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Literature summary for 3.1.4.4 extracted from

  • Peltz, A.; Sherwani, S.I.; Kotha, S.R.; Mazerik, J.N.; O'Connor Butler, E.S.; Kuppusamy, M.L.; Hagele, T.; Magalang, U.J.; Kuppusamy, P.; Marsh, C.B.; Parinandi, N.L.
    Calcium and calmodulin regulate mercury-induced phospholipase D activation in vascular endothelial cells (2009), Int. J. Toxicol., 28, 190-206.
    View publication on PubMed
Search for more literature for 3.1.4.4

Activating Compound

Activating Compound Comment Organism Structure
Hg2+ mercury chloride, and methylmercury, activates PLD, the stimulation is regulated by Ca2+ and calmodulin, mechanism, overview. Calcium chelating agents and calcium depletion, e.g. by EGTA, calmodulin inhibitors, e.g. calmidazolium chloride and trifluoperazine, and L-type calcium channel blockers nifedipine, nimodipine, and diltiazem attenuate the stimulation of PLD by mercury, overview Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular endothelial cell from pulmonary artery Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor Bos taurus ?
-
 ?

Synonyms

Synonyms Comment Organism
PLD
-
 Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Bos taurus

General Information

General Information Comment Organism
physiological function PLD generates bioactive lipid second messengers in vascular endothelial cells Bos taurus