Information on EC 2.7.11.1 - non-specific serine/threonine protein kinase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY
2.7.11.1
-
RECOMMENDED NAME
GeneOntology No.
non-specific serine/threonine protein kinase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + a protein = ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
ATP + a protein = ADP + a phosphoprotein
show the reaction diagram
active site structure
-
ATP + a protein = ADP + a phosphoprotein
show the reaction diagram
active site and activation loop structure and conformation, Lys233, Cys250, Asp368, and Thr386 are important for activity, the substrate binding groove determines the substrate specificity via residues Val318 and Ala448
-
ATP + a protein = ADP + a phosphoprotein
show the reaction diagram
catalytic mechanism and regulation of PKN
-
ATP + a protein = ADP + a phosphoprotein
show the reaction diagram
glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26
-
ATP + a protein = ADP + a phosphoprotein
show the reaction diagram
Lys45 is important for PknH catalytic and autophosphorylation activity
-
ATP + a protein = ADP + a phosphoprotein
show the reaction diagram
the enzyme shows Mn2+-dependent serine/threonine kinase and Ca2+-dependent histidine kinase, EC 2.7.13.3, activities
Q9SDY2
ATP + a protein = ADP + a phosphoprotein
show the reaction diagram
the CK1 family shows a strong preference both in vitro and in vivo for primed, pre-phosphorylated substrates. CK1 family members prefer acidic substrates in vitro, most notably those with acidic residues in the N-3 position, e.g. D-X-X-S/T. The most effective motif contains a phospho-residue in the N-3 position, such as pS/pT-X-X-S/T, where pS/pT refers to a phospho-serine or phospho-threonine, X refers to any amino acid, and the underlined residues refer to the target site
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (non-specific)
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
A-kinase
-
-
-
-
A-T, mutated
-
-
-
-
A-T, mutated homolog
-
-
-
-
AMH type II receptor
-
-
-
-
Anti-sigma B factor rsbT
-
-
-
-
AP50 kinase
-
-
-
-
Ataxia telangiectasia mutated
-
-
-
-
Ataxia telangiectasia mutated homolog
-
-
-
-
ATP-protein transphosphorylase
-
-
-
-
betaIIPKC
-
-
-
-
Breast-tumor-amplified kinase
-
-
-
-
Calcium-dependent protein kinase C
-
-
-
-
Calcium/phospholipid-dependent protein kinase
-
-
-
-
cAMP-dependent protein kinase A
-
-
-
-
casein kinase
-
-
-
-
casein kinase 2
-
-
-
-
casein kinase I
-
-
-
-
casein kinase II
-
-
-
-
casein kinase-2
-
-
-
-
CDC25 suppressing protein kinase
-
-
-
-
Cell division cycle 2-like
-
-
-
-
CK-2
-
-
-
-
CK2
-
-
-
-
CK2-alpha
-
-
-
-
CKI
-
-
-
-
CKII
-
-
-
-
CLP-36 interacting kinase
-
-
-
-
cyclic AMP-dependent protein kinase
-
-
-
-
cyclic AMP-dependent protein kinase A
-
-
-
-
cyclic monophosphate-dependent protein kinase
-
-
-
-
cyclic nucleotide-dependent protein kinase
-
-
-
-
cyclin-dependent kinase
-
-
-
-
cytidine 3',5'-cyclic monophosphate-responsive protein kinase
-
-
-
-
DNA-PKcs
-
-
-
-
DNPK1
-
-
-
-
dSTPK61
-
-
-
-
G11 protein
-
-
-
-
hARK1
-
-
-
-
histone kinase
-
-
-
-
hPDK1
-
-
-
-
Hpr kinase
-
-
-
-
hPSK
-
-
-
-
HSPK 21
-
-
-
-
HSPK 36
-
-
-
-
hydroxyalkyl-protein kinase
-
-
-
-
Kinase interacting with stathmin
-
-
-
-
kinase, casein (phosphorylating)
-
-
-
-
kinase, protamine (phosphorylating)
-
-
-
-
kinase, protein (phosphorylating)
-
-
-
-
kinase, protein, A (phosphorylating)
-
-
-
-
kinase, protein, C (phosphorylating)
-
-
-
-
Lymphocyte-oriented kinase
-
-
-
-
M phase-specific cdc2 kinase
-
-
-
-
mitogen-activated S6 kinase
-
-
-
-
mPDK1
-
-
-
-
MPSK
-
-
-
-
Myristoylated and palmitoylated serine-threonine kinase
-
-
-
-
NY-REN-55 antigen
-
-
-
-
P-CIP2
-
-
-
-
P460
-
-
-
-
p46Eg265
-
-
-
-
p46XlEg22
-
-
-
-
p82 kinase
-
-
-
-
pEg2
-
-
-
-
phosphorylase b kinase kinase
-
-
-
-
Phototropin
-
-
-
-
Pim-2h
-
-
-
-
PKA
-
-
-
-
PkB kinase
-
-
-
-
pp39-mos
-
-
-
-
Pre-mRNA protein kinase
-
-
-
-
protamine kinase
-
-
-
-
protein glutamyl kinase
-
-
-
-
protein kinase (phosphorylating)
-
-
-
-
Protein kinase B kinase
-
-
-
-
protein kinase CK2
-
-
-
-
Protein kinase Krct
-
-
-
-
Protein kinase MST
-
-
-
-
protein kinase p58
-
-
-
-
Protein kinase PKL12
-
-
-
-
protein phosphokinase
-
-
-
-
protein serine kinase
-
-
-
-
protein serine-threonine kinase
-
-
-
-
protein-aspartyl kinase
-
-
-
-
protein-cysteine kinase
-
-
-
-
protein-serine kinase
-
-
-
-
protein-serine/threonine kinase
-
-
-
-
PRP4 kinase
-
-
-
-
PRP4 pre-mRNA processing factor 4 homolog
-
-
-
-
PSK-H1
-
-
-
-
Raf kinase
-
-
-
-
Raf-1
-
-
-
-
ratAurA
-
-
-
-
ribosomal protein S6 kinase II
-
-
-
-
ribosomal S6 protein kinase
-
-
-
-
RP1 protein
-
-
-
-
S-receptor kinase
-
-
-
-
serine kinase
-
-
-
-
serine protein kinase
-
-
-
-
serine(threonine) protein kinase
-
-
-
-
serine-specific protein kinase
-
-
-
-
serine/threonine kinase
-
-
-
-
Serine/threonine kinase 15
-
-
-
-
Serine/threonine kinase Ayk1
-
-
-
-
serine/threonine protein kinase
-
-
-
-
Serine/threonine-protein kinase NRK2
-
-
-
-
Serine/threonine-protein kinase NYD-SPK
-
-
-
-
SRK
-
-
-
-
Ste20-like kinase
-
-
-
-
STE20-like kinase MST1
-
-
-
-
STE20-like kinase MST2
-
-
-
-
STE20-like kinase MST3
-
-
-
-
Switch protein/serine kinase
-
-
-
-
T-antigen kinase
-
-
-
-
threonine-specific protein kinase
-
-
-
-
Twitchin kinase
-
-
-
-
type-2 casein kinase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
191808-15-8
phosphoinositide dependent protein kinase 1
340830-03-7
-
37278-10-7
-
377752-08-4
ribosomal protein S6 kinase 2
389133-24-8
ribosomal S6 kinase 3
52660-18-1
casein kinase, protein kinase CK2
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
90698-26-3
ribosomal protein S6 kinase 1
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain PCC 7120
SwissProt
Manually annotated by BRENDA team
14 isozymes of the three main CDPK subgroups: CPKs 2, 4, 5, 11 and 25 from subgroup 1, CPKs 3, 9 and 19 from subgroup 2, and CPKs 7, 8, 10, 13, 30 and 32 from subgroup 3
-
-
Manually annotated by BRENDA team
alpha chain 1
SwissProt
Manually annotated by BRENDA team
alpha chain 2
SwissProt
Manually annotated by BRENDA team
genes cka1, cka2, cka3, and cka4 encoding the four subunits
-
-
Manually annotated by BRENDA team
isozyme CPK1
SwissProt
Manually annotated by BRENDA team
Arabidopsis thaliana Col-0
-
UniProt
Manually annotated by BRENDA team
Arabidopsis thaliana Col-0
genes cka1, cka2, cka3, and cka4 encoding the four subunits
-
-
Manually annotated by BRENDA team
Arabidopsis thaliana Col0
14 isozymes of the three main CDPK subgroups: CPKs 2, 4, 5, 11 and 25 from subgroup 1, CPKs 3, 9 and 19 from subgroup 2, and CPKs 7, 8, 10, 13, 30 and 32 from subgroup 3
-
-
Manually annotated by BRENDA team
at least 3 different isozymes PKNalpha/PKN-1/PAK-1, PKNbeta, and PRK2/PKNgamma/PAK-2
-
-
Manually annotated by BRENDA team
Bacillus anthracis 7702
-
-
-
Manually annotated by BRENDA team
alpha‘-chain
SwissProt
Manually annotated by BRENDA team
at least 3 different isozymes PKNalpha/PKN-1/PAK-1, PKNbeta, and PRK2/PKNgamma/PAK-2
-
-
Manually annotated by BRENDA team
alpha-chain
SwissProt
Manually annotated by BRENDA team
at least 3 different isozymes PKNalpha/PKN-1/PAK-1, PKNbeta, and PRK2/PKNgamma/PAK-2
-
-
Manually annotated by BRENDA team
alpha-chain
SwissProt
Manually annotated by BRENDA team
at least 3 different isozymes PKNalpha/PKN-1/PAK-1, PKNbeta, and PRK2/PKNgamma/PAK-2
-
-
Manually annotated by BRENDA team
isozymes alpha, beta, gamma1, gamm2, gamma3, delta, and epsilon
-
-
Manually annotated by BRENDA team
human pathogenic, pro-biotic, and antibiotic-producing
-
-
Manually annotated by BRENDA team
alpha-chain
SwissProt
Manually annotated by BRENDA team
alpha‘-chain
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
alpha-chain
SwissProt
Manually annotated by BRENDA team
alpha‘-chain
SwissProt
Manually annotated by BRENDA team
at least 3 different isozymes PKNalpha/PKN-1/PAK-1, PKNbeta, and PRK2/PKNgamma/PAK-2
-
-
Manually annotated by BRENDA team
constitutive enzyme
-
-
Manually annotated by BRENDA team
gene ULK3
UniProt
Manually annotated by BRENDA team
isozyme CKIdelta
-
-
Manually annotated by BRENDA team
isozymes alpha, beta, gamma1, gamm2, gamma3, delta, and epsilon
-
-
Manually annotated by BRENDA team
small intestine SPAK-like kinase; intestinal inflammation-associated colonic epithelial isozyme
SwissProt
Manually annotated by BRENDA team
HSV-1, gene US3
-
-
Manually annotated by BRENDA team
VZV-32, propagated in MeWo human melanoma cells
-
-
Manually annotated by BRENDA team
gene kpnK or KPN_04169
-
-
Manually annotated by BRENDA team
Klebsiella pneumoniae MGH78578
gene kpnK or KPN_04169
-
-
Manually annotated by BRENDA team
two eukaryotic-type Ser/Thr-kinases encoded by lmo1820 and lmo0618
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
alpha‘-chain
SwissProt
Manually annotated by BRENDA team
at least 3 different isozymes PKNalpha/PKN-1/PAK-1, PKNbeta, and PRK2/PKNgamma/PAK-2
-
-
Manually annotated by BRENDA team
isozyme Tssk4; isozyme Tssk4, is also named Tssk5
UniProt
Manually annotated by BRENDA team
p70 ribosomal S6 kinase 1 S6K1 and its homologue ribosomal S6 kinase 2 S6K2
-
-
Manually annotated by BRENDA team
testis-specific serine/threonine protein kinase 5 variant alpha; alternatively spliced variant alpha of the testis-specific isozyme
UniProt
Manually annotated by BRENDA team
testis-specific serine/threonine protein kinase 5 variant beta; alternatively spliced variant beta of the testis-specific isozyme
SwissProt
Manually annotated by BRENDA team
testis-specific serine/threonine protein kinase 5 variant delta; alternatively spliced variant delta of the testis-specific isozyme
SwissProt
Manually annotated by BRENDA team
testis-specific serine/threonine protein kinase 5 variant gamma; alternatively spliced variant gamma of the testis-specific isozyme
SwissProt
Manually annotated by BRENDA team
strains H37Rv and H37Ra, PknH is specific for mycobacteria of the Mycobacterium tuberculosis complex
-
-
Manually annotated by BRENDA team
clone NtCK2a1; cv. Samsun NN
SwissProt
Manually annotated by BRENDA team
cv. Petit Havana
SwissProt
Manually annotated by BRENDA team
NTHK2
SwissProt
Manually annotated by BRENDA team
rainbow trout
-
-
Manually annotated by BRENDA team
alpha-chain
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
isolate Dd2
SwissProt
Manually annotated by BRENDA team
alpha-chain
SwissProt
Manually annotated by BRENDA team
at least 3 different isozymes PKNalpha/PKN-1/PAK-1, PKNbeta, and PRK2/PKNgamma/PAK-2
-
-
Manually annotated by BRENDA team
isozyme RSK1, i.e. p90 ribosomal S6 kinase or 14-3-3
-
-
Manually annotated by BRENDA team
male adult Wistar rats, 3 splicing forms CK1epsilon-1 - CK1epsilon-3
SwissProt
Manually annotated by BRENDA team
male Sprague Dawley rats, gene CK2alpha
-
-
Manually annotated by BRENDA team
male Wistar rats, SAST124, a splice variant of SAST
-
-
Manually annotated by BRENDA team
splicing form CKIepsilon-2; male adult Wistar rats, 3 splicing forms CKIepsilon-1 - CKIepsilon-3
SwissProt
Manually annotated by BRENDA team
splicing form CKIepsilon-3; male adult Wistar rats, 3 splicing forms CKIepsilon-1 - CKIepsilon-3
SwissProt
Manually annotated by BRENDA team
Wistar albino
-
-
Manually annotated by BRENDA team
baker's yeast
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae BY4742
gene ENV7
-
-
Manually annotated by BRENDA team
strain 8325
-
-
Manually annotated by BRENDA team
Staphylococcus aureus 8325
strain 8325
-
-
Manually annotated by BRENDA team
strain Cp 1015
-
-
Manually annotated by BRENDA team
strain CP1015, gene stkP
-
-
Manually annotated by BRENDA team
Streptococcus pneumoniae Cp 1015
strain Cp 1015
-
-
Manually annotated by BRENDA team
Streptococcus pneumoniae CP1015
strain CP1015, gene stkP
-
-
Manually annotated by BRENDA team
strain A3(2), gene afsK
-
-
Manually annotated by BRENDA team
strain A3(2), gene afsK
-
-
Manually annotated by BRENDA team
strain P2, ORF sso0469 encodes PK3
-
-
Manually annotated by BRENDA team
strain P2, ORF sso0469 encodes PK3
-
-
Manually annotated by BRENDA team
strain PCC 6803, gene spkA
-
-
Manually annotated by BRENDA team
alpha-chain
SwissProt
Manually annotated by BRENDA team
strain Copenhagen
SwissProt
Manually annotated by BRENDA team
strain Copenhagen
SwissProt
Manually annotated by BRENDA team
alpha'-chain
SwissProt
Manually annotated by BRENDA team
at least 3 different isozymes PKNalpha/PKN-1/PAK-1, PKNbeta, and PRK2/PKNgamma/PAK-2
-
-
Manually annotated by BRENDA team
isozymes alpha, beta, gamma1, gamm2, gamma3, delta, and epsilon
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
alpha-chain
SwissProt
Manually annotated by BRENDA team
casein kinase II subunit alpha
SwissProt
Manually annotated by BRENDA team
Zea mays Mona
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
-
calcium-dependent protein kinases, which contain both calmodulin-like calcium binding and serine/threonine protein kinase domains, are only present in plants and some protozoans
evolution
-
casein kinase2 is an evolutionarily conserved serine/threonine protein kinase composed of two catalytic alpha-subunits and two regulatory beta-subunits. Although most of the molecular components responsible for circadian function are not conserved between kingdoms, CK2 is a well-conserved clock component modulating the stability and subcellular localization of essential clock proteins
evolution
-
CK1 belongs to the CK1 family of serine/threonine kinases, CK1 is evolutionary conserved within eukaryotes
evolution
-
classification of amino acid residues in the ATP-binding site of the enzyme in diverse Gram-positive bacteria, 20 groups, phylogenetic tree and homology modeling, overview
evolution
-
gene ENV7 is a widely conserved orthologue of the serine/threonine kinase 16 (STK16) gene, phylogenetic anaysis
evolution
Q6PHR2
human serine/threonine kinase ULK3 is annotated as belonging to unc-51-like family of serine/threonine kinases, but shares similarity with STK36 and dFu proteins
evolution
-
MPK38 is a member of the AMPK family
evolution
Q9ZSA2
the enzyme belongs to the calcium-dependent protein kinases, that comprise a family of plant serine/threonine protein kinases in which the calcium sensing domain and the kinase effector domain are combined within one molecule
evolution
-
the enzyme is a member of the testis specific serine/threonine kinase family
evolution
Saccharomyces cerevisiae BY4742
-
gene ENV7 is a widely conserved orthologue of the serine/threonine kinase 16 (STK16) gene, phylogenetic anaysis
-
evolution
Arabidopsis thaliana Col0
-
calcium-dependent protein kinases, which contain both calmodulin-like calcium binding and serine/threonine protein kinase domains, are only present in plants and some protozoans
-
evolution
Arabidopsis thaliana Col-0
-
casein kinase2 is an evolutionarily conserved serine/threonine protein kinase composed of two catalytic alpha-subunits and two regulatory beta-subunits. Although most of the molecular components responsible for circadian function are not conserved between kingdoms, CK2 is a well-conserved clock component modulating the stability and subcellular localization of essential clock proteins, the enzyme belongs to the calcium-dependent protein kinases, that comprise a family of plant serine/threonine protein kinases in which the calcium sensing domain and the kinase effector domain are combined within one molecule
-
malfunction
-
a pknB deletion strain showed 32-fold-higher sensitivity to tunicamycin
malfunction
-
downregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer
malfunction
-
ROCKII knockout mice develop with impaired motor function, ROCKII-deficient dorsal root ganglion neurons are less sensitive to inhibition by Nogo protein or by chondroitin sulfate proteoglycan in vitro, after dorsal root crush injury, the ROCKII-deficient mice recover use of the affected forepaw more quickly than do controls, after the spinal cord injury ROCKII-deficient mice show enhanced local growth of raphespinal axons in the caudal spinal cord and corticospinal axons into the lesion site
malfunction
-
STK11 has been identified as a large-scale deletion in a patient with schizophrenia and Peutz-Jeghers syndrome
malfunction
-
Bacillus anthracis STPK101, a null mutant lacking serine/threonine phosphatase, BA-Stp1, EC 3.1.3.16, and serine/threonine kinase, BA-Stk1, is impaired in its ability to survive within macrophages, and this correlates with an observed reduction in virulence in a mouse model of pulmonary anthrax
malfunction
-
ENV7 deletion leads to internal accumulation of precursor carboxypeptidase Y, a vacuolar hydrolytic enzyme that transits the rough endoplasmic reticulum, Golgi apparatus, and late endosome prior to arrival at the vacuole, where it is processed to mature form via PEP4-dependent proteolytic cleavage. env7DELTA is defective in maintaining fragmented vacuoles during hyperosmotic response and in buds
malfunction
-
inhibition of Akt activity results in the significant activation of PHLPP activity compared to insulin-treated conditions. Knocking down Akt1 does not affect photoreceptors during light stress
malfunction
Q6PHR2
kinase-deficient mutants of ULK3 are inactive in regulation of GLI protein activity
malfunction
-
LKB1-deficient mice exhibit a developmental block at the double-negative cell stage DN3 to DN4 transition. T-cell-specific deletion of LKB1 results in reduced survival of double-positive thymocytes and impaired generation of both CD4 and CD8 single-positive thymocytes. Disruption of LKB1 not only prevents the activation of AMPK but also impairs the expression of anti-apoptotic protein Bcl-XL. Ectopic expression of either Bcl-XL or the constitutively active AMPK mutant T172D significantly rescues double-positive thymocytes from LKB1 deficiency-induced cell death. Ectopic expression of the constitutively active AMPK mutant restores the expression of Bcl-XL in LKB1-deficient double-positive thymocytes
malfunction
Q9ZSA2
loss-of-function seedlings of cpk21 are more tolerant to hyperosmotic stress and mutant plants show increased stress responses with respect to marker gene expression and metabolite accumulation, phenotypes, overview
malfunction
-
Pim-2 short interfering RNA reduces mutiple myeloma cell viability in cocultures with bone marrow stromal cells and osteoclasts. Pim-2 inhibition suppresses mutiple myeloma cell survival, cooperatively with rapamycin
malfunction
-
targeted deletion of the tandemly arranged genes Tssk1 and Tssk2 in mouse results in male infertility, with loss of the cytoplasmic chromatoid body-derived ring structure, and with elongating spermatids possessing a collapsed mitochondrial sheath
malfunction
-
the DkpnK mutant exhibits higher sensitivity to gastrointestinal and oxidative stresses. Deletion of kpnK result in a two to threefold increased susceptibility towards imipenem, cefepime, ceftriaxone and ceftazidime, gene kpnK participates in antibiotic resistance. Deletion of gene kpnK influences active efflux in Klebsiella pneumoniae. The downregulation of the MDR efflux pumps might be the molecular mechanism underlying the sensitivity of kpnK mutant to hydrophobic agents
malfunction
P9WI77
the enzyme-deletion mutant DELTApknE shows in presence of stress (pH, surfactant and cell wall-damaging agents) and anti-tuberculosis drugs a defective growth in pH 7.0 and lysozyme (a cell wall-damaging agent) with better survival in pH 5.5, SDS, and kanamycin (a second-line anti-tuberculosis drug). DELTApknE is reduced in cell size during growth in liquid media and exhibits hypervirulence in a guinea pig model of infection
malfunction
-
the overall activity of the CK2 holoenzyme is affected by the cka1a2a3 triple mutations, and phosphorylation of CCA1 is reduced in the triple mutant. The photoperiodic flowering response, which is regulated by circadian rhythms, is reduced in the cka1a2a3 triple mutant and the plants flower later under long-day conditions
malfunction
-
TPL2 inhibitor suppresses MEK/ERK/p90RSK, MKK4/JNK/c-Jun, and Akt/p70S6K, whereas the phosphorylation of p38 is unchanged
malfunction
Saccharomyces cerevisiae BY4742
-
ENV7 deletion leads to internal accumulation of precursor carboxypeptidase Y, a vacuolar hydrolytic enzyme that transits the rough endoplasmic reticulum, Golgi apparatus, and late endosome prior to arrival at the vacuole, where it is processed to mature form via PEP4-dependent proteolytic cleavage. env7DELTA is defective in maintaining fragmented vacuoles during hyperosmotic response and in buds
-
malfunction
Staphylococcus aureus 8325
-
a pknB deletion strain showed 32-fold-higher sensitivity to tunicamycin
-
malfunction
Arabidopsis thaliana Col-0
-
the overall activity of the CK2 holoenzyme is affected by the cka1a2a3 triple mutations, and phosphorylation of CCA1 is reduced in the triple mutant. The photoperiodic flowering response, which is regulated by circadian rhythms, is reduced in the cka1a2a3 triple mutant and the plants flower later under long-day conditions, loss-of-function seedlings of cpk21 are more tolerant to hyperosmotic stress and mutant plants show increased stress responses with respect to marker gene expression and metabolite accumulation, phenotypes, overview
-
malfunction
-
the enzyme-deletion mutant DELTApknE shows in presence of stress (pH, surfactant and cell wall-damaging agents) and anti-tuberculosis drugs a defective growth in pH 7.0 and lysozyme (a cell wall-damaging agent) with better survival in pH 5.5, SDS, and kanamycin (a second-line anti-tuberculosis drug). DELTApknE is reduced in cell size during growth in liquid media and exhibits hypervirulence in a guinea pig model of infection
-
malfunction
Klebsiella pneumoniae MGH78578
-
the DkpnK mutant exhibits higher sensitivity to gastrointestinal and oxidative stresses. Deletion of kpnK result in a two to threefold increased susceptibility towards imipenem, cefepime, ceftriaxone and ceftazidime, gene kpnK participates in antibiotic resistance. Deletion of gene kpnK influences active efflux in Klebsiella pneumoniae. The downregulation of the MDR efflux pumps might be the molecular mechanism underlying the sensitivity of kpnK mutant to hydrophobic agents
-
malfunction
Bacillus anthracis 7702
-
Bacillus anthracis STPK101, a null mutant lacking serine/threonine phosphatase, BA-Stp1, EC 3.1.3.16, and serine/threonine kinase, BA-Stk1, is impaired in its ability to survive within macrophages, and this correlates with an observed reduction in virulence in a mouse model of pulmonary anthrax
-
metabolism
-
baicalin triggers autophagy through inhibition of the AKT signaling pathway in T-24 cells, overview
metabolism
-
regulatory interactions of a serine/threonine phosphatase, BA-Stp1, EC 3.1.3.16, and serine/threonine kinase, BA-Stk1, pair in Bacillus anthracis: dephosphorylation of BA-Stk1 by BA-Stp1 alters the BA-Stk1 kinase activity
metabolism
Q9ZSA2
