Activating Compound | Comment | Organism | Structure |
---|---|---|---|
3',5'-AMP | not | Bos taurus | |
3',5'-AMP | i.e. cAMP, activation | Bos taurus | |
additional information | no activation by cGMP | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | mitochondrial kinase, not cytosolic | Bos taurus | |
KCl | not | Bos taurus | |
additional information | cGMP, heat-stable inhibitor of cAMP-dependent protein kinase; EGTA, calmodulin; heparin, Ca2+/calmodulin, phosphatidylserine and/or diolein (in the absence or presence of Ca2+); no inhibition by cAMP | Bos taurus | |
NaCl | not | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | two mitochondrial kinases I and II and a cytosolic kinase | Bos taurus | 5829 | - |
mitochondrion | two mitochondrial kinases I and II and a cytosolic kinase | Bos taurus | 5739 | - |
soluble | - |
Bos taurus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement | Bos taurus | |
Mg2+ | Km-values: 1.8 mM (cytosolic kinase) and 0.04 mM (mitochondrial kinase) | Bos taurus | |
Mg2+ | 1.5 mM (mitochondrial kinase) | Bos taurus | |
Mg2+ | 10 mM (cytosolic kinase) | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
43000 | - |
gel filtration | Bos taurus |
45000 | - |
1 * 45000, SDS-PAGE | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
cytosolic | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | cortex | Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
17.38 | - |
- |
Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + bovine serum albumin | mitochondrial protamine kinases | Bos taurus | ? | - |
? | |
ATP + bovine serum albumin | not cytosolic kinase | Bos taurus | ? | - |
? | |
ATP + bovine serum albumin | phosphorylated at 48% the rate of protamine | Bos taurus | ? | - |
? | |
ATP + casein | not mitochondrial protamine kinases | Bos taurus | ? | - |
? | |
ATP + casein | phosphorylated at 5% the rate of protamine, cytosolic kinase | Bos taurus | ? | - |
? | |
ATP + glycogen synthase | from rabbit skeletal muscle | Bos taurus | ? | - |
? | |
ATP + glycogen synthase | mitochondrial protamine kinases | Bos taurus | ? | - |
? | |
ATP + glycogen synthase | not cytosolic kinase | Bos taurus | ? | - |
? | |
ATP + glycogen synthase | phosphorylated at 15% the rate of protamine | Bos taurus | ? | - |
? | |
ATP + histone H1 | mitochondrial protamine kinases | Bos taurus | ? | - |
? | |
ATP + histone H1 | not cytosolic | Bos taurus | ? | - |
? | |
ATP + histone IIB | phosphorylated at 8% the rate of protamine, cytosolic kinase | Bos taurus | ? | - |
? | |
ATP + histone IIB | not mitochondrial protamine kinases | Bos taurus | ? | - |
? | |
ATP + protamine | preferred substrate | Bos taurus | ADP + O-phosphoprotamine | - |
? | |
ATP + protamine | no substrates are histone H4, ovalbumin, synthetic peptide poly(Glu,Tyr) (4:1) | Bos taurus | ADP + O-phosphoprotamine | - |
? | |
ATP + protamine | no substrates are GTP | Bos taurus | ADP + O-phosphoprotamine | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 45000, SDS-PAGE | Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.7 | 9 | broad, protamine as substrate | Bos taurus |