Activating Compound | Comment | Organism | Structure |
---|---|---|---|
gastrin | bind to the cysteine-rich domain C1b, activates, triggers nuclear accumulation of PPKD2 in AGS-B cancer cells | Homo sapiens | |
additional information | PKD2 is activated via G protein-coupled receptors | Homo sapiens | |
Phorbol esters | bind to the cysteine-rich domain C1b | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of EGFP- or FLAG-tagged wild-type or domain-deletion mutants of PKD2 in HEK-293 cells, gastric cancer AGS-B cells, and in PANC-1 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the pleckstrin homology PH domain is a negative regulator of PKD2 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
additional information | nucleocytoplasmic shuttling regulated by a CRm-1-dependent mechanism, involving the C1b domain, and the C1a domain containing a nuclear export signal sequence | Homo sapiens | - |
- |
nucleus | - |
Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | PKD2 regulation involving ligand-binding domains of the enzyme, isozyme PKD2 might play a role in the nucleus after activation by G protein-coupled receptors, overview, intracellular trafficking of PKD2, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | PKD2 performs autophosphorylation | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone H1 | PDK2 | Homo sapiens | ADP + phosphorylated histone H1 | - |
? | |
additional information | PKD2 regulation involving ligand-binding domains of the enzyme, isozyme PKD2 might play a role in the nucleus after activation by G protein-coupled receptors, overview, intracellular trafficking of PKD2, overview | Homo sapiens | ? | - |
? | |
additional information | PKD2 performs autophosphorylation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | PKD2 belongs to the PKD family of serine/threonine kinases | Homo sapiens |
PKD2 | - |
Homo sapiens |
protein kinase D2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |