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Literature summary for 3.1.4.4 extracted from

  • Everett, P.B.; Senogles, S.E.
    D3 dopamine receptor signals to activation of phospholipase D through a complex with Rho (2010), J. Neurochem., 112, 963-971.
    View publication on PubMed
Search for more literature for 3.1.4.4

Activating Compound

Activating Compound Comment Organism Structure
4beta-phorbol-12,13-didecanoate i.e. 4betaPDD, a phorbol ester Homo sapiens
ionomycin a Ca2+ ionophore Homo sapiens
R(+)-hydroxy(dipropylamino)tetralin hydrobromide i.e. (+)7-OH DPAT, stimulates D3 receptor-mediated PLD activity Homo sapiens
RhoA protein recombinant D3 dopamine receptor, D2S receptor, signals to activation of phospholipase D through a complex with RhoA in HEK-293 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + H2O Homo sapiens
-
 choline + phosphatidic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + ethanol PLD also performs transphosphatidylation using ethanol as phosphatidyl acceptor Homo sapiens choline + phosphatidyl ethanol
-
 ?
phosphatidylcholine + H2O
-
 Homo sapiens choline + phosphatidic acid
-
 ?

Synonyms

Synonyms Comment Organism
PLD
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens