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Literature summary for 2.7.11.1 extracted from

  • Cerda, O.; Caceres, M.; Park, K.; Leiva-Salcedo, E.; Romero, A.; Varela, D.; Trimmer, J.; Stutzin, A.
    Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca2+-activated non-selective cation channel TRPM4 (2015), Pflugers Arch., 467, 1723-1732 .
No PubMed abstract available
Search for more literature for 2.7.11.1

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + TRPM4 Homo sapiens i.e. transient receptor potential melastatin-like 4, phosphorylation at Ser839 ADP + phospho-TRPM4
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + TRPM4 i.e. transient receptor potential melastatin-like 4, phosphorylation at Ser839 Homo sapiens ADP + phospho-TRPM4
-
 ?
additional information TRPM4 phosphorylation site determination by peptide mapping Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
casein kinase 1
-
 Homo sapiens
CK1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function casein kinase 1 (CK1) phosphorylates S839 and is responsible for the basolateral localization of transient receptor potential melastatin-like 4, TRPM4, a plasma membrane Ca2+-activated non-selective cation channel expressed in a wide range of human tissues. TRPM4 participates in a variety of physiological processes such as T cell activation, myogenic vasoconstriction, and allergic reactions. Role for S839 phosphorylation in the basolateral expression of TRPM4 channels in epithelial cells. Human TRPM4 contains about 130 serine and threonine and about 27 tyrosine residues in its sequence that can be potentially phosphorylated by different kinases. CK1 activity regulates TRPM4 basolateral localization Homo sapiens