role of CPK21 within a calcium-regulated protein kinase network consisting of mutual interfering signaling components
metabolism
-
roles of CK1 in Wnt signaling, detailed overview
metabolism
-
the serine/threonine kinase LKB1 is the main upstream kinase of the AMP-activated protein kinase cascade that senses cellular energy state and adjusts cellular metabolism
metabolism
Arabidopsis thaliana Col-0
-
role of CPK21 within a calcium-regulated protein kinase network consisting of mutual interfering signaling components
-
physiological function
-
protein kinase Balpha is involved in inositol lipid signalling, a pleckstrin homology (PH) domain binds phosphatidylinositol 3,4,5-trisphosphate which is required for PKB phosphorylation and activation
physiological function
-
DAP-kinase is an essential regulator of autophagy, DAP-kinase is a tumor suppressor that mediates several cell death pathways, such as apoptosis and programmed necrosis
physiological function
-
Glc7 is required for recovery from a double-strand break-induced checkpoint, while it is dispensable for checkpoint inactivation during methylmethane sulfonate exposure, Glc7 is not required for homologous recombination-mediated double-strand break repair
physiological function
-
PKA activity, without directly phosphorylating P2X(4)R, markedly enhances ATP-stimulated P2X(4)R currents and hence cytosolic Ca2+ signals
physiological function
-
protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility via slingshot, protein kinase D1 inhibits barbed end formation and directed cell migration
physiological function
-
ZIPK is a tumor suppressor and plays an important role in gastric carcinoma development through its pro-apoptotic function
physiological function
-
Akt is an important kinase that is activated by a variety of growth factors and insulin. The insulin receptor-activated phosphoinositide 3-kinase/Akt pathway and serine/threonine kinase Akt activation controls the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL, which themselves regulate the dephosphorylation of Akt isoforms, location of PHLPPL in rod photoreceptors and absence of PHLPP from rods. PHLPPL activity is regulated by all three Akt isoforms
physiological function
Q9ZSA2
calcium-dependent protein kinases and CBL/CBL interacting protein kinase pairs are able to translate the transient change in the cytosolic free calcium concentration into a phosphorylation signal, CDPKs function in calcium-mediated abiotic stress signaling. CDPKs participate at multiple steps in abscisic acid-dependent and -independent abiotic stress signaling
physiological function
-
involvement of ESTK in regulating bacterial physiology, stress response and drug resistance. Roles of gene kpnK in oxidative and nitrosative stress tolerance and in other stress-associated challenge, overview. Additional regulatory role of KpnK on MDR efflux pumps
physiological function
-
LKB1 is a key signaling kinase that regulates cellular growth
physiological function
-
LKB1 is a serine/threonine kinase that directly activates the energy sensor AMP-activated protein kinase in response to bioenergetic stress, to rising AMP:ATP ratio, and mainly acts as a tumor suppressor that controls cell polarity and proliferation. Cell phenotypes,overview
physiological function
-
MPK38 is functionally linked to the p53 signaling pathway. MPK38 directly associates with p53 without relying on additional proteins in mammalian cells. The C-terminal regulatory domain, residues 270-643, of MPK38 is responsible for p53 binding, while the N-terminal domain is unable to bind p53. Binding is mediated by the the DNA-binding domain and the basic domain, not by the transactivation domain, of p53, MPK38 interaction with p53 deletion mutants, overview. MPK38 acts as a positive regulator of p53, while expression of MPK38 itself has little effect on p53-induced transcription. MPK38 upregulates the expression of p53 targets in a kinase-dependent manner, and it promotes translocation of p53 from cytosol to the nucleus, overview. MPK38 stimulates p53-induced apoptosis and cell cycle arrest
physiological function
-
phosphorylation of clock proteins by the enzyme plays a critical role in generating proper circadian rhythms. CK2alpha subunits are important components of the Arabidopsis circadian system and their effects on rhythms are in part due to their phosphorylation of CIRCADIAN CLOCK ASSOCIATED1
physiological function
-
phosphorylation of Ser2 plays a role in regulation of nucleocytoplasmic shuttling of eukaryotic translation initiation factor 5A in plant cells
physiological function
-
possible role for STK16-related kinases in regulation of the endomembrane architecture. Env7 negatively regulates fusion at the vacuole membrane
physiological function
-
PrkA probably is involved in the regulation of a variety of fundamental biological processes, functional classification of the PrkAc putative interactors, overview
physiological function
-
the CK1 family of serine/threonine kinases regulates diverse cellular processes, including circadian rhythms, Wnt signaling, membrane trafficking, cytoskeleton maintenance, DNA replication, DNA damage response, RNA metabolism and parasitic infections, through binding to and phosphorylation a myriad of protein substrates. CK1 isoforms are key regulators of several cellular growth and survival processes, including Wnt and Hedgehog signaling, cell cycle control, DNA repair and apoptosis. CK1 is involved in scaffold binding and kinase regulation in Wnt signaling and circadian rhythms. CK1is itself regulated by posttranslationalmodification, including autophosphorylation. CK1alpha is a essential component of the Wnt/beta-catenin signaling pathway. It binds to axin, and phosphorylates beta-catenin on serine 45, thereby creating a GSK3 recognition site and ultimately causing the degradation of beta-catenin. CK1delta/epsilon are implicated in colon, pancreatic and breast cancer progression via the suppression of apoptosis, regulation of mitotic function, and/or activation of beta-catenin signaling. CK1epsilon is a pro-survival factor in cancer cells in vitro
physiological function
-
the enzyme is involved in spermatogenesis
physiological function
P9WI77
the enzyme is involved in the adaptive responses and contributes to the suppression of apoptosis
physiological function
-
the enzyme is necessary for the final processing step of maturing the 18S ribosomal rRNA
physiological function
Q6PHR2
the serine/threonine kinase ULK3 acts as a positive regulator of Hedgehog pathway and Gli proteins, ULK3 catalytical activity is crucial for its function in SHH pathway, overview. The Hedgehog signaling pathway plays crucial roles in embryonic development and is implicated in tissue homeostasis maintenance and neurogenesis in adults. ULK3 enhances endogenous and overexpressed GLI1 and GLI2 transcriptional activity in cultured cells, and ULK3 kinase activity is required for nuclear translocation of GLI1 from cytosol
physiological function
-
TPL2 regulates MEK and MKK4 without affecting p38 in the TNF-alpha-induced signaling pathway. TPL2 is involved in TNF-alpha-induced COX-2 upregulation
physiological function
A3QQQ9
Tssk4 kinase activity might be involved in spermiogenesis, Tssk4 is constantly expressed in the whole process of spermiogenesis. The autophosphorylation of Tssk4 at Thr197 is essential to its kinase activity
physiological function
-
upon activation by a stimulus, calcium-dependent protein kinases transduce the signal through phosphorylation cascades to induce downstream responses, including transcriptional regulation
physiological function
-
upregulation of Pim-2 is an anti-apoptotic mechanism for mutiple myeloma cell survival
physiological function
Saccharomyces cerevisiae BY4742
-
possible role for STK16-related kinases in regulation of the endomembrane architecture. Env7 negatively regulates fusion at the vacuole membrane
-
physiological function
Arabidopsis thaliana Col0
-
upon activation by a stimulus, calcium-dependent protein kinases transduce the signal through phosphorylation cascades to induce downstream responses, including transcriptional regulation
-
physiological function
Arabidopsis thaliana Col-0
-
phosphorylation of clock proteins by the enzyme plays a critical role in generating proper circadian rhythms. CK2alpha subunits are important components of the Arabidopsis circadian system and their effects on rhythms are in part due to their phosphorylation of CIRCADIAN CLOCK ASSOCIATED1, calcium-dependent protein kinases and CBL/CBL interacting protein kinase pairs are able to translate the transient change in the cytosolic free calcium concentration into a phosphorylation signal, CDPKs function in calcium-mediated abiotic stress signaling. CDPKs participate at multiple steps in abscisic acid-dependent and -independent abiotic stress signaling
-
physiological function
-
the enzyme is involved in the adaptive responses and contributes to the suppression of apoptosis
-
physiological function
Zea mays Mona
-
phosphorylation of Ser2 plays a role in regulation of nucleocytoplasmic shuttling of eukaryotic translation initiation factor 5A in plant cells
-
physiological function
Klebsiella pneumoniae MGH78578
-
involvement of ESTK in regulating bacterial physiology, stress response and drug resistance. Roles of gene kpnK in oxidative and nitrosative stress tolerance and in other stress-associated challenge, overview. Additional regulatory role of KpnK on MDR efflux pumps
-
metabolism
Bacillus anthracis 7702
-
regulatory interactions of a serine/threonine phosphatase, BA-Stp1, EC 3.1.3.16, and serine/threonine kinase, BA-Stk1, pair in Bacillus anthracis: dephosphorylation of BA-Stk1 by BA-Stp1 alters the BA-Stk1 kinase activity
-
additional information
-
calcium binding differentially affects CDPK isoforms that may be activated by distinct molecular mechanisms
additional information
-
molecular modeling, docking study and structural analysis, homology model for TPL2, overview
additional information
A3QQQ9
self-association of Tssk4
additional information
-
structure of catalytic sites of CK1 isozymes, overview. A spontaneously occurring human mutation of a CK1 priming site in PER2, Ser662, leads to decreased phosphorylation of stabilizing sites in PER2 and accelerated circadian rhythms
additional information
-
the C-terminal domain sequence of PrkA shows the presence of several copies of extracellular PASTA domains, i.e. penicillin-binding protein and Ser/Thr kinase associate, a wel conserved intracellular kinase domain, and a N-terminal region (residues 1-338), which is orientated toward the cytoplasm
additional information
-
the enzyme's N-terminal Cys13 to -15 track is essential for Env7 vacuolar membrane anchoring and kinase activity
additional information
Saccharomyces cerevisiae BY4742
-
the enzyme's N-terminal Cys13 to -15 track is essential for Env7 vacuolar membrane anchoring and kinase activity
-
additional information
Arabidopsis thaliana Col0
-
calcium binding differentially affects CDPK isoforms that may be activated by distinct molecular mechanisms
-
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ADP + casein
AMP + phosphorylated casein
show the reaction diagram
-
phosphorylated on threonine residues
-
-
?
ATP + 3-hydroxy-3-methylglutaryl-CoA reductase
ADP + phosphorylated 3-hydroxy-3-methylglutaryl-CoA reductase
show the reaction diagram
-
-
-
-
?
ATP + 4E-BP1 protein
ADP + phosphorylated 4E-BP1 protein
show the reaction diagram
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
O13839, O59790, O74135, O74536, O94751, P07334, P08092, P34208, P36616, P38938, P40231, P40233, P40234, P40235, P40236, P50526, P50527, P50582, P87050, Q07538, Q09170, Q10056, Q10292, Q9UQY9
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P22211
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P25333
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P36002
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P47116
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P23291, P23292, P32361, P38691, Q03497
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P29295, Q12505
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
O10269
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P41415
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P41719
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P41720
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Q99mw1
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Q9BXU1
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
autophosphorylation
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P53323
autophosphorylation
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Q62761, Q62762, Q62763
autophosphorylation when incubated with ATP and Mg2+
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
O15726
strong preference for ATP over GTP
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P54737, P54738
Pkn5 is autophosphorylated only at Ser
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
self-catalyzed phosphate incorporation into both Ser and Tyr residues of AfsK
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P54737, P54738
Pkn6 is autophosphorylated both at Ser and Thr
-
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
autophosphorylation on Thr
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is essential for viral replication
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
not essential for cell viability, Cki2, may contribute to the regulation of cell morphology
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is a regulator of DNA strand-break repair
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
enzyme is involved in the regulation of DNA repair
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
enzyme plays a pivotal role in eukaryotic cell regulation
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
gene disruption reveals that cki3+ is dispensable for cell viability, and cells lacking functional cki3+ exhibit no characteristic phenotype
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
casein kinase 1 alpha gene is developmentally regulated and the kinase activity of the protein is induced by DNA damage. Possible requirement in mechanisms associated with DNA repair during early embryogenesis
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P54737, P54738
Pkn5 negatively regulates Myxococcus xanthus development
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
AfsK plays a regulatory role in aerial mycelium formation in Streptomyces griseus
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P54737, P54738
expressed constitutively throughout the life cycle, with slight increases at an early stage of development
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P54736
the enzyme blocks the secretion of beta-lactamase by phosphorylation
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
pknA is required for both normal cellular growth and differentiation
-
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P54737, P54738
Pkn6 may be a transmembrane sensor of external signals for development
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
involvement of afsK in the regulation of secondary metabolism
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P22211
the enzyme is required to promote the activity of at least six distinct transport systems for nitrogenous nutrients under conditions of nitrogen catabolite derepression
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is a negative regulator of both sexual conjugation and meiosis
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P47116
STK1 mostly affects a lower-affinity, low-capacity polyamine transport activity
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
enzyme is not essential for vegetative growth
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the SKS1 protein kinase is a multicopy suppressor of the snf3 mutation of Saccharomyces cerevisiae
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme enhances spermine uptake in Saccharomyces cerevisiae
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
in some cancers displaying chromosomal instability the loss of this checkpoint is associated with the mutational inactivation of a human homologue of the yeast BUB1 gene
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is essential for the fission yeast spindle checkpoint response to spindle damage and to defects in centromere function. Activation of the checkpoint results in the recruitment of Bub1 to centromeres and a delay in the completion of mitosis. Bub1 also has a crucial role in normal, unperturbed mitoses. Loss of bub1 function causes chromosomes to lag on the anaphase spindle and an increased frequency of chromosome loss. bub1(+)function is essential to maintain correct ploidy through mitosis
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is required for function of the spindle assembly checkpoint
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
O43683
the enzyme is required for function of the spindle assembly checkpoint
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
cell cycle-dependent expression, Bub1b has a putative destruction box that can target proteins for degradation by proteosomes during mitosis
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Q9Z1S0
cell cycle-dependent expression, Bub1b has a putative destruction box that can target proteins for degradation by proteosomes during mitosis
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P41695
the enzyme is involved in spindle assembly during the cell cycle
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
hBUBR1 may regulate multiple functions that include the kinetochore and the spindle midzone
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
O08901
kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
hBub1 is an important component of the spindle checkpoint pathway. hBub1 expression is restricted to proliferating cells and appears to be involved in regulating cell cycle progression
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
Bub1 is required for binding Bub3
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
huCdc7 may regulate processes of DNA replication by modulating MCM functions
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
HsCdc7 may phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is required for the initiation of mitotic DNA synthesis. It is necessary for genetic recombination during meiosis and for the formation of ascospores, involved in an error-prone DNA repair pathway
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is required for inhibition of mitosis until completion of S phase, it may also be involved in proper execution of mitosis
-
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
enzyme is required for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is dispensable for mitotic growth and premeiotic DNA replication, its primary role is in meiosis
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P53323
the enzyme is essential for normal cell life
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is required for inositol phototrophy in Saccharomyces cerevisiae
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
Ire1p is required for activation of the unfolded protein response. It senses the accumulation of unfolded proteins in the ER and transmits the signal across the membrane toward the transcription machinery, possibly by phosphorylating downstream components of the UPR pathway
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is required for signaling from the ER to the nucleus
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
phosphorylation of exogenous substrates takes place on serine and, occasionally, threonine, but the enzyme displays a strong preference for threonine as the phospho-acceptor amino acid residue, overview, no activity with GTP except for the autophosphorylation reaction in vitro which functions with GTP and also GDP
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
PK2 phosphorylate itself as well as several exogenous proteins, including mixed histones, casein, bovine serum albumin, and reduced carboxyamidomethylated and maleylated lysozyme, on serine residues, overview, autophosphorylation of rSsoPK2 can be uncoupled from the phosphorylation of exogenous proteins by manipulation of the temperature or mutagenic alteration of the enzyme, autophosphorylation is detected only at temperatures above 60°C, whereas phosphorylation of exogenous proteins is detectable at 37°C
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Q97ZY9
protein kinase activity, with a noticeable preference for phosphorylating proteins of acidic character. No activity with basic proteins such as histones or myelin basic protein. The protein kinase also can phosphorylate itself on serine and threonine residues. No autophosphorylation of the protein kinase can be detected prior to addition of exogenous substrate proteins. Thr-151 is a site of autophosphorylation, and that autophosphorylation of this residue enhances the catalytic efficiency of the enzyme
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P28523
the enzyme shows dual-cosubstrate specificity because it provides enough space for a hydrogenbonding frame-shift at the nucleotide-binding site and because water molecules allow the purine bases to use the full hydrogen-bonding potential of this site
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is essential for viral replication
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
phosphorylation of exogenous substrates takes place on serine and, occasionally, threonine, but the enzyme displays a strong preference for threonine as the phospho-acceptor amino acid residue, overview, no activity with GTP except for the autophosphorylation reaction in vitro which functions with GTP and also GDP
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Q97ZY9
protein kinase activity, with a noticeable preference for phosphorylating proteins of acidic character. No activity with basic proteins such as histones or myelin basic protein. The protein kinase also can phosphorylate itself on serine and threonine residues. No autophosphorylation of the protein kinase can be detected prior to addition of exogenous substrate proteins. Thr-151 is a site of autophosphorylation, and that autophosphorylation of this residue enhances the catalytic efficiency of the enzyme
-
-
?
ATP + AaSTPK
ADP + phosphorylated-AaSTPK
show the reaction diagram
O66844
enzyme is autophosphorylated on a threonine residue
-
-
?
ATP + ABCA1 NBD1-R1 protein
ADP + phosphorylated ABCA1 NBD1-R1 protein
show the reaction diagram
-
substrate protein is a recombinant construct of wild-type and mutant nucleotide binding domain 1 and cytoplasmic domain R1 of ATP-binding cassette transporter protein A1 expressed in Escherichia coli, phosphorylation at T1242, T1243, and S1255
-
-
?
