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Literature summary for 3.1.4.4 extracted from
- Evidence that alpha-synuclein does not inhibit phospholipase D (2009), Biochemistry, 48, 1077-1083.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of isozymes PLD1b and PLD2a in HEK-293, HeLa, or undifferentiated PC12 cells | Homo sapiens |
| functional overexpression of SPO14 in yeast cells deficient in an essential phosphatidylinositol and phosphatidylcholine transfer protein, i.e. sec14-1/cki1DELTA cells, is not sufficient to rescue the alpha-synuclein-induced growth defect | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-synuclein | - |
Saccharomyces cerevisiae | |
| additional information | alpha-synuclein, a small cytosolic protein, does not inhibit phospholipase D | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | membrane-associated enzyme | Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens |  |
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + H2O | Homo sapiens | - |
choline + phosphatidic acid | - |
? | |
| phosphatidylcholine + H2O | Saccharomyces cerevisiae | - |
choline + phosphatidic acid | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isozymes PLD1b and PLD2a | - |
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + H2O | - |
Homo sapiens | choline + phosphatidic acid | - |
? | |
| phosphatidylcholine + H2O | - |
Saccharomyces cerevisiae | choline + phosphatidic acid | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PLD | - |
Homo sapiens |
| PLD | - |
Saccharomyces cerevisiae |
| SPO14 | - |
Saccharomyces cerevisiae |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
| 37 | - |
assay at | Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
| 7.5 | - |
assay at | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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