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Literature summary for 2.7.11.1 extracted from

  • Seong, H.; Ha, H.
    Murine protein serine-threonine kinase 38 activates p53 function through Ser 15 phosphorylation (2012), J. Biol. Chem., 287, 20797-20810.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.1

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant GST-tagged MPK38 in human in MCF-7, HEK-293, H-1299, and HCT-116 cells, coexpression with FLAG-tagged p53 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of kinase-dead Mpk38 and enzyme knockout by Mpk38-specific siRNA Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme performs autophosphorylation Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + p53 protein at Ser15 Mus musculus ADP + phosphorylated p53 protein
-
 ?
additional information the enzyme performs autophosphorylation Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
MPK38
-
 Mus musculus
murine protein serine-threonine kinase 38
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
evolution MPK38 is a member of the AMPK family Mus musculus
physiological function MPK38 is functionally linked to the p53 signaling pathway. MPK38 directly associates with p53 without relying on additional proteins in mammalian cells. The C-terminal regulatory domain, residues 270-643, of MPK38 is responsible for p53 binding, while the N-terminal domain is unable to bind p53. Binding is mediated by the the DNA-binding domain and the basic domain, not by the transactivation domain, of p53, MPK38 interaction with p53 deletion mutants, overview. MPK38 acts as a positive regulator of p53, while expression of MPK38 itself has little effect on p53-induced transcription. MPK38 upregulates the expression of p53 targets in a kinase-dependent manner, and it promotes translocation of p53 from cytosol to the nucleus, overview. MPK38 stimulates p53-induced apoptosis and cell cycle arrest Mus musculus