Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of the enzyme-deletion mutant DELTApknE. Mutant DELTApknE in presence of stress (pH, surfactant and cell wall-damaging agents) and anti-tuberculosis drugs shows defective growth in pH 7.0 and lysozyme with better survival in pH 5.5, SDS, and kanamycin. DELTApknE is resistant to kanamycin | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WI77 | gene pknE | - |
Mycobacterium tuberculosis H37Rv | P9WI77 | gene pknE | - |
Synonyms | Comment | Organism |
---|---|---|
PknE | - |
Mycobacterium tuberculosis |
serine/threonine protein kinase | - |
Mycobacterium tuberculosis |
StpK | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
malfunction | the enzyme-deletion mutant DELTApknE shows in presence of stress (pH, surfactant and cell wall-damaging agents) and anti-tuberculosis drugs a defective growth in pH 7.0 and lysozyme (a cell wall-damaging agent) with better survival in pH 5.5, SDS, and kanamycin (a second-line anti-tuberculosis drug). DELTApknE is reduced in cell size during growth in liquid media and exhibits hypervirulence in a guinea pig model of infection | Mycobacterium tuberculosis |
physiological function | the enzyme is involved in the adaptive responses and contributes to the suppression of apoptosis | Mycobacterium tuberculosis |