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Literature summary for 2.7.11.1 extracted from

  • Zhao, X.; Zhuang, S.; Chen, Y.; Boss, G.R.; Pilz, R.B.
    Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3 (2005), J. Biol. Chem., 280, 32683-32692.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
lithium
-
Rattus norvegicus
additional information phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase 3 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + C/EBPalpha Rattus norvegicus
-
ADP + phosphorylated C/EBPalpha
-
?
ATP + C/EBPbeta Rattus norvegicus
-
ADP + phosphorylated C/EBPbeta
-
?
additional information Rattus norvegicus phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase 3 inducing dephosphorylation of C/EBPbeta important in regulation of gene expression during cell proliferation, differentiation, and apoptosis Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
osteoblast
-
Rattus norvegicus
-
UMR-106 cell primary osteoblast cells Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + C/EBPalpha
-
Rattus norvegicus ADP + phosphorylated C/EBPalpha
-
?
ATP + C/EBPalpha phosphorylation at consensus sequence (S/T)XXX(S/T) with X representing any amino acid Rattus norvegicus ADP + phosphorylated C/EBPalpha
-
?
ATP + C/EBPbeta
-
Rattus norvegicus ADP + phosphorylated C/EBPbeta
-
?
ATP + C/EBPbeta phosphorylation at multiple sites, preferably at Thr189 and Ser185, reduced activity with mutants T189A and S185A, mutation of either site appears to impair phosphorylation of neighbouring sites Rattus norvegicus ADP + phosphorylated C/EBPbeta
-
?
additional information phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3
-
Rattus norvegicus
GSK-3beta
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus