Any feedback?
Literature summary for 3.1.4.4 extracted from
- Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity (2009), Bioorg. Med. Chem. Lett., 19, 1916-1920.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (1S,2S)-N-[(1S)-2-[4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-2-phenylcyclopropanecarboxamide | - |
Homo sapiens |  |
| (1S,2S)-N-[(1S)-2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-2-phenylcyclopropanecarboxamide | - |
Homo sapiens | |
| (1S,2S)-N-[(1S)-2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-2-phenylcyclopropanecarboxamide | - |
Homo sapiens | |
| (1S,2S)-N-[(1S)-2-[4-(6-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-2-phenylcyclopropanecarboxamide | - |
Homo sapiens | |
| (1S,2S)-N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-2-phenylcyclopropanecarboxamide | - |
Homo sapiens | |
| (1S,2S)-N-[2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-2-phenylcyclopropanecarboxamide | - |
Homo sapiens | |
| 3,4-difluoro-N-[(1S)-2-[4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | - |
Homo sapiens | |
| 3,4-difluoro-N-[2-[4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]benzamide | - |
Homo sapiens | |
| 4-chloro-N-[(1S)-2-[4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | - |
Homo sapiens | |
| 4-chloro-N-[(1S)-2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | - |
Homo sapiens | |
| 4-chloro-N-[(1S)-2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | - |
Homo sapiens | |
| 4-chloro-N-[2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]benzamide | - |
Homo sapiens | |
| 4-chloro-N-[2-[4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]benzamide | - |
Homo sapiens | |
| 4-fluoro-N-[(1S)-2-[4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | - |
Homo sapiens | |
| 4-fluoro-N-[(1S)-2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | - |
Homo sapiens | |
| 4-fluoro-N-[2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]benzamide | - |
Homo sapiens | |
| 6-fluoro-N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]naphthalene-2-carboxamide | - |
Homo sapiens | |
| N-[(1S)-2-[4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]naphthalene-2-carboxamide | - |
Homo sapiens | |
| N-[(1S)-2-[4-(5-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-3,4-difluorobenzamide | - |
Homo sapiens | |
| N-[(1S)-2-[4-(5-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-4-chlorobenzamide | - |
Homo sapiens | |
| N-[(1S)-2-[4-(5-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]naphthalene-2-carboxamide | - |
Homo sapiens | |
| N-[(1S)-2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-3,4-difluorobenzamide | - |
Homo sapiens | |
| N-[(1S)-2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-4-fluorobenzamide | - |
Homo sapiens | |
| N-[(1S)-2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]naphthalene-2-carboxamide | - |
Homo sapiens | |
| N-[(1S)-2-[4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]naphthalene-2-carboxamide | - |
Homo sapiens | |
| N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-3,4-dihydronaphthalene-2-carboxamide | - |
Homo sapiens | |
| N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-3-phenylprop-2-ynamide | - |
Homo sapiens | |
| N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]naphthalene-2-carboxamide | - |
Homo sapiens | |
| N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]quinoline-3-carboxamide | - |
Homo sapiens | |
| N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]quinoline-6-carboxamide | - |
Homo sapiens | |
| N-[2-[4-(4-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-fluorobenzamide | - |
Homo sapiens | |
| N-[2-[4-(5-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-chlorobenzamide | - |
Homo sapiens | |
| N-[2-[4-(5-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-fluorobenzamide | - |
Homo sapiens | |
| N-[2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-methylbenzamide | - |
Homo sapiens | |
| N-[2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]naphthalene-2-carboxamide | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O14939 | - |
- |
| Homo sapiens | Q13393 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phospholipase D1 | - |
Homo sapiens |
| phospholipase D2 | - |
Homo sapiens |
| PLD1 | - |
Homo sapiens |
| PLD2 | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000002 | - |
isoform PLD1 | Homo sapiens | (1S,2S)-N-[2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-2-phenylcyclopropanecarboxamide | |
| 0.000002 | - |
isoform PLD1 | Homo sapiens | N-[(1S)-2-[4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]naphthalene-2-carboxamide | |
| 0.000003 | - |
isoform PLD1 | Homo sapiens | N-[(1S)-2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-3,4-difluorobenzamide | |
| 0.000003 | - |
isoform PLD1 | Homo sapiens | N-[2-[4-(5-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-chlorobenzamide | |
| 0.0000035 | - |
isoform PLD1 | Homo sapiens | N-[(1S)-2-[4-(5-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-3,4-difluorobenzamide | |
| 0.0000037 | - |
isoform PLD1 | Homo sapiens | (1S,2S)-N-[(1S)-2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-2-phenylcyclopropanecarboxamide | |
| 0.000004 | - |
isoform PLD1 | Homo sapiens | 3,4-difluoro-N-[2-[4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]benzamide | |
| 0.000004 | - |
isoform PLD1 | Homo sapiens | N-[(1S)-2-[4-(5-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-4-chlorobenzamide | |
| 0.000004 | - |
isoform PLD1 | Homo sapiens | N-[2-[4-(5-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-fluorobenzamide | |
| 0.000004 | - |
isoform PLD1 | Homo sapiens | N-[2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]naphthalene-2-carboxamide | |
| 0.0000055 | - |
isoform PLD1 | Homo sapiens | N-[(1S)-2-[4-(5-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]naphthalene-2-carboxamide | |
| 0.0000064 | - |
isoform PLD1 | Homo sapiens | 4-chloro-N-[(1S)-2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | |
| 0.000007 | - |
isoform PLD1 | Homo sapiens | 4-chloro-N-[2-[4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]benzamide | |
| 0.0000074 | - |
isoform PLD1 | Homo sapiens | 4-chloro-N-[(1S)-2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | |
| 0.000008 | - |
isoform PLD1 | Homo sapiens | (1S,2S)-N-[(1S)-2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-2-phenylcyclopropanecarboxamide | |
| 0.000008 | - |
isoform PLD1 | Homo sapiens | N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]quinoline-3-carboxamide | |
| 0.00001 | - |
isoform PLD1 | Homo sapiens | N-[(1S)-2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-4-fluorobenzamide | |
| 0.00001 | - |
isoform PLD1 | Homo sapiens | N-[2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-methylbenzamide | |
| 0.000011 | - |
isoform PLD1 | Homo sapiens | 4-fluoro-N-[(1S)-2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | |
| 0.000012 | - |
isoform PLD1 | Homo sapiens | (1S,2S)-N-[(1S)-2-[4-(6-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-2-phenylcyclopropanecarboxamide | |
| 0.000012 | - |
isoform PLD1 | Homo sapiens | 4-fluoro-N-[2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]benzamide | |
| 0.000014 | - |
isoform PLD2 | Homo sapiens | 3,4-difluoro-N-[2-[4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]benzamide | |
| 0.000018 | - |
isoform PLD1 | Homo sapiens | 4-chloro-N-[2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]benzamide | |
| 0.000021 | - |
isoform PLD1 | Homo sapiens | N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]naphthalene-2-carboxamide | |
| 0.000021 | - |
isoform PLD1 | Homo sapiens | N-[2-[4-(4-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-fluorobenzamide | |
| 0.000035 | - |
isoform PLD1 | Homo sapiens | (1S,2S)-N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-2-phenylcyclopropanecarboxamide | |
| 0.000038 | - |
isoform PLD1 | Homo sapiens | 3,4-difluoro-N-[(1S)-2-[4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | |
| 0.00004 | - |
isoform PLD1 | Homo sapiens | N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-3-phenylprop-2-ynamide | |
| 0.000042 | - |
isoform PLD2 | Homo sapiens | 4-chloro-N-[2-[4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]benzamide | |
| 0.000042 | - |
isoform PLD2 | Homo sapiens | N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]quinoline-3-carboxamide | |
| 0.000043 | - |
isoform PLD1 | Homo sapiens | 4-chloro-N-[(1S)-2-[4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | |
| 0.000046 | - |
isoform PLD1 | Homo sapiens | N-[(1S)-2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]naphthalene-2-carboxamide | |
| 0.000061 | - |
isoform PLD2 | Homo sapiens | 4-chloro-N-[2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]benzamide | |
| 0.000066 | - |
isoform PLD1 | Homo sapiens | N-[(1S)-2-[4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]naphthalene-2-carboxamide | |
| 0.00007 | - |
isoform PLD1 | Homo sapiens | N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]quinoline-6-carboxamide | |
| 0.000076 | - |
isoform PLD2 | Homo sapiens | N-[2-[4-(5-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-fluorobenzamide | |
| 0.000097 | - |
