Application | Comment | Organism |
---|---|---|
synthesis | creation of a high performance PLD with superior transphosphatidylation activity and low hydrolysis activity can be very useful for the synthesis of phospholipids used in pharmaceuticals, foods, cosmetics, and other industries | Streptomyces cinnamoneus |
synthesis | creation of a high performance PLD with superior transphosphatidylation activity and low hydrolysis activity can be very useful for the synthesis of phospholipids used in pharmaceuticals, foods, cosmetics, and other industries | Streptomyces antibioticus |
synthesis | creation of a high performance PLD with superior transphosphatidylation activity and low hydrolysis activity can be very useful for the synthesis of phospholipids used in pharmaceuticals, foods, cosmetics, and other industries | Streptomyces halstedii |
synthesis | creation of a high performance PLD with superior transphosphatidylation activity and low hydrolysis activity can be very useful for the synthesis of phospholipids used in pharmaceuticals, foods, cosmetics, and other industries | Streptomyces septatus |
synthesis | creation of a high performance PLD with superior transphosphatidylation activity and low hydrolysis activity can be very useful for the synthesis of phospholipids used in pharmaceuticals, foods, cosmetics, and other industries | Streptomyces sp. |
Cloned (Comment) | Organism |
---|---|
PLD DNA and amino acid sequence determination, comparison, and analysis | Streptomyces cinnamoneus |
PLD DNA and amino acid sequence determination, comparison, and analysis | Streptomyces antibioticus |
PLD DNA and amino acid sequence determination, comparison, and analysis | Streptomyces halstedii |
PLD DNA and amino acid sequence determination, comparison, and analysis | Streptomyces septatus |
PLD DNA and amino acid sequence determination, comparison, and analysis | Streptomyces sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | Streptomyces cinnamoneus | - |
choline + phosphatidic acid | - |
? | |
phosphatidylcholine + H2O | Streptomyces antibioticus | - |
choline + phosphatidic acid | - |
? | |
phosphatidylcholine + H2O | Streptomyces halstedii | - |
choline + phosphatidic acid | - |
? | |
phosphatidylcholine + H2O | Streptomyces septatus | - |
choline + phosphatidic acid | - |
? | |
phosphatidylcholine + H2O | Streptomyces sp. | - |
choline + phosphatidic acid | - |
? | |
phosphatidylglycerol + H2O | Streptomyces cinnamoneus | - |
glycerol + phosphatidic acid | - |
? | |
phosphatidylglycerol + H2O | Streptomyces antibioticus | - |
glycerol + phosphatidic acid | - |
? | |
phosphatidylglycerol + H2O | Streptomyces halstedii | - |
glycerol + phosphatidic acid | - |
? | |
phosphatidylglycerol + H2O | Streptomyces septatus | - |
glycerol + phosphatidic acid | - |
? | |
phosphatidylglycerol + H2O | Streptomyces sp. | - |
glycerol + phosphatidic acid | - |
? | |
phosphatidylserine + H2O | Streptomyces cinnamoneus | - |
serine + phosphatidic acid | - |
? | |
phosphatidylserine + H2O | Streptomyces antibioticus | - |
serine + phosphatidic acid | - |
? | |
phosphatidylserine + H2O | Streptomyces halstedii | - |
serine + phosphatidic acid | - |
? | |
phosphatidylserine + H2O | Streptomyces septatus | - |
serine + phosphatidic acid | - |
? | |
phosphatidylserine + H2O | Streptomyces sp. | - |
serine + phosphatidic acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces antibioticus | - |
- |
- |
Streptomyces cinnamoneus | - |
- |
- |
Streptomyces halstedii | - |
- |
- |
Streptomyces septatus | - |
- |
- |
Streptomyces sp. | P84147 | PMF strain | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a phosphatidylcholine + H2O = choline + a phosphatidate | catalytic mechanism, PLD uses a ping-pong type of reaction through the formation of a covalent phosphatidyl-enzyme intermediate, structure-function relationship, and substrate recognition and specificity, overview | Streptomyces cinnamoneus | |
a phosphatidylcholine + H2O = choline + a phosphatidate | catalytic mechanism, PLD uses a ping-pong type of reaction through the formation of a covalent phosphatidyl-enzyme intermediate, structure-function relationship, and substrate recognition and specificity, overview | Streptomyces antibioticus | |
