Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(5Z)-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylidene)-2-thioxoimidazolidin-4-one | - |
Homo sapiens | |
(S)-2-(2-aminopyrimidiny-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridinione | - |
Homo sapiens | |
2-(2-aminopyrimidin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one | - |
Homo sapiens | |
2-phenyl-5-(pyridin-4-yl)-1H-pyrrole-3-carboxamide | - |
Homo sapiens | |
6-(3-chlorophenyl)-4-(1H-indazol-5-yl)pyrimidin-2(1H)-one | - |
Homo sapiens | |
7,9-dimethyl-8-(prop-2-en-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amine | - |
Homo sapiens | |
BMS-863233 | - |
Homo sapiens | |
N-ethyl-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-3a,6a-dihydro-1H-thieno[3,2-c]pyrazole-5-carboxamide | - |
Homo sapiens | |
N-[2-(4-fluorophenyl)ethyl]-5-[2-[(methylsulfonyl)amino]pyrimidin-4-yl]thiophene-2-carboxamide | - |
Homo sapiens | |
P53 | - |
Homo sapiens | |
PHA-767491 | nanomolar, ATP-competitive, Cdc7 inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Cdk2 interacting protein | Homo sapiens | - |
ADP + phosphorylated Cdk2 interacting protein | - |
? | |
ATP + cell division cycle 7 | Homo sapiens | - |
ADP + phosphorylated cell division cycle 7 | - |
? | |
ATP + claspin | Homo sapiens | - |
ADP + phosphorylated claspin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
additional information | both proteins show increased expression in 50% of the examined tumor cell lines of the NCI-60 panel and an additional panel of 5 leukemia cell lines. Expression is also confirmed in primary patient samples of breast, colon and lung | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Cdk2 interacting protein | - |
Homo sapiens | ADP + phosphorylated Cdk2 interacting protein | - |
? | |
ATP + cell division cycle 7 | - |
Homo sapiens | ADP + phosphorylated cell division cycle 7 | - |
? | |
ATP + claspin | - |
Homo sapiens | ADP + phosphorylated claspin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cdc7 kinase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000002 | - |
- |
Homo sapiens | (S)-2-(2-aminopyrimidiny-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridinione | |
0.000003 | - |
- |
Homo sapiens | 2-phenyl-5-(pyridin-4-yl)-1H-pyrrole-3-carboxamide | |
0.000005 | - |
- |
Homo sapiens | 6-(3-chlorophenyl)-4-(1H-indazol-5-yl)pyrimidin-2(1H)-one | |
0.000007 | - |
- |
Homo sapiens | 2-(2-aminopyrimidin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one | |
0.00001 | - |
- |
Homo sapiens | PHA-767491 | |
0.001 | - |
IC50 less than 0.001 mM | Homo sapiens | N-ethyl-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-3a,6a-dihydro-1H-thieno[3,2-c]pyrazole-5-carboxamide |