Application | Comment | Organism |
---|---|---|
molecular biology | EmbR2 is a regulator of PknH activation, thus directly participating in the control of the PknH/EmbR pair | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EmbR2 | EmbR2, a homologue of EmbR, inhibits PknH by binding to at least two of the three threonine sites known to undergo autophosphorylation in PknH which leads to a dose-response inhibition of the autokinase activity. Moreover, EmbR2 inhibits PknH-dependent phosphorylation of EmbR in a dose-dependent manner | Mycobacterium tuberculosis | |
O6-cyclohexylmethylguanine | - |
Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WI71 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WI71 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | PknH autophosphorylates itsself | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + EmbR | PknH phosphorylates the transcriptional regulator EmbR, but not its homologue EmbR2 | Mycobacterium tuberculosis | ADP + phosphorylated-EmbR | - |
? | |
ATP + EmbR | PknH phosphorylates the transcriptional regulator EmbR, but not its homologue EmbR2 | Mycobacterium tuberculosis H37Rv | ADP + phosphorylated-EmbR | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mycobacterial serine/threonine protein kinase | - |
Mycobacterium tuberculosis |
PknH | - |
Mycobacterium tuberculosis |
serine-threonine kinase | - |
Mycobacterium tuberculosis |
StpK | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0011 | - |
- |
Mycobacterium tuberculosis | EmbR2 | |
0.005 | - |
- |
Mycobacterium tuberculosis | O6-cyclohexylmethylguanine |