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Literature summary for 2.7.11.1 extracted from
- Casein kinase II-dependent phosphorylation of DNA topoisomerase II suppresses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast (2019), J. Biol. Chem., 294, 3772-3782 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + topoisomerase II | Schizosaccharomyces pombe | - |
ADP + phosphorylated topoisomerase II | - |
? |  |
| ATP + topoisomerase II | Schizosaccharomyces pombe 972 | - |
ADP + phosphorylated topoisomerase II | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schizosaccharomyces pombe | P40231 | - |
- |
| Schizosaccharomyces pombe 972 | P40231 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + topoisomerase II | - |
Schizosaccharomyces pombe | ADP + phosphorylated topoisomerase II | - |
? | |
| ATP + topoisomerase II | Ser1363 and Ser1364 in topoisomerase II are targeted by Cka1/CKII kinase | Schizosaccharomyces pombe | ADP + phosphorylated topoisomerase II | - |
? | |
| ATP + topoisomerase II | - |
Schizosaccharomyces pombe 972 | ADP + phosphorylated topoisomerase II | - |
? | |
| ATP + topoisomerase II | Ser1363 and Ser1364 in topoisomerase II are targeted by Cka1/CKII kinase | Schizosaccharomyces pombe 972 | ADP + phosphorylated topoisomerase II | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| casein kinase II | - |
Schizosaccharomyces pombe |
| CKII kinase | - |
Schizosaccharomyces pombe |
General Information
| General Information | Comment | Organism |
|---|---|---|
| drug target | possible benefits of applying CKII inhibitors in combination with topo II catalytic inhibitors for effective prevention of mitotic chromosome segregation in tumor cells | Schizosaccharomyces pombe |
| evolution | CKII-mediated phosphorylation of the topo II C-terminal domain appears to be evolutionarily conserved, including in humans | Schizosaccharomyces pombe |
| metabolism | attenuation of CKII-controlled topoisomerase II phosphorylation along with catalytic topo II inhibition may promote anticancer effects | Schizosaccharomyces pombe |
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