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Literature summary for 2.7.11.1 extracted from

  • Karthikeyan, C.; Jharia, P.; Waiker, D.; Nusbaum, A.; Amawi, H.; Kirwen, E.; Christman, R.; Arudra, S.; Meijer, L.; Tiwari, A.; Trivedi, P.
    N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1delta/epsion inhibitors synthesis, biological evaluation and molecular modeling studies (2017), Bioorg. Med. Chem. Lett., 27, 2663-2667 .
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
6,7-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)quinazolin-4-amine elicits selective cytotoxic activity against the pancreas ductal adenocarcinoma (PANC-1) cell line Homo sapiens
harmine
-
 Homo sapiens
N-[5-(4-fluorophenyl)-1H-pyrazol-3-yl]-6,7-dimethoxyquinazolin-4-amine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P48730
-
-

Synonyms

Synonyms Comment Organism
casein kinase 1 delta
-
 Homo sapiens
CK1delta
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0014
-
 pH and temperature not specified in the publication Homo sapiens N-[5-(4-fluorophenyl)-1H-pyrazol-3-yl]-6,7-dimethoxyquinazolin-4-amine
0.0016
-
 pH and temperature not specified in the publication Homo sapiens 6,7-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)quinazolin-4-amine
0.0018
-
 pH and temperature not specified in the publication Homo sapiens harmine

General Information

General Information Comment Organism
drug target N-[5-(4-fluorophenyl)-1H-pyrazol-3-yl]-6,7-dimethoxyquinazolin-4-amine is a valuable lead molecules with great potential for CK1delta inhibitor development targeting neurodegenerative disorders and cancer Homo sapiens