling pathways, overview. Activation is completely blocked by ketanserin Mus musculus
serotonin i.e. 5-hydroxytryptamine, 5-HT, activates PLD via the 5-HT 2A receptor, leading to the generation of phosphatidic acid that promotes smooth muscle cell proliferation through activations of mammalian target of rapamycin, mTOR, S6K1 and MAPK but not the Rho or PI3-kinase/Akt signaling pathways, overview. Activation is completely blocked by ketanserin Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of wild-type and inactive mutant PLD1 in bovine pulmonary artery smooth muscle cells Homo sapiens
overexpression of wild-type and inactive mutant PLD2 in bovine pulmonary artery smooth muscle cells Mus musculus

Protein Variants

Protein Variants Comment Organism
K758R catalytically inactive PLD2 mutant Mus musculus
K898R catalytically inactive PLD1 mutant Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + H2O Mus musculus
-
 choline + phosphatidic acid
-
 ?
phosphatidylcholine + H2O Homo sapiens
-
 choline + phosphatidic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozymes PLD1 and PLD2
-
Mus musculus
-
 isozymes PLD1 and PLD2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor leading to formation of phosphatidylbutan-1-ol Mus musculus ?
-
 ?
additional information PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor leading to formation of phosphatidylbutan-1-ol Homo sapiens ?
-
 ?
phosphatidylcholine + H2O
-
 Mus musculus choline + phosphatidic acid
-
 ?
phosphatidylcholine + H2O
-
 Homo sapiens choline + phosphatidic acid
-
 ?

Synonyms

Synonyms Comment Organism
PLD
-
 Mus musculus
PLD
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function phospholipase D signaling is involved in serotonin-induced mitogenesis of pulmonary artery smooth muscle cells. PLD activation participates in the cellular proliferation response to serotonin Mus musculus
physiological function phospholipase D signaling is involved in serotonin-induced mitogenesis of pulmonary artery smooth muscle cells. PLD activation participates in the cellular proliferation response to serotonin Homo sapiens