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Literature summary for 2.7.11.1 extracted from

  • Shang, P.; Baarends, W.; Hoogerbrugge, J.; Ooms, M.; Van Cappellen, W.; De Jong, A.; Dohle, G.; Van Eenennaam, H.; Gossen, J.; Grootegoed, J.
    Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases (2010), J. Cell Sci., 123, 331-339.
    View publication on PubMed
Search for more literature for 2.7.11.1

Cloned(Commentary)

Cloned (Comment) Organism
Tssk1 and Tssk2 genes are tandemly located on chromosome 16 separated by an intergenic region of only 3.06 kb Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of Tssk1/2 (+/-) and (-/-) knockout mice, the latter show male infertility and highly reduced sperm numbers, while unaltered body, testis, and epididymis weight, compared to the wild-type mice, phenotypes, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm associated with the cytoplasmic chromatoid body-derived ring structure Mus musculus 5737
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
spermatid accumulation of TSSK1 and TSSK2 in elongating spermatids, together with the testis-specific kinase substrate, in a ring-shaped structure around the base of the flagellum and in a cytoplasmic satellite. At later steps of spermatid differentiation, the ring is found at the caudal end of the newly formed mitochondrial sheath. TSSK1- and TSSK2-dependent functions of a transformed CB in post-meiotic cytodifferentiation of spermatids,overview Mus musculus
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testis
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 Mus musculus
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Synonyms

Synonyms Comment Organism
testis-specific serine/threonine kinase
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 Mus musculus
TSSK1
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 Mus musculus
TSSK2
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 Mus musculus

General Information

General Information Comment Organism
malfunction targeted deletion of the tandemly arranged genes Tssk1 and Tssk2 in mouse results in male infertility, with loss of the cytoplasmic chromatoid body-derived ring structure, and with elongating spermatids possessing a collapsed mitochondrial sheath Mus musculus
physiological function the enzyme is involved in spermatogenesis Mus musculus