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Literature summary for 3.1.4.4 extracted from

  • Hornberger, T.A.; Chu, W.K.; mak, Y.W.; Hsiung, J.W.; Huang, S.A.; Chien, S.
    The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle (2006), Proc. Natl. Acad. Sci. USA, 103, 4741-4746.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information mechanical stimulation of skeletal muscle with intermittent passive stretch ex vivo induces phospholipase D activation, phosphatidic acid accumulation, and signaling by mTOR, i.e. mammalian target of rapamycin Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1-butanol inhibits the mechanically induced increase in phosphatidic acid in skeletal muscle and mechanical activation of signaling by mTOR, i.e. mammalian target of rapamycin Mus musculus
neomycin inhibits the mechanically induced increase in phosphatidic acid in skeletal muscle Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus mechanical stimuli activate mTOR (mammalian target of rapamycin) signaling through a phospholipase D-dependent increase in phosphatidic acid ?
-
?
additional information Mus musculus mechanical stimuli activate signaling by mTOR, i.e. mammalian target of rapamycin, in skeletal muscle through an enzyme-dependent increase in phosphatidic acid ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle LยดPLD1 and PLD2 are localized to the Z-band in the skeletal muscle, a critical site of mechanical force transmission Mus musculus
-
skeletal muscle isoforms PLD1 and PLD2 are localized to the z-band of skeletal muscle Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information mechanical stimuli activate mTOR (mammalian target of rapamycin) signaling through a phospholipase D-dependent increase in phosphatidic acid Mus musculus ?
-
?
additional information mechanical stimuli activate signaling by mTOR, i.e. mammalian target of rapamycin, in skeletal muscle through an enzyme-dependent increase in phosphatidic acid Mus musculus ?
-
?