Literature summary for 3.1.4.4 extracted from

Huang, Y.; Zhang, X.Y.; Liu, F.; Chen, H.L.
Regulation of phospholipase D from human hepatocarcinoma cell line by purine nucleotides and protein kinase A (2000), Mol. Cell. Biochem., 207, 3-8.

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Activating Compound

Activating Compound	Comment	Organism	Structure
ADP	at 1 mM, 200% of control activity	Homo sapiens
ATP	at 1 mM, 320% of control activity, 1 mM ATP + 0.1 mM GTP, 720% of control activity, effect is abolished by neomycin	Homo sapiens
cAMP	at 1 mM, 273% of control activity	Homo sapiens
GDP	at 1 mM, 312% of control activity	Homo sapiens
GTP	at 0.1 mM, 273% of control activity, 1 mM ATP + 0.1 mM GTP, 720% of control activity, effect is abolished by neomycin	Homo sapiens
GTPgammaS	at 0.005 mM, 446% of control activity	Homo sapiens
additional information	not activating: AMP	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
neomycin	abolishes activation by GTP or ATP	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	hepatocarcinoma cell culture	Homo sapiens	-

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Release 2023.1 (January 2023)