isoform PLD2 | Homo sapiens | N-[2-[4-(5-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-chlorobenzamide | |
| 0.0001 | - |
isoform PLD1 | Homo sapiens | (1S,2S)-N-[(1S)-2-[4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-2-phenylcyclopropanecarboxamide | |
| 0.00011 | - |
isoform PLD1 | Homo sapiens | N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-3,4-dihydronaphthalene-2-carboxamide | |
| 0.00012 | - |
isoform PLD1 | Homo sapiens | 6-fluoro-N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]naphthalene-2-carboxamide | |
| 0.00013 | - |
isoform PLD1 | Homo sapiens | 4-fluoro-N-[(1S)-2-[4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | |
| 0.00014 | - |
isoform PLD2 | Homo sapiens | N-[2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]naphthalene-2-carboxamide | |
| 0.000187 | - |
isoform PLD2 | Homo sapiens | N-[(1S)-2-[4-(5-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-3,4-difluorobenzamide | |
| 0.00024 | - |
isoform PLD2 | Homo sapiens | N-[2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-methylbenzamide | |
| 0.0003 | - |
isoform PLD2 | Homo sapiens | N-[2-[4-(4-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-fluorobenzamide | |
| 0.00036 | - |
isoform PLD2 | Homo sapiens | N-[(1S)-2-[4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]naphthalene-2-carboxamide | |
| 0.000375 | - |
isoform PLD2 | Homo sapiens | 4-fluoro-N-[2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]benzamide | |
| 0.00038 | - |
isoform PLD2 | Homo sapiens | N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]naphthalene-2-carboxamide | |
| 0.00052 | - |
isoform PLD2 | Homo sapiens | (1S,2S)-N-[2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-2-phenylcyclopropanecarboxamide | |
| 0.00073 | - |
isoform PLD2 | Homo sapiens | N-[(1S)-2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-3,4-difluorobenzamide | |
| 0.00073 | - |
isoform PLD2 | Homo sapiens | N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-3-phenylprop-2-ynamide | |
| 0.00074 | - |
isoform PLD2 | Homo sapiens | N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]quinoline-6-carboxamide | |
| 0.00085 | - |
isoform PLD2 | Homo sapiens | 6-fluoro-N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]naphthalene-2-carboxamide | |
| 0.00086 | - |
isoform PLD2 | Homo sapiens | N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-3,4-dihydronaphthalene-2-carboxamide | |
| 0.00089 | - |
isoform PLD2 | Homo sapiens | N-[(1S)-2-[4-(5-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-4-chlorobenzamide | |
| 0.000933 | - |
isoform PLD2 | Homo sapiens | N-[(1S)-2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]naphthalene-2-carboxamide | |
| 0.00104 | - |
isoform PLD2 | Homo sapiens | 4-chloro-N-[(1S)-2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | |
| 0.00115 | - |
isoform PLD2 | Homo sapiens | (1S,2S)-N-[(1S)-2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-2-phenylcyclopropanecarboxamide | |
| 0.0012 | - |
isoform PLD2 | Homo sapiens | 4-chloro-N-[(1S)-2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | |
| 0.0014 | - |
isoform PLD2 | Homo sapiens | N-[(1S)-2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-4-fluorobenzamide | |
| 0.0031 | - |
isoform PLD2 | Homo sapiens | 4-fluoro-N-[(1S)-2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | |
| 0.0038 | - |
isoform PLD2 | Homo sapiens | (1S,2S)-N-[(1S)-2-[4-(6-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-2-phenylcyclopropanecarboxamide | |
| 0.0039 | - |
isoform PLD2 | Homo sapiens | (1S,2S)-N-[2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-2-phenylcyclopropanecarboxamide | |
| 0.0039 | - |
isoform PLD2 | Homo sapiens | N-[(1S)-2-[4-(5-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]naphthalene-2-carboxamide | |
| 0.0064 | - |
isoform PLD2 | Homo sapiens | (1S,2S)-N-[(1S)-2-[4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-2-phenylcyclopropanecarboxamide | |
| 0.01 | - |
isoform PLD2 | Homo sapiens | 4-fluoro-N-[(1S)-2-[4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | |
| 0.012 | - |
isoform PLD2 | Homo sapiens | 4-chloro-N-[(1S)-2-[4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | |
| 0.013 | - |
isoform PLD2 | Homo sapiens | N-[(1S)-2-[4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]naphthalene-2-carboxamide | |
| 0.014 | - |
isoform PLD2 | Homo sapiens | 3,4-difluoro-N-[(1S)-2-[4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]benzamide | |
| 0.02 | - |
isoform PLD2 | Homo sapiens | (1S,2S)-N-[(1S)-2-[4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]-1-methylethyl]-2-phenylcyclopropanecarboxamide | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