a phosphatidylcholine + H2O = choline + a phosphatidate | catalytic mechanism, PLD uses a ping-pong type of reaction through the formation of a covalent phosphatidyl-enzyme intermediate, structure-function relationship, and substrate recognition and specificity, overview | Streptomyces halstedii | |
a phosphatidylcholine + H2O = choline + a phosphatidate | catalytic mechanism, PLD uses a ping-pong type of reaction through the formation of a covalent phosphatidyl-enzyme intermediate, structure-function relationship, and substrate recognition and specificity, overview | Streptomyces septatus | |
a phosphatidylcholine + H2O = choline + a phosphatidate | catalytic mechanism, PLD uses a ping-pong type of reaction through the formation of a covalent phosphatidyl-enzyme intermediate, structure-function relationship, and substrate recognition and specificity, overview | Streptomyces sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PLD performs two different reactions: a hydrolytic reaction and a transphosphatidylation reaction, the latter with a primary alcohol, both pathway share a common intermediate, mechanism, overview | Streptomyces cinnamoneus | ? | - |
? | |
additional information | PLD performs two different reactions: a hydrolytic reaction and a transphosphatidylation reaction, the latter with a primary alcohol, both pathway share a common intermediate, mechanism, overview | Streptomyces antibioticus | ? | - |
? | |
additional information | PLD performs two different reactions: a hydrolytic reaction and a transphosphatidylation reaction, the latter with a primary alcohol, both pathway share a common intermediate, mechanism, overview | Streptomyces halstedii | ? | - |
? | |
additional information | PLD performs two different reactions: a hydrolytic reaction and a transphosphatidylation reaction, the latter with a primary alcohol, both pathway share a common intermediate, mechanism, overview | Streptomyces septatus | ? | - |
? | |
additional information | PLD performs two different reactions: a hydrolytic reaction and a transphosphatidylation reaction, the latter with a primary alcohol, both pathway share a common intermediate, mechanism, overview | Streptomyces sp. | ? | - |
? | |
phosphatidylcholine + H2O | - |
Streptomyces cinnamoneus | choline + phosphatidic acid | - |
? | |
phosphatidylcholine + H2O | - |
Streptomyces antibioticus | choline + phosphatidic acid | - |
? | |
phosphatidylcholine + H2O | - |
Streptomyces halstedii | choline + phosphatidic acid | - |
? | |
phosphatidylcholine + H2O | - |
Streptomyces septatus | choline + phosphatidic acid | - |
? | |
phosphatidylcholine + H2O | - |
Streptomyces sp. | choline + phosphatidic acid | - |
? | |
phosphatidylglycerol + H2O | - |
Streptomyces cinnamoneus | glycerol + phosphatidic acid | - |
? | |
phosphatidylglycerol + H2O | - |
Streptomyces antibioticus | glycerol + phosphatidic acid | - |
? | |
phosphatidylglycerol + H2O | - |
Streptomyces halstedii | glycerol + phosphatidic acid | - |
? | |
phosphatidylglycerol + H2O | - |
Streptomyces septatus | glycerol + phosphatidic acid | - |
? | |
phosphatidylglycerol + H2O | - |
Streptomyces sp. | glycerol + phosphatidic acid | - |
? | |
phosphatidylserine + H2O | - |
Streptomyces cinnamoneus | serine + phosphatidic acid | - |
? | |
phosphatidylserine + H2O | - |
Streptomyces antibioticus | serine + phosphatidic acid | - |
? | |
phosphatidylserine + H2O | - |
Streptomyces halstedii | serine + phosphatidic acid | - |
? | |
phosphatidylserine + H2O | - |
Streptomyces septatus | serine + phosphatidic acid | - |
? | |
phosphatidylserine + H2O | - |
Streptomyces sp. | serine + phosphatidic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the PLD superfamily containing two HKD motifs | Streptomyces cinnamoneus |
More | the enzyme belongs to the PLD superfamily containing two HKD motifs | Streptomyces antibioticus |
More | the enzyme belongs to the PLD superfamily containing two HKD motifs | Streptomyces halstedii |
More | the enzyme belongs to the PLD superfamily containing two HKD motifs | Streptomyces septatus |
More | the enzyme belongs to the PLD superfamily containing two HKD motifs | Streptomyces sp. |
PLD | - |
Streptomyces cinnamoneus |
PLD | - |
Streptomyces antibioticus |
PLD | - |
Streptomyces halstedii |
PLD | - |
Streptomyces septatus |
PLD | - |
Streptomyces sp. |