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Literature summary for 2.7.11.1 extracted from

  • Alessi, D.R.; Andjelkovic, M.; Caudwell, B.; Cron, P.; Morrice, N.; Cohen, P.; Hemmings, B.A.
    Mechanism of activation of protein kinase B by insulin and IGF-1 (1996), EMBO J., 15, 6541-6551.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
Insulin activated endogenous protein kinase B alpha12fold in L6 myotubes, while after transfection into 293 cells PKBalpha is activated 20fold and 50fold in response to insulin and IGF-1 respectively. In both cells, the activation of PKBalpha is accompanied by its phosphorylation at Thr308 and Ser473 Homo sapiens
additional information PKBalpha becomes phosphorylated and activated in insulin/IGF-1-stimulated cells by an upstream kinase(s) Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P31749
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Synonyms

Synonyms Comment Organism
protein kinase B alpha
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 Homo sapiens
RAC-alpha serine/threonine kinase
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 Homo sapiens
RAC/Akt kinase
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 Homo sapiens