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Literature summary for 3.1.4.4 extracted from

  • Lavieri, R.; Scott, S.A.; Lewis, J.A.; Selvy, P.E.; Armstrong, M.D.; Alex Brown, H.; Lindsley, C.W.
    Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity (2009), Bioorg. Med. Chem. Lett., 19, 2240-2243.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.4

Inhibitors

Inhibitors Comment Organism Structure
(1S,2S)-N-[(1S)-1-methyl-2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-2-phenylcyclopropanecarboxamide
-
 Homo sapiens
(1S,2S)-N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-2-phenylcyclopropanecarboxamide
-
 Homo sapiens
3,4-difluoro-N-[(1S)-1-methyl-2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]benzamide
-
 Homo sapiens
3-methyl-N-[(1S)-1-methyl-2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]benzamide
-
 Homo sapiens
4-amino-3-methoxy-N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]benzamide
-
 Homo sapiens
N-[(1S)-1-methyl-2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]naphthalene-2-carboxamide
-
 Homo sapiens
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
-
 Homo sapiens
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-1-benzothiophene-2-carboxamide
-
 Homo sapiens
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-3-phenylprop-2-ynamide
-
 Homo sapiens
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]naphthalene-2-carboxamide
-
 Homo sapiens
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]quinoline-3-carboxamide
-
 Homo sapiens
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]quinoxaline-2-carboxamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O14939
-
-
Homo sapiens Q13393
-
-

Synonyms

Synonyms Comment Organism
phospholipase D1
-
 Homo sapiens
phospholipase D2
-
 Homo sapiens
PLD1
-
 Homo sapiens
PLD2
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000025
-
 isoform PLD1 Homo sapiens N-[(1S)-1-methyl-2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]naphthalene-2-carboxamide
0.00003
-
 isoform PLD2 Homo sapiens N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-1-benzothiophene-2-carboxamide
0.00009
-
 isoform PLD2 Homo sapiens N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]quinoline-3-carboxamide
0.00011
-
 isoform PLD2 Homo sapiens N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]naphthalene-2-carboxamide
0.00014
-
 isoform PLD2 Homo sapiens N-[(1S)-1-methyl-2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]naphthalene-2-carboxamide
0.00015
-
 isoform PLD1 Homo sapiens 3,4-difluoro-N-[(1S)-1-methyl-2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]benzamide
0.00015
-
 isoform PLD1 Homo sapiens N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-1-benzothiophene-2-carboxamide
0.0002
-
 isoform PLD2 Homo sapiens 3,4-difluoro-N-[(1S)-1-methyl-2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]benzamide
0.00055
-
 isoform PLD2 Homo sapiens 4-amino-3-methoxy-N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]benzamide
0.00099
-
 isoform PLD2 Homo sapiens N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
0.001
-
 isoform PLD1 Homo sapiens N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]naphthalene-2-carboxamide
0.0016
-
 isoform PLD2 Homo sapiens N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-3-phenylprop-2-ynamide
0.0019
-
 isoform PLD1 Homo sapiens N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]quinoline-3-carboxamide
0.0021
-
 isoform PLD1 Homo sapiens N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-3-phenylprop-2-ynamide
0.0026
-
 isoform PLD1 Homo sapiens (1S,2S)-N-[(1S)-1-methyl-2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-2-phenylcyclopropanecarboxamide
0.0034
-
 isoform PLD1 Homo sapiens 3-methyl-N-[(1S)-1-methyl-2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]benzamide
0.00425
-
 isoform PLD1 Homo sapiens N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
0.0059
-
 isoform PLD1 Homo sapiens 4-amino-3-methoxy-N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]benzamide
0.02
-
 isoform PLD1 Homo sapiens (1S,2S)-N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-2-phenylcyclopropanecarboxamide
0.02
-
 isoform PLD1 Homo sapiens N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]quinoxaline-2-carboxamide
0.02
-
 isoform PLD2 Homo sapiens (1S,2S)-N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-2-phenylcyclopropanecarboxamide
0.02
-
 isoform PLD2 Homo sapiens N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]quinoxaline-2-carboxamide
0.027
-
 isoform PLD2 Homo sapiens 3-methyl-N-[(1S)-1-methyl-2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]benzamide
0.03
-
 isoform PLD2 Homo sapiens (1S,2S)-N-[(1S)-1-methyl-2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-2-phenylcyclopropanecarboxamide