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Literature summary for 3.1.4.4 extracted from

  • Issuree, P.D.; Pushparaj, P.N.; Pervaiz, S.; Melendez, A.J.
    Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities (2009), FASEB J., 23, 2412-2424.
    View publication on PubMed
Search for more literature for 3.1.4.4

Inhibitors

Inhibitors Comment Organism Structure
1-butanol treatment of human neutrophils to butan-1-ol significantly dampenes functional responses such as degranualtion, chemotaxis, and oxidative burst Homo sapiens
1-butanol
-
 Mus musculus
resveratrol a phytoalexin with antiinflammatory activity in C5 anaphylatoxin-stimulated primary neutrophils, blocks PLD activity and membrane recruitment Homo sapiens
resveratrol a phytoalexin with antiinflammatory activity in C5 anaphylatoxin-stimulated primary neutrophils and in a mouse model of acute peritonitis, blocks PLD activity and membrane recruitment Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane translocation of OLD to the plasma membrane Mus musculus 5886
-
plasma membrane translocation of OLD to the plasma membrane Homo sapiens 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 male BALB/c mice
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-
neutrophil C5 anaphylatoxin-stimulated primary neutrophils Mus musculus
-
neutrophil C5 anaphylatoxin-stimulated primary neutrophils Homo sapiens
-

Synonyms

Synonyms Comment Organism
PLD
-
 Mus musculus
PLD
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction pretreatment of human neutrophils with PLD inhibitor resveratrol significantly blocks oxidative burst, leukocyte migration, degranulation, and inflammatory cytokine production involving inhibition of sphingosine kinase activity and ERK1/2 phosphorylation Homo sapiens
malfunction pretreatment of mouse neutrophils with PLD inhibitor resveratrol significantly blocks oxidative burst, leukocyte migration, degranulation, and inflammatory cytokine production involving inhibition of sphingosine kinase activity and ERK1/2 phosphorylation Mus musculus