Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ionomycin | - |
Homo sapiens | |
okadaic acid | - |
Homo sapiens | |
phorbol ester | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
PLD2 from PC-3 cells, stable expression of active and inactive HA-tagged PLD2 in EL4 lymphoma cells, i.e. C5 cells, devoid of endogeneous PLD1 and PLD2. Proliferation and Erk activation are unchanged in cells transfected with active PLD2, while proliferation rate is decreased in cells expressing inactive PLD2. Basal tyrosine phosphorylation of focal adhesion kinase is increased in cells expressing active PLD2, as is phosphorylation of Akt; while inactive PLD2 has no effect. Expression of active PLD2 is associated with increased spreading and elongation of cells on tissue culture plastic, whereas inactive PLD2 inhibits cell spreading. Inactive PLD2 also inhibits cell adhesion, migration, and serum-induced invasion. Cells expressing active PLD2 form metastases in syngeneic mice, as do the parental cells, cells expressing inactive PLD2 form fewer metastases than parental cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme PLD2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DU-145 cell | - |
Homo sapiens | - |
additional information | isozyme PLD2 is widely expressed in mammalian cells | Homo sapiens | - |
OVCAR-3 cell | - |
Homo sapiens | - |
PC-12K cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phospholipase D2 | - |
Homo sapiens |
PLD2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | PLD2 is active in lymphoma cell metastasis, cells expressing active PLD2 form metastases in syngeneic mice | Homo sapiens |
physiological function | PLD2 is involved in activation of phosphorylation of focal adhesion kinase, and it plays a role in spreading and elongation of cells. Active PLD2 enhances FAK phosphorylation, Akt activation, and cell invasion in EL4 lymphoma cells, overview | Homo sapiens |