Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lithium | - |
Rattus norvegicus | |
additional information | phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase 3 | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + C/EBPalpha | Rattus norvegicus | - |
ADP + phosphorylated C/EBPalpha | - |
? | |
ATP + C/EBPbeta | Rattus norvegicus | - |
ADP + phosphorylated C/EBPbeta | - |
? | |
additional information | Rattus norvegicus | phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase 3 inducing dephosphorylation of C/EBPbeta important in regulation of gene expression during cell proliferation, differentiation, and apoptosis | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
osteoblast | - |
Rattus norvegicus | - |
UMR-106 cell | primary osteoblast cells | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + C/EBPalpha | - |
Rattus norvegicus | ADP + phosphorylated C/EBPalpha | - |
? | |
ATP + C/EBPalpha | phosphorylation at consensus sequence (S/T)XXX(S/T) with X representing any amino acid | Rattus norvegicus | ADP + phosphorylated C/EBPalpha | - |
? | |
ATP + C/EBPbeta | - |
Rattus norvegicus | ADP + phosphorylated C/EBPbeta | - |
? | |
ATP + C/EBPbeta | phosphorylation at multiple sites, preferably at Thr189 and Ser185, reduced activity with mutants T189A and S185A, mutation of either site appears to impair phosphorylation of neighbouring sites | Rattus norvegicus | ADP + phosphorylated C/EBPbeta | - |
? | |
additional information | phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3 | - |
Rattus norvegicus |
GSK-3beta | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |