Literature summary for 3.1.4.4 extracted from

Panda, A.; Thakur, R.; Krishnan, H.; Naik, A.; Shinde, D.; Raghu, P.
Functional analysis of mammalian phospholipase D enzymes (2018), Biosci. Rep., 38, BSR20181690 .

Search for more literature for 3.1.4.4

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Drosophila melanogaster	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13393	isoform PLD1	-
Homo sapiens	Q14939	isoform PLD2	-

General Information

General Information	Comment	Organism
physiological function	reconstitution of human PLD1 is able to completely rescue retinal degeneration in a loss of function Drosophila PLD mutant. PLD1 is unable to restore the levels of a subset of unique species of phosphatidic acid in Drosophila. Both Drosophila PLD and human PLD1 are uniquely distributed to the subplasma membrane region in photoreceptors	Homo sapiens
physiological function	reconstitution of human PLD2 is only partly able to rescue retinal degeneration in a loss of function Drosophila PLD mutant. PLD2 is unable to restore the levels of a subset of unique species of phosphatidic acid in Drosophila. Contrary to the Drosophila enzyme, isoform PLD2 does not localize with subplasma membrane actin	Homo sapiens

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Release 2023.1 (January 2023)