Literature summary for 2.7.11.1 extracted from

Hess, G.F.; Drong, R.F.; Weiland, K.L.; Slightom, J.L.; Sclafani, R.A.; Hollingsworth, R.E.
A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines (1998), Gene, 211, 133-140.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	predominantly localized in	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00311	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	expressed in many normal tissues, but overexpressed in certain tumor types and all transformed cell lines examined. In some of the tumors tested, CDC7Hs expression correlates with expression of a proliferation marker, the histone H3 gene. In other cases, no such correlation was observed. CDC7Hs expression may be associated hyperproliferation in some tumors and neoplastic transformation in others	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + histone H1	-	Homo sapiens	ADP + phosphorylated histone H1	-	?

Synonyms

Synonyms	Comment	Organism
Cdc7Hs protein	-	Homo sapiens
cell division cycle 7-related protein kinase	-	Homo sapiens

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Release 2023.1 (January 2023)