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Literature summary for 3.1.4.4 extracted from

  • Idkowiak-Baldys, J.; Baldys, A.; Raymond, J.R.; Hannun, Y.A.
    Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner (2009), J. Biol. Chem., 284, 22322-22331.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in C-6 glioma cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-butanol
-
 Homo sapiens
additional information no inhibition by 2-butanol Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozymes PLD1 and PLD2
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
PLD
-
 Homo sapiens
PLD1
-
 Homo sapiens
PLD2
-
 Homo sapiens

General Information

General Information Comment Organism
additional information stimulation of the serotonin 5-HT2A receptor and the angiotensin II receptor, AT1AR, two G-protein-coupled receptors, leads to their sequestration from endosomes to into a Rab11-positive juxtanuclear compartment in a PKC- and PLD-dependent manner, detailed overview. The PKC- and PLD-dependent sequestration of receptors results in co-sequestration of other plasma membrane proteins and receptors, e.g. of epidermal growth factor receptor and protease activated receptor-1 Homo sapiens