ATP + ABCA1 NBD2-R2 protein
ADP + phosphorylated ABCA1 NBD2-R2 protein
show the reaction diagram
-
substrate protein is a recombinant construct of wild-type and mutant nucleotide binding domain 2 and cytoplasmic domain R2 of ATP-binding cassette transporter protein A1 expressed in Escherichia coli
-
-
?
ATP + Ac-LRRASLG
ADP + Ac-LRRApSLG
show the reaction diagram
-
an efficient fluorescence assay for serine/threonine kinases using a peptide array is developed. Assay is based on chemical reactions specific to phosphoserine and phosphothreonine residues, that is, base-mediated beta-elimination of the phosphate group and subsequent Michael addition of a thiol-containing fluorescent reagent. This procedure enables the covalent introduction of a fluorescent moiety into the phosphorylated peptide. Novel fluorescent reagents are designed for this purpose and synthesized. As a model peptide, a well-known PKA consensus sequence Kemptide 49 is chosen
-
-
?
ATP + Ac-RPRAASF
ADP + Ac-Ac-RPRAApSF
show the reaction diagram
-
an efficient fluorescence assay for serine/threonine kinases using a peptide array is developed. Assay is based on chemical reactions specific to phosphoserine and phosphothreonine residues, that is, base-mediated beta-elimination of the phosphate group and subsequent Michael addition of a thiol-containing fluorescent reagent. This procedure enables the covalent introduction of a fluorescent moiety into the phosphorylated peptide. Novel fluorescent reagents are designed for this purpose and synthesized
-
-
?
ATP + acetyl-CoA carboxylase
ADP + phosphorylated acetyl-CoA carboxylase
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA carboxylase
ADP + phosphorylated acetyl-CoA carboxylase
show the reaction diagram
-
phosphorylation and inactivation
-
-
?
ATP + adenomatous polyposis coli protein
ADP + phosphorylated adenomatous polyposis coli protein
show the reaction diagram
-
i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon
-
-
?
ATP + adenylosuccinate synthase
ADP + phosphorylated adenylosuccinate synthase
show the reaction diagram
Staphylococcus aureus, Staphylococcus aureus 8325
-
PknB specifically phosphorylates adenylosuccinate synthase, phosphorylated adenylosuccinate synthase shows a 1.8fold decrease in enzymatic activity compared to unphosphorylated enzyme
-
-
?
ATP + AfsR
ADP + ?
show the reaction diagram
-
phosphorylation at both Ser and Thr residues
-
-
?
ATP + AfsR protein
ADP + AfsR phosphoprotein
show the reaction diagram
-
kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview, phosphorylation of serine and threonine residues by activated kinase AfsK, and by PkaG and SCD10.09, the Streptomyces coelicolor strain A3(2) contains more than 40 enzymes phosphorylating the substrate AsfR
-
-
?
ATP + AfsR protein
ADP + AfsR phosphoprotein
show the reaction diagram
-
kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview, phosphorylation of serine and threonine residues by activated kinase AfsK, and by PkaG and SCD10.09, the Streptomyces coelicolor strain A3(2) contains more than 40 enzymes phosphorylating the substrate AsfR
-
-
?
ATP + AIB1 protein
ADP + phosphorylated AIB1 protein
show the reaction diagram
-
phosphorylation at S601 by isozyme CK1delta
-
-
?
ATP + Akt
ADP + phosphorylated Akt
show the reaction diagram
-
CK2 phosphorylates and activates Akt directly, CK2 phosphorylates and activates Akt directly, phosphorylation at Ser473
-
-
?
ATP + Akt (MBP)
ADP + phosphorylated-Akt
show the reaction diagram
-
purified Pak1 can directly phosphorylate Akt only at Ser473, suggesting that Pak1 may be a relevant PDK2 responsible for AKT Ser473 phosphorylation in cardiomyocytes
-
-
?
ATP + alpha-casein
ADP + phosphorylated alpha-casein
show the reaction diagram
-
casein kinase 1alpha
-
-
?
ATP + alpha-casein
ADP + phosphorylated alpha-casein
show the reaction diagram
O30245
dephosphorylated alpha-casein
-
-
?
ATP + AMP-activated protein kinase
ADP + phosphorylated AMP-activated protein kinase
show the reaction diagram
-
-
-
-
?
ATP + apoptosis signal-regulating kinase 1
ADP + phosphorylated-apoptosis signal-regulating kinase 1
show the reaction diagram
Q61846
MPK28 stimulates APK1 activity by Thr838 phosphorylation
-
-
?
ATP + axin
ADP + phosphorylated axin
show the reaction diagram
-
glycogen synthase kinase 3
-
-
?
ATP + BAF155
ADP + phosphorylated BAF155
show the reaction diagram
-
BAF155 is a hSWI/SNF protein that contains three Akt consensus sites, phosphorylation site analysis using recombinant full-length and truncated substrate versions, overview
-
-
?
ATP + BAF170
ADP + phosphorylated BAF170
show the reaction diagram
-
BAF170 is a hSWI/SNF protein that contains one Akt consensus site
-
-
?
ATP + beta-casein
ADP + phosphorylated beta-casein
show the reaction diagram
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
-
-
-
-
?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
show the reaction diagram
-
-
by isozymes CK1delta and CK1epsilon
-
`
ATP + beta-catenin
ADP + phosphorylated beta-catenin
show the reaction diagram
-
glycogen synthase kinase 3
-
-
?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
show the reaction diagram
-
phosphorylation at Ser45, priming GSK3beta phosphorylation
-
-
?
ATP + beta-hydroxy beta-methylglutaryl-coenzyme A reductase
ADP + phosphorylated beta-hydroxy beta-methylglutaryl-coenzyme A reductase
show the reaction diagram
-
phosphorylation and inactivation
-
-
?
ATP + bovine serum albumin
?
show the reaction diagram
-
mitochondrial protamine kinases, not cytosolic kinase
-
-
?
ATP + bovine serum albumin
?
show the reaction diagram
-
phosphorylated at 40-70% the rate of protamine
-
-
?
ATP + bovine serum albumin
?
show the reaction diagram
-
phosphorylated at 48% the rate of protamine
-
-
?
ATP + bovine serum albumin
ADP + phosphorylated bovine serum albumin
show the reaction diagram
-
-
-
-
?
ATP + bovine serum albumin
ADP + phosphorylated bovine serum albumin
show the reaction diagram
-
-
-
-
?
ATP + Bub3
ADP + phosphorylated Bub3
show the reaction diagram
-
-
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
show the reaction diagram
-
-
-
-
?
ATP + C/EBPalpha
ADP + phosphorylated C/EBPalpha
show the reaction diagram
-
phosphorylation at consensus sequence (S/T)XXX(S/T) with X representing any amino acid
-
-
?
ATP + C/EBPbeta
ADP + phosphorylated C/EBPbeta
show the reaction diagram
-
phosphorylation at multiple sites, preferably at Thr189 and Ser185, reduced activity with mutants T189A and S185A, mutation of either site appears to impair phosphorylation of neighbouring sites
-
-
?
ATP + calmodulin
ADP + phosphorylated calmodulin
show the reaction diagram
-
phosphorylation by isozyme CK1alpha
-
-
?
ATP + CARMA1 protein
ADP + phosphorylated CARMA1
show the reaction diagram
-
i.e. CARD11 protein, phosphorylation at S608 by isozyme CK1alpha
-
-
?
ATP + casein
?
show the reaction diagram
-
poor substrate
-
-
?
ATP + casein
?
show the reaction diagram
-
not mitochondrial protamine kinases, phosphorylated at 5% the rate of protamine, cytosolic kinase
-
-
?
ATP + casein
?
show the reaction diagram
-
phosphorylated at 5% the rate of protamine, cytosolic kinase
-
-
?
ATP + casein
ADP + phosphocasein
show the reaction diagram
-
-
-
-
?
ATP + casein
ADP + phosphocasein
show the reaction diagram
-
-
-
-
?
ATP + casein
ADP + phosphorylated casein
show the reaction diagram
-
-
-
-
?
ATP + casein
ADP + phosphorylated casein
show the reaction diagram
-
-
-
-
?
ATP + casein
ADP + phosphorylated casein
show the reaction diagram
Q06486
-
-
-
?
ATP + casein
ADP + phosphorylated casein
show the reaction diagram
Q62761, Q62762, Q62763
-
-
-
?
ATP + casein
ADP + phosphorylated casein
show the reaction diagram
P53323
-
-
-
?
ATP + casein
ADP + phosphorylated casein
show the reaction diagram
-
substrate of CK1 and CK2
-
-
?
ATP + casein
ADP + phosphorylated casein
show the reaction diagram
-
substrate of TSSK3
-
-
?
ATP + casein
ADP + phosphorylated casein
show the reaction diagram
-
the chromophoric domain light-oxygen-voltage-sensing 2 LOV2 of phototropin acts as a blue light-regulated molecular switch
-
-
?
ATP + casein
ADP + phosphorylated casein
show the reaction diagram
-
phosphorylated on threonine residues
-
-
?
ATP + casein
ADP + phopshorylated cysein
show the reaction diagram
Q97ZY9
-
-
-
?
ATP + Cdc25A
ADP + phosphorylated Cdc25A
show the reaction diagram
-
phosphorylation at S79 and S82 by isozyme CK1alpha
-
-
?
ATP + Cdc25C
ADP + ?
show the reaction diagram
-
Chk2 phosphorylated Cdc25C on Ser216
-
-
?
ATP + Cdc25C
ADP + phosphorylated Cdc25C
show the reaction diagram
Q6DE87
-
-
-
?
ATP + Cdc25C
ADP + phosphorylated Cdc25C
show the reaction diagram
Q9Z265
phosphorylated Cdc25C on Ser216
-
-
?
ATP + Cdc42Hs
ADP + ?
show the reaction diagram
O96013
PAK4 interacts only with the activated form of Cdc42Hs through its GTPase-binding domain
-
-
?
ATP + Cdk2 interacting protein
ADP + phosphorylated Cdk2 interacting protein
show the reaction diagram
-
-
-
-
?
ATP + cell division cycle 7
ADP + phosphorylated cell division cycle 7
show the reaction diagram
-
-
-
-
?
ATP + chicken basic protein
ADP + phosphorylated chicken basic protein
show the reaction diagram
Klebsiella pneumoniae, Klebsiella pneumoniae MGH78578
-
-
-
-
?
ATP + CIRCADIAN CLOCK ASSOCIATED1
ADP + phosphorylated CIRCADIAN CLOCK ASSOCIATED1
show the reaction diagram
-
transcription factor CIRCADIAN CLOCK ASSOCIATED1, i.e. CCA1
-
-
?
ATP + CIRCADIAN CLOCK ASSOCIATED1
ADP + phosphorylated CIRCADIAN CLOCK ASSOCIATED1
show the reaction diagram
Arabidopsis thaliana Col-0
-
transcription factor CIRCADIAN CLOCK ASSOCIATED1, i.e. CCA1
-
-
?
ATP + claspin
ADP + phosphorylated claspin
show the reaction diagram
-
-
-
-
?
ATP + claudin-4
ADP + phosphorylated claudin-4
show the reaction diagram
-
recombinant WNK1 or WNK4 with recombinant protein substrate, both expressed in Escherichia coli
-
-
?
ATP + CPS.A subunit
ADP + phosphorylated-CPS.A subunit
show the reaction diagram
O66844
AaSTPK also phosphorylates one threonine residue on the carbamoyl phosphate synthetase, CPS.A subunit
-
-
?
ATP + CREB
ADP + phosphorylated CREB
show the reaction diagram
Q6SA08
phosphorylation by TSSK5 at Ser133 stimulates the cAMP responsive element/cAMP responsive element binding protein CRE/CREB responsive pathway in recombinant HEK293 cells, i.e. cAMP responsive element binding protein, phosphorylation by TSSK5 at Ser133, no activity with CREB S133A mutant
-
-
?
ATP + Daxx
ADP + phosphorylated Daxx
show the reaction diagram
-
Daxx is a protein acting in TGF-beta-induced JNK activation and in apoptosis, recombinant Daxx expressed as GST-fusion protein in Escherichia coli
-
-
?
ATP + DDDDVASLPGLRRR
ADP + ?
show the reaction diagram
Q06486
-
-
-
?
ATP + Dnmt1 protein
ADP + phosphorylated Dnmt1 protein
show the reaction diagram
-
phosphorylation at S147 by isozymes CK1delta and CK1epsilon
-
-
?
ATP + EmbR
ADP + phosphorylated-EmbR
show the reaction diagram
P9WI71
PknH phosphorylates the transcriptional regulator EmbR, but not its homologue EmbR2
-
-
?
ATP + eukaryotic protein synthesis initiation factor
?
show the reaction diagram
-
i.e. eIF-4E, 1 mol phosphate per mol eIF-4E
-
-
?
ATP + FADD protein
ADP + phosphorylated FADD protein
show the reaction diagram
-
phosphorylation at S194 by isozyme CK1alpha
-
-
?
ATP + geminin
ADP + phosphorylated geminin
show the reaction diagram
-
a cell cycle regulatory protein
-
-
?
ATP + Gli protein
ADP + phosphorylated Gli protein
show the reaction diagram
-
the Gli proteins are important in regulation of Hedgehog signaling, overview
-
-
?
ATP + Gli1 protein
ADP + phosphorylated Gli1 protein
show the reaction diagram
Q6PHR2
low activity
-
-
?
ATP + Gli2 protein
ADP + phosphorylated Gli2 protein
show the reaction diagram
Q6PHR2
high activity
-
-
?
ATP + Gli3 protein
ADP + phosphorylated Gli3 protein
show the reaction diagram
Q6PHR2
low activity
-
-
?
ATP + glycogen synthase
?
show the reaction diagram
-
from rabbit skeletal muscle, mitochondrial protamine kinases, not cytosolic kinase
-
-
?
ATP + glycogen synthase
?
show the reaction diagram
-
phosphorylated at 15% the rate of protamine
-
-
?
ATP + glycogen synthase
ADP + phosphorylated glycogen synthase
show the reaction diagram
-
glycogen synthase kinase 3, glycogen synthase kinase 3 is involved in the insulin signaling pathway regulating glycogen synthesis via glycogen synthase antagonizing insulin
-
-
?
ATP + glycogen synthase kinase 3
ADP + phosphorylated glycogen synthase kinase 3
show the reaction diagram
-
PKB protein kinase, PKB protein kinase, phosphorylation at S21 and S9
-
-
?
ATP + glycogen synthase kinase-3 (GSK-3) fusion protein
ADP + phosphorylated- glycogen synthase kinase-3 fusion protein
show the reaction diagram
-
-
-
-
?
ATP + GST-CREB2 protein
ADP + phosphorylated GST-CREB2 protein
show the reaction diagram
-
-
-
-
?
ATP + GST-NFAT3D4-261-365
ADP + phosphorylated GST-NFAT3D4-261-365
show the reaction diagram
-
-
-
-
?
ATP + histine H2A
ADP + histidine gammaH2A
show the reaction diagram
-
phosphorylation on serine 129 in vivo
Glc7 dephosphorylates histidine gammaH2A in vitro
-
?
ATP + histone
ADP + phosphorylated histone
show the reaction diagram
-
-
-
-
?
ATP + histone
ADP + phosphorylated histone
show the reaction diagram
-
-
-
-
?
ATP + histone
ADP + phosphorylated histone
show the reaction diagram
-
-
-
-
?
ATP + histone
ADP + phosphorylated histone
show the reaction diagram
-
-
-
-
?
ATP + histone
ADP + phosphorylated histone
show the reaction diagram
O30245
-
-
-
?
ATP + histone
ADP + phosphorylated histone
show the reaction diagram
Q9ZSA2
-
-
-
?
ATP + histone
ADP + phosphorylated histone
show the reaction diagram
-
histones from calf thymus, phosphorylation on Ser
-
-
?
ATP + histone
ADP + phosphorylated histone
show the reaction diagram
Arabidopsis thaliana Col0
-
-
-
-
?
ATP + histone
ADP + phosphorylated histone
show the reaction diagram
Arabidopsis thaliana Col-0
Q9ZSA2
-
-
-
?
ATP + histone f1
?
show the reaction diagram
-
lysine-rich histone, phosphorylated at a specific serine residue
-
-
?
ATP + histone fraction II
?
show the reaction diagram
-
slightly lysine-rich, from trout testes
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
-
-
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
-
-
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
O00311
-
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
-
PDK2
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
Q9BXA6
substrate from calf, substrate of SSTK
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
Q925K9
substrate from calf, substrate of SSTK
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
-
substrate of TSSK3
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
Saccharomyces cerevisiae BY4742
-
-
-
-
?
ATP + histone H1
?
show the reaction diagram
-
mitochondrial protamine kinases
-
-
?
ATP + histone H1
?
show the reaction diagram
-
not microsomal kinases
-
-
-
ATP + histone H1
?
show the reaction diagram
-
not cytosolic
-
-
?
ATP + histone H1
?
show the reaction diagram
-
phosphorylated at 80% the rate of protamine
-
-
?
ATP + histone H2A
ADP + phosphorylated histone H2A
show the reaction diagram
Q9BXA6
recombinant human substrate, substrate of SSTK
-
-
?
ATP + histone H2A
ADP + phosphorylated histone H2A
show the reaction diagram
Q925K9
recombinant human substrate, substrate of SSTK
-
-
?
ATP + histone H2AX
ADP + phosphorylated histone H2AX
show the reaction diagram
Q9BXA6
recombinant human substrate, substrate of SSTK
-
-
?
ATP + histone H2AX
ADP + phosphorylated histone H2AX
show the reaction diagram
Q925K9
recombinant human substrate, substrate of SSTK
-
-
?
ATP + histone H2B
ADP + phosphorylated histone H2B
show the reaction diagram
-
-
-
-
?
ATP + histone H2B
ADP + phosphorylated histone H2B
show the reaction diagram
Q9BXA6
recombinant human substrate, substrate of SSTK
-
-
?
ATP + histone H2B
ADP + phosphorylated histone H2B
show the reaction diagram
Q925K9
recombinant human substrate, substrate of SSTK
-
-
?
ATP + histone H2B
ADP + phosphorylated histone H2B
show the reaction diagram
Saccharomyces cerevisiae BY4742
-
-
-
-
?
ATP + histone H3
ADP + phosphorylated histone
show the reaction diagram
-
Ark1 phosphorylates Ser10 of histone H3 in vivo
-
-
?
ATP + histone H3
?
show the reaction diagram
-
Ark1 phosphorylates Ser10 of histone H3 in vivo
-
-
?
ATP + histone H3
ADP + phosphorylated histone H3
show the reaction diagram
-
-
-
-
?
ATP + histone H3
ADP + phosphorylated histone H3
show the reaction diagram
-
-
-
-
?
ATP + histone H3
ADP + phosphorylated histone H3
show the reaction diagram
-
RSK2 is a key regulator of histone H3 phosphorylation
-
-
?
ATP + histone H3
ADP + phosphorylated histone H3
show the reaction diagram
Saccharomyces cerevisiae BY4742
-
-
-
-
?
ATP + histone H4
ADP + phosphorylated histone H4
show the reaction diagram
Q9BXA6
recombinant substrate from Xenopus laevis, substrate of SSTK
-
-
?
ATP + histone H4
ADP + phosphorylated histone H4
show the reaction diagram
Q925K9
recombinant substrate from Xenopus laevis, substrate of SSTK
-
-
?
ATP + histone H4
ADP + phosphorylated histone H4
show the reaction diagram
-
phosphorylated on threonine and on serine residues
-
-
?
ATP + histone IIA
?
show the reaction diagram
-
poor substrate for cAMP-independent protamine kinase
-
-
?
ATP + histone IIB
?
show the reaction diagram
-
phosphorylated at 8% the rate of protamine, cytosolic kinase
-
-
?
ATP + histone IIB
?
show the reaction diagram
-
not mitochondrial protamine kinases
-
-
?
ATP + histone III
ADP + phosphorylated histone III
show the reaction diagram
-
-
-
-
?
ATP + hypoxia-inducible factor-1
ADP + phosphorylated hypoxia-inducible factor-1
show the reaction diagram
-
i.e. HIF-1, casein kinase 2 inhibits the activation of HIF-1 activity by phosphorylation and thereby stabilization of the protein, CK2 is involved in and influenced by hypoxia, overview, i.e. HIF-1
-
-
?
ATP + IFNAR1 protein
ADP + phosphorylated IFNAR1 protein
show the reaction diagram
-
phosphorylation at S535 by isozyme CK1alpha
-
-
?
ATP + IgG2A heavy chain
ADP + phosphorylated IgG2A heavy chain
show the reaction diagram
-
substrate protein from mouse
-
-
?
ATP + KKRAARASSNVFA
ADP + ?
show the reaction diagram
-
phosphorylation of the peptide is undetectable at 25°C. Phosphorylation takes place at measurable rates if the assay temperature is raised to 65°C or if poly(Glu4:Tyr) is included in the assay mixture
-
-
?
ATP + KKRAARATSNVFA
ADP + KKRAARApTSNVFA
show the reaction diagram
-
-
-
-
?
ATP + KKRNRRLSVA
ADP + KKRNRRL-phosphoserine-VA
show the reaction diagram
-
peptide substrate of NDR1
-
-
?
ATP + KKRNRRLSVA
ADP + phosphorylated-KKRNRRLSVA
show the reaction diagram
Q15208
-
-
-
?
ATP + KLP10A protein
ADP + phosphorylated KLP10A protein
show the reaction diagram
-
phosphorylation at S573 by isozyme CK1alpha
-
-
?
ATP + lamin A/C
ADP + phosphorylated lamin A/C
show the reaction diagram
-
phosphorylation of host cell lamin by US3 kinase, phosphorylation of host cell lamin by US3 kinase at multiple sites in vitro, eventhough lamin A/C contains only one putative consensus sequence
-
-
?
ATP + late gene expression factor LEF-8
ADP + phosphorylated-late gene expression factor LEF-8
show the reaction diagram
-
-
-
-
?
ATP + Lys-Lys-Phe-Asn-Arg-Thr-Leu-Ser-Val-Ala
ADP + ?
show the reaction diagram
P49137
-
-
-
-
ATP + Lys-Lys-Phe-Asn-Arg-Thr-Leu-Ser-Val-Ala
ADP + ?
show the reaction diagram
-
-
-
-
?
ATP + lysozyme
ADP + phopshorylated lysozyme
show the reaction diagram
-
reduced carboxyamidomethylated and maleylated lysozyme
-
-
?
ATP + M3-muscarnic receptor
ADP + phosphorylated M3-muscarnic receptor
show the reaction diagram
-
-
-
-
?
ATP + maize eukaryotic translation initiation factor 5A
ADP + phosphorylated maize eukaryotic translation initiation factor 5A
show the reaction diagram
-
phosphorylation at Ser2 by CK2. Zea mays, Arabidopsis thaliana, and Saccharomyces cerevisiae eIF5A wild-type proteins are efficient substrates, while their S2A mutants are not phosphorylated, the S4A mutant is phosphorylated
-
-
?
ATP + maize eukaryotic translation initiation factor 5A
ADP + phosphorylated maize eukaryotic translation initiation factor 5A
show the reaction diagram
Zea mays Mona
-
phosphorylation at Ser2 by CK2. Zea mays, Arabidopsis thaliana, and Saccharomyces cerevisiae eIF5A wild-type proteins are efficient substrates, while their S2A mutants are not phosphorylated, the S4A mutant is phosphorylated
-
-
?
ATP + maltose-binding protein
ADP + phosphorylated maltose-binding protein
show the reaction diagram
-
-
-
-
?
ATP + MARCKS protein
ADP + MARCKS phosphoprotein
show the reaction diagram
-
isozyme PKNalpha
-
-
?
ATP + MB protein
ADP + MB phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + MCM2
ADP + ?
show the reaction diagram
-
wild-type huCdc7 protein expressed in COS7 cells phosphorylates MCM2 and MCM3 proteins in vitro
-
-
?
ATP + MCM3
ADP + ?
show the reaction diagram
-
wild-type huCdc7 protein expressed in COS7 cells phosphorylates MCM2 and MCM3 proteins in vitro
-
-
?
ATP + mPer1
ADP + phosphorylated mPer1
show the reaction diagram
Q99PS2, Q9JJ75, Q9JJ76
CK1epsilon-1
-
-
?
ATP + mPer1
ADP + phosphorylated mPer1
show the reaction diagram
Q99PS2, Q9JJ75, Q9JJ76
CKIepsilon-3
-
-
?
ATP + myelic basic protein
ADP + myelic basic phosphoprotein
show the reaction diagram
-
phosphorylation of serine and threonine residues by PknB
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
-
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
-
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
-
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
-
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
-
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
O30245
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
-
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
-
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
-
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
Q9BXA6
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
Q925K9
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
Q6E0B2
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
A3QQQ9, A3QQR1, A9P6P7, A9P6P9
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
-
myelin basic proteins from bovine brain, phosphorylation on Ser
-
-
-
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
-
PknB, PknD, PknE, and PknF
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
-
recombinant WNK1 or WNK4 expressed in Escherichia coli
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
-
substrate of TSSK3
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
Saccharomyces cerevisiae BY4742
-
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
Staphylococcus aureus 8325
-
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
Bacillus anthracis 7702
-
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
-
-
-
-
?
ATP + myelin basic protein (MBP)
ADP + phosphorylated-myelin basic protein
show the reaction diagram
-
-
-
-
?
ATP + NKCC1-(1-260)
ADP + phosphorylated NKCC1-(1-260)
show the reaction diagram
-
i.e. Na+-K+-2Cl- co-transporter-1-(1-260) construct, recombinant WNK1 or WNK4 with recombinant protein substrate, both expressed in Escherichia coli
-
-
?
ATP + NS5A protein
ADP + phosphorylated NS5A protein
show the reaction diagram
-
recombinant NS5A expressed in Sf9 cells, substrate is a hepatitis C virus protein playing a critical role in virus replication and conferring interferon resistance to the virus, the viral protein is phosphorylated by diverse serine/threonine protein kinases, phosphorylation patterns, overview
-
-
?
ATP + NS5A protein
ADP + phosphorylated NS5A protein
show the reaction diagram
-
recombinant NS5A expressed in Sf9 cells, substrate is a hepatitis C virus protein playing a critical role in virus replication and conferring interferon resistance to the virus, the viral protein is phosphorylated by several serine/threonine protein kinases, e.g. casein kinase 1, phosphorylation pattern, overview
-
-
?
ATP + NS5A protein
ADP + phosphorylated NS5A protein
show the reaction diagram
-
recombinant NS5A expressed in Sf9 cells, substrate is a hepatitis C virus protein playing a critical role in virus replication and conferring interferon resistance to the virus, the viral protein is phosphorylated by several STE or AGC type protein kinases CK2, AKT1, SGK1, 90S6K, STE, phosphorylation patterns, overview
-
-
?
ATP + OdhI
ADP + phosphorylated-OdhI
show the reaction diagram
Q6M299, Q6M3Q8, Q8NU97, Q8NU98
following phosphorylation by PknA, PknG can transphosphorylate its specific substrate 2-oxoglutarate dehydrogenase inhibitor protein (OdhI) in vitro
-
-
?
ATP + ORF62 protein
ADP + ORF62 phosphoprotein
show the reaction diagram
-
protein substrate from Varicella-Zoster virus, no activity with a truncated ORF62 mutant
-
-
?
ATP + ORF63 protein
ADP + ORF63 phosphoprotein
show the reaction diagram
-
protein substrate from Varicella-Zoster virus
-
-
?
ATP + oxidative stress response kinase 1 OSR1
ADP + phosphorylated oxidative stress response kinase 1 OSR1
show the reaction diagram
-
recombinant WNK1 or WNK4 with recombinant protein substrate, both expressed in Escherichia coli, phosphorylation at Ser325 and Thr185, the latter is required for activation of OSR1
-
-
?
ATP + p53 protein
ADP + phosphorylated p53 protein
show the reaction diagram
-
at Ser15
-
-
?
ATP + partially dephosphorylated casein
ADP + ?
show the reaction diagram
-
-
-
-
?
ATP + peptide LRRKtide
ADP + phosphorylated peptide LRRKtide
show the reaction diagram
-
high activity towards the peptidic substrate LRRKtide
-
-
?
ATP + PHLPP1 protein
ADP + phosphorylated PHLPP1 protein
show the reaction diagram
-
phosphorylation at T851 by isozyme CK1alpha
-
-
?
ATP + phospho-glycogen synthase peptide
ADP + ?
show the reaction diagram
-
-
-
-
?
ATP + phosphoglucosamine mutase
ADP + phosphorylated phosphoglucosamine mutase
show the reaction diagram
Streptococcus pneumoniae, Streptococcus pneumoniae Cp 1015
-
-
-
-
?
ATP + phosphoglycogen synthase peptide 2
ADP + phosphorylated phosphoglycogen synthase peptide 2
show the reaction diagram
-
-
-
-
?
ATP + phosphoglycogen synthase peptide 2
ADP + phosphorylated phosphoglycogen synthase peptide 2
show the reaction diagram
-
-
-
-
?
ATP + phospholipase D
ADP + phosphorylated phospholipase D
show the reaction diagram
-
CKII is involved in 4beta-phorbol 12-myristate 13-acetate-induced phospholipase D activation, of PLD1 or PLD2 activity as well as basal PLD activity
-
-
?
ATP + phosvitin
ADP + ?
show the reaction diagram
Q06486
-
-
-
?
ATP + phosvitin
ADP + ?
show the reaction diagram
Q62761, Q62762, Q62763
-
-
-
?
ATP + PKB protein kinase
ADP + phosphorylated PKB protein kinase
show the reaction diagram
-
PDK1 kinase, phosphorylates Thr308 and Ser473, which is required for activation of PKB, PDK1 kinase
-
-
?
ATP + PKD2 protein
ADP + phosphorylated PKD2 protein
show the reaction diagram
-
phosphorylation at S244 by isozymes CK1alpha, CK1delta, and CK1epsilon
-
-
?
ATP + PknG
ADP + phosphorylated-PknG
show the reaction diagram
Q6M299, Q6M3Q8, Q8NU97, Q8NU98
activation of PknG is part of a phosphorylation cascade mechanism that relies on PknA activity
-
-
?
ATP + plant ribosomal proteins
ADP + phosphorylated plant ribosomal proteins
show the reaction diagram
-
two plant ribosomal proteins of 14000 Da and 16000 Da can be phosphorylated by the Atpk1 protein kinase
-
-
?
ATP + procaspase-2
ADP + phosphorylated procaspase-2
show the reaction diagram
-
phosphorylation of procaspase-2 by CK2 prevents the activation of caspase activity by inhibiting the dimerization of procaspase-2, CK2 activity is involved in the direct regulation of the caspase-8 pathway, where it can control caspase-8 activity through the phosphorylation of ARC or by preventing the ability of caspase-8 to cleave its target Bid
-
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
-
-
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
-
-
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
-
-
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
preferred substrate
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
preferred substrate
-
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
preferred substrate
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
phosphorylates threonine residues, phosphorylates serine
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
phosphorylates serine
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
phosphorylates serine
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
transfers terminal phosphoryl group from ATP into O-phosphoseryl linkages in the acceptor molecule
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
no substrates are rabbit muscle glycogen phosphorylase b, human gamma-globulin
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
no substrates are histone H4, ovalbumin, synthetic peptide poly(Glu,Tyr) (4:1)
-
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
phosphorylates little, if any activity with branched-chain alpha-keto acid dehydrogenase, pyruvate dehydrogenase, casein, ovalbumin or histone H2B
-
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
no substrates are GTP
-
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
no substrates are GTP, no substrates are GTP or UTP
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
no substrates are acidic proteins, e.g. casein, phosvitin
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
no substrates are acidic proteins, e.g. casein, phosvitin
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
no substrates are acidic proteins, e.g. casein, phosvitin
-
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
no substrates are acidic proteins, e.g. casein, phosvitin
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
no substrates are acidic proteins, e.g. casein, phosvitin
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
-
phosphorylates histone fraction I (lysine-rich) and histone fractions III and IV (arginine-rich), from trout testes
-
?
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
-
GST-Limk1-fusion protein can autophosphorylate on serine, tyrosine and threonine residues in vitro
-
-
?
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
P53667
phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O14965
-
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
Q12469
-
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
autophosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
Q62101
autophosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
Q63484
autophosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
autophosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O88506
autophosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
autophosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
autophosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
Q63285
autophosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O48963
blue light-dependent autophosphorylating
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
Q62101
Ser916 is an in vivo autophosphorylation site
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
P11801
autophosphorylates exclusively serines within its COOH-terminal region in an intermolecular fashion
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
autophosphorylated in vitro in its PS domain
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
minimum sequence required for efficient phosphorylation is Xaa-Xaa-Hyd-Xaa-Arg-Xaa-Xaa-Ser-Xaa-Xaa, where Hyd is a bulky hydrophobic residue (in decreasing order), Phe, Leu, Val, Ala, MAPKAP kinase-2 can not tolerate a proline residue at position n + 1
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
Q91604
autophosphorylation of Thr192
-
-
-
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
Ser/Thr kinase
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
phosphotyrosine as well as phosphoserine/threonine are found in autophosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
enzyme is essential for the late nuclear division in the yeast
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O88506
enzyme activates the p38 pathway, SPAK may act as a novel mediator of stress-activated signals
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O96013
the enzyme is an effector for Cdc42Hs and is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O14427
enzyme is required for virulence and hyphal formation of Candida albicans
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O88643, Q61036
potentially important role in the control of the cellular architecture and/or signaling in the central nervous system
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O88643, Q61036
potentially important role in the control of the cellular architecture and/or signaling in the central nervous system
-
-
-
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O75914
PAK3 may be critical for human cognitive function
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
the enzyme regulates the structure of the actin cytoskeleton in mammalian cells, and may serve as an effector for effector for Cdc42 and Rac1 in proll motility
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
the enzyme is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
the enzyme is necessary for mating
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
Pak1 protein is likely to be an effector for Cdc42p or a related GTPase, Pak1p may be involved in the maintenance of cell polarity and in mating
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
the enzyme is involved in budding and cytokinesis and interacts with Cdc42, a GTPase required for polarized cell growth
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
Q13153
hPAK1 is a GTPase effector controlling a downstream MAP kinase pathway. PAK kinase plays a key part in linking extracellular signals from membrane components, such as receptor-associated G proteins and Rho-related GTPases, to nuclear responses, such as transcriptional activation
-
-
?
ATP + protein
ADP + a phosphoprotein
show the reaction diagram
O75716
-
-
-
?
ATP + protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + protein
ADP + a phosphoprotein
show the reaction diagram
O88697
-
-
-
?
ATP + protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + protein
ADP + a phosphoprotein
show the reaction diagram
P57760
-
-
-
?
ATP + protein
?
show the reaction diagram
-
PKL12 may play a role in a very general cellular function, probably related with the secretory pathway
-
-
?
ATP + protein
?
show the reaction diagram
-
EDPK plays a crucial role in intracellular signaling not only during mouse development but also in adult tissues
-
-
?
ATP + protein Cubitus interruptus
ADP + phosphorylated protein Cubitus interruptus
show the reaction diagram
-
Ci proteins are important in regulation of Hedgehog signaling, overview
-
-
?
ATP + protein Cubitus interruptus
ADP + phosphorylated protein Cubitus interruptus
show the reaction diagram
-
i.e. Ci, e.g. Ci-75 or Ci-155
-
-
?
ATP + protein INI
ADP + phosphorylated INI
show the reaction diagram
-
INI is a hSWI/SNF protein
-
-
?
ATP + protein kinase C
ADP + phosphorylated protein kinase C
show the reaction diagram
-
isozyme PKNalpha
-
-
?
ATP + protein kinase Czeta
ADP + phosphorylated protein kinase Czeta
show the reaction diagram
Q9Z2A0
phosphorylation and activation of protein kinase Czeta
-
-
?
ATP + protein LRP6
ADP + phosphorylated protein LRP6
show the reaction diagram
-
CKIgamma
-
-
?
ATP + protein p21
ADP + phosphoprotein p21
show the reaction diagram
-
threonine 57, threonine 145, serine 98, serine 130, and serine 146 are phosphorylated by JNK, JNK mediates stabilization of protein p21 via the phosphorylation of threonine 57
-
-
?
ATP + protein TCF3
ADP + phosphorylated protein TCF3
show the reaction diagram
-
CKIepsilon
-
-
?
ATP + Rec8 protein
ADP + phosphorylated Rec8 protein
show the reaction diagram
-
phosphorylation at S412 by isozyme CK1delta and CK1epsilon, and at S400, S402, S404, S410, T414, and S416
-
-
?
ATP + reduced carboxyamidomethylated and maleylated lysozyme
ADP + phosphorylated reduced carboxyamidomethylated and maleylated lysozyme
show the reaction diagram
-
phosphorylated on threonine residues
-
-
?
ATP + reduced carboxymethylated lysozyme
ADP + phopshorylated reduced carboxymethylated lysozyme
show the reaction diagram
Q97ZY9
-
-
-
?
ATP + ribosomal protein S6
ADP + phosphorylated ribosomal protein S6
show the reaction diagram
Q6TQF8
specifically phosphorylated by S6K
-
-
?
ATP + RRRDDDSDDD
ADP + RRRDDDphosphoSDDD
show the reaction diagram
-
a CK2-specific synthetic peptide substrate
-
-
?
ATP + RRRDDDSDDD
ADP + RRRDDDpSDDD
show the reaction diagram
P28523
synthetic peptide substrate
-
-
?
ATP + RRRLSSLRA
ADP + RRRLSpSLRA
show the reaction diagram
-
enzyme activities are determined by measuring initial velocities for His6-S6K1aII(DELTA AID)-T389E catalyzed phosphorylation of a commercially available S6K/RSK model peptide substrate 1 (S6K1-Tide, RRRLSSLRA)
-
-
?
ATP + RRSSSY
ADP + RRSS-phosphoS-Y
show the reaction diagram
-
peptide substrate of TSSK3 consisting of the consensus sequence
-
-
?
ATP + RSK peptide
ADP + RSK phosphopeptide
show the reaction diagram
Q6TQF8
-
-
-
?
ATP + RSRSRSRSRSRSPPPVSK
ADP + phosphorylated RSRSRSRSRSRSPPPVSK
show the reaction diagram
-
SC35-derived peptide 180-197, recombinant GSK-3beta
-
-
?
ATP + Rv2175
ADP + phosphorylated-Rv2175
show the reaction diagram
P9WI63
-
-
-
?
ATP + S6 protein of the 40s ribosomal subunit
ADP + phosphorylated S6 protein of the 40s ribosomal subunit
show the reaction diagram
P67999
the mitogen-activated protein kinase plays a central role in the control of mRNA translation. It physiologically phosphorylates the S6 protein of the 40s ribosomal subunit in response to mitogenic stimuli and is a downstream component of the rapamycin-sensitive pathway, which includes the 12-kDa FK506 binding protein and includes rapamycin and the 12-kDa FK506 binding protein target 1
-
-
?
ATP + SC35
ADP + phosphorylated SC35
show the reaction diagram
-
substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors, substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors, recombinant GSK-3beta
-
-
?
ATP + several 40S ribosomal polypeptides
?
show the reaction diagram
-
e.g. S6, 2.5 mol phosphate per mol S6
-
-
-
ATP + SF2/ASF
ADP + phosphorylated SF2/ASF
show the reaction diagram
Q13523
-
-
-
?
ATP + SF2/ASF
ADP + phosphorylated SF2/ASF
show the reaction diagram
-
SF2/ASF is a human SR splicing factor, phosphorylation in the RS domain
-
-
?
ATP + SIV/17E-Fr Nef protein
ADP + phosphorylated SIV/17E-Fr Nef protein
show the reaction diagram
-
phosphorylation at Ser12, the protein kinase CK2 associates with the Nef proteins from the Human immunodeficiency virus and the macrophage-tropic neurovirulent Simian immunodeficiency virus clone, SIV/17E-Fr, the Nef protein play important roles in viral disease progression, phosphorylation at Ser12, no or poor activity with SIV/17E-Fr Nef protein mutants S12P and D15A, respectively, in transfected 293T cells, Asp15 of the substrate is important for phosphorylation
-
-
?
ATP + SLR1 protein
ADP + phosphorylated SLR1 protein
show the reaction diagram
-
phosphorylation at S196 and SS510
-
-
?
ATP + Snail protein
ADP + phosphorylated Snail protein
show the reaction diagram
-
phosphorylation at S104 and S07 by isozyme CK1epsilon
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
Q9QZR5
-
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
-
dsk1 protein may play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
-
enzyme acts as a corepressors for homeodomain transcription factors
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
-
enzyme regulates the activation and adhesion of T cells. CD43 may mediate its biologic effects through activation of a kinase cascade, resulting in the regulation of cell growth
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
-
implication of KIS in the control of trafficking and/or splicing of RNAs probably through phosphorylation of associated factors
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
Q63285
implication of KIS in the control of trafficking and/or splicing of RNAs probably through phosphorylation of associated factors
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
Q9H2X6
enzyme plays a role as a co-repressor for homeodomain transcription factors
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
-
enzyme is essential for growth
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
P49762
enzyme is essential for eye and embryonic development
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
-
enzyme may play a role in mitosis
-
-
?
ATP + SSH1L protein
ADP + SSH1L phosphoprotein
show the reaction diagram
-
PKD1 phosphorylates the SSH enzyme SSH1L at serine 978
-
-
?
ATP + stathmin
ADP + phosphorylated stathmin
show the reaction diagram
-
phosphorylates on Ser
-
-
?
ATP + stathmin
ADP + phosphorylated stathmin
show the reaction diagram
Q63285
phosphorylates on Ser
-
-
?
ATP + STE/SPS1-related proline/alanine-rich kinase SPAK
ADP + phosphorylated STE/SPS1-related proline/alanine-rich kinase SPAK
show the reaction diagram
-
recombinant WNK1 or WNK4 with recombinant protein substrate, both expressed in Escherichia coli
-
-
?
ATP + synaptotagmin 2
ADP + phosphorylated synaptotagmin 2
show the reaction diagram
-
WNK1 specific substrate
-
-
?
ATP + synthetic peptide
?
show the reaction diagram
-
Arg-Arg-Leu-Ser-Ser-Leu-Arg-Ala
-
-
?
ATP + syntide-2
ADP + phosphorylated syntide-2
show the reaction diagram
Arabidopsis thaliana, Arabidopsis thaliana Col0
-
very low activity with iozyme CPK13, higher activity with isozyme CPK19, isozyme specific activities, overview
-
-
?
ATP + syntide2
ADP + phosphorylated syntide2
show the reaction diagram
Arabidopsis thaliana, Arabidopsis thaliana Col-0
Q9ZSA2
-
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
show the reaction diagram
-
tau in Alzheimer disease brain is highly phosphorylated and aggregates into paired helical filaments comprising characteristic neurofibrillary tangles, overview, determination of several phosphorylation sites, e.g. Ser258, Ser289, Ser262, and Ser356 within the microtubule-binding repeats or at Ser184 and Ser185 of the central region, for casein kinase I, casein kinase 2, and glycogen synthase kinase-3beta in insoluble tau, PHF-tau, extracted from Alzheimer brain and of tau from control healthy brain by mass spectrometry, overview
-
-
?
ATP + TEM-beta-lactamase
ADP + phosphorylated TEM-beta-lactamase
show the reaction diagram
P54736
the enzyme is phosphorylated only at Thr residues, shifting its apparent molecular mass from 29000 Da to 44000 Da. The phosphorylated beta-lactamase is unable to be secreted into the periplasmic space and localized in the cytoplasmic and membrane fractions
-
-
?
ATP + testis-specific serine-threonine kinase 3
ADP + phosphorylated testis-specific serine-threonine kinase 3
show the reaction diagram
-
substrate of phosphoinositide-dependent kinase-1 leading to activation, substrate of recombinant Myc-tagged catalytic subunit of PDK1 leading to activation
-
-
?
ATP + tomato mosaic virus movement protein
ADP + phosphorylated tomato mosaic virus movement protein
show the reaction diagram
Q8LP30
recombinant CK2 catalytic subunit, substrate is phosphorylated at S261 and T256 of the C-terminus
-
-
?
ATP + Trx-His-S-CREB protein
ADP + phosphorylated Trx-His-S-CREB protein
show the reaction diagram
A3QQQ9, A3QQR1, A9P6P7, A9P6P9
i.e. thioredoxin fusion cAMP responsive element binding protein, phosphorylation at Ser133
-
-
?
ATP + UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
ADP + phosphorylated-UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
show the reaction diagram
P9WI83
evidence is provided that mycobacterial mMurD is a substrate of PknA
-
-
?
ATP + Varicella-Zoster viral gB protein
ADP + phosphorylated Varicella-Zoster viral gB protein
show the reaction diagram
-
phosphorylation at S34 in the sequence QSEDIT
-
-
?
ATP + vimentin
ADP + phosphorylated vimentin
show the reaction diagram
-
isozyme PKNalpha
-
-
?
ATP + vimentin
ADP + phosphorylated vimentin
show the reaction diagram
Q924X7
kinase assays demonstrate that Stk33 is able to specifically phosphorylate the non-alpha-helical amino-terminal domain of vimentin in vitro
-
-
?
ATP + YAP protein
ADP + phosphorylated YAP protein
show the reaction diagram
-
phosphorylation at S384 and S387 by isozymes CK1delta and CK1epsilon
-
-
?
ATP + [FRAT-2 protein]
ADP + phosphorylated [FRAT-2 protein]
show the reaction diagram
-
i.e. frequently rearranged in advanced T-cell lymphoma protein 2, phosphorylation by GSK3beta
-
-
?
ATP + [M3 muscarinic acetylcholine receptor]
ADP + phospho-[M3 muscarinic acetylcholine receptor]
show the reaction diagram
-
recombinant substrate expressed in HEK-293 and CHO cells, casein kinase 1alpha
-
-
?
ATP + [tau-protein]
ADP + O-phospho -[tau-protein]
show the reaction diagram
-
tau is primarily found in neurons, regulation of tau phosphorylation by GSK3beta via interaction with FRAT-1 and FRAT-2, i.e. frequently rearranged in advanced T-cell lymphoma proteins, phosphorylation of primed and unprimed sites by GSK3beta, wild-type and recombinant tau, recombinant GSK3beta S9A
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
-
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
-
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
-
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
abnormal hyperphosphorylation of tau by GSK-3 is associated with Alzheimer's disease and other tauopathies leading to neuronal degeneration
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
activity in organisms with mutated APP and tau, not in wild-type, overview
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
phosphorylation of tau, especially at the primed epitope T231 negatively regulates tau-microtubule interactions, different effects of phosphorylation on primed T231 and unprimed S396/S404 epitopes of tau, overview
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
substrate of GSK3beta in brain
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
substrate of GSK3beta in brain
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
phosphorylation at the C-terminus, lower activity with C-terminally truncated tau D421 compared to the wild-type tau, the truncated tau protein forms sarcosyl-insoluble aggregates
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
phosphorylation by GSK-3 at Ser404, Ser396, Ser198, Ser199, and Ser202
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
substrate of GSK-3 in brain
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
-
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
P19139
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
-
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
-
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
P19454
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
-
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
P19784, P68400
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
-
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
P18334
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
P28020
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
Q02720
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
P20427
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
P21868, P21869
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
Q08466
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
P28547
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
O54833
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
-
-
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
Q60737
-
-
-
?
casein + GTP
phosphorylated casein + GDP
show the reaction diagram
P18334
-
-
-
?
casein + GTP
phosphorylated casein + GDP
show the reaction diagram
Q08466
-
-
-
?
GDP + casein
GMP + phosphorylated casein
show the reaction diagram
-
phosphorylated on threonine residues
-
-
?
GTP + a protein
GDP + a phosphoprotein
show the reaction diagram
P28523
the enzyme shows dual-cosubstrate specificity because it provides enough space for a hydrogenbonding frame-shift at the nucleotide-binding site and because water molecules allow the purine bases to use the full hydrogen-bonding potential of this site
-
-
?
GTP + AaSTPK
GDP + phosphorylated-AaSTPK
show the reaction diagram
O66844
enzyme is autophosphorylated on a threonine residue
-
-
?
GTP + casein
GDP + phosphorylated casein
show the reaction diagram
-
phosphorylated on threonine residues
-
-
?
GTP + CPS.A subunit
GDP + phosphorylated-CPS.A subunit
show the reaction diagram
O66844
-
-
-
?
RRRDDDSDDD + ATP
? + ADP
show the reaction diagram
P20427
-
-
-
?
GTP + partially dephosphorylated casein
GDP + ?
show the reaction diagram
-
the enzyme catalyzes the transfer of phosphate from GTP at approximately two-thirds the rate observed with ATP
-
-
?
additional information
?
-
O13310
-
-
-
-
additional information
?
-
P38679
-
-
-
-
additional information
?
-
O35280
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
P51955, P51956
-
-
-
-
additional information
?
-
P47196, P47197
interaction between RAC-PK and protein kinase C
-
-
-
additional information
?
-
-
guanylate kinase activity
-
-
-
additional information
?
-
-
stress-induced activation of MAPKAPK-2, in turn, results in the phosphorylation of small heat-shock proteins
-
-
-
additional information
?
-
-
the 41000 Da polypeptide of the enzyme and the 32000 Da polypeptide both incorporate phosphate during autophosphorylation
-
-
-
additional information
?
-
P18334
enzyme undergoes autophosphorylation
-
-
-
additional information
?
-
-
LIMK may be involved in developmental or oncogenic processes through interactions with LIM-containing proteins
-
-
-
additional information
?
-
P53668
Kiz-1 may play distinct roles in dividing cells and in differentiated neurons
-
-
-
additional information
?
-
-
Williams syndrome is a complex neurodevelopmental disorder arising from a microdeletion at Chr band 7q11.23, which results in a hemizygous condition for a number of genes, LIMK1, WBSCR1, and RFC2
-
-
-
additional information
?
-
-
LIMK1 may be particularly relevant when explaining cognitive defects observed in WS patients
-
-
-
additional information
?
-
-
LIM-kinase 1 hemizygosity is implicated in impaired visuospatial constructive cognition
-
-
-
additional information
?
-
-
the enzyme is part of a growth control pathway which is at least partially redundant with the cAMP pathway
-
-
-
additional information
?
-
P11792
the enzyme positively regulates the progression of yeast cells through the G1 phase of the cell cycle
-
-
-
additional information
?
-
-
deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy
-
-
-
additional information
?
-
-
AKT1 gene is not a major contributor to susceptibility to type II diabetes mellitus in Ashkenazi Jews
-
-
-
additional information
?
-
O00141
K+-channel activation by all three isoforms of serum-dependent and glucocorticoid-dependent protein kinase SGK
-
-
-
additional information
?
-
-
the enzyme acts in concert with Akt to propagate the effects of PI3K activation within the nucleus and to mediate the biological outputs of PI3K signaling, including cell survival and cell cycle progression
-
-
-
additional information
?
-
-
NPH1 is an autophosphorylating flavoprotein photoreceptor mediating phototropic responses in higher plants
-
-
-
additional information
?
-
O42626
the enzyme is required to repress entry into the conidiation program
-
-
-
additional information
?
-
Q9WVC6
induction of enzymatically active Sgk functions as a key cell survival component in response to different environmental stress stimuli
-
-
-
additional information
?
-
-
transcript levels are strongly altered during anisotonic and isotonic cell volume changes
-
-
-
additional information
?
-
P31751
AKT2 may contribute to the pathogenesis of ovarian carcinomas
-
-
-
additional information
?
-
P42818
enzyme may function in the adaptation of plant cells to cold or high-salt conditions
-
-
-
additional information
?
-
P22204, P32328
the DBF20 mRNA is expressed at a low level and not under cell-cycle control
-
-
-
additional information
?
-
P21901
kinase plays a part in regulating events associated with fertilization
-
-
-
additional information
?
-
P22204, P32328
DBF2 mRNA is expressed under cell-cycle control at or near START
-
-
-
additional information
?
-
P12688, P18961
enzyme is required for cell growth
-
-
-
additional information
?
-
-
atpk1 is involved in the control of plant growth and development
-
-
-
additional information
?
-
-
DBF2 is likely to encode a protein kinase that may function in initiation of DNA synthesis and also in late nuclear division
-
-
-
additional information
?
-
Q06226
the enzyme is transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells, hormone-regulated protein kinase gene with a functionally defined p53 promoter recognition element
-
-
-
additional information
?
-
-
the enzyme is transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells, hormone-regulated protein kinase gene with a functionally defined p53 promoter recognition element
-
-
-
additional information
?
-
-
induction of sgk gene may be associated with a series of axonal regenerations after brain injury, and in addition, the sgk gene may also play important roles in the development of particular groups of neurons in the postnatal brain
-
-
-
additional information
?
-
P42818
may function in the adaptation of plant cells to cold or high-salt conditions
-
-
-
additional information
?
-
Q06226
enzyme is induced during ovarian cell differentiation
-
-
-
additional information
?
-
-
T-PK may have specialized functions in different areas of central nervous system. Alterations of this complex expression pattern can be responsible for the mental status impairment observed in myotonic dystrophy patients
-
-
-
additional information
?
-
-
enzyme may have a role in the development of mental symptoms in severe cases of myotonic dystrophy
-
-
-
additional information
?
-
-
the enzyme is highly regulated at the transcriptional level by glucocorticoid hormones
-
-
-
additional information
?
-
Q06226
SGK is a component of the phosphoinositide 3 (PI 3)-kinase signaling pathway
-
-
-
additional information
?
-
Q9Z1M4
enzyme is important for cell growth
-
-
-
additional information
?
-
P51812
mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation
-
-
-
additional information
?
-
-
mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation
-
-
-
additional information
?
-
Q9UK32
ribosomal S6-kinase RSK4 is commonly deleted in patients with complex X-linked mental retardation, RSK4 plays a role in normal neuronal development. RSK4 is completely deleted in eight patients with the contiguous gene syndrome including MRX, partially deleted in a patient with DFN3 and present in patients with an Xq21 deletion and normal intellectual abilities
-
-
-
additional information
?
-
-
decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy
-
-
-
additional information
?
-
-
inherited defects in insulin-stimulated activation of muscle glycogen synthesis in patients with insulin-resistant NIDDM may be located further upstream of ISPK-1 in the insulin action cascade
-
-
-
additional information
?
-
Q60823
Akt2 expression is activated during cellular differentiation and suggest that it functions in the signaling pathways of some adult tissues
-
-
-
additional information
?
-
-
associates with mitotic structures in a stage dependent manner and is required for chromosome segregation
-
-
-
additional information
?
-
P24719
protein kinase is required for meiotic recombination
-
-
-
additional information
?
-
P38991
type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation, required during the later part of each cell cycle
-
-
-
additional information
?
-
-
required for chromosome synapsis and recombination
-
-
-
additional information
?
-
-
enzyme plays a critical role in regulation by carbon catabolite repression
-
-
-
additional information
?
-
O88866
the enzyme plays a role in development
-
-
-
additional information
?
-
-
nim1+ is a negative regulator of the wee1+ mitotic inhibitor, another protein kinase homolog. The combined mitotic induction activities of nim1+ and cdc25+ counteract the wee1+ mitotic inhibitor in a regulatory network that appears also to involve the cdc2+ protein kinase, which is required for mitosis
-
-
-
additional information
?
-
-
Chk1 acts as an integrator for Atm and Atr signals and may be involved in monitoring the processing of meiotic recombination CHK1 gene is a candidate tumor suppressor gene
-
-
-
additional information
?
-
-
enzyme plays a role in germ line establishment
-
-
-
additional information
?
-
-
kinase functions downstream of ATM protein in the cellular response to DNA damage
-
-
-
additional information
?
-
-
in response to DNA damage, Chk1 phosphorylates and inhibits Cdc25C, thus preventing activation of the Cdc2-cyclin B complex and mitotic entry
-
-
-
additional information
?
-
-
in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis
-
-
-
additional information
?
-
Q9Z265
in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis
-
-
-
additional information
?
-
-
heterozygous germ line mutations in hCHK2 occur in Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in the TP53 gene. hCHK2 is a tumor suppressor gene conferring predisposition to sarcoma, breast cancer, and brain tumors
-
-
-
additional information
?
-
O70405
Unc51.1 signals the program of gene expression leading to the formation of granule cell axons
-
-
-
additional information
?
-
-
required to give a normal cell cycle response to nitrogen starvation
-
-
-
additional information
?
-
Q9GM70
kinase-related apoptosis-inducing protein kinase 1 may play an important role in the core apoptosis program in osteoclast
-
-
-
additional information
?
-
-
required for alteration of growth polarity and actin localization
-
-
-
additional information
?
-
O15075
likely role for DCAMKL1 transmembrane protein in developing and adult brain, possibly in a pathway of cortical development
-
-
-
additional information
?
-
-
Cdc25 mitotic inducer is targeted by chk1 DNA damage checkpoint kinase
-
-
-
additional information
?
-
-
enzyme controls the DNA damage response
-
-
-
additional information
?
-
-
enzyme mediates checkpoint pathway
-
-
-
additional information
?
-
-
required for pattern formation within embryonic segments and imaginal discs, possible roles of the FUSED protein in signal transduction pathways required for intercellular communication at different stages of development
-
-
-
additional information
?
-
P38990
Pak1 may function by modifying and partially stabilizing thermolabile DNA polymerases, perhaps during DNA repair
-
-
-
additional information
?
-
-
chk1 protein kinase links the rad checkpoint pathway to cdc2
-
-
-
additional information
?
-
P38147
Chk1 is required for function of the DNA damage checkpoint in Saccharomyces cerevisiae
-
-
-
additional information
?
-
P22987
important for growth polarity
-
-
-
additional information
?
-
P52497
enzyme is essential for the derepression of catabolic repression
-
-
-
additional information
?
-
P53104
the enzyme is required for the autophagic process in Saccharomyces cerevisiae
-
-
-
additional information
?
-
Q12263
deletion of GIN4 is not lethal but leads to a striking reorganization of the septins accompanied by morphogenetic abnormalities and a defect in cell separation
-
-
-
additional information
?
-
-
the enzyme is a regulator of G2/M progression and cytokinesis
-
-
-
additional information
?
-
Q15831
mutations of STK11 cause Peutz-Jeghers syndrome
-
-
-
additional information
?
-
-
kinase Cdr2 regulates the onset of mitosis in fission yeast
-
-
-
additional information
?
-
-
Peutz-Jeghers syndrome is an autosomal-dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer, germline mutations in STK11, probably in conjunction with acquired genetic defects of the second allele in somatic cells, cause the manifestations of PJ syndrome
-
-
-
additional information
?
-
-
enzyme plays a major role in the regulation of lipid metabolism, be involved in the regulation of a wide range of metabolic pathways
-
-
-
additional information
?
-
Q02723
RKIN1 protein has a role in the control of carbon metabolism in endosperms of rye
-
-
-
additional information
?
-
Q6DE87
Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control
-
-
-
additional information
?
-
Q00372
the enzyme is essential for the derepression of glucose repression, interacts with additional regulatory pathways and affects the expression of multiple target genes
-
-
-
additional information
?
-
Q6DE87
the damage/replication G2 checkpoint kinase Chk1 phosphorylates and inhibits Cdc25C, a Cdc2 Tyr-15 phosphatase, thereby directly linking the G2 checkpoint to negative regulation of Cdc2. Might function either as a G2 checkpoint kinase or as an ordinary cell cycle regulator in prophase-I-arrested oocytes
-
-
-
additional information
?
-
-
Peutz-Jeghers syndrome is the first cancer-susceptibility syndrome to be identified that is due to inactivating mutations in a protein kinase, STK11
-
-
-
additional information
?
-
-
the enzyme is a key component of the DNA replication-monitoring S/G2 checkpoint system. Its primary role is to monitor DNA synthesis by interacting with DNA polymerase alpha and send a signal to block the onset of mitosis while DNA synthesis is in progress
-
-
-
additional information
?
-
P53682
enzyme is involved in the synthesis of seed storage compounds during seed development
-
-
-
additional information
?
-
Q38997
may play an important role in a signal transduction cascade regulating gene expression and carbohydrate metabolism
-
-
-
additional information
?
-
Q23023
protein phosphorylation by the unc-51 product is important for axonal elongation and possibly for axonal guidance
-
-
-
additional information
?
-
Q02720
the enzyme is essential for vegetative growth of Dictyostelium discoideum, the alpha subunit is expressed constitutively like its mRNA during the life cycle
-
-
-
additional information
?
-
P19139
enzyme is implicated in the control of cell growth and proliferation. Androgenic regulation of CK-2 gene transcription is not an early event related to androgen action, but is substantial in the prereplicative phase of prostatic cell proliferation mediated by androgen. Androgenic stimulation of the mRNA expression for the alpha and beta subunits of CK-2 appears to be differential
-
-
-
additional information
?
-
P18334
translational and/or post-translational mechanisms play an important role in the developmental regulation of casein kinase II activity
-
-
-
additional information
?
-
-
plays a role in the translation of cell polarity into polarized growth, but not in the establishment of polarity itself
-
-
-
additional information
?
-
-
key regulatory enzyme involved in many cellular processes, including the control of growth and cell division
-
-
-
additional information
?
-
Q60737
the casein kinase II gene can serve as an oncogene, and its dysregulated expression is capable of transforming lymphocytes in a two-step pathway with c-myc
-
-
-
additional information
?
-
O54833
unbalanced expression of CK2 catalytic subunit synergizes with Ha-ras in cell transformation
-
-
-
additional information
?
-
Q13523
NH2-terminal region of hPRP4 may play regulatory roles under an unidentified signal transduction pathway through Clk1
-
-
-
additional information
?
-
-
enzyme is involved in pre-mRNA splicing
-
-
-
additional information
?
-
-
calmodulin-binding region of titin can play a regulatory role for the enzyme
-
-
-
additional information
?
-
-
the cek1+ gene is not an essential gene. Protein phosphorylation by cek1 may facilitate the progression of anaphase through direct or indirect interaction with the cut8 protein
-
-
-
additional information
?
-
Q13043, Q13188
enzyme may function at an early step in phosphorylation events that are specific responses to some forms of chemical stress or extreme heat shock
-
-
-
additional information
?
-
P51955, P51956
Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2, may function at the onset of mitosis
-
-
-
additional information
?
-
-
AfsK is a Hanks-type protein kinase
-
-
-
additional information
?
-
-
enzyme is involved in stress response and adaptation to environmental changes in mycobacteria
-
-
-
additional information
?
-
-
glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26, phosphorylating tau protein at serine and threonine residues
-
-
-
additional information
?
-
-
GSK-3 affects the tau-mRNA splicing of exon 10 via phosphorylation of the splicing factors of the serine/arginine-rich splicing factor SR family, e.g. SC35, leading to priming and dislocation of the splicing factor, aberrant tau splicing contributes to tauopathies including Alzheimer's disease, overview
-
-
-
additional information
?
-
-
GSK3beta works coordinatedly with PKA, EC 2.7.11.11, on tau phosphorylation
-
-
-
additional information
?
-
-
HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in hepatoma cells, HIPK2 triggers promyelotic leukemia nuclear body disruption and release of Daxx
-
-
-
additional information
?
-
-
isozyme RSK1, i.e. 14-3-3, is regulated by inhibitory binding of 14-3-3beta, a RSK1-binding protein, to Lys49 of the enzyme, Lys49 is also responsible for interaction of RSK1 with Bcr, Raf, and Cbl
-
-
-
additional information
?
-
O30245
kinase Rio2 is required for rRNA cleavage in 40S ribosomal subunit maturation
-
-
-
additional information
?
-
-
mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase
-
-
-
additional information
?
-
-
mechanism of S6K2 regulation via phosphorylation and autoinhibition with T338 playing the key role, S6K2 is regulated in a mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase MEK-dependent manner, overview
-
-
-
additional information
?
-
-
naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of organisms with Alzheimer's disease leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of patients suffering Alzheimer's disease leads to age-dependent memory deficits
-
-
-
additional information
?
-
-
naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of patients suffering Alzheimer's disease leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of patients suffering Alzheimer's disease leads to age-dependent memory deficits
-
-
-
additional information
?
-
Q9SDY2
NTHK2 is an ethylene receptor protein
-
-
-
additional information
?
-
-
phosphorylated tau is important in cytoskeleton assembly
-
-
-
additional information
?
-
-
phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis
-
-
-
additional information
?
-
-
photoregulation of phototropin, overview
-
-
-
additional information
?
-
-
PKD2 regulation involving ligand-binding domains of the enzyme, isozyme PKD2 might play a role in the nucleus after activation by G protein-coupled receptors, overview, intracellular trafficking of PKD2, overview
-
-
-
additional information
?
-
-
protein kinase StkP and Mn2+-dependent cytosolic protein phosphatase PhpP act as a functional pair in vivo
-
-
-
additional information
?
-
-
regulation mechanism and biological function of PKN
-
-
-
additional information
?
-
-
regulation mechanism and biological function of PKN, PKNalpha is involved in insulin-induced actin cytoskeleton reorganization and cell adhesion, overview, isozyme PKNalpha is involved in glucose transport in 3T3/L1 cells
-
-
-
additional information
?
-
-
regulation mechanism and biological function of PKN, PKNalpha is involved in insulin-induced actin cytoskeleton reorganization and cell adhesion, overview, PKNalpha is involved in vesicle transport in the endoplasmic reticulum, PKNalpha is cleaved by caspase-3 or related proteases in apoptotic Jurkat and U-937 cells contributing to signal transduction, PKN interacts with papillomaviral oncoproteins being involved in tumorigenesis, overview
-
-
-
additional information
?
-
-
regulation mechanism and biological function of PKN, PKNalpha is involved in insulin-induced actin cytoskeleton reorganization, overview
-
-
-
additional information
?
-
-
regulation mechanism and biological function of PKN, the enzyme is involved in cell cycle control
-
-
-
additional information
?
-
Q9BXA6
serine/threonine protein kinase is SSTK essential for male fertility
-
-
-
additional information
?
-
Q925K9
serine/threonine protein kinase SSTK is essential for male fertility, a DNA condensation defect in SSTK null mutants occurred in elongating spermatids at a step in spermiogenesis coincident with chromatin displacement of histones by transition proteins
-
-
-
additional information
?
-
-
tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain, inhibition of tau hyperphosphorylation inhibits an associated loss in spatial memory
-
-
-
additional information
?
-
-
the enzyme participates in Alzheimer's disease
-
-
-
additional information
?
-
-
WKN1 and WKN4 are involved in regulation of ion transport across diverse epithelia, WKN4 reduces the activity of Na-Cl-cotransporter activity and the potassium channel ROMK by reducing their appearance in the plasma membrane
-
-
-
additional information
?
-
-
WNK1 causes a hereditary form of hypertension, pseudohypoaldosteronism type II
-
-
-
additional information
?
-
-
AfsK, PkaG, and SCD10 perform autophosphorylation
-
-
-
additional information
?
-
-
CKII phosphorylates serine or threonine residues with an acidic amino acid in the +2 or +3 position
-
-
-
additional information
?
-
-
enzyme assay under dim red light conditions, phototropin performs autophosphorylation
-
-
-
additional information
?
-
-
enzyme performs autophosphorylation, PKN binds several associated proteins via its ACC domain
-
-
-
additional information
?
-
-
enzyme performs autophosphorylation, PKN binds several associated proteins via its ACC domain, i.e. RhoA, a small GTPase, which binds to the ACC domain of PKNalpha forming a catalytic active site
-
-
-
additional information
?
-
-
enzyme performs autophosphorylation, PKN binds several associated proteins via its ACC domain, i.e. RhoA, a small GTPase, which binds to the ACC domain of PKNalpha forming a catalytic active site, isozyme PRK2/PKNgamma/PAK-2 binds to the large non-transmembrane protein Tyr phosphatase PTP-BL involved in the modulation of cytoskeleton, mediated by PSD-95
-
-
-
additional information
?
-
-
GSK-3 catalyzes tau phosphorylation in the brain, while it performs phosphorylation of glycogen synthase and other proteins in other tissues
-
-
-
additional information
?
-
-
GSK-3alphabeta catalyzes tau phosphorylation in brain, but phosphorylation of glycogen synthase and other proteins, EC 2.7.11.1, in different tissues
-
-
-
additional information
?
-
-
GSK3beta catalyzes tau phosphorylation in brain, EC 2.7.11.26, but phosphorylation of glycogen synthase and other proteins in different tissues
-
-
-
additional information
?
-
-
GSK3beta catalyzes tau phosphorylation, EC 2.7.11.1, in brain, but phosphorylation of glycogen synthase and other proteins in different tissues
-
-
-
additional information
?
-
-
GSK3beta catalyzes tau phosphorylation, EC 2.7.11.26, in brain, but phosphorylation of glycogen synthase and other proteins in different tissues
-
-
-
additional information
?
-
-
NDR1 performs autophosphorylation at S281, T444, and T74 dependent on intracellular Ca2+
-
-
-
additional information
?
-
Q709M0, Q709M1
PK1 performs autophosphorylation
-
-
-
additional information
?
-
Q709M0, Q709M1
PK2 performs autophosphorylation
-
-
-
additional information
?
-
-
PKD2 performs autophosphorylation
-
-
-
additional information
?
-
-
PknB performs autophosphorylation
-
-
-
additional information
?
-
-
PknB, PknD, PknE, and PknF perform autophosphorylation
-
-
-
additional information
?
-
-
PknH performs autophosphorylation
-
-
-
additional information
?
-
O30245
Rio2 performs autophosphorylation
-
-
-
additional information
?
-
-
StkP performs autophosphorylation, StkP is dephosphorylated by PhpP, a PP2C-type protein phosphatase
-
-
-
additional information
?
-
-
substrate ABC transporter protein structure, phosphorylation of the ABCA1 transporter reduces its flippase activity, overview
-
-
-
additional information
?
-
Q9SDY2
substrate specificity of full-length enzyme and truncated mutant enzymes, overview, NTHK2 kinase performs autophosphorylation, the enzyme shows Mn2+-dependent serine/threonine kinase and Ca2+-dependent histidine kinase, EC 2.7.13.3, activities
-
-
-
additional information
?
-
-
substrate specificity of GSK3beta
-
-
-
additional information
?
-
-
substrate specificity of PDK1, PDK1 binds the hydrophobic motif of substrates via its PIF pocket, GSK3 substrates need to bind tightly to the enzyme for phosphorylation
-
-
-
additional information
?
-
Q925K9
substrate specificity with diverse peptide substrates, overview, SSTK forms stable complexes with heat shock signal proteins HSP90-1beta, HSC70, and HSP70-1, which seems to be necessary for activity
-
-
-
additional information
?
-
Q9BXA6
substrate specificity with diverse peptide substrates, overview, SSTK forms stable complexes with heat shock signate proteins HSP90-1beta, HSC70, and HSP70-1, which seems to be necessary for activity
-
-
-
additional information
?
-
-
the enzyme performs autophosphorylation
-
-
-
additional information
?
-
-
the minimal consensus sequence of ORF47 is S/T-X-D/E-D/E, no activity of ORF47 with glutathione S-transferase, or Varicella-Zoster viral gB protein
-
-
-
additional information
?
-
-
TSSK3 performs autophosphorylation
-
-
-
additional information
?
-
-
WKN1 and WKN4 perform autophosphorylation
-
-
-
additional information
?
-
-
WNK1 interacts with OSR1 and SPAK, overview
-
-
-
additional information
?
-
-
WNK1 performs autophosphorylation at S382 for activation
-
-
-
additional information
?
-
-
CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling by activation of Akt and inactivation of SGK1 through protein phosphatase 2A
-
-
-
additional information
?
-
-
CK2 is a highly conserved serine/threonine kinase involved in several intracellular pathways, which control, among others, cell cycle, proliferation, apoptosis and transformation, overview, protein kinase AKT interacts with CK2 subunits in vivo as well as in vitro enhancing AKT activity, overview
-
-
-
additional information
?
-
-
CK2 is involved in phosphorylation of a large portion of the proteome, overview, increased enzyme activity in associated with a number of pathological processes, including cancer, infectious diseases, neurodegeneration, and cardiovascular pathologies playing a global anti-apoptotic role, overview
-
-
-
additional information
?
-
-
CK2 phosphorylates about 300 different cellular proteins, ranging from transcription factors to proteins involved in chromatin structure and cell division, CK2 induces neoplastic growth when overexpressed
-
-
-
additional information
?
-
-
CK2 plays a role in the protection of cells from apoptosis via the regulation of tumor suppressor and oncogene activity and stability, e.g. in the NF-kappaB or the Wnt signaling pathways, molecular mechanisms, detailed overview, CK2 activity is linked to Her-2/neu oncogene, which is overexpressed in 30% of breast cancers, regulation of apoptotic machinery by CK2 and its anti-apoptotic effect, overview, role of CK2 in chromosomal DNA strand break repair and the maintenance of genomic integrity, mutational study, overview
-
-
-
additional information
?
-
-
high CK2 activity occurs in solid tumors due to growth-related functions and to suppression of cellular apoptosis, nuclear localization of domain CK2alpha is associated with high-grade tumors and a poor prognostic factor, overview
-
-
-
additional information
?
-
-
members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt, overview
-
-
-
additional information
?
-
-
multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase
-
-
-
additional information
?
-
A3QQQ9, A3QQR1, A9P6P7, A9P6P9
phosphorylation on serine/threonine or tyrosine residues of target proteins is an essential and significant regulatory mechanism in signal transduction during many cellular and life processes, including spermatogenesis, oogenesis and fertilization, overview
-
-
-
additional information
?
-
-
RSK2 is a critical serine/threonine kinase for the regulation of cell transformation, RSK is regulated by the tumor promoters epidermal growth factor EGF or 12-O-tetradecanoylphorbol-13-acetate, TPA, overview
-
-
-
additional information
?
-
-
SpkA is a regulator of expression of three putative pilA operons, formation of thick pili, and cell motility, DNA microarray and electron microscopy analysis, overview
-
-
-
additional information
?
-
-
the enzyme alters localization of lamin A/C in infected cells, recombinantly expressed lamin as GFP-tagged protein in Hep-G2 cells, enzyme inactivation causes capsids to aggregate aberrantly between the inner and outer nuclear membranes within evaginations/extensions of the perinuclear space, overview, US3 kinase activity regulates HSV-1 capsid nuclear regress at least in part by phosphorylation of lamin A/C
-
-
-
additional information
?
-
-
the enzyme inhibits NF-kappaB activity via interaction with the leucine-rich repeat domain of the Salmonella enterica serovar typhimurium-derived effector SspH1 in infected intestine-407 cells, overview
-
-
-
additional information
?
-
Q6E0B2
the enzyme is involved in the inflammation cascade in intestine and colon epithelium
-
-
-
additional information
?
-
-
the eukaryotic-type serine/threonine protein kinase StkP is a global regulator of gene expression in Streptococcus pneumoniae, and is important for the resistance of the organism to various stress conditions, StkP positively controls the transcription of a set of genes encoding functions involved in cell wall metabolism, pyrimidine biosynthesis, DNA repair, iron uptake, and oxidative stress response, overview
-
-
-
additional information
?
-
-
CK2 contains a consensus sequence in which a carboxylic acid side chain at position n+3 relative to the target serine/threonine residue plays a crucial role for activity, CK2 shows a broad substrate specificity of diverse proteins
-
-
-
additional information
?
-
-
CK2 inhibition increases SGK1 phosphorylation at Ser422
-
-
-
additional information
?
-
-
members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt, however, no Akt consensus sequences are found on BRG1, hBrm, BAF60, BAF57, or on INI1, overview
-
-
-
additional information
?
-
A3QQQ9, A3QQR1, A9P6P7, A9P6P9
only splicing variant TSSK5alpha exhibits kinase activity
-
-
-
additional information
?
-
-
protein kinase AKT interacts with CK2 subunits in vivo as well as in vitro enhancing AKT activity, overview
-
-
-
additional information
?
-
A3QQQ9, A3QQR1, A9P6P7, A9P6P9
splicing variant TSSK5beta is inactive
-
-
-
additional information
?
-
A3QQQ9, A3QQR1, A9P6P7, A9P6P9
splicing variant TSSK5delta is inactive
-
-
-
additional information
?
-
A3QQQ9, A3QQR1, A9P6P7, A9P6P9
splicing variant TSSK5gamma is inactive
-
-
-
additional information
?
-
-
StkP performs autophosphorylation
-
-
-
additional information
?
-
-
the catalytic kinase domain, residues 561-942, of PKN1 is active with out the regulatory domain
-
-
-
additional information
?
-
-
the pleiotropic protein kinase CK2 possesses many protein interaction sites
-
-
-
additional information
?
-
-
the enzyme performs autophosphorylation in vitro
-
-
-
additional information
?
-
-
enzyme binds both soluble inositol polyphosphates and inositol phospholipids
-
-
-
additional information
?
-
-
Glc7 promotes resumption of DNA replication by inactivating Rad53
-
-
-
additional information
?
-
-
neither of the pyrimidine nucleotide triphosphates tested, CTP and UTP, serves as substrates and neither does AMP, GMP, or pyrophosphate
-
-
-
additional information
?
-
-
KpnK specifically phosphorylates serine and threonine residues, and KpnK shows autophosphorylation activity
-
-
-
additional information
?
-
-
CK1 exhibits autophosphorylation activity
-
-
-
additional information
?
-
-
PrkA is able to autophosphorylate specific Thr residues within its activation loop sequence
-
-
-
additional information
?
-
-
TPL2 inhibitor suppresses MEK/ERK/p90RSK, MKK4/JNK/c-Jun, and Akt/p70S6K, whereas the phosphorylation of p38 is unchanged
-
-
-
additional information
?
-
A3QQQ9
Tssk4 has autophosphorylation activity and self-association character in vitro. Autophosphorylation of Tssk4 at Thr197 in the T-loop region is essential to its kinase activity
-
-
-
additional information
?
-
Q6PHR2
ULK3 shows autophosphorylation activity
-
-
-
additional information
?
-
-
AfsK is a Hanks-type protein kinase, AfsK, PkaG, and SCD10 perform autophosphorylation
-
-
-
additional information
?
-
Streptococcus pneumoniae CP1015
-
the eukaryotic-type serine/threonine protein kinase StkP is a global regulator of gene expression in Streptococcus pneumoniae, and is important for the resistance of the organism to various stress conditions, StkP positively controls the transcription of a set of genes encoding functions involved in cell wall metabolism, pyrimidine biosynthesis, DNA repair, iron uptake, and oxidative stress response, overview
-
-
-
additional information
?
-
Streptococcus pneumoniae Cp 1015
-
protein kinase StkP and Mn2+-dependent cytosolic protein phosphatase PhpP act as a functional pair in vivo, StkP performs autophosphorylation, StkP is dephosphorylated by PhpP, a PP2C-type protein phosphatase
-
-
-
additional information
?
-
Klebsiella pneumoniae MGH78578
-
KpnK specifically phosphorylates serine and threonine residues, and KpnK shows autophosphorylation activity
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 4E-BP1 protein
ADP + phosphorylated 4E-BP1 protein
show the reaction diagram
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P47116
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is essential for viral replication
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
not essential for cell viability, Cki2, may contribute to the regulation of cell morphology
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is a regulator of DNA strand-break repair
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
enzyme is involved in the regulation of DNA repair
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
enzyme plays a pivotal role in eukaryotic cell regulation
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
gene disruption reveals that cki3+ is dispensable for cell viability, and cells lacking functional cki3+ exhibit no characteristic phenotype
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
casein kinase 1 alpha gene is developmentally regulated and the kinase activity of the protein is induced by DNA damage. Possible requirement in mechanisms associated with DNA repair during early embryogenesis
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P54737, P54738
Pkn5 negatively regulates Myxococcus xanthus development
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
AfsK plays a regulatory role in aerial mycelium formation in Streptomyces griseus
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P54737, P54738
expressed constitutively throughout the life cycle, with slight increases at an early stage of development
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P54736
the enzyme blocks the secretion of beta-lactamase by phosphorylation
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
pknA is required for both normal cellular growth and differentiation
-
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P54737, P54738
Pkn6 may be a transmembrane sensor of external signals for development
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
involvement of afsK in the regulation of secondary metabolism
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P22211
the enzyme is required to promote the activity of at least six distinct transport systems for nitrogenous nutrients under conditions of nitrogen catabolite derepression
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is a negative regulator of both sexual conjugation and meiosis
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P47116
STK1 mostly affects a lower-affinity, low-capacity polyamine transport activity
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
enzyme is not essential for vegetative growth
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the SKS1 protein kinase is a multicopy suppressor of the snf3 mutation of Saccharomyces cerevisiae
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme enhances spermine uptake in Saccharomyces cerevisiae
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
in some cancers displaying chromosomal instability the loss of this checkpoint is associated with the mutational inactivation of a human homologue of the yeast BUB1 gene
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is essential for the fission yeast spindle checkpoint response to spindle damage and to defects in centromere function. Activation of the checkpoint results in the recruitment of Bub1 to centromeres and a delay in the completion of mitosis. Bub1 also has a crucial role in normal, unperturbed mitoses. Loss of bub1 function causes chromosomes to lag on the anaphase spindle and an increased frequency of chromosome loss. bub1(+)function is essential to maintain correct ploidy through mitosis
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is required for function of the spindle assembly checkpoint
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
O43683
the enzyme is required for function of the spindle assembly checkpoint
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
cell cycle-dependent expression, Bub1b has a putative destruction box that can target proteins for degradation by proteosomes during mitosis
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Q9Z1S0
cell cycle-dependent expression, Bub1b has a putative destruction box that can target proteins for degradation by proteosomes during mitosis
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P41695
the enzyme is involved in spindle assembly during the cell cycle
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
hBUBR1 may regulate multiple functions that include the kinetochore and the spindle midzone
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
O08901
kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
hBub1 is an important component of the spindle checkpoint pathway. hBub1 expression is restricted to proliferating cells and appears to be involved in regulating cell cycle progression
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
Bub1 is required for binding Bub3
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
huCdc7 may regulate processes of DNA replication by modulating MCM functions
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
HsCdc7 may phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is required for the initiation of mitotic DNA synthesis. It is necessary for genetic recombination during meiosis and for the formation of ascospores, involved in an error-prone DNA repair pathway
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is required for inhibition of mitosis until completion of S phase, it may also be involved in proper execution of mitosis
-
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
enzyme is required for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is dispensable for mitotic growth and premeiotic DNA replication, its primary role is in meiosis
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P53323
the enzyme is essential for normal cell life
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is required for inositol phototrophy in Saccharomyces cerevisiae
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
Ire1p is required for activation of the unfolded protein response. It senses the accumulation of unfolded proteins in the ER and transmits the signal across the membrane toward the transcription machinery, possibly by phosphorylating downstream components of the UPR pathway
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is required for signaling from the ER to the nucleus
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the enzyme is essential for viral replication
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + adenomatous polyposis coli protein
ADP + phosphorylated adenomatous polyposis coli protein
show the reaction diagram
-
i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon
-
-
?
ATP + AfsR protein
ADP + AfsR phosphoprotein
show the reaction diagram
-
kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview
-
-
?
ATP + Akt
ADP + phosphorylated Akt
show the reaction diagram
-
CK2 phosphorylates and activates Akt directly
-
-
?
ATP + alpha-casein
ADP + phosphorylated alpha-casein
show the reaction diagram
-
casein kinase 1alpha
-
-
?
ATP + AMP-activated protein kinase
ADP + phosphorylated AMP-activated protein kinase
show the reaction diagram
-
-
-
-
?
ATP + axin
ADP + phosphorylated axin
show the reaction diagram
-
glycogen synthase kinase 3
-
-
?
ATP + BAF155
ADP + phosphorylated BAF155
show the reaction diagram
-
-
-
-
?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
show the reaction diagram
-
glycogen synthase kinase 3
-
-
?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
show the reaction diagram
-
phosphorylation at Ser45, priming GSK3beta phosphorylation
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
show the reaction diagram
-
-
-
-
?
ATP + C/EBPalpha
ADP + phosphorylated C/EBPalpha
show the reaction diagram
-
-
-
-
?
ATP + C/EBPbeta
ADP + phosphorylated C/EBPbeta
show the reaction diagram
-
-
-
-
?
ATP + Cdk2 interacting protein
ADP + phosphorylated Cdk2 interacting protein
show the reaction diagram
-
-
-
-
?
ATP + cell division cycle 7
ADP + phosphorylated cell division cycle 7
show the reaction diagram
-
-
-
-
?
ATP + CIRCADIAN CLOCK ASSOCIATED1
ADP + phosphorylated CIRCADIAN CLOCK ASSOCIATED1
show the reaction diagram
Arabidopsis thaliana, Arabidopsis thaliana Col-0
-
transcription factor CIRCADIAN CLOCK ASSOCIATED1, i.e. CCA1
-
-
?
ATP + claspin
ADP + phosphorylated claspin
show the reaction diagram
-
-
-
-
?
ATP + CREB
ADP + phosphorylated CREB
show the reaction diagram
Q6SA08
phosphorylation by TSSK5 at Ser133 stimulates the cAMP responsive element/cAMP responsive element binding protein CRE/CREB responsive pathway in recombinant HEK293 cells
-
-
?
ATP + Daxx
ADP + phosphorylated Daxx
show the reaction diagram
-
Daxx is a protein acting in TGF-beta-induced JNK activation and in apoptosis
-
-
?
ATP + geminin
ADP + phosphorylated geminin
show the reaction diagram
-
a cell cycle regulatory protein
-
-
?
ATP + Gli protein
ADP + phosphorylated Gli protein
show the reaction diagram
-
the Gli proteins are important in regulation of Hedgehog signaling, overview
-
-
?
ATP + glycogen synthase
ADP + phosphorylated glycogen synthase
show the reaction diagram
-
glycogen synthase kinase 3 is involved in the insulin signaling pathway regulating glycogen synthesis via glycogen synthase antagonizing insulin
-
-
?
ATP + glycogen synthase kinase 3
ADP + phosphorylated glycogen synthase kinase 3
show the reaction diagram
-
PKB protein kinase
-
-
?
ATP + histine H2A
ADP + histidine gammaH2A
show the reaction diagram
-
phosphorylation on serine 129 in vivo
Glc7 dephosphorylates histidine gammaH2A in vitro
-
?
ATP + histone H3
?
show the reaction diagram
-
Ark1 phosphorylates Ser10 of histone H3 in vivo
-
-
?
ATP + histone H3
ADP + phosphorylated histone H3
show the reaction diagram
-
RSK2 is a key regulator of histone H3 phosphorylation
-
-
?
ATP + hypoxia-inducible factor-1
ADP + phosphorylated hypoxia-inducible factor-1
show the reaction diagram
-
i.e. HIF-1, casein kinase 2 inhibits the activation of HIF-1 activity by phosphorylation and thereby stabilization of the protein, CK2 is involved in and influenced by hypoxia, overview
-
-
?
ATP + lamin A/C
ADP + phosphorylated lamin A/C
show the reaction diagram
-
phosphorylation of host cell lamin by US3 kinase
-
-
?
ATP + M3-muscarnic receptor
ADP + phosphorylated M3-muscarnic receptor
show the reaction diagram
-
-
-
-
?
ATP + maize eukaryotic translation initiation factor 5A
ADP + phosphorylated maize eukaryotic translation initiation factor 5A
show the reaction diagram
Zea mays, Zea mays Mona
-
-
-
-
?
ATP + peptide LRRKtide
ADP + phosphorylated peptide LRRKtide
show the reaction diagram
-
high activity towards the peptidic substrate LRRKtide
-
-
?
ATP + phospholipase D
ADP + phosphorylated phospholipase D
show the reaction diagram
-
CKII is involved in 4beta-phorbol 12-myristate 13-acetate-induced phospholipase D activation, of PLD1 or PLD2 activity as well as basal PLD activity
-
-
?
ATP + PKB protein kinase
ADP + phosphorylated PKB protein kinase
show the reaction diagram
-
PDK1 kinase, phosphorylates Thr308 and Ser473, which is required for activation of PKB
-
-
?
ATP + procaspase-2
ADP + phosphorylated procaspase-2
show the reaction diagram
-
phosphorylation of procaspase-2 by CK2 prevents the activation of caspase activity by inhibiting the dimerization of procaspase-2, CK2 activity is involved in the direct regulation of the caspase-8 pathway, where it can control caspase-8 activity through the phosphorylation of ARC or by preventing the ability of caspase-8 to cleave its target Bid
-
-
?
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
-
GST-Limk1-fusion protein can autophosphorylate on serine, tyrosine and threonine residues in vitro
-
-
?
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
P53667
phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O14965
-
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
Q12469
-
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
enzyme is essential for the late nuclear division in the yeast
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O88506
enzyme activates the p38 pathway, SPAK may act as a novel mediator of stress-activated signals
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O96013
the enzyme is an effector for Cdc42Hs and is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O14427
enzyme is required for virulence and hyphal formation of Candida albicans
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O88643, Q61036
potentially important role in the control of the cellular architecture and/or signaling in the central nervous system
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O88643, Q61036
potentially important role in the control of the cellular architecture and/or signaling in the central nervous system
-
-
-
ATP + protein
ADP + phosphoprotein
show the reaction diagram
O75914
PAK3 may be critical for human cognitive function
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
the enzyme regulates the structure of the actin cytoskeleton in mammalian cells, and may serve as an effector for effector for Cdc42 and Rac1 in proll motility
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
the enzyme is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
the enzyme is necessary for mating
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
Pak1 protein is likely to be an effector for Cdc42p or a related GTPase, Pak1p may be involved in the maintenance of cell polarity and in mating
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
the enzyme is involved in budding and cytokinesis and interacts with Cdc42, a GTPase required for polarized cell growth
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
Q13153
hPAK1 is a GTPase effector controlling a downstream MAP kinase pathway. PAK kinase plays a key part in linking extracellular signals from membrane components, such as receptor-associated G proteins and Rho-related GTPases, to nuclear responses, such as transcriptional activation
-
-
?
ATP + protein
?
show the reaction diagram
-
PKL12 may play a role in a very general cellular function, probably related with the secretory pathway
-
-
?
ATP + protein
?
show the reaction diagram
-
EDPK plays a crucial role in intracellular signaling not only during mouse development but also in adult tissues
-
-
?
ATP + protein Cubitus interruptus
ADP + phosphorylated protein Cubitus interruptus
show the reaction diagram
-
Ci proteins are important in regulation of Hedgehog signaling, overview
-
-
?
ATP + protein kinase Czeta
ADP + phosphorylated protein kinase Czeta
show the reaction diagram
Q9Z2A0
phosphorylation and activation of protein kinase Czeta
-
-
?
ATP + protein LRP6
ADP + phosphorylated protein LRP6
show the reaction diagram
-
CKIgamma
-
-
?
ATP + protein TCF3
ADP + phosphorylated protein TCF3
show the reaction diagram
-
CKIepsilon
-
-
?
ATP + ribosomal protein S6
ADP + phosphorylated ribosomal protein S6
show the reaction diagram
Q6TQF8
specifically phosphorylated by S6K
-
-
?
ATP + S6 protein of the 40s ribosomal subunit
ADP + phosphorylated S6 protein of the 40s ribosomal subunit
show the reaction diagram
P67999
the mitogen-activated protein kinase plays a central role in the control of mRNA translation. It physiologically phosphorylates the S6 protein of the 40s ribosomal subunit in response to mitogenic stimuli and is a downstream component of the rapamycin-sensitive pathway, which includes the 12-kDa FK506 binding protein and includes rapamycin and the 12-kDa FK506 binding protein target 1
-
-
?
ATP + SC35
ADP + phosphorylated SC35
show the reaction diagram
-
substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors
-
-
?
ATP + SIV/17E-Fr Nef protein
ADP + phosphorylated SIV/17E-Fr Nef protein
show the reaction diagram
-
phosphorylation at Ser12, the protein kinase CK2 associates with the Nef proteins from the Human immunodeficiency virus and the macrophage-tropic neurovirulent Simian immunodeficiency virus clone, SIV/17E-Fr, the Nef protein play important roles in viral disease progression
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
Q9QZR5
-
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
-
dsk1 protein may play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
-
enzyme acts as a corepressors for homeodomain transcription factors
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
-
enzyme regulates the activation and adhesion of T cells. CD43 may mediate its biologic effects through activation of a kinase cascade, resulting in the regulation of cell growth
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
-
implication of KIS in the control of trafficking and/or splicing of RNAs probably through phosphorylation of associated factors
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
Q63285
implication of KIS in the control of trafficking and/or splicing of RNAs probably through phosphorylation of associated factors
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
Q9H2X6
enzyme plays a role as a co-repressor for homeodomain transcription factors
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
-
enzyme is essential for growth
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
P49762
enzyme is essential for eye and embryonic development
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
-
enzyme may play a role in mitosis
-
-
?
ATP + SSH1L protein
ADP + SSH1L phosphoprotein
show the reaction diagram
-
PKD1 phosphorylates the SSH enzyme SSH1L at serine 978
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
show the reaction diagram
-
tau in Alzheimer disease brain is highly phosphorylated and aggregates into paired helical filaments comprising characteristic neurofibrillary tangles, overview
-
-
?
ATP + testis-specific serine-threonine kinase 3
ADP + phosphorylated testis-specific serine-threonine kinase 3
show the reaction diagram
-
substrate of phosphoinositide-dependent kinase-1 leading to activation
-
-
?
ATP + [tau-protein]
ADP + O-phospho -[tau-protein]
show the reaction diagram
-
tau is primarily found in neurons, regulation of tau phosphorylation by GSK3beta via interaction with FRAT-1 and FRAT-2, i.e. frequently rearranged in advanced T-cell lymphoma proteins
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
-
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
abnormal hyperphosphorylation of tau by GSK-3 is associated with Alzheimer's disease and other tauopathies leading to neuronal degeneration
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
activity in organisms with mutated APP and tau, not in wild-type, overview
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
phosphorylation of tau, especially at the primed epitope T231 negatively regulates tau-microtubule interactions, different effects of phosphorylation on primed T231 and unprimed S396/S404 epitopes of tau, overview
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
substrate of GSK3beta in brain
-
-
?
additional information
?
-
O13310
-
-
-
-
additional information
?
-
P38679
-
-
-
-
additional information
?
-
O35280
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
P51955, P51956
-
-
-
-
additional information
?
-
-
stress-induced activation of MAPKAPK-2, in turn, results in the phosphorylation of small heat-shock proteins
-
-
-
additional information
?
-
-
LIMK may be involved in developmental or oncogenic processes through interactions with LIM-containing proteins
-
-
-
additional information
?
-
P53668
Kiz-1 may play distinct roles in dividing cells and in differentiated neurons
-
-
-
additional information
?
-
-
Williams syndrome is a complex neurodevelopmental disorder arising from a microdeletion at Chr band 7q11.23, which results in a hemizygous condition for a number of genes, LIMK1, WBSCR1, and RFC2
-
-
-
additional information
?
-
-
LIMK1 may be particularly relevant when explaining cognitive defects observed in WS patients
-
-
-
additional information
?
-
-
LIM-kinase 1 hemizygosity is implicated in impaired visuospatial constructive cognition
-
-
-
additional information
?
-
-
the enzyme is part of a growth control pathway which is at least partially redundant with the cAMP pathway
-
-
-
additional information
?
-
P11792
the enzyme positively regulates the progression of yeast cells through the G1 phase of the cell cycle
-
-
-
additional information
?
-
-
deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy
-
-
-
additional information
?
-
-
AKT1 gene is not a major contributor to susceptibility to type II diabetes mellitus in Ashkenazi Jews
-
-
-
additional information
?
-
O00141
K+-channel activation by all three isoforms of serum-dependent and glucocorticoid-dependent protein kinase SGK
-
-
-
additional information
?
-
-
the enzyme acts in concert with Akt to propagate the effects of PI3K activation within the nucleus and to mediate the biological outputs of PI3K signaling, including cell survival and cell cycle progression
-
-
-
additional information
?
-
-
NPH1 is an autophosphorylating flavoprotein photoreceptor mediating phototropic responses in higher plants
-
-
-
additional information
?
-
O42626
the enzyme is required to repress entry into the conidiation program
-
-
-
additional information
?
-
Q9WVC6
induction of enzymatically active Sgk functions as a key cell survival component in response to different environmental stress stimuli
-
-
-
additional information
?
-
-
transcript levels are strongly altered during anisotonic and isotonic cell volume changes
-
-
-
additional information
?
-
P31751
AKT2 may contribute to the pathogenesis of ovarian carcinomas
-
-
-
additional information
?
-
P42818
enzyme may function in the adaptation of plant cells to cold or high-salt conditions
-
-
-
additional information
?
-
P22204, P32328
the DBF20 mRNA is expressed at a low level and not under cell-cycle control
-
-
-
additional information
?
-
P21901
kinase plays a part in regulating events associated with fertilization
-
-
-
additional information
?
-
P22204, P32328
DBF2 mRNA is expressed under cell-cycle control at or near START
-
-
-
additional information
?
-
P12688, P18961
enzyme is required for cell growth
-
-
-
additional information
?
-
-
atpk1 is involved in the control of plant growth and development
-
-
-
additional information
?
-
-
DBF2 is likely to encode a protein kinase that may function in initiation of DNA synthesis and also in late nuclear division
-
-
-
additional information
?
-
Q06226
the enzyme is transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells, hormone-regulated protein kinase gene with a functionally defined p53 promoter recognition element
-
-
-
additional information
?
-
-
the enzyme is transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells, hormone-regulated protein kinase gene with a functionally defined p53 promoter recognition element
-
-
-
additional information
?
-
-
induction of sgk gene may be associated with a series of axonal regenerations after brain injury, and in addition, the sgk gene may also play important roles in the development of particular groups of neurons in the postnatal brain
-
-
-
additional information
?
-
P42818
may function in the adaptation of plant cells to cold or high-salt conditions
-
-
-
additional information
?
-
Q06226
enzyme is induced during ovarian cell differentiation
-
-
-
additional information
?
-
-
T-PK may have specialized functions in different areas of central nervous system. Alterations of this complex expression pattern can be responsible for the mental status impairment observed in myotonic dystrophy patients
-
-
-
additional information
?
-
-
enzyme may have a role in the development of mental symptoms in severe cases of myotonic dystrophy
-
-
-
additional information
?
-
-
the enzyme is highly regulated at the transcriptional level by glucocorticoid hormones
-
-
-
additional information
?
-
Q06226
SGK is a component of the phosphoinositide 3 (PI 3)-kinase signaling pathway
-
-
-
additional information
?
-
Q9Z1M4
enzyme is important for cell growth
-
-
-
additional information
?
-
P51812
mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation
-
-
-
additional information
?
-
-
mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation
-
-
-
additional information
?
-
Q9UK32
ribosomal S6-kinase RSK4 is commonly deleted in patients with complex X-linked mental retardation, RSK4 plays a role in normal neuronal development. RSK4 is completely deleted in eight patients with the contiguous gene syndrome including MRX, partially deleted in a patient with DFN3 and present in patients with an Xq21 deletion and normal intellectual abilities
-
-
-
additional information
?
-
-
decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy
-
-
-
additional information
?
-
-
inherited defects in insulin-stimulated activation of muscle glycogen synthesis in patients with insulin-resistant NIDDM may be located further upstream of ISPK-1 in the insulin action cascade
-
-
-
additional information
?
-
Q60823
Akt2 expression is activated during cellular differentiation and suggest that it functions in the signaling pathways of some adult tissues
-
-
-
additional information
?
-
-
associates with mitotic structures in a stage dependent manner and is required for chromosome segregation
-
-
-
additional information
?
-
P24719
protein kinase is required for meiotic recombination
-
-
-
additional information
?
-
P38991
type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation, required during the later part of each cell cycle
-
-
-
additional information
?
-
-
required for chromosome synapsis and recombination
-
-
-
additional information
?
-
-
enzyme plays a critical role in regulation by carbon catabolite repression
-
-
-
additional information
?
-
O88866
the enzyme plays a role in development
-
-
-
additional information
?
-
-
nim1+ is a negative regulator of the wee1+ mitotic inhibitor, another protein kinase homolog. The combined mitotic induction activities of nim1+ and cdc25+ counteract the wee1+ mitotic inhibitor in a regulatory network that appears also to involve the cdc2+ protein kinase, which is required for mitosis
-
-
-
additional information
?
-
-
Chk1 acts as an integrator for Atm and Atr signals and may be involved in monitoring the processing of meiotic recombination CHK1 gene is a candidate tumor suppressor gene
-
-
-
additional information
?
-
-
enzyme plays a role in germ line establishment
-
-
-
additional information
?
-
-
kinase functions downstream of ATM protein in the cellular response to DNA damage
-
-
-
additional information
?
-
-
in response to DNA damage, Chk1 phosphorylates and inhibits Cdc25C, thus preventing activation of the Cdc2-cyclin B complex and mitotic entry
-
-
-
additional information
?
-
-
in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis
-
-
-
additional information
?
-
Q9Z265
in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis
-
-
-
additional information
?
-
-
heterozygous germ line mutations in hCHK2 occur in Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in the TP53 gene. hCHK2 is a tumor suppressor gene conferring predisposition to sarcoma, breast cancer, and brain tumors
-
-
-
additional information
?
-
O70405
Unc51.1 signals the program of gene expression leading to the formation of granule cell axons
-
-
-
additional information
?
-
-
required to give a normal cell cycle response to nitrogen starvation
-
-
-
additional information
?
-
Q9GM70
kinase-related apoptosis-inducing protein kinase 1 may play an important role in the core apoptosis program in osteoclast
-
-
-
additional information
?
-
-
required for alteration of growth polarity and actin localization
-
-
-
additional information
?
-
O15075
likely role for DCAMKL1 transmembrane protein in developing and adult brain, possibly in a pathway of cortical development
-
-
-
additional information
?
-
-
Cdc25 mitotic inducer is targeted by chk1 DNA damage checkpoint kinase
-
-
-
additional information
?
-
-
enzyme controls the DNA damage response
-
-
-
additional information
?
-
-
enzyme mediates checkpoint pathway
-
-
-
additional information
?
-
-
required for pattern formation within embryonic segments and imaginal discs, possible roles of the FUSED protein in signal transduction pathways required for intercellular communication at different stages of development
-
-
-
additional information
?
-
P38990
Pak1 may function by modifying and partially stabilizing thermolabile DNA polymerases, perhaps during DNA repair
-
-
-
additional information
?
-
-
chk1 protein kinase links the rad checkpoint pathway to cdc2
-
-
-
additional information
?
-
P38147
Chk1 is required for function of the DNA damage checkpoint in Saccharomyces cerevisiae
-
-
-
additional information
?
-
P22987
important for growth polarity
-
-
-
additional information
?
-
P52497
enzyme is essential for the derepression of catabolic repression
-
-
-
additional information
?
-
P53104
the enzyme is required for the autophagic process in Saccharomyces cerevisiae
-
-
-
additional information
?
-
Q12263
deletion of GIN4 is not lethal but leads to a striking reorganization of the septins accompanied by morphogenetic abnormalities and a defect in cell separation
-
-
-
additional information
?
-
-
the enzyme is a regulator of G2/M progression and cytokinesis
-
-
-
additional information
?
-
Q15831
mutations of STK11 cause Peutz-Jeghers syndrome
-
-
-
additional information
?
-
-
kinase Cdr2 regulates the onset of mitosis in fission yeast
-
-
-
additional information
?
-
-
Peutz-Jeghers syndrome is an autosomal-dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer, germline mutations in STK11, probably in conjunction with acquired genetic defects of the second allele in somatic cells, cause the manifestations of PJ syndrome
-
-
-
additional information
?
-
-
enzyme plays a major role in the regulation of lipid metabolism, be involved in the regulation of a wide range of metabolic pathways
-
-
-
additional information
?
-
Q02723
RKIN1 protein has a role in the control of carbon metabolism in endosperms of rye
-
-
-
additional information
?
-
Q6DE87
Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control
-
-
-
additional information
?
-
Q00372
the enzyme is essential for the derepression of glucose repression, interacts with additional regulatory pathways and affects the expression of multiple target genes
-
-
-
additional information
?
-
Q6DE87
the damage/replication G2 checkpoint kinase Chk1 phosphorylates and inhibits Cdc25C, a Cdc2 Tyr-15 phosphatase, thereby directly linking the G2 checkpoint to negative regulation of Cdc2. Might function either as a G2 checkpoint kinase or as an ordinary cell cycle regulator in prophase-I-arrested oocytes
-
-
-
additional information
?
-
-
Peutz-Jeghers syndrome is the first cancer-susceptibility syndrome to be identified that is due to inactivating mutations in a protein kinase, STK11
-
-
-
additional information
?
-
-
the enzyme is a key component of the DNA replication-monitoring S/G2 checkpoint system. Its primary role is to monitor DNA synthesis by interacting with DNA polymerase alpha and send a signal to block the onset of mitosis while DNA synthesis is in progress
-
-
-
additional information
?
-
P53682
enzyme is involved in the synthesis of seed storage compounds during seed development
-
-
-
additional information
?
-
Q38997
may play an important role in a signal transduction cascade regulating gene expression and carbohydrate metabolism
-
-
-
additional information
?
-
Q23023
protein phosphorylation by the unc-51 product is important for axonal elongation and possibly for axonal guidance
-
-
-
additional information
?
-
Q02720
the enzyme is essential for vegetative growth of Dictyostelium discoideum, the alpha subunit is expressed constitutively like its mRNA during the life cycle
-
-
-
additional information
?
-
P19139
enzyme is implicated in the control of cell growth and proliferation. Androgenic regulation of CK-2 gene transcription is not an early event related to androgen action, but is substantial in the prereplicative phase of prostatic cell proliferation mediated by androgen. Androgenic stimulation of the mRNA expression for the alpha and beta subunits of CK-2 appears to be differential
-
-
-
additional information
?
-
P18334
translational and/or post-translational mechanisms play an important role in the developmental regulation of casein kinase II activity
-
-
-
additional information
?
-
-
plays a role in the translation of cell polarity into polarized growth, but not in the establishment of polarity itself
-
-
-
additional information
?
-
-
key regulatory enzyme involved in many cellular processes, including the control of growth and cell division
-
-
-
additional information
?
-
Q60737
the casein kinase II gene can serve as an oncogene, and its dysregulated expression is capable of transforming lymphocytes in a two-step pathway with c-myc
-
-
-
additional information
?
-
O54833
unbalanced expression of CK2 catalytic subunit synergizes with Ha-ras in cell transformation
-
-
-
additional information
?
-
Q13523
NH2-terminal region of hPRP4 may play regulatory roles under an unidentified signal transduction pathway through Clk1
-
-
-
additional information
?
-
-
enzyme is involved in pre-mRNA splicing
-
-
-
additional information
?
-
-
calmodulin-binding region of titin can play a regulatory role for the enzyme
-
-
-
additional information
?
-
-
the cek1+ gene is not an essential gene. Protein phosphorylation by cek1 may facilitate the progression of anaphase through direct or indirect interaction with the cut8 protein
-
-
-
additional information
?
