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Literature summary for 2.7.11.1 extracted from

  • Zhang, W.; Inouye, M.; Inouye, S.
    Reciprocal regulation of the differentiation of Myxococcus xanthus by Pkn5 and Pkn6, eukaryotic-like Ser/Thr protein kinases (1996), Mol. Microbiol., 20, 435-447.
    View publication on PubMed
Search for more literature for 2.7.11.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Myxococcus xanthus
Pkn6-PhoA fusion protein expressed in Escherichia coli Myxococcus xanthus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Myxococcus xanthus 5737
-
membrane the Pkn6-PhoA fusion protein in Escherichia coli has a single transmembrane domain with the N-terminal domain in the cytoplasm and the C-terminal domain outside the cytoplasmic membrane Myxococcus xanthus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Myxococcus xanthus Pkn5 negatively regulates Myxococcus xanthus development ADP + a phosphoprotein
-
 ?
ATP + a protein Myxococcus xanthus expressed constitutively throughout the life cycle, with slight increases at an early stage of development ADP + a phosphoprotein
-
 ?
ATP + a protein Myxococcus xanthus Pkn6 may be a transmembrane sensor of external signals for development ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Myxococcus xanthus P54737
-
-
Myxococcus xanthus P54738
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein autophosphorylation only at Ser Myxococcus xanthus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein Pkn5 is autophosphorylated only at Ser Myxococcus xanthus ADP + a phosphoprotein
-
 ?
ATP + a protein Pkn6 is autophosphorylated both at Ser and Thr Myxococcus xanthus ADP + a phosphoprotein
-
 ?
ATP + a protein Pkn5 negatively regulates Myxococcus xanthus development Myxococcus xanthus ADP + a phosphoprotein
-
 ?
ATP + a protein expressed constitutively throughout the life cycle, with slight increases at an early stage of development Myxococcus xanthus ADP + a phosphoprotein
-
 ?
ATP + a protein Pkn6 may be a transmembrane sensor of external signals for development Myxococcus xanthus ADP + a phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
serine/threonine-protein kinase pkn5
-
 Myxococcus xanthus
serine/threonine-protein kinase pkn6
-
 Myxococcus xanthus