Literature summary for 2.7.11.1 extracted from

Cahill, D.P.; Lengauer, C.; Yu, J.; Riggins, G.J.; Willson, J.K.; Markowitz, S.D.; Kinzler, K.W.; Vogelstein, B.
Mutations of mitotic checkpoint genes in human cancers (1998), Nature, 392, 300-303.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + a protein	Homo sapiens	in some cancers displaying chromosomal instability the loss of this checkpoint is associated with the mutational inactivation of a human homologue of the yeast BUB1 gene	ADP + a phosphoprotein	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O43683	-	-
Homo sapiens	O60566	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
thymus	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + a protein	in some cancers displaying chromosomal instability the loss of this checkpoint is associated with the mutational inactivation of a human homologue of the yeast BUB1 gene	Homo sapiens	ADP + a phosphoprotein	-	?

Synonyms

Synonyms	Comment	Organism
mitotic checkpoint serine/threonine-protein kinase BUB1	-	Homo sapiens
mitotic checkpoint serine/threonine-protein kinase BUB1 beta	-	Homo sapiens

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Release 2023.1 (January 2023)