-
Q13043, Q13188
enzyme may function at an early step in phosphorylation events that are specific responses to some forms of chemical stress or extreme heat shock
-
-
-
additional information
?
-
P51955, P51956
Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2, may function at the onset of mitosis
-
-
-
additional information
?
-
-
AfsK is a Hanks-type protein kinase
-
-
-
additional information
?
-
-
enzyme is involved in stress response and adaptation to environmental changes in mycobacteria
-
-
-
additional information
?
-
-
glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26, phosphorylating tau protein at serine and threonine residues
-
-
-
additional information
?
-
-
GSK-3 affects the tau-mRNA splicing of exon 10 via phosphorylation of the splicing factors of the serine/arginine-rich splicing factor SR family, e.g. SC35, leading to priming and dislocation of the splicing factor, aberrant tau splicing contributes to tauopathies including Alzheimer's disease, overview
-
-
-
additional information
?
-
-
GSK3beta works coordinatedly with PKA, EC 2.7.11.11, on tau phosphorylation
-
-
-
additional information
?
-
-
HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in hepatoma cells, HIPK2 triggers promyelotic leukemia nuclear body disruption and release of Daxx
-
-
-
additional information
?
-
-
isozyme RSK1, i.e. 14-3-3, is regulated by inhibitory binding of 14-3-3beta, a RSK1-binding protein, to Lys49 of the enzyme, Lys49 is also responsible for interaction of RSK1 with Bcr, Raf, and Cbl
-
-
-
additional information
?
-
O30245
kinase Rio2 is required for rRNA cleavage in 40S ribosomal subunit maturation
-
-
-
additional information
?
-
-
mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase
-
-
-
additional information
?
-
-
mechanism of S6K2 regulation via phosphorylation and autoinhibition with T338 playing the key role, S6K2 is regulated in a mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase MEK-dependent manner, overview
-
-
-
additional information
?
-
-
naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of organisms with Alzheimer's disease leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of patients suffering Alzheimer's disease leads to age-dependent memory deficits
-
-
-
additional information
?
-
-
naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of patients suffering Alzheimer's disease leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of patients suffering Alzheimer's disease leads to age-dependent memory deficits
-
-
-
additional information
?
-
Q9SDY2
NTHK2 is an ethylene receptor protein
-
-
-
additional information
?
-
-
phosphorylated tau is important in cytoskeleton assembly
-
-
-
additional information
?
-
-
phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis
-
-
-
additional information
?
-
-
photoregulation of phototropin, overview
-
-
-
additional information
?
-
-
PKD2 regulation involving ligand-binding domains of the enzyme, isozyme PKD2 might play a role in the nucleus after activation by G protein-coupled receptors, overview, intracellular trafficking of PKD2, overview
-
-
-
additional information
?
-
-
protein kinase StkP and Mn2+-dependent cytosolic protein phosphatase PhpP act as a functional pair in vivo
-
-
-
additional information
?
-
-
regulation mechanism and biological function of PKN
-
-
-
additional information
?
-
-
regulation mechanism and biological function of PKN, PKNalpha is involved in insulin-induced actin cytoskeleton reorganization and cell adhesion, overview, isozyme PKNalpha is involved in glucose transport in 3T3/L1 cells
-
-
-
additional information
?
-
-
regulation mechanism and biological function of PKN, PKNalpha is involved in insulin-induced actin cytoskeleton reorganization and cell adhesion, overview, PKNalpha is involved in vesicle transport in the endoplasmic reticulum, PKNalpha is cleaved by caspase-3 or related proteases in apoptotic Jurkat and U-937 cells contributing to signal transduction, PKN interacts with papillomaviral oncoproteins being involved in tumorigenesis, overview
-
-
-
additional information
?
-
-
regulation mechanism and biological function of PKN, PKNalpha is involved in insulin-induced actin cytoskeleton reorganization, overview
-
-
-
additional information
?
-
-
regulation mechanism and biological function of PKN, the enzyme is involved in cell cycle control
-
-
-
additional information
?
-
Q9BXA6
serine/threonine protein kinase is SSTK essential for male fertility
-
-
-
additional information
?
-
Q925K9
serine/threonine protein kinase SSTK is essential for male fertility, a DNA condensation defect in SSTK null mutants occurred in elongating spermatids at a step in spermiogenesis coincident with chromatin displacement of histones by transition proteins
-
-
-
additional information
?
-
-
tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain, inhibition of tau hyperphosphorylation inhibits an associated loss in spatial memory
-
-
-
additional information
?
-
-
the enzyme participates in Alzheimer's disease
-
-
-
additional information
?
-
-
WKN1 and WKN4 are involved in regulation of ion transport across diverse epithelia, WKN4 reduces the activity of Na-Cl-cotransporter activity and the potassium channel ROMK by reducing their appearance in the plasma membrane
-
-
-
additional information
?
-
-
WNK1 causes a hereditary form of hypertension, pseudohypoaldosteronism type II
-
-
-
additional information
?
-
-
CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling by activation of Akt and inactivation of SGK1 through protein phosphatase 2A
-
-
-
additional information
?
-
-
CK2 is a highly conserved serine/threonine kinase involved in several intracellular pathways, which control, among others, cell cycle, proliferation, apoptosis and transformation, overview, protein kinase AKT interacts with CK2 subunits in vivo as well as in vitro enhancing AKT activity, overview
-
-
-
additional information
?
-
-
CK2 is involved in phosphorylation of a large portion of the proteome, overview, increased enzyme activity in associated with a number of pathological processes, including cancer, infectious diseases, neurodegeneration, and cardiovascular pathologies playing a global anti-apoptotic role, overview
-
-
-
additional information
?
-
-
CK2 phosphorylates about 300 different cellular proteins, ranging from transcription factors to proteins involved in chromatin structure and cell division, CK2 induces neoplastic growth when overexpressed
-
-
-
additional information
?
-
-
CK2 plays a role in the protection of cells from apoptosis via the regulation of tumor suppressor and oncogene activity and stability, e.g. in the NF-kappaB or the Wnt signaling pathways, molecular mechanisms, detailed overview, CK2 activity is linked to Her-2/neu oncogene, which is overexpressed in 30% of breast cancers, regulation of apoptotic machinery by CK2 and its anti-apoptotic effect, overview, role of CK2 in chromosomal DNA strand break repair and the maintenance of genomic integrity, mutational study, overview
-
-
-
additional information
?
-
-
high CK2 activity occurs in solid tumors due to growth-related functions and to suppression of cellular apoptosis, nuclear localization of domain CK2alpha is associated with high-grade tumors and a poor prognostic factor, overview
-
-
-
additional information
?
-
-
members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt, overview
-
-
-
additional information
?
-
-
multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase
-
-
-
additional information
?
-
A3QQQ9, A3QQR1, A9P6P7, A9P6P9
phosphorylation on serine/threonine or tyrosine residues of target proteins is an essential and significant regulatory mechanism in signal transduction during many cellular and life processes, including spermatogenesis, oogenesis and fertilization, overview
-
-
-
additional information
?
-
-
RSK2 is a critical serine/threonine kinase for the regulation of cell transformation, RSK is regulated by the tumor promoters epidermal growth factor EGF or 12-O-tetradecanoylphorbol-13-acetate, TPA, overview
-
-
-
additional information
?
-
-
SpkA is a regulator of expression of three putative pilA operons, formation of thick pili, and cell motility, DNA microarray and electron microscopy analysis, overview
-
-
-
additional information
?
-
-
the enzyme alters localization of lamin A/C in infected cells, recombinantly expressed lamin as GFP-tagged protein in Hep-G2 cells, enzyme inactivation causes capsids to aggregate aberrantly between the inner and outer nuclear membranes within evaginations/extensions of the perinuclear space, overview, US3 kinase activity regulates HSV-1 capsid nuclear regress at least in part by phosphorylation of lamin A/C
-
-
-
additional information
?
-
-
the enzyme inhibits NF-kappaB activity via interaction with the leucine-rich repeat domain of the Salmonella enterica serovar typhimurium-derived effector SspH1 in infected intestine-407 cells, overview
-
-
-
additional information
?
-
Q6E0B2
the enzyme is involved in the inflammation cascade in intestine and colon epithelium
-
-
-
additional information
?
-
-
the eukaryotic-type serine/threonine protein kinase StkP is a global regulator of gene expression in Streptococcus pneumoniae, and is important for the resistance of the organism to various stress conditions, StkP positively controls the transcription of a set of genes encoding functions involved in cell wall metabolism, pyrimidine biosynthesis, DNA repair, iron uptake, and oxidative stress response, overview
-
-
-
additional information
?
-
-
enzyme binds both soluble inositol polyphosphates and inositol phospholipids
-
-
-
additional information
?
-
-
Glc7 promotes resumption of DNA replication by inactivating Rad53
-
-
-
additional information
?
-
-
KpnK specifically phosphorylates serine and threonine residues, and KpnK shows autophosphorylation activity
-
-
-
additional information
?
-
-
AfsK is a Hanks-type protein kinase
-
-
-
additional information
?
-
Streptococcus pneumoniae CP1015
-
the eukaryotic-type serine/threonine protein kinase StkP is a global regulator of gene expression in Streptococcus pneumoniae, and is important for the resistance of the organism to various stress conditions, StkP positively controls the transcription of a set of genes encoding functions involved in cell wall metabolism, pyrimidine biosynthesis, DNA repair, iron uptake, and oxidative stress response, overview
-
-
-
additional information
?
-
Streptococcus pneumoniae Cp 1015
-
protein kinase StkP and Mn2+-dependent cytosolic protein phosphatase PhpP act as a functional pair in vivo
-
-
-
additional information
?
-
Klebsiella pneumoniae MGH78578
-
KpnK specifically phosphorylates serine and threonine residues, and KpnK shows autophosphorylation activity
-
-
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
3-phosphoinositide
O55173
enzyme is dependent on
3-phosphoinositide
Q9Z2A0
enzyme is dependent on
ATP
-
binding site structure
ATP
-
dependent on, cannot be substituted by other nucleotide triphosphates like CTP or GTP
ATP
Q99PS2, Q9JJ75, Q9JJ76
;
ATP
Q709M0, Q709M1
;
ATP
-
binding site structure involving Lys233
ATP
-
binding structure involving residues K168, S53, and D166, overview
ATP
-
the ATP binding site of TPL2 is located between the N-lobe and C-lobe of the kinase domain
ATP
-
physicochemical properties of amino acid residues in the ATP-binding site of the enzyme, overview. Nine residues are identified that line the surface of the adenine-binding pocket, and ESTPKs are classified based on these signatures
flavin
-
flavoprotein; LOV1 and LOV2 may be flavin-binding domains that regulate kinase activity in response to blue light-induced redox changes
FMN
-
apoprotein noncovalently binds FMN to form the holoprotein nph1
MgATP2-
O66844
preferred substrate
MnATP2-
O66844
-
MnGTP2-
O66844
-
additional information
-
no activity with GTP
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
-
autophosphorylation activity is repressed upon addition of Ca2+/calmodulin
Ca2+
P28583
activity is dependent on
Ca2+
P49101
enzyme contains a neural visinin-like calcium-binding domain
Ca2+
P53682
enzyme is dependent on Ca2+
Ca2+
P53683, P53684
enzyme is dependent on Ca2+; enzyme is dependent on Ca2+
Ca2+
-
3-6fold stimulation
Ca2+
Q62915
N-terminal Ca2+, calmodulin-dependent protein kinase sequence
Ca2+
-
has regulatory function for NDR protein kinase, mechanism, overview
Ca2+
Q9SDY2
can substitute for Mn2+ in serine/threonine kinase activity
Ca2+
-
can partly substitute for Mn2+, activates
Ca2+
Q06850
dependent on
Ca2+
-
can only poorly substitute for Mn2+
Ca2+
-
dependent on, the enzymes contain calmodulin-like calcium binding domains, the EF-hands. The plant isozymes display highly variable calcium-dependences for their kinase activities: seven CPKs from subgroups 1 and 2 are clearly sensitive to calcium with different intensities, whereas six CPKs from subgroup 3 exhibit low or no calcium sensitivity to two generic substrates. But all plant isozymes bind calcium, except for CPK25, which is calcium-independent owing to the absence of functional EF-hands. Calcium binding differentially affects CDPK isoforms that may be activated by distinct molecular mechanisms
Ca2+
-
low activity, can only partly substitute for Mn2+
Ca2+
Q9ZSA2
dependent on. The CaM-like domain of CPK21 contains, like calmodulin, four single consensus EF-hand motifs forming two pairs of calciumbinding sites
Co2+
-
requirement, 1-10 mM, can replace Mg2+ to some extent, inhibits above 30 mM
High ionic strength
-
activation, e.g. NaCl, NH4Cl, KCl, sodium acetate, essential for maximal phosphate incorporation with protamine as substrate, histone phosphorylation is suppressed
Mg2+
Q91604
reaction prefers Mn2+ to Mg2+
Mg2+
Q62761, Q62762, Q62763
,autophosphorylation when incubated with ATP and Mg2+
Mg2+
-
requirement
Mg2+
-
inhibits above 30 mM; requirement
Mg2+
-
1.5 mM (mitochondrial kinase)
Mg2+
-
requirement
Mg2+
-
10 mM; activation
Mg2+
-
10 mM (cytosolic kinase); 1.5 mM (mitochondrial kinase); Km-values: 1.8 mM (cytosolic kinase) and 0.04 mM (mitochondrial kinase); requirement
Mg2+
-
1 mM (eIF-4E as substrate)
Mg2+
-
requirement
Mg2+
-
binding site structure
Mg2+
Q6TQF8
-
Mg2+
-
Mg2+ or Mn2+, dependent on
Mg2+
Q709M0, Q709M1
;
Mg2+
-
less effective than Mn2+
Mg2+
-
maximal kinase activity is detected in the presence of up to 5-10 mM Mg2+
Mg2+
-
potential divalent metal ion cofactors Mn2+ and Mg2+
Mg2+
-
required
Mg2+
-
dependent on
Mg2+
Q97ZY9
activity requires the presence of a divalent metal ion cofactor. Mn2+ is most effective at supporting protein kinase activity. Mg2+ is moderately effective, while Ca2+, Ni2+, and Zn2+ are ineffective as cofactors
Mn2+
Q91604
reaction prefers Mn2+ to Mg2+
Mn2+
-
can replace Mg2+ to some extent; inhibits above 30 mM; requirement, 1-10 mM
Mn2+
-
can replace Mg2+ with 20% efficiency
Mn2+
-
can replace Mg2+ with 8% efficiency
Mn2+
-
preferred cation, StkP
Mn2+
-
preferred cation, optimal at 10 mM
Mn2+
-
Mg2+ or Mn2+, dependent on
Mn2+
Q9SDY2
dependent on, required for serine/threonine kinase activity
Mn2+
-
strictly required, activates
Mn2+
Q709M0, Q709M1
;
Mn2+
-
-
Mn2+
-
preferred metal ion cofactor, especially for the autophosphorylation reaction
Mn2+
-
preferred metal ion cofactor
Mn2+
-
preferred cofactor, maximal kinase activity is detected in the presence of up to 5 mM Mn2+
Mn2+
-
potential divalent metal ion cofactors Mn2+ and Mg2+
Mn2+
-
enzyme KpnK is dependent on Mn2+
Mn2+
-
activates
Mn2+
-
required
Mn2+
-
can substitute for Mg2+
Ni2+
-
can only poorly substitute for Mn2+
Zn2+
-
bound to the zinc finger core at residues 105-147 and coordinated by Cys109, Cys114, Cys137 ans Cys140, of the beta subunit dimer
Zn2+
-
can only partially substitute for Mn2+
Mn2+
Q97ZY9
activity requires the presence of a divalent metal ion cofactor. Mn2+ is most effective at supporting protein kinase activity. Mg2+ is moderately effective, while Ca2+, Ni2+, and Zn2+ are ineffective as cofactors
additional information
-
no activation by Ca2+ or Zn2+
additional information
-
divalent cations are required for activity
additional information
-
no activity with cations other than Mg2+ or Mn2+
additional information
Q9SDY2
the enzyme shows Mn2+-dependent serine/threonine kinase and Ca2+-dependent histidine kinase, EC 2.7.13.3, activities
additional information
-
no activity with Mg2+ alone, no activity with Cu2+ or Zn2+
additional information
-
no activity with Zn2+, Ni2+, and Mg2+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(5-oxo-5,6-dihydroindolo[1,2-a]quinazolin-7-yl)acetic acid
-
i.e. IQA
(5Z)-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylidene)-2-thioxoimidazolidin-4-one
-
-
(S)-2-(2-aminopyrimidiny-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridinione
-
-
(Z)-5-(4-propoxybenzylidene) thiazolidine-2,4-dione
-
a Pim-2 inhibitor
-
1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine
-
i.e. ML-9, 0.5-1.0 mM, 50% inhibition
-
1-(5-isoquinolinylsulfonyl)-2-methylpiperazine
-
i.e. H-7
-
1-oleoyl-2-acetylglycerol
-
inhibits phorbol ester binding
14-3-3beta
-
a p90 ribosomal S6 kinase isoform 1-binding protein that negatively regulates RSK1 kinase activity, interaction via Lys49 of 14-3-3beta and S154 of phosphorylated RSK1, phosphorylation of RSK1 is required for interaction, no binding of mutant 14-3-3beta K49Q or K49A
-
2-(2-aminopyrimidin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
-
-
2-Aminopurine
-
-
2-chloro-N-(4-(5-fluoro-2-(4-hydroxyphenylamino)pyrimidin-4-ylamino)phenyl)benzamide
O14965
-
2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole
-
i.e DMAT
2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole
-
i.e. DMAT
2-phenyl-5-(pyridin-4-yl)-1H-pyrrole-3-carboxamide
-
-
3,8-dibromo-7-hydroxy-4-methyl-2H-chromen-2-one
-
i.e. DBC
3-{3-[4-(1-Methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl carbamimidothioate
-
-
4,5,6,7-tetrabromo-1H-benzotriazole
-
i.e. TBB
4,5,6,7-tetrabromobenzimidazole
-
i.e. TBBz or TBI
4-(2-(4-(2-(4-acetylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)-N-(2-chlorophenyl)benzamide
O14965
-
4-hydroxy-trans-2-nonenal
-
i.e. 4-HNE, binds to the enzyme at Lys197 and inhibits its activity by 69% by inhibiting its posttranslational phosphorylation. 4-HNE binding has no effect on the association of LKB1 with its adaptor proteins, sterile-20-related adaptor and mouse protein 25
5-fluoro-N2,N4-bis(4-methoxyphenyl)pyrimidine-2,4-diamine
O14965
-
5-fluoro-N2,N4-di(m-tolyl)pyrimidine-2,4-diamine
O14965
-
6-(3-chlorophenyl)-4-(1H-indazol-5-yl)pyrimidin-2(1H)-one
-
-
7,9-dimethyl-8-(prop-2-en-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amine
-
-
8-hydroxy-4-methyl-9-nitro-2H-benzo[g]chromen-2-one
-
i.e. NBC
AKTX
-
Akt inhibitor
-
alsterpaullone
-
inhibition of AMPK, GSK3beta, S6K1, PKBalpha, PDK1, MAPKAP-K2
alsterpaullone
-
weak inhibition of CK1, inhibition of CK2, and slightly of MAPKAP-K1a
AMP-PNP
-
ATP analogue adenosine 5'-(beta,gamma-imino)triphosphate
AMP-PNP
-
ATP analogue adenosine 5'-(beta,gamma-imino)triphosphate
apigenin
-
a CKII-specific inhibitior
apigenin
-
-
ATP
-
substrate inhibition. At ATP concentrations above 0.1 mM, kinase activity begins to drop until at 100 mM it becomes almost unmeasurable
auoinhibitory domain of S6K1
-
-
-
Baicalin
-
one of the major compounds in the Chinese medical herb Scutellaria baicalensis, reduces enzyme expression and activity in badder cancer cells T24
benzene 1,2,3,4-tetrakisphosphate
-
-
benzene 1,2,3,5-tetrakisphosphate
-
-
benzene 1,2,3-trisphosphate
-
-
benzene 1,2,4,5-tetrakisphosphate
-
-
benzene 1,2,4-trisphosphate
-
-
benzene 1,3,5-trisphosphate
-
-
biphenyl 2,3',4,5',6-pentakisphosphate
-
-
BMS-863233
-
-
Ca2+
-
-
Ca2+
-
mitochondrial kinase, not cytosolic
Ca2+
-
not
Catalytic subunit of protein phosphatase 2A
-
-
-
Catalytic subunit of protein phosphatase 2A
-
Mg2+, Mn2+, Ca2+, EDTA, EGTA or vanadate does not; NaCl, diphosphate, phosphate, NaF or ATP protects
-
CKI-7
O15726
-
CKI-7
-
-
CKI-7
-
half-maximally at 0.0112 mM
Co2+
-
above 30 mM, activating below 20 mM
D-myo-Inositol 1,3,4,5-tetrakisphosphate
-
-
diC8-phosphatidylinositol 3,4,5-trisphosphate
-
-
EDTA
Q9SDY2
-
Ellagic acid
-
-
EmbR2
P9WI71
EmbR2, a homologue of EmbR, inhibits PknH by binding to at least two of the three threonine sites known to undergo autophosphorylation in PknH which leads to a dose-response inhibition of the autokinase activity. Moreover, EmbR2 inhibits PknH-dependent phosphorylation of EmbR in a dose-dependent manner
-
emodin
-
a CKII-specific inhibitior
emodin